chemoP Cancer Research Results

chemoP, ChemoProtective: Click to Expand ⟱

Source:

Type:

Protects normal cells against the effect of Chemo.

Scientific Papers found: Click to Expand⟱

3290-

SIL,

A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents

-

Analysis,

Var,

NA

hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,

3288-

SIL,

Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations

-

Review,

Var,

NA

Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,

3282-

SIL,

Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions

-

Review,

Var,

NA

hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,

3646-

SIL,

"Silymarin", a promising pharmacological agent for treatment of diseases

-

Review,

Var,

NA

*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,

1316-

SIL,

Chemo,

Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity

-

Analysis,

Var,

NA

TumCCA↑, p42↓, P450↓, OATPs↓, chemoP↑, ChemoSen↑,

3051-

SK,

Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation

-

Review,

Var,

NA

Nrf1↑, Apoptosis↑, TumCP↓, eff⇅, chemoP↑, eff↑, VCAM-1↓, Hif1a↓,

1512-

Squ,

Combination therapy in combating cancer

-

Review,

Var,

NA

ChemoSideEff↓, *ROS↓, *GSH↑, eff↑, chemoP↑,

1688-

SSE,

Potential Role of Selenium in the Treatment of Cancer and Viral Infections

-

Review,

Var,

NA

IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, Synergy↑,

4753-

SSE,

Chemo,

Selenium and Lung Cancer: A Systematic Review and Meta Analysis

-

Review,

Lung,

NA

Risk⇅, chemoP↑, radioP↑,

5079-

SSE,

Rad,

The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues

-

in-vitro,

Lung,

A549

-

in-vitro,

Nor,

BEAS-2B

chemoP↑, eff↝, ROS↑, MMP↓, Cyt‑c↑, TumCG↓, RadioS↝, other↝,

4748-

SSE,

Chemo,

antiOx,

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in gastric cancer patients receiving adjuvant oxaliplatin and capecitabine after gastrectomy: a retrospective pilot study

-

Trial,

GC,

NA

injection of selenium (2,000 μg/day) before chemotherapy

28 patients receiving adjuvant capecitabine plus oxaliplatin

toxicity↓, chemoP∅, *neuroP↑, *Dose↝,

4743-

SSE,

Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients

-

Review,

Var,

NA

eff↝, chemoP↝, radioP↝,

4742-

SSE,

Antitumor Effects of Selenium

-

Review,

Var,

NA

-

Review,

Arthritis,

NA

-

Review,

Sepsis,

NA

*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,

4741-

SSE,

Selenium in Oncological Intervention

-

Review,

Var,

NA

Risk↓, *other↝, Risk↓, AntiTum↑, chemoR↓, chemoP↑,

4740-

SSE,

Optimising Selenium for Modulation of Cancer Treatments

-

Review,

Var,

NA

*selenoP↑, *Dose↓, Risk↓, *toxicity↝, Dose↑, chemoP↑, radioP↑,

2119-

TQ,

Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant

-

Review,

Var,

NA

*ROS↓, ROS↑, chemoP↑, RenoP↑, hepatoP↑, NLRP3↓, neuroP↑, NF-kB↓, P21↑, HDAC↓, Apoptosis↑, TumCP↓, GSH↓, GADD45A↑, GSK‐3β↑,

2127-

TQ,

Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways

-

Review,

GBM,

NA

chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,

2085-

TQ,

Anticancer Activities of Nigella Sativa (Black Cumin)

-

Review,

Var,

NA

MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑, *antiAll↑,

2090-

TQ,

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

-

Review,

Var,

NA

AntiCan↑, ChemoSen↑, RadioS↑, chemoP↑, *radioP↑,

2094-

TQ,

Cytotoxicity of Nigella sativa Extracts Against Cancer Cells: A Review of In Vitro and In Vivo Studies

-

Review,

Var,

NA

ROS↑, angioG↓, TumMeta↓, VEGF↓, MMPs↓, P53↑, BAX↑, Casp↑, Bcl-2↓, survivin↓, *ROS↓, ChemoSen↑, chemoP↑, MDR1↓, BioAv↓, BioAv↑,

2100-

TQ,

Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant

-

Review,

Var,

NA

ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,

3397-

TQ,

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

-

Review,

CRC,

NA

6-112uM (table 1)

ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,

5904-

TV,

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

-

Review,

Var,

NA

-

Review,

Stroke,

NA

-

Review,

Diabetic,

NA

-

Review,

Obesity,

NA

-

Review,

AD,

NA

-

Review,

Arthritis,

NA

*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,

4875-

Uro,

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

-

Review,

AD,

NA

-

Review,

Stroke,

NA

-

Review,

ostP,

NA

-

Review,

IBD,

NA

*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,

4833-

Uro,

Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine

-

Review,

Var,

NA

392 to 566 µM across various breast cancer cell lines

-

Review,

AD,

NA

-

Review,

IBD,

NA

BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,

4849-

Uro,

Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway

-

vitro+vivo,

GC,

NA

TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, TumAuto↑, TumCG↓, chemoP↑, ChemoSen↑,

7887-

VT,

IVT,

Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention

-

Review,

AD,

NA

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

4890-

ZER,

Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite

-

in-vitro,

Nor,

RAW264.7

*iNOS↓, *COX2/PTGS2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,

Showing Research Papers: 201 to 228 of 228
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 228

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 8, antiOx⇅, 1, Bil↝, 1, Catalase↓, 2, Catalase↑, 4, GPx↓, 1, GPx↑, 2, GPx4↓, 3, GSH↓, 15, GSH↑, 3, GSH∅, 1, GSR↓, 1, GSTs↓, 1, GSTs↑, 1, H2O2↑, 1, i-H2O2↓, 1, HO-1↓, 3, HO-1↑, 3, HO-2↑, 1, i-Iron↓, 1, c-Iron↑, 1, lipid-P↓, 4, lipid-P↑, 4, MDA↓, 2, MDA↑, 1, NOX4↑, 1, NQO1↓, 1, NQO1↑, 1, Nrf1↑, 1, NRF2↓, 5, NRF2↑, 6, Prx6↑, 1, PrxI↓, 1, PrxI∅, 1, PrxII↑, 1, PrxII∅, 1, ROS↓, 11, ROS↑, 76, ROS⇅, 6, ROS↝, 1, ROS∅, 1, i-ROS↑, 1, mt-ROS↑, 3, SOD↓, 3, SOD↑, 3, SOD2↓, 2, Thiols↓, 1, Trx↓, 1, TrxR↑, 1, uricA↓, 1, VitC↓, 1, VitE↓, 1, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1, CDC25↓, 1, compI↓, 2, compII↓, 1, EGF↓, 1, ETC↓, 2, Insulin↓, 1, MKK7↓, 1, mtDam↓, 1, mtDam↑, 5, PGC-1α↑, 1, SIRT3↓, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1, 5LO↓, 1, ACSL4↑, 2, ALAT↓, 4, AMP↑, 1, AMPK↑, 2, p‑AMT/GCST/T-protein↑, 1, ATP↓, 4, BHB↑, 1, FASN↓, 3, GLO-I↓, 1, glucoNG↓, 1, glucose↝, 1, GlucoseCon↓, 1, GlucoseCon∅, 1, GlutMet↓, 1, Glycolysis↓, 4, GSK‐3β↓, 3, GSK‐3β↑, 5, p‑GSK‐3β↓, 1, H2S↑, 1, HK2↓, 2, HMG-CoA↓, 1, HMGCS2↑, 1, lactateProd∅, 1, LDHA↓, 3, lipoGen↓, 1, NAD↑, 1, NADPH↓, 1, PCK1↓, 1, PDK1 / PDPK1↓, 2, PFK1↓, 1, PKM2↓, 3, PPP↓, 1, SCD1↓, 1, SIRT1↓, 2, SIRT1↑, 2, SREBP1/SREBF1↓, 1, TCA↓, 1, Warburg↓, 1,

Cell Death(tgid=5) ⓘ

AIF↑, 4, APAF1↑, 3, Apoptosis?, 1, Apoptosis↓, 4, Apoptosis↑, 61, m-Apoptosis↑, 1, ASC↓, 1, BAD↓, 1, BAD↑, 1, Bak↑, 2, BAX↓, 1, BAX↑, 29, Bax:Bcl2↑, 3, Bcl-2↓, 31, Bcl-2↑, 1, Bcl-xL↓, 8, BIM↓, 1, BIM↑, 1, Casp↑, 19, Casp1↓, 1, Casp12↑, 1, Casp3↑, 30, cl‑Casp3↑, 3, proCasp3↑, 1, Casp7↑, 4, cl‑Casp7↑, 2, Casp8↑, 7, proCasp8↑, 1, Casp9↓, 2, Casp9↑, 17, cl‑Casp9↑, 3, proCasp9↑, 1, cFLIP↓, 1, Cyt‑c↑, 21, Cyt‑c↝, 1, Diablo↑, 2, DR5↑, 5, Fas↓, 1, Fas↑, 5, FasL↓, 1, FasL↑, 1, Ferroptosis↑, 5, GSDMD↑, 1, IAP1↓, 4, IAP2/BIRC3↓, 4, iNOS↓, 6, Mcl-1↓, 6, p‑MDM2↓, 1, MOMP↑, 1, p38↓, 1, p38↑, 6, p‑p38↓, 3, p‑p38↑, 2, Pyro↑, 1, survivin↓, 15, TumCD↓, 1, TumCD↑, 8, XIAP↓, 7, YAP/TEAD↓, 1, YAP/TEAD↝, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 37, Akt↑, 2, p‑Akt↓, 7, p‑Akt↑, 1, cMET↓, 1, p‑cMET↑, 1, cSrc↓, 1, EGFR↓, 8, EGFR↑, 1, p‑EGFR↓, 1, ERK↓, 21, p‑ERK↓, 3, p‑ERK↑, 1, HCAR2↑, 1, HER2/EBBR2↓, 1, HGF/c-Met↓, 2, IKKα↓, 1, IκB↓, 1, JAK↓, 2, JAK1↓, 2, JAK2↓, 1, JNK↓, 2, JNK↑, 4, p‑JNK↓, 1, p‑JNK↑, 3, MAPK↓, 13, MAPK↑, 4, MEK↓, 2, MKK4↓, 1, mTOR↓, 15, p‑mTOR↓, 1, mTORC2↓, 1, p42↓, 1, p‑p70S6↑, 1, PI3K↓, 30, PI3K↑, 2, p‑PI3K↓, 3, PKCδ↓, 3, PTEN↓, 1, PTEN↑, 4, Raf↓, 2, e-Raf↓, 1, RAS↓, 5, RAS↑, 1, Sp1/3/4↓, 1, p‑Src↓, 1, STAT↓, 2, STAT3↓, 17, p‑STAT3↓, 2, p‑STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1, ChrMod↑, 1, cJun↓, 1, cJun↑, 1, cMyc↓, 4, cMyc↑, 1, DNMT1↓, 1, DNMT3B↓, 1, DNMTs↓, 2, EZH2↓, 1, FOXO↑, 2, FOXO1↑, 1, H3↓, 1, p‑H3↓, 1, H4↓, 1, HATs↑, 2, HDAC↓, 10, HDAC2↓, 1, HDAC3↓, 1, miR-106b↓, 1, miR-124-3p↓, 1, miR-203↑, 1, miR-34a↑, 1, Myc↑, 1, MYCN↓, 1, OCT4↓, 2, other?, 1, other↑, 2, other↝, 10, PhotoS↑, 2, Prot↓, 1, sonoS↑, 1, tumCV↓, 14,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 5, eIF2α↑, 2, p‑eIF2α↑, 1, ER Stress↑, 7, GRP78/BiP↑, 3, GRP94↑, 1, HSP70/HSPA5↓, 1, HSP90↓, 2, IRE1∅, 1, NQO2↑, 1, p‑PERK↑, 1, UPR↑, 3,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3, Beclin-1/ATG6↑, 4, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3A↑, 1, LC3II↑, 5, LC3s↑, 1, p62↓, 1, TumAuto↑, 8, TumAuto↝, 2,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1, DNAdam↓, 1, DNAdam↑, 18, DNArepair↓, 1, ERCC1↓, 1, P53?, 1, P53↓, 1, P53↑, 21, p‑P53↑, 2, PARP↑, 5, cl‑PARP↓, 1, cl‑PARP↑, 19, PCNA↓, 10, Telomerase↓, 3, TOP1↓, 2, TOP2↓, 1, γH2AX↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 2, CDK1↑, 1, CDK2↓, 5, CDK4↓, 9, CDK6↓, 2, CDK6↑, 1, CHK1↓, 1, CHK1↑, 1, Chk2↑, 1, Cyc↓, 1, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 5, CycB/CCNB1↑, 1, cycD1/CCND1↓, 17, cycE/CCNE↓, 4, E2Fs↓, 1, GADD34↑, 1, GADD45A↑, 2, Ki-67↓, 7, mitA↑, 1, P21↓, 1, P21↑, 14, p27/CDKN1B↓, 1, p27/CDKN1B↑, 5, pRB↓, 1, p‑pRB↓, 2, RB1↑, 1, TumCCA↓, 2, TumCCA↑, 53,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1, BMPs↑, 1, CD133↓, 1, CD34↓, 1, cFos↑, 1, CSCs?, 1, CSCs↓, 9, Diff↑, 2, FGF↓, 1, HH↓, 1, HH↝, 1, IGF-1↓, 4, IGFBP3↑, 1, Ki-67↓, 7, LRP6↓, 1, mTORC1↓, 1, Nanog↓, 1, Nestin↓, 1, NOTCH↓, 2, NOTCH1↓, 7, OGFr↑, 3, SCF↓, 1, Shh↓, 1, TumCG↓, 27, TumCG↑, 1, TumCP↓, 51, TumCP↑, 3, Wnt↓, 11,

Migration(tgid=13) ⓘ

AntiAg↑, 1, AP-1↓, 2, AXL↓, 2, BACH1↓, 1, CA↓, 1, Ca+2↓, 1, Ca+2↑, 9, Cav1↓, 1, Cdc42↓, 1, Cofilin↓, 1, E-cadherin↓, 2, E-cadherin↑, 6, EMT↓, 12, EpCAM↓, 1, F-actin↓, 1, FAK↓, 3, p‑FAK↓, 2, fascin↓, 1, Fibronectin↓, 1, ITGB1↓, 1, LAMs↓, 1, MALAT1↓, 1, MET↓, 1, p‑MET↓, 1, MMP1↓, 1, MMP13↓, 1, MMP2↓, 20, MMP3↓, 2, MMP7↓, 1, MMP9↓, 21, MMPs↓, 12, N-cadherin↓, 6, PDGF↓, 2, Rac1↓, 1, Rho↓, 2, ROCK1↓, 1, Slug↓, 1, Snail↓, 3, TGF-β↓, 5, TGF-β1↓, 1, TIMP1↑, 5, TIMP2↑, 2, TumCI↓, 19, TumCMig↓, 23, TumMeta↓, 25, TumMeta↑, 1, Twist↓, 3, Tyro3↓, 1, uPA↓, 4, Vim↓, 7, Vim↑, 1, Zeb1↓, 2, β-catenin/ZEB1↓, 13, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32, angioG↑, 1, CD31/PECAM-1↓, 3, HIF-1↓, 3, Hif1a↓, 21, LOX1↓, 1, VCAM-1↓, 2, VEGF↓, 30, VEGFR2/KDR/Flk1↓, 5,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2, CellMemb↑, 1, CLDN1↓, 1, EPR↑, 2, GastroP↑, 1, GLUT1↓, 1, GLUT2↓, 1, MMP↓, 30, NHE1↓, 1, OATPs↓, 2, TRPM7↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1, CD4+↑, 1, CD44↓, 2, CD47↓, 1, CD8+↑, 3, COX1↓, 1, COX1↑, 1, COX2/PTGS2↓, 26, CXCR4↓, 6, DCells↑, 1, HCAR2↑, 1, HMGB1↓, 2, ICAM-1↓, 1, IFN-γ↓, 1, IFN-γ↑, 1, IL1↓, 2, IL10↓, 2, IL10↑, 1, IL12↑, 1, IL1β↓, 10, IL2↓, 1, IL2↑, 4, IL6↓, 15, IL8↓, 3, Imm↑, 16, Imm↝, 1, INF-γ↑, 1, INF-γ↝, 1, Inflam↓, 19, Inflam↑, 2, M2 MC↓, 1, MDSCs↓, 1, Neut↑, 2, NF-kB↓, 45, NF-kB↑, 1, p‑NF-kB↑, 1, NK cell↑, 5, NLRP3↓, 3, NLRP3↑, 2, p65↓, 2, p‑p65↓, 1, PD-1↓, 2, PD-L1↓, 4, PD-L1↑, 1, PGE2↓, 7, PGE2↑, 1, PSA↓, 5, T-Cell↑, 1, Th1 response↑, 1, Th2↑, 1, TLR4↓, 1, TNF-α↓, 18, TNF-α↑, 2,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↓, 1, TrkB↓, 1,

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2, CYP19↓, 1, ER-α36↓, 1, PPARγ↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, BioAv↓, 14, BioAv↑, 18, BioAv↝, 4, chemoR↓, 1, ChemoSen?, 1, ChemoSen↑, 106, ChemoSen⇅, 1, ChemoSen↝, 1, ChemoSen∅, 2, CompStab↓, 2, CYP1A1↓, 3, CYP1A1↑, 1, CYP1A2↓, 1, CYP3A4↓, 1, Dose?, 2, Dose↑, 9, Dose↝, 43, Dose∅, 1, eff↓, 8, eff↑, 32, eff⇅, 1, eff↝, 9, eff∅, 1, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 6, MDR1↓, 4, MRP1/ABCC1↓, 2, P-gp/ABCB1↓, 6, P450↓, 3, RadioS↑, 23, RadioS↝, 1, selectivity↑, 38, Synergy↑, 33,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 4, ALP↓, 1, AR↓, 2, AST↓, 2, Bil↝, 1, BUN↓, 3, CEA↓, 1, creat↓, 3, EGFR↓, 8, EGFR↑, 1, p‑EGFR↓, 1, EZH2↓, 1, HemoG↑, 1, HER2/EBBR2↓, 1, IL6↓, 15, LDH↑, 1, e-LDH↑, 1, Myc↑, 1, NSE↓, 1, PC↑, 1, PD-L1↓, 4, PD-L1↑, 1, PSA↓, 5, RBC↑, 3, Verbal↑, 1, WBC↑, 2,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiCan↓, 1, AntiCan↑, 23, AntiCan∅, 1, AntiDiabetic↑, 1, antiNeop↑, 1, AntiTum↑, 12, Appetite↑, 2, BowelM↑, 1, breath↑, 1, cachexia↓, 2, cardioP↑, 10, chemoP?, 1, chemoP↓, 3, chemoP↑, 181, chemoP↝, 1, chemoP∅, 1, chemoPv↑, 5, ChemoSideEff↓, 4, cognitive↑, 2, fatigue↓, 1, fatigue∅, 1, hepatoP↑, 17, hepatoP∅, 1, memory↑, 1, Mucositis↓, 1, Nausea↓, 1, neuroP↓, 1, neuroP↑, 7, NP/CIPN↓, 3, OS↓, 2, OS↑, 12, OS⇅, 1, Pain↓, 7, PFS↑, 1, QoL↑, 20, QoL∅, 2, radioP↑, 29, radioP↝, 1, Remission↑, 1, RenoP↑, 9, RenoP∅, 1, Risk↓, 19, Risk↑, 2, Risk⇅, 1, Sleep↑, 2, Strength↑, 2, toxicity↓, 11, toxicity↑, 1, toxicity↝, 4, toxicity∅, 2, TumVol?, 1, TumVol↓, 10, TumVol↑, 1, TumW↓, 1, Weight↑, 5, Weight∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, GutMicro↑, 4, Sepsis↓, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 608

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4, antiOx↑, 60, ARE↑, 1, Catalase↑, 24, Copper↓, 1, Fenton↓, 2, GPx↑, 23, GPx1↑, 1, GPx4↓, 1, GPx4↑, 1, GSH↑, 28, GSR↑, 4, GSTs↑, 9, H2O2↓, 1, HDL↑, 2, HO-1↓, 2, HO-1↑, 21, Iron↓, 2, Iron↑, 1, Keap1↓, 2, Keap1↝, 1, lipid-P↓, 18, MDA↓, 18, MDA↑, 1, MPO↓, 6, MPO↑, 2, NADH↓, 1, NOX↓, 1, NOX4↓, 2, NQO1↑, 3, NRF2↑, 39, RNS↓, 3, ROS↓, 67, ROS↝, 1, ROS∅, 2, mt-ROS?, 1, SAM-e↑, 1, selenoP↑, 2, SOD↑, 34, SOD1↑, 3, SOD2↑, 2, TAC↑, 1, TBARS↓, 2, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1, compII↑, 1, compIII↑, 1, DRP1/DNM1L↓, 1, FIS1↓, 1, Insulin↓, 1, Insulin↑, 1, MFN2↑, 2, mtDam↓, 1, PGC-1α↑, 2, PGC-1α↝, 1, PINK1↑, 1, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1, 5LO↓, 1, ACC↓, 1, Acetyl-CoA↓, 1, adiP↑, 1, ALAT↓, 9, AMPK↑, 5, ATP↑, 4, ATP↝, 1, CRM↓, 1, FABP4↓, 1, FASN↓, 1, FFA/NEFA↓, 1, glucose↓, 4, glucose↝, 1, GlucoseCon↑, 1, GSK‐3β↑, 1, H2S↑, 1, KeyT↝, 1, LDL↓, 4, NAD↝, 1, NADPH↓, 4, NADPH↑, 1, PLA2↓, 1, SIRT1↑, 4, SREBF2⇅, 1,

Cell Death(tgid=5) ⓘ

AIF↓, 1, Apoptosis↓, 10, ASK1↓, 1, BAX↓, 1, Bax:Bcl2↓, 1, Bcl-2↑, 2, Bcl-xL↑, 1, Casp12↓, 1, Casp3↓, 12, cl‑Casp8↑, 1, Casp9↓, 5, Cyt‑c↓, 1, Fas↓, 1, FasL↓, 1, Ferroptosis↓, 2, GranB/GZMB↓, 1, iNOS↓, 8, necrosis↓, 1, p38↓, 2, p‑p38↓, 1, TUNEL↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2, Akt↑, 5, Akt↝, 1, AMPKα↑, 1, ERK↓, 2, IGF-1R↓, 1, IKKα↑, 1, IκB?, 1, JAK↓, 1, JAK2↑, 1, JNK↓, 1, p‑JNK↓, 2, MAPK↓, 2, MAPK↑, 1, MAPK↝, 1, mTOR↓, 3, p‑mTOR↓, 1, PDGFR-BB↓, 1, PI3K↓, 2, PI3K↑, 2, PKCδ?, 1, PKCδ↓, 1, PTEN↓, 1, STAT3↓, 1, STAT3↑, 1, STAT3↝, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4, ATF2↑, 1, ATF4↓, 1, FOXO3↑, 1, HDAC↑, 1, miR-34a↓, 1, other?, 2, other↓, 5, other↑, 10, other↝, 2, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2, p‑eIF2α↓, 1, ER Stress↓, 3, GRP78/BiP↓, 2, XBP-1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3II↑, 1, MitoP↓, 1, p62↑, 1, PARK2↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4, DNArepair↑, 1, P53↓, 3, P53↑, 1, PARP1↓, 1, PCNA↑, 1, SIRT6↑, 1, Telomerase↓, 1, TOP1↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1, GADD45A↑, 1, P21↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1, CEBPA↓, 1, EP2↓, 1, HH↓, 1, IGF-1↑, 1, mTORC1↓, 1, neuroG↑, 1, p300↓, 1, TumCP↓, 1,

Migration(tgid=13) ⓘ

AntiAg↓, 2, AntiAg↑, 5, AP-1↓, 3, Ca+2↓, 1, Ca+2↝, 2, Cartilage↑, 1, COL1↓, 1, E-cadherin↑, 1, EMT↓, 1, MMP13↓, 1, MMP2↓, 1, MMPs↓, 1, p‑Rac1↓, 1, serineP↓, 1, TGF-β↓, 1, TGF-β↑, 2, TGF-β1↓, 1, TIMP1↓, 1, TumCI↓, 1, TumCMig↓, 1, uPA↑, 1, Vim↓, 1, α-SMA↓, 1, α-SMA↝, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, Hif1a↑, 1, NO↓, 5, VCAM-1↓, 2,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5, BBB∅, 1, GastroP↑, 1, GLUT4↑, 1, H+/K+-ATPase↓, 1, IBI↑, 1, memfluid↑, 1, MMP↑, 5, TRPM7↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1, CD4+↑, 2, CD8+↑, 1, COX1↓, 3, COX2/PTGS2↓, 15, COX2/PTGS2↑, 1, FOXP3↑, 1, HMGB1↓, 2, IFN-γ↓, 2, IL10↓, 4, IL10↑, 5, IL17↓, 1, IL18↓, 1, IL1β↓, 13, IL2↓, 1, IL4↓, 3, IL4↑, 2, IL6↓, 23, IL8↓, 2, Imm↑, 6, Imm↝, 1, Inflam↓, 64, LPS↓, 2, M2 MC↑, 2, pol-M2 MC↑, 1, MCP1/CCL2↓, 3, MyD88↓, 1, NF-kB↓, 20, NLRP3↓, 4, PGE2↓, 7, TLR4↓, 3, TNF-α↓, 27, Treg lymp↝, 1, TRIF↓, 1, VitD↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 1, AChE↓, 4, BChE↓, 2, BDNF↑, 2, MAOA↓, 1, MAOB↓, 1, NGF↑, 1, TrkB↑, 1, β-Endo↑, 1,

Protein Aggregation(tgid=19) ⓘ

APP↓, 1, Aβ↓, 2, BACE/β-secretase↓, 1, p‑tau↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, ACE2↓, 1, BNP↓, 1, NR1H4↑, 1, PPARγ↓, 1, testos↑, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19, BioAv↑, 21, BioAv↝, 14, BioEnh↑, 2, ChemoSen↑, 1, CYP3A2↓, 1, Dose?, 3, Dose↓, 2, Dose↑, 2, Dose↝, 14, eff↑, 9, GSTA1↑, 2, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 8, P-gp/ABCB1↓, 2, selectivity↑, 3, Synergy↑, 7,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9, ALB↝, 1, ALP↓, 3, AST↓, 12, BloodF↑, 1, BMD↑, 3, BP↓, 4, BUN?, 1, BUN↓, 4, Calcium↑, 1, creat↓, 9, hs-CRP↓, 1, IL6↓, 23, IRes↝, 1, KeyT↝, 1, LDH↓, 4, Mag↑, 1, NOS2↓, 1, SpO2↑, 1, TC↓, 1, TG/TAG↓, 1, TMAO↓, 1, Urea↓, 2, VitD↑, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 5, antiAll↑, 8, AntiArt↑, 1, AntiCan↑, 10, AntiDiabetic↓, 1, AntiDiabetic↑, 11, antiPs↑, 2, AntiTum↓, 1, AntiTum↑, 3, cardioP?, 2, cardioP↑, 25, chemoP↑, 46, chemoPv↑, 3, ChemoSideEff↓, 1, cognitive↓, 1, cognitive↑, 11, cough?, 1, hepatoP↓, 1, hepatoP↑, 25, memory↑, 5, motorD↑, 1, Mucositis↓, 1, neuroP↓, 1, neuroP↑, 28, Obesity↓, 8, OS↑, 4, Pain↓, 4, QoL↑, 1, radioP↑, 8, RenoP↑, 15, Risk↓, 1, SoreThr?, 1, Strength↑, 1, Stress↓, 1, Stroke↓, 5, toxicity↓, 24, toxicity↑, 1, toxicity↝, 9, toxicity∅, 1, Weight↓, 1, Weight↑, 1, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4, AntiFungal↑, 3, AntiViral↑, 5, Bacteria↓, 8, Diar↓, 1, GutMicro↑, 9, Sepsis↓, 3,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2, Ingr↝, 2,
Total Targets: 360

Scientific Paper Hit Count for: chemoP, ChemoProtective

21 Chemotherapy
14 Cisplatin
11 Silymarin (Milk Thistle) silibinin
10 Hydrogen Gas
9 Selenium
8 doxorubicin
8 Selenite (Sodium)
7 Curcumin
7 Thymoquinone
6 Melatonin
5 Allicin (mainly Garlic)
5 Anti-oxidants
5 Radiotherapy/Radiation
5 phytic acid, Inositol hexakisphosphate
4 Astragalus
4 Quercetin
4 Fucoidan
4 Honokiol
4 Inositol
4 Licorice
4 Luteolin
4 Lycopene
4 Morin
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Paclitaxel/Taxol
3 Coenzyme Q10
3 EGCG (Epigallocatechin Gallate)
3 diet Short Term Fasting
3 Dandelion Root
3 HydroxyTyrosol
3 isoorientin
3 Licochalcone A
3 low dose naltrexone
3 Linalool
3 Magnetic Fields
3 Urolithin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 beta-glucans
2 Brucea javanica
2 brusatol
2 Boron
2 Butyrate
2 Propolis -bee glue
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Chrysin
2 Garcinol
2 Docosahexaenoic Acid
2 Ellagic acid
2 Fisetin
2 Flaxseed/Linseed
2 Shilajit/Fulvic Acid
2 iodine
2 5-fluorouracil
2 Metformin
2 Oleuropein
2 Rosmarinic acid
2 Rutin
2 Selenium NanoParticles
1 Silver-NanoParticles
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Anethole/trans-Anethole
1 Atorvastatin
1 immunotherapy
1 Baicalein
1 Berberine
1 Gold NanoParticles
1 Beta-Caryophyllene
1 Betulinic acid
1 Bromelain
1 α-Bisabolol / Chamomile oil
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cat’s Claw
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 Vitamin E
1 Calorie Restriction Mimetics
1 HydroxyCitric Acid
1 Crocetin
1 diet Plant based
1 Diindolylmethane
1 Indole-3-carbinol
1 Lemongrass Extract/Citral
1 Disulfiram
1 Copper and Cu NanoParticles
1 Echinacea
1 Docetaxel
1 Emodin
1 Eugenol
1 Exercise
1 Formononetin
1 carboplatin
1 Gallic acid
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Hyperoside
1 MCT, metronomic chemo
1 Isoliquiritigenin
1 isoflavones
1 isoquercitrin
1 Kaempferol
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Magnolol
1 Matrine
1 Magnetic Field Rotating
1 Moringa oleifera
1 Methylsulfonylmethane
1 Naringin
1 Aidi injection
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Piperine
1 Psoralidin
1 benzo(a)pyrene
1 buckwheat sprouts
1 irinotecan
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Squalene
1 Vitexin
1 Isovitexin
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1171  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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