Imm Cancer Research Results

Imm, immunostimulatory: Click to Expand ⟱

Source:

Type:

Enhance the immune response in patients.

Scientific Papers found: Click to Expand⟱

9304-

MushMait,

Oral administration of soluble β-glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice

-

in-vivo,

Var,

NA

mice

TumCG↓, Imm↑, T-Cell↑, eff↑,

9306-

MushMait,

Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation

-

in-vitro,

BC,

MCF7

Ingr↝, Imm↑, AntiTum↑, Dose↝, Bak↓, Cyt‑c↓,

9309-

MushMait,

Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial

-

Trial,

Nor,

NA

randomized, double-blind, placebo-controlled trial over 18 wk targeting 47 healthy Japanese individuals aged 60 y or older.

*Dose↝, *cognitive↑, *NK cell↑, *Imm↑, *other↝,

5611-

NaHCO3,

NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells

-

vitro+vivo,

HCC,

HepG2

tumCV↓, TumCG↓, pH↑, Synergy↑, Imm↑,

5617-

NaHCO3,

Microenvironmental alkalization promotes the therapeutic effects of MSLN-CAR-T cells

-

vitro+vivo,

Var,

NA

Imm↑, eff↑, pH↑,

5612-

NaHCO3,

immuno,

Neutralization of tumor acidity improves anti-tumor responses to immunotherapies

-

vitro+vivo,

Var,

B16-F10

mice

Imm↑, eff↑, e-pH↑, TumCG↓, TumMeta↓, eff↑,

5610-

NaHCO3,

doxoR,

Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin

-

vitro+vivo,

BC,

4T1

mice bearing orthotropic 4T1 breast cancer tumors

pH↑, Imm↑, eff↑, ChemoSen↑, TumVol↓, eff↑,

5608-

NaHCO3,

Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism

-

Study,

Var,

NA

TumCG↓, TumMeta↓, e-pH↑, Pyro↑, Imm↑, Na+↑,

5604-

NaHCO3,

Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity

-

vitro+vivo,

Melanoma,

B16-BL6

Six-week-old female BALB/c mice and C57BL/6 J mice

-

in-vitro,

BC,

4T1

eff↑, eff↑, TumMeta↓, pH↑, CaMKII ↑, CREB↑, PGC-1α↑, AntiTum↑, Imm↑, CD8+↑, TAMS↑,

9213-

Nast,

ITCs,

An Epidemiological Study on the Effectiveness of Nasturtium Herb and Horseradish Root (Angocin®Anti-Infekt N) as well as Other Phytopharmaceuticals, Synthetic Products, and Antibiotics on the Course of Acute Upper Respiratory Tract Infection (aURTI)

-

Analysis,

Inf,

NA

A total of 3501 Angocin® patients and 17,505 patients in each further cohort were investigated

*eff↑, *other↝, *Dose↝, *Inf↓, *Bacteria↓, *Inflam↓, *AntiViral↑, *Imm↑, *AntiBio↑,

6775-

Neem,

Nimb,

Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment

-

Review,

Nor,

NA

*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,

5936-

P,

The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data

-

Review,

IBD,

NA

*Pain↓, *other↝, *Bacteria↓, *Inflam↓, *Imm↑, *eff↑, *toxicity↓,

8987-

PCorn,

A comprehensive review on purple corn kernels: phytochemical composition, bioactivity, bioaccessibility, health benefits, and industry applications

-

Review,

Nor,

NA

*Ingr↑, *GutMicro↑, *AntiDiabetic↑, *cardioP↑, *antiOx↑, *Inflam↓, *AntiCan↑, *neuroP↑, *Imm↝,

9013-

Phyco,

Phycocyanin: Biomedical Activities and Related Mechanisms of Action

-

Review,

Nor,

NA

*antiOx↑, *Imm↑, *Inflam↓, *AntiTum↑, *neuroP↑, *hepatoP↑, *cardioP↑,

9012-

Phyco,

Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies

-

Review,

Var,

NA

*Ingr↝, *antiOx↑, *Inflam↓, Imm↑, AntiCan↑, *toxicity↓, *Dose↝, *GutMicro↑, *IBI↑, Apoptosis↑, TumCCA↑, DNArepair↓, ROS↑, Cyt‑c↑, BAX↑, cl‑PARP1↑, CellShr↑, TumCMig↓, COX2/PTGS2↓, E-cadherin↑, MMP2↓, MMP9↓, HIF-1↓, angioG↓, MCP1/CCL2↓, MIP-1β↑, Ca+2↑, Cal9↑, Wnt↓, β-catenin/ZEB1↓, PPARα↑, PPARγ↑, eff↝, Half-Life↓, Synergy↑, ChemoSen↑, chemoP↑, EMT↓, N-cadherin↓, E-cadherin↑, TumCMig↓, TumCI↓, selectivity↑,

9011-

Phyco,

Phycocyanin: A Potential Drug for Cancer Treatment

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,

5209-

PI,

Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells

-

in-vitro,

Pca,

DU145

TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, MMP9↓, p‑mTOR↓, TumMeta↓, *antiOx↓, *Inflam↓, *hepatoP↑, *Imm↑, *AntiCan↑,

9114-

PRO,

Repurposing Drugs in Oncology (ReDO)—Propranolol as an anti-cancer agent

-

Review,

Var,

NA

ADRB2↓, TumCP↓, TumCI↓, Imm↑, angioG↓, BioAv↑, Half-Life↝, BBB↑, BioAv↝, MMP2↓, MMP9↓, VEGF↓,

6220-

Se,

CUR,

Rad,

Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy

-

in-vitro,

Lung,

A549

RadioS↑, TumCD↑, ROS↑, Imm↑, angioG↓, BioAv↑, TumCP↓, Apoptosis↓, TumMeta↓, CompStab↑,

4485-

Se,

Selenium stimulates the antitumour immunity: Insights to future research

-

Review,

Var,

NA

*antiOx↑, chemoPv↑, ROS↑, Imm↑, selenoP↑, *IL2↑, *IL4↑, *TNF-α↓, *TGF-β↓, *EMT↓, Risk↓, *GPx↑, *TrxR↑,

4603-

SeNPs,

Therapeutic applications of selenium nanoparticles

-

Review,

Var,

NA

AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, Synergy↑, *Synergy↑,

4608-

SeNPs,

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

-

Review,

Var,

NA

-

NA,

AD,

NA

*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, Synergy↑, other↝, *Synergy↑, *Aβ↓, *Synergy↑,

9033-

SP,

Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential

-

Review,

Var,

NA

Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,

9036-

SP,

The efficacy of dietary Spirulina as an adjunct to chemotherapy to improve immune function and reduce myelosuppression in patients with malignant tumors

-

Trial,

Var,

NA

cancer patients receiving four cycles of chemotherapy were randomized into control or treatment groups. 40 participants in the control group and 60 in the treatment group

Mye↓, CD8+↑, Imm↑, Dose↝,

5074-

SSE,

Application of Sodium Selenite in the Prevention and Treatment of Cancers

-

Review,

Var,

NA

Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,

5082-

SSE,

Rationale for the treatment of cancer with sodium selenite

-

Review,

Var,

NA

Risk↑, antiOx↑, ROS↑, Imm↑, NK cell↑, angioG↓, toxicity↓,

5087-

SSE,

Sodium Selenite Alleviates Breast Cancer-Related Lymphedema Independent of Antioxidant Defense System

-

Trial,

BC,

NA

 five sessions of 0.9% saline and 500 μg sodium selenite (Selenase®) IV injections

double-blind, controlled trial was conducted on 26 participants

eff↑, Inflam↓, Imm↑, ROS↑, *NK cell↑,

4498-

SSE,

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

-

Review,

Var,

NA

-

Review,

AD,

NA

-

Review,

IBD,

NA

*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,

4742-

SSE,

Antitumor Effects of Selenium

-

Review,

Var,

NA

-

Review,

Arthritis,

NA

-

Review,

Sepsis,

NA

*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,

6767-

Thyme,

Thymol, thyme, and other plant sources: Health and potential uses

-

Review,

Nor,

NA

*AntiBio↑, *Inflam↓, *Imm↑, *other↝, *Half-Life↝, *Obesity↓, *GutMicro↑,

5904-

TV,

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

-

Review,

Var,

NA

-

Review,

Stroke,

NA

-

Review,

Diabetic,

NA

-

Review,

Obesity,

NA

-

Review,

AD,

NA

-

Review,

Arthritis,

NA

*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,

4833-

Uro,

Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine

-

Review,

Var,

NA

392 to 566 µM across various breast cancer cell lines

-

Review,

AD,

NA

-

Review,

IBD,

NA

BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,

9151-

WN,

Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome

-

Review,

Var,

NA

-

Review,

Col,

NA

Ingr↝, GutMicro↑, Inflam↓, Imm↑, *cardioP↑, *AntiDiabetic↑, *AntiAge↑, Risk↓, Ingr↝, RANTES↓, eff↑, IL10↓, TumW↓, Risk↓, Risk↓,

4885-

ZER,

Anti-cancer potential of zerumbone in cancer and glioma: current trends and future perspectives

-

Review,

Var,

NA

AntiTum↑, *Imm↑, AntiCan↑,

Showing Research Papers: 201 to 234 of 234
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 234

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

NA↑, 2, NA↝, 2,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5, ARE↓, 1, Catalase↓, 2, Catalase↑, 1, GPx4↓, 6, GSH↓, 6, GSH↑, 1, GSTs↑, 1, H2O2↑, 1, HO-1↓, 2, HO-1↑, 2, Iron↑, 2, Iron↝, 1, c-Iron↑, 1, Keap1↑, 1, lipid-P↓, 1, lipid-P↑, 5, MDA↓, 3, MDA↑, 2, NADH↓, 1, NRF2↓, 3, NRF2↑, 2, Prx↓, 1, PrxII↓, 1, ROS↓, 4, ROS↑, 54, ROS⇅, 2, i-ROS↑, 1, mt-ROS↑, 1, selenoP↑, 1, SOD↓, 2, SOD↑, 1, Trx↓, 1, TrxR↓, 1, TrxR1↓, 1, xCT/SLC7A11↓, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4, IronCh∅, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1, CDC25↓, 2, compI↓, 1, ETC↓, 2, ETC↝, 1, Insulin↓, 1, mtDam↑, 11, OXPHOS↓, 3, OXPHOS↑, 1, PGC-1α↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3, ACSL4↑, 2, ALAT↓, 5, AMP↑, 1, AMPK↑, 5, ATP↓, 8, DHODH↓, 1, FASN↓, 1, G6PD↓, 1, GLS↓, 1, glucoNG↓, 1, glucose↓, 1, glucose↝, 1, GlucoseCon↓, 1, Glycolysis↓, 7, GSK‐3β↓, 4, HK2↓, 3, lactateProd↑, 1, LDHA↓, 1, LDL↓, 1, LDL↑, 1, lipoGen↓, 1, PDK1 / PDPK1↓, 2, PKM2↓, 1, PKM2↑, 1, SCD1↓, 2, SIRT1↓, 2, SIRT1↑, 1, SREBP1/SREBF1↓, 1, SREBP2↓, 1, Warburg↓, 1,

Cell Death(tgid=5) ⓘ

AIF↑, 1, APAF1↑, 3, Apoptosis↓, 2, Apoptosis↑, 53, mt-Apoptosis↑, 2, BAD↑, 1, Bak↓, 2, BAX↓, 1, BAX↑, 20, Bax:Bcl2↑, 4, Bcl-2↓, 19, Bcl-xL↓, 3, BID↑, 1, BIM↑, 1, Casp↑, 12, Casp3↓, 1, Casp3↑, 25, cl‑Casp3↑, 1, Casp7↑, 6, Casp8↑, 6, Casp9↓, 1, Casp9↑, 17, cl‑Casp9↑, 1, CellShr↑, 2, cFLIP↓, 1, Cyt‑c↓, 2, Cyt‑c↑, 16, DR5↑, 2, FADD↑, 1, Fas?, 1, Fas↓, 1, Fas↑, 5, FasL↓, 1, FasL↑, 1, Ferroptosis↑, 7, IAP1↓, 2, IAP2/BIRC3↓, 2, ICD↑, 1, iNOS↓, 2, MDM2↓, 2, MOMP↑, 4, necrosis↑, 2, NOXA↑, 1, p38↑, 2, Pyro↑, 3, survivin↓, 6, TNFR 1↑, 1, TumCD↓, 1, TumCD↑, 10, XIAP↓, 5,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 29, p‑Akt↓, 2, CaMKII ↑, 1, p‑cMET↑, 1, CREB↑, 1, EGFR↓, 4, EGFR↑, 1, ERK↓, 12, ERK↑, 2, p‑ERK↓, 1, HCAR2↑, 1, HER2/EBBR2↓, 2, IGF-1R↓, 1, JAK↓, 1, JAK3↓, 1, JNK↓, 6, JNK↑, 3, MAPK↓, 8, MAPK↑, 1, mTOR↓, 12, p‑mTOR↓, 1, P70S6K↓, 2, PI3K↓, 25, p‑PI3K↓, 1, PKCδ↓, 4, PP2A↑, 1, PRAS40↑, 1, PTEN↑, 2, RAS↓, 1, RIP1↓, 1, Sp1/3/4↓, 2, STAT↓, 1, STAT3↓, 11, THEM4/CTMP↑, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1, ChrMod↑, 1, cMyc↓, 1, cMyc↑, 1, DNMTs↓, 1, EZH2↓, 1, FOXO↑, 1, FOXO1↑, 2, FOXO3↑, 1, FOXO4↑, 1, HDAC↓, 2, HES1↓, 2, miR-124-3p↓, 1, miR-133a-3p↑, 1, miR-21↓, 1, miR-25-5p↓, 1, miR-34a↓, 1, Myc↑, 1, OCT4↓, 1, other↓, 2, other↑, 7, other↝, 16, other∅, 1, PhotoS↑, 3, SD↑, 1, sonoS↑, 1, SOX4↓, 1, tumCV↓, 13,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4, CRT↑, 1, CUL1↝, 1, CUL5↝, 1, eIF2α↓, 1, eIF2α↑, 1, p‑eIF2α↑, 1, ER Stress↑, 18, HSP27↓, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 3, HSP90↓, 3, HSP90↑, 1, HSPs↑, 1, PERK↑, 2, UPR↑, 3,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1, ATG16L1↑, 1, ATG3↑, 1, ATG5↑, 2, ATG7↑, 1, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 5, LC3‑Ⅱ/LC3‑Ⅰ↑, 2, LC3B-II↑, 1, LC3I↑, 1, p62↓, 1, p62↑, 1, RUBCN↓, 1, TumAuto↓, 2, TumAuto↑, 16, TumAuto↝, 1, mt-TumAuto↑, 1, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 1, DNAdam↑, 18, DNArepair↓, 4, DNArepair↑, 1, hTERT/TERT↓, 1, P53↑, 9, PARP↑, 3, cl‑PARP↑, 8, cl‑PARP1↑, 2, PCNA↓, 1, Telomerase↓, 2, γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3, CDK2↓, 3, CDK4↓, 4, CDK6↓, 1, CDK6↑, 1, Chk2↑, 1, ChrCon↑, 1, CycB/CCNB1↓, 4, cycD1/CCND1↓, 7, cycD1/CCND1↑, 1, cycE/CCNE↓, 3, Ki-67↓, 1, P21↓, 3, P21↑, 6, p27/CDKN1B↓, 2, pRB↓, 1, p‑pRB↓, 2, TumCCA↑, 46, WEE1↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, p‑4E-BP1↓, 1, ALDH↓, 1, CD133↓, 3, CSCs?, 1, CSCs↓, 13, CSCs↑, 1, Diff↑, 5, FGF↓, 1, GH↓, 1, Gli↓, 1, HH↓, 2, IGF-1↓, 2, IGF-2↓, 1, IGFBP1↑, 1, JAG1↓, 1, Ki-67↓, 1, mTORC1↓, 2, Nanog↓, 1, NOTCH↓, 1, NOTCH1↓, 7, NOTCH3↓, 1, STAT1↑, 1, TumCG↓, 29, TumCG↑, 1, TumCP↓, 39, TumCP↑, 1, Wnt↓, 13,

Migration(tgid=13) ⓘ

AP-1↓, 3, Ca+2↑, 12, Ca+2↝, 1, Cal9↑, 1, Chl↓, 1, Cofilin↓, 1, COL1↓, 2, E-cadherin↑, 8, EMT↓, 19, FAK↓, 2, fascin↓, 1, Fibronectin↓, 1, MALAT1↓, 1, MET↓, 1, MMP-10↓, 1, MMP1↓, 1, MMP2↓, 16, MMP2↑, 1, MMP3↓, 1, MMP9↓, 21, MMP9↑, 1, MMPs↓, 9, N-cadherin↓, 4, Na+↑, 1, ROCK1↓, 1, Slug↓, 3, Smad1↓, 1, Snail↓, 3, TGF-β↓, 1, TGF-β1↓, 1, TIMP1↑, 3, TIMP2↓, 2, TIMP2↑, 1, pol-TregCell↓, 1, TRIB3↑, 1, TSC1↑, 1, TSP-1↑, 2, TumCA↓, 1, TumCI↓, 21, TumCMig↓, 20, TumMeta↓, 32, TumMeta↑, 4, Twist↓, 1, uPA↓, 2, Vim↓, 5, Zeb1↓, 1, β-catenin/ZEB1↓, 16,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 39, angioG↑, 2, CD31/PECAM-1↓, 1, HIF-1↓, 1, Hif1a↓, 7, Hypoxia↓, 3, VCAM-1↓, 1, VEGF↓, 22, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1, CellMemb↑, 3, CLDN1↑, 1, CX43/GJA1↓, 1, EPR↑, 5, GLUT1↓, 2, IBI↑, 2, MMP↓, 17, MPT↑, 2, Na+↑, 1, OCLN↑, 1, TJ↑, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1, CD4+↓, 1, CD4+↑, 8, CD44↓, 4, CD47↓, 1, CD59↑, 1, CD8+↑, 11, cGAS–STING↑, 2, COX1↓, 1, COX2/PTGS2↓, 14, CXCL16↓, 1, CXCR4↓, 4, DCells↓, 1, DCells↑, 2, Dectin1↝, 1, DR4↑, 1, Eos↑, 1, FOXP3↑, 1, Gal-3↓, 1, HCAR2↑, 1, HLA-I/II↑, 1, HMGB1↓, 1, ICAM-1↓, 2, IFN-γ↓, 4, IFN-γ↑, 4, IL10↓, 1, IL10↑, 3, IL12↑, 1, IL17↑, 1, IL18↑, 1, IL1β↓, 3, IL1β↑, 1, IL2↓, 4, IL2↑, 4, IL4↓, 1, IL4↑, 1, IL6↓, 8, IL6↑, 1, Imm↑, 131, Imm⇅, 1, Imm↝, 13, INF-γ↝, 1, Inflam↓, 15, LPS↓, 1, pol-M1↑, 2, M2 MC↓, 2, MCP1/CCL2↓, 3, MCT1↓, 1, MIP-1β↑, 1, Neut↓, 1, Neut↑, 3, NF-kB?, 1, NF-kB↓, 21, NF-kB↑, 2, NK cell↑, 20, NLRP3↓, 1, NLRP3↑, 1, PD-1↝, 1, PD-L1↓, 6, PD-L1↑, 1, PGE2↓, 4, PSA↓, 1, RANTES↓, 1, T-Cell↑, 5, Th1 response↑, 1, Th17↑, 1, TLR4↓, 1, TNF-α↓, 7, TNF-α↑, 4, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1, TRADD↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 4, pH↝, 2, e-pH↓, 1, e-pH↑, 2, TAMS↑, 1,

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ADRB2↓, 1, AR↓, 1, Estro↝, 1, PPARα↑, 1, PPARγ↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2, BioAv↓, 5, BioAv↑, 16, BioAv↝, 7, BioEnh↑, 1, chemoR↓, 1, ChemoSen↑, 58, CompStab↓, 1, CompStab↑, 1, CYP1A1↓, 1, CYP3A4↓, 1, CYP3A4⇅, 1, DDS↑, 6, Dose?, 1, Dose↓, 1, Dose↑, 4, Dose↝, 38, eff↓, 4, eff↑, 53, eff↝, 6, Half-Life↓, 1, Half-Life↑, 3, Half-Life↝, 1, MDR1↓, 4, P-gp/ABCB1↓, 6, RadioS↑, 22, selectivity?, 1, selectivity↑, 19, Synergy?, 1, Synergy↑, 38,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5, anemia↓, 1, AR↓, 1, AST↓, 3, BloodF↑, 3, BMD↑, 1, BUN↓, 1, CA19-9↓, 1, CEA↓, 2, CIT↓, 2, creat↓, 1, EGFR↓, 4, EGFR↑, 1, EZH2↓, 1, HER2/EBBR2↓, 2, hTERT/TERT↓, 1, IL6↓, 8, IL6↑, 1, IRes↓, 1, Myc↑, 1, Mye↓, 1, PC↑, 1, PD-L1↓, 6, PD-L1↑, 1, PSA↓, 1, RBC↑, 2, TG/TAG↓, 1, TRIB3↑, 1, WBC↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiArt↑, 2, AntiCan↓, 1, AntiCan↑, 22, antiD↑, 1, antiNeop↑, 3, antiPs↑, 1, AntiTum↑, 19, APG↓, 1, Appetite↑, 1, BowelM↑, 1, breath↑, 1, cachexia↓, 1, cardioP↑, 1, CardioT↑, 1, chemoP↑, 26, chemoPv↑, 4, ChemoSideEff↓, 2, fatigue↓, 2, hepatoP↓, 1, hepatoP↑, 5, kidSt↓, 1, LC↑, 1, Mucositis↓, 2, neuroP↑, 3, NP/CIPN↓, 2, OS↑, 18, OS⇅, 1, Pain↓, 3, PFS↑, 3, QoL↑, 13, radioP↑, 11, Remission↑, 1, RenoP↑, 3, Risk↓, 16, Risk↑, 1, Sleep↑, 2, Strength↑, 2, toxicity↓, 16, toxicity↑, 1, toxicity↝, 3, TumVol↓, 8, TumW↓, 5, Weight↑, 2, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1, Dectin1↝, 1, GutMicro↑, 12, Sepsis↓, 2,

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1, Ingr?, 1, Ingr↝, 11,
Total Targets: 550

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6, antiOx↑, 55, ARE↑, 1, Catalase↓, 1, Catalase↑, 13, DPPH↓, 1, Fenton↓, 1, GPx↓, 1, GPx↑, 13, GPx4↑, 1, GSH↓, 1, GSH↑, 12, GSR↑, 1, GSTs↑, 3, H2O2↓, 1, HDL↑, 2, HO-1↑, 6, hyperG↓, 1, Iron∅, 1, i-Iron↓, 1, Keap1↑, 1, lipid-P↓, 17, MDA↓, 11, MPO↓, 2, NADH↓, 1, NRF2↑, 11, RNS↓, 1, ROS?, 1, ROS↓, 40, ROS↝, 1, selenoP↑, 2, SOD↓, 1, SOD↑, 21, TAC↑, 4, TBARS↓, 2, TrxR↑, 1, uricA↓, 1, VitC↑, 2, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, FPN↑, 1, IronCh↑, 2, TfR1/CD71↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1, compII↑, 1, compIII↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 5, 5LO↝, 1, ACSL4↓, 1, ALAT↓, 7, AMPK↓, 1, AMPK↑, 3, ATP↓, 1, ATP↑, 2, DHODH↓, 1, FABP4↓, 1, glucose↓, 4, glucose↝, 1, GSK‐3β↓, 1, LDL↓, 6, NAD↓, 1, SIRT1↑, 1, SREBF2⇅, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 8, BAX↓, 3, Bcl-2↓, 1, Bcl-2↑, 1, Casp12↓, 1, Casp3↓, 4, Casp9↓, 1, Cyt‑c↓, 2, Ferroptosis↓, 2, GranB/GZMB↓, 1, iNOS↓, 5, necrosis↓, 1, p38↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2, Akt↑, 5, p‑Akt↑, 1, AMPKα↑, 1, CREB↑, 1, p‑JNK↓, 1, MAPK↓, 2, mTOR↓, 5, mTOR↑, 1, PI3K↓, 3, PI3K↑, 2, PKCδ↓, 1, PTEN↓, 1, STAT3↑, 1, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5, ATF4↓, 2, HDAC↑, 1, HOTAIR↑, 1, other↓, 4, other↑, 4, other↝, 11,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2, p‑eIF2α↓, 1, ER Stress↓, 1, GRP78/BiP↓, 1, XBP-1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3II↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3, P53↓, 2, Telomerase↓, 1, TOP1↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1, P21↓, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

AntiAg↓, 2, AntiAg↑, 8, Cartilage↑, 1, EMT↓, 1, MMP13↓, 1, TGF-β↓, 2, TGF-β↑, 1, TGF-β1↓, 2, Tyro3↓, 1, uPA↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1, Hif1a↓, 1, Hif1a↑, 1, NO↓, 3, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, GastroP↑, 5, IBI↑, 2, memfluid↑, 1, MMP↑, 2, MUC5AC↓, 1, TRPM7↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1, CD14↑, 1, CD4+↑, 5, CD8+↑, 2, COX1↓, 3, COX2/PTGS2↓, 13, DCells↑, 1, Dectin1↑, 1, IFN-γ↓, 3, IFN-γ↑, 2, IgA↑, 1, IL1?, 1, IL1↓, 1, IL10?, 1, IL10↓, 3, IL10↑, 5, IL12↓, 1, IL17↓, 3, IL1β↓, 7, IL2↑, 1, IL4↓, 1, IL4↑, 3, IL6?, 2, IL6↓, 16, IL6↑, 2, IL8↓, 2, Imm↓, 2, Imm↑, 83, Imm⇅, 2, Imm↝, 4, Inflam?, 1, Inflam↓, 76, LPS↓, 1, MCP1/CCL2↓, 2, MyD88↓, 1, NeuroI↓, 1, Neut↑, 1, NF-kB↓, 15, NK cell↑, 10, NLRP3↓, 4, PGE2↓, 3, Th1 response↑, 1, TLR4↓, 1, TNF-α?, 1, TNF-α↓, 22, TNF-α↑, 4, Treg lymp↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, AChE↓, 8, ADAM10↑, 1, BChE↓, 5, BDNF↓, 1, BDNF↑, 3, proBDNF↑, 1, GABA↑, 1, MAOA↓, 1, MAOB↓, 1, NGF↑, 1, TrkB↑, 1, β-Endo↑, 1,

Protein Aggregation(tgid=19) ⓘ

APOE4↓, 1, APP↓, 1, cl‑APP↑, 1, Aβ↓, 9, Aβ42↓, 1, BACE/β-secretase↓, 5, PSEN1/PS1↑, 1, tau↓, 1, p‑tau↓, 2, XO↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 2, PPARγ↑, 2, TSHR↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11, BioAv↑, 20, BioAv⇅, 1, BioAv↝, 8, ChemoSen↑, 2, Dose?, 1, Dose↓, 1, Dose↑, 2, Dose↝, 20, eff↓, 1, eff↑, 14, eff↝, 1, GSTA1↑, 1, Half-Life↓, 1, Half-Life↝, 4, P450↓, 1, Synergy↑, 8,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7, anemia↓, 1, AST↓, 8, BMD↑, 1, BP↓, 6, creat↓, 3, CRP↓, 3, Ferritin↓, 1, HemoG↑, 1, IL6?, 2, IL6↓, 16, IL6↑, 2, LDH↓, 1, LDH↑, 1, NLR↓, 1, NOS2↓, 1, RBC↑, 1, TMAO↓, 1, Urea↓, 2,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2, AntiAge↑, 5, antiAll↑, 3, AntiArt↑, 6, AntiCan↑, 18, antiD↑, 1, AntiDiabetic↓, 2, AntiDiabetic↑, 30, antiPs↑, 2, AntiTum↓, 1, AntiTum↑, 8, ANXi↓, 1, cardioP↑, 27, chemoP↑, 2, chemoPv↑, 3, cognitive↑, 15, diuretic↑, 3, hepatoP↓, 1, hepatoP↑, 30, Learn↑, 1, memory↑, 10, Mood↑, 1, motorD↑, 2, neuroP?, 1, neuroP↓, 1, neuroP↑, 34, Obesity↓, 13, OS↑, 2, Pain↓, 6, QoL↑, 3, radioP↑, 3, RenoP↑, 6, Risk↓, 3, Sleep↑, 2, Stroke↓, 3, toxicity?, 1, toxicity↓, 28, toxicity↑, 2, toxicity↝, 6, toxicity∅, 1, Weight↓, 1, Weight↝, 1, Wound Healing↑, 15,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, AntiBio↑, 14, AntiFungal↑, 6, AntiP↑, 2, AntiViral↑, 10, Bacteria↓, 21, Bacteria↑, 1, Dectin1↑, 1, Diar↓, 3, GutMicro↑, 20, Inf↓, 1, Sepsis↓, 2,

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1, Catechins↑, 1, FA↑, 1, Flav↑, 1, GA↑, 1, Ingr↑, 1, Ingr↝, 9, Phen↑, 1, QC↑, 1,
Total Targets: 309

Scientific Paper Hit Count for: Imm, immunostimulatory

14 Echinacea
13 beta-glucans
9 immunotherapy
9 chitosan
8 Lactoferrin/Talactoferrin
6 Dandelion Root
6 Electrical Pulses
6 phytic acid, Inositol hexakisphosphate
6 MCT, metronomic chemo
6 Bicarbonate(Sodium)
5 Hyperthermia
5 Inositol
5 Mushroom Maitake
5 Selenite (Sodium)
4 Astragalus
4 Curcumin
4 Radiotherapy/Radiation
4 Magnetic Fields
4 Magnetic Field Rotating
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Bifidobacterium
3 Chemotherapy
3 Centella asiatica / Gotu kola → asiaticoside
3 Chyawanprash
3 Cichoric acid / Chicoric acid
3 diet Fermented Foods
3 Fucoidan
3 Germanium Organic/Ge-132 / propagermanium (organogermanium)
3 Mistletoe/Viscum album Extracts
3 Phycocyanin
2 Aloe anthraquinones
2 Butyrate
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Cat’s Claw
2 Chlorogenic acid
2 Carica papaya leaf extract
2 Cucurbitacin
2 Chlorella (Chlorella vulgaris)
2 Date Fruit Extract
2 Docosahexaenoic Acid
2 diet Short Term Fasting
2 Diindolylmethane
2 Indole-3-carbinol
2 Disulfiram
2 doxorubicin
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Hydrogen Gas
2 Isobavachalcone
2 Inulin Prebiotic
2 Ivermectin
2 Isovitexin
2 Licochalcone A
2 Luteolin
2 Moringa oleifera
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Selenium
2 Selenium NanoParticles
2 Spirulina(Arthrospira/Limnospira)
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Anethole/trans-Anethole
1 Aspirin
1 Astaxanthin
1 Bevacizumab (brand Avastin)
1 Bromelain
1 Boswellia (frankincense)
1 Black phosphorus
1 Bruteridin(bergamot juice)
1 α-Bisabolol / Chamomile oil
1 Black turtle bean
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 Chlorophyllin
1 Chocolate
1 Carvone
1 diet FMD Fasting Mimicking Diet
1 D-limonene
1 Copper and Cu NanoParticles
1 flavonoids
1 Flaxseed/Linseed
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Gossypol/AT-101
1 hydroxychloroquine
1 Gemcitabine (Gemzar)
1 Paclitaxel/Taxol
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 iodine
1 Isorhamnetin
1 Juglone
1 Kaempferol
1 Lactobacillus
1 probiotics
1 Lapachol
1 Matrine
1 Mung Bean Sprouts
1 Vitexin
1 Modified Citrus Pectin
1 Metformin
1 Melatonin
1 Mucuna pruriens/Velvet Bean
1 Mushroom Chaga, Inonotus obliquus
1 5-fluorouracil
1 Nasturtium, Indian Cress
1 Isothiocyanates
1 Neem
1 Nimbolide
1 Peppermint
1 Purple Corn / Purple Maize
1 Piperine
1 Propranolol
1 Thyme
1 Thymol-Thymus vulgaris
1 Urolithin
1 Walnut
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1332  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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