| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| - | vitro+vivo, | Lung, | NA |
| 5081- | SSE, | Application Notes and Protocols: Selenite as a Selenium Source in Cell Culture Media Supplementation |
| - | Review, | Var, | NA |
| 5080- | SSE, | Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1 |
| - | in-vitro, | GC, | HGC27 | - | in-vitro, | GC, | NCI-N87 |
| 5077- | SSE, | Antitumor effects of sodium selenite on acute lymphocytic leukemia |
| - | in-vitro, | AML, | NA |
| 5076- | SSE, | Sodium selenite inhibits the growth of cervical cancer cells through the PI3K/AKT pathway |
| - | in-vivo, | Cerv, | HeLa | - | in-vivo, | Cerv, | SiHa |
| 5075- | SSE, | Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma |
| - | vitro+vivo, | RCC, | 786-O |
| 5111- | SSE, | Sodium selenite induces apoptosis via ROS-mediated NF-κB signaling and activation of the Bax-caspase-9-caspase-3 axis in 4T1 cells |
| - | in-vitro, | BC, | 4T1 |
| 5110- | SSE, | Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells |
| - | in-vitro, | AML, | APL NB4 |
| 5108- | SSE, | Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis |
| - | in-vitro, | AML, | U937 |
| 5107- | SSE, | Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells |
| - | vitro+vivo, | AML, | APL NB4 |
| 5106- | SSE, | GSH, | Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells |
| - | in-vitro, | Liver, | HepG2 |
| 5105- | SSE, | Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells |
| - | in-vitro, | Pca, | LNCaP |
| 5089- | SSE, | Se, | Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line |
| - | in-vitro, | Pca, | LNCaP |
| 4739- | SSE, | Chemo, | Rad, | Therapeutic Benefits of Selenium in Hematological Malignancies |
| - | Review, | Var, | NA |
| 4742- | SSE, | Antitumor Effects of Selenium |
| - | Review, | Var, | NA | - | Review, | Arthritis, | NA | - | Review, | Sepsis, | NA |
| 6431- | T4O, | Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo |
| - | vitro+vivo, | NSCLC, | A549 |
| 6436- | T4O, | Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression |
| - | in-vitro, | Melanoma, | A431 |
| 6435- | T4O, | Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models |
| - | in-vitro, | Melanoma, | NA |
| 6434- | T4O, | Terpinen-4-ol, The Main Component of Melaleuca Alternifolia (Tea Tree) Oil Inhibits the In Vitro Growth of Human Melanoma Cells |
| - | in-vitro, | Melanoma, | NA |
| 6433- | T4O, | CET, | Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers |
| - | in-vitro, | Colon, | HT29 | - | in-vitro, | CRC, | HCT116 | - | in-vitro, | PC, | COLO357 | - | Human, | Colon, | NA |
| 6432- | T4O, | Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species |
| - | in-vitro, | CRC, | HCT116 |
| 3957- | Taur, | Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases |
| - | Study, | Nor, | NA |
| 3955- | Taur, | Mechanism of neuroprotective function of taurine |
| - | in-vitro, | Nor, | NA |
| 3950- | Taur, | Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes |
| - | Review, | Diabetic, | NA | - | Review, | Stroke, | NA | - | Review, | AD, | NA |
| 9291- | TERPs, | Plant-derived terpenoids modulating cancer cell metabolism and cross-linked signaling pathways: an updated reviews |
| - | Review, | Var, | NA |
| 5327- | TFdiG, | Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells |
| - | in-vitro, | Ovarian, | A2780S |
| 5331- | TFdiG, | Anti-Cancer Properties of Theaflavins |
| - | Review, | Var, | NA |
| 5333- | TFdiG, | Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts |
| - | vitro+vivo, | OS, | MG63 |
| 5334- | TFdiG, | Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling |
| - | in-vitro, | Thyroid, | 8505C |
| 139- | Tomatine, | CUR, | Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells |
| - | in-vitro, | Pca, | PC3 |
| 962- | TQ, | Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | Nor, | hTERT-HPNE | - | in-vitro, | PC, | AsPC-1 | - | in-vitro, | PC, | Bxpc-3 |
| 1052- | TQ, | Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD-L1 in MDA-MB-231 Triple-Negative Breast Cancer Cells |
| - | in-vitro, | BC, | MDA-MB-231 |
| 5221- | TQ, | Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells |
| - | in-vitro, | AML, | HL-60 |
| 1309- | TQ, | QC, | Thymoquinone and quercetin induce enhanced apoptosis in non-small cell lung cancer in combination through the Bax/Bcl2 cascade |
| - | in-vitro, | Lung, | NA |
| 1308- | TQ, | Thymoquinone induces apoptosis via targeting the Bax/BAD and Bcl-2 pathway in breast cancer cells |
| - | in-vitro, | BC, | MCF7 |
| 1930- | TQ, | Therapeutic implications and clinical manifestations of thymoquinone |
| - | Review, | Var, | NA |
| 1933- | TQ, | Thymoquinone: potential cure for inflammatory disorders and cancer |
| - | Review, | Var, | NA |
| 1935- | TQ, | Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis |
| - | Review, | OS, | NA |
| 2112- | TQ, | Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breastcancer cells |
| - | in-vitro, | BC, | MCF7 |
| 2119- | TQ, | Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant |
| - | Review, | Var, | NA |
| 2120- | TQ, | Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3 |
| - | in-vitro, | Melanoma, | A431 |
| 2127- | TQ, | Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways |
| - | Review, | GBM, | NA |
| 2129- | TQ, | doxoR, | Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells |
| - | in-vitro, | BC, | MCF7 |
| 2095- | TQ, | Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis |
| - | Review, | Var, | NA |
| 2097- | TQ, | Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells |
| - | in-vitro, | Cerv, | HeLa |
| 2099- | TQ, | Cisplatin, | Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo |
| - | in-vitro, | Lung, | H460 | - | in-vitro, | Lung, | H146 | - | in-vivo, | NA, | NA |
| 2104- | TQ, | The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | Cerv, | HeLa |
| 2105- | TQ, | Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation |
| - | in-vitro, | PC, | AsPC-1 | - | in-vitro, | PC, | MIA PaCa-2 | - | in-vitro, | PC, | Hs766t | - | in-vivo, | NA, | NA |
| 2106- | TQ, | Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy |
| - | Review, | Var, | NA |
| 2109- | TQ, | Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro |
| - | in-vitro, | AML, | CEM |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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