mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Scientific Papers found: Click to Expand⟱
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, Synergy↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
2313- Flav,    Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
- Review, Var, NA
Warburg↓, antiOx↑, angioG↓, Glycolysis↓, PKM2↓, PKM2:PKM1↓, β-catenin/ZEB1↓, cMyc↓, HK2↓, Akt↓, mTOR↓, GLUT1↓, Hif1a↓,
6984- Form,    Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
- in-vitro, Colon, HCT116 - Review, IBD, RAW264.7
*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1/ATG6↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
5151- GamB,    Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Bcl-2↓, BAX↑, cl‑PARP1↑, cl‑Casp3↑, cl‑Casp9↑, PI3K↓, p‑Akt↓, p‑mTOR↓, PTEN↑,
1969- GamB,    Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
AntiTum↑, TumCI↓, Apoptosis↑, ROS↑, Cyt‑c↑, Akt↓, mTOR↓, TumCG↓, TumMeta↓,
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓, CompStab↝,
802- GAR,    Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway
- in-vitro, GC, HGC27
TumCP↓, TumCI↓, Apoptosis↑, PI3K/Akt↓, Akt↓, p‑mTOR↓, cycD1/CCND1↓, MMP2↓, MMP9↓, BAX↑, Bcl-2↓,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, Synergy↑, ChemoSen↑,
6569- Ger,    Geraniol inhibits cell growth and promotes caspase-dependent apoptosis in nasopharyngeal cancer C666-1 cells via inhibiting PI3K/Akt/mTOR signaling pathway
- in-vitro, NPC, C666-1
tumCV↓, MMP↓, Apoptosis↑, TBARS↑, GSH↓, SOD↓, BAX↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, mTOR↓, DNAdam↑, ROS↑,
7201- GGB,    Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway
- vitro+vivo, GC, AGS - in-vitro, GC, HGC27
TumCI↓, TumCMig↓, Apoptosis↑, Pyro↑, BAX↑, GSDMD↑, Bcl-2↓, TumCG↓, EMT↓, PCNA↓, N-cadherin↓, E-cadherin↑, PI3K↓, Akt↓, mTOR↓, Dose↝,
7277- GGB,    Ginkgolide B inhibits hydrogen peroxide-induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells
- in-vitro, Nor, H9c2
*cardioP↑, *Bcl-2↑, *cl‑Casp3↓, *BAX↓, *PI3K↑, *Akt↑, *mTOR↑,
7288- GGB,    Anti-Angiogenic Properties of Ginsenoside Rg3 Epimers: In Vitro Assessment of Single and Combination Treatments
- in-vitro, BC, MDA-MB-231
TumCMig↓, TumCP↓, Apoptosis↑, VEGF↓, AQPs↓, Akt↓, p‑mTOR↓, eff↑,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7252- Gink,    STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells
- in-vitro, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, J82 - in-vitro, Nor, SV-HUC-1
tumCV↓, selectivity↑, TumCMig↓, EMT↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, STEAP3↓, Bax:Bcl2↑, cl‑Casp3↑,
7256- Gink,    Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation
- in-vivo, Stroke, NA
*Stroke↓, *Apoptosis↓, *Casp3↓, *BAX↓, *Bcl-2↑, *p‑Akt↑, *p‑mTOR↑,
7285- Gins,    Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429
- in-vitro, GC, AGS
ChemoSen↑, miR-429↑, SOX2↓, PI3K↓, Akt↓, mTOR↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
2507- H2,    Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *Apoptosis↓, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *Beclin-1/ATG6↑, *p62↓, *mTOR↓,
292- HCA,    Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway
- in-vitro, AML, K562
ACLY↓, TumCG↓, AMPK↑, mTOR↑, UPR↑, eIF2α↑, ATF4↑, TumCCA↑, DNAdam↑,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
- Review, Var, NA
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2888- HNK,    Honokiol mediated inhibition of PI3K/mTOR pathway: A potential strategy to overcome immunoresistance in glioma, breast and prostate carcinoma without impacting T cell function
- in-vitro, Var, PC3 - in-vitro, BC, BT549
PI3K↓, mTOR↓, Inflam↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2892- HNK,    Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, H385 - in-vitro, Nor, BEAS-2B
TumCCA↑, Apoptosis↑, SIRT3↑, Hif1a↓, selectivity↑, p‑mTOR↓, p70S6↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
4688- HNK,    Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling
- vitro+vivo, RCC, A498
CSCs↓, EMT↓, TumCG↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, PTEN↑, Wnt↓, β-catenin/ZEB1↓,
7537- HT,    Hydroxytyrosol Alleviated Hypoxia-Mediated PC12 Cell Damage through Activating PI3K/AKT/mTOR-HIF-1 α Signaling
- in-vitro, Nor, PC12
*ROS↓, *mtDam↓, *PI3K↑, *Akt↑, *mTOR↑, *Hif1a↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4212- Hup,    Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
- in-vitro, Nor, HT22
*ROS↓, *p‑Akt↓, *p‑mTOR↓, *p‑p70S6↓, *BDNF↑, *Apoptosis↓, *Casp3↓, *Bcl-2↑,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7552- HYP,    Hyperoside exerts potent anticancer activity in skin cancer
- vitro+vivo, Melanoma, NA
AntiCan↑, *Inflam↓, *antiOx↑, PI3K↓, Akt↓, mTOR↓, TumCP↓, Apoptosis↑, TumAuto↑, chemoPv↑,
7553- HYP,    Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro
- in-vitro, NSCLC, A549 - in-vitro, Nor, BEAS-2B
LC3II↑, selectivity↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, p‑4E-BP1↓, p‑ERK↑, tumCV↓, Apoptosis↑,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7642- IP6,    Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway
- in-vitro, CRC, NA
AntiCan↑, TumCP↓, Apoptosis↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, AKT1↓, S6K↓, mTOR↓,
8280- ISL,    ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro
- vitro+vivo, HCC, SMMC-7721 cell
tumCV↓, TumCP↓, Apoptosis↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, TumCG↓, LC3II↑, cl‑Casp3↑, eff↑,
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,
7755- ISL,    Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *p‑T-cadherin↓, *ROS↓, *ATP↑, *p‑DRP1/DNM1L↝, *MFN1↝, *MFN2↝, *neuroP↑, *cognitive↑, *mTOR↓, *ERK↓, *GSK‐3β↑,

Showing Research Papers: 201 to 250 of 489
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 489

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 7,   ARE↑, 1,   Catalase↓, 7,   Catalase↑, 3,   Copper↓, 1,   Copper↑, 1,   Fenton↑, 3,   GPx↓, 2,   GPx↑, 1,   GPx4↓, 9,   GSH↓, 23,   GSH↑, 6,   GSR↓, 2,   GSTs↓, 2,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 6,   HO-1↓, 8,   HO-1↑, 19,   hyperG↓, 1,   Iron↓, 2,   Iron↑, 9,   i-Iron↓, 1,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 6,   lipid-P↑, 12,   MDA↓, 4,   MDA↑, 11,   MPO↓, 1,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 3,   NRF2↓, 22,   NRF2↑, 23,   NRF2↝, 3,   p‑NRF2↓, 1,   Prx4↑, 1,   PYCR1↓, 2,   ROS↓, 34,   ROS↑, 214,   ROS⇅, 8,   ROS↝, 3,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD?, 1,   SOD↓, 9,   SOD↑, 8,   mt-SOD↑, 1,   SOD1↑, 2,   SOD2↓, 3,   SOD2↑, 2,   TAC↓, 2,   TBARS↑, 1,   Thiols↓, 1,   TKT↝, 1,   Trx↑, 1,   Trx1↑, 2,   TrxR↓, 8,   TrxR↑, 1,   TrxR1↓, 3,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FTH1↓, 2,   NCOA4↑, 2,   STEAP3↓, 1,   Tf↓, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 8,   CDC25↓, 13,   compI↓, 5,   compIII↓, 3,   compV↓, 1,   EGF↓, 5,   EGF↑, 1,   ETC↓, 4,   ETC↑, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 7,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 18,   OCR↓, 9,   OCR↑, 4,   OXPHOS↓, 6,   OXPHOS↑, 7,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↑, 3,   PGC-1α↑, 1,   PINK1↑, 3,   SIRT3↓, 1,   SIRT3↑, 4,   VDAC1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 4,   AApath↓, 1,   ACC↓, 1,   ACC↑, 4,   p‑ACC↑, 1,   p‑ACC-α↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   adiP↑, 1,   ALAT↓, 2,   ALDOA↓, 1,   AMP↓, 2,   AMPK↓, 4,   AMPK↑, 62,   AMPK↝, 1,   p‑AMPK↑, 10,   ATGL/PNPLA2↓, 1,   ATP↓, 26,   ATP↑, 1,   mt-ATP↓, 2,   CAIX/CA9↓, 2,   CRM↑, 1,   ECAR↓, 5,   ENO1↓, 2,   FABP4↑, 1,   FASN↓, 6,   FASN↑, 1,   FBPase↑, 1,   FDG↓, 1,   FFA/NEFA↓, 1,   G6PD↓, 2,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 2,   glucoNG↑, 1,   glucose↓, 4,   GlucoseCon↓, 20,   GlutMet↓, 2,   glyC↓, 1,   Glycolysis↓, 50,   Glycolysis↝, 1,   p‑GS3Kβ↓, 1,   GSK‐3β↓, 16,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 4,   p‑GSK‐3β↑, 1,   HK1↓, 1,   HK2↓, 21,   HMG-CoA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 21,   lactateProd↑, 1,   LDHA↓, 11,   LDL↓, 2,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↓, 2,   NADPH↓, 3,   NPC1L1↓, 1,   PDK1 / PDPK1↓, 13,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 4,   PFK1↓, 3,   PFK2↓, 1,   PFKFB3↓, 2,   PFKP↓, 1,   PKM2↓, 28,   PKM2↑, 1,   PKM2:PKM1↓, 1,   Pyruv↓, 1,   R5P↝, 1,   p‑S6↓, 3,   SCD1↓, 2,   SCP2↓, 1,   SIRT1↓, 5,   SIRT1↑, 10,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 1,   TCA↑, 3,   TumCM/A↓, 1,   Warburg↓, 18,  

Cell Death(tgid=5) ⓘ

AIF↑, 8,   APAF1↑, 11,   Apoptosis?, 3,   Apoptosis↓, 1,   Apoptosis↑, 193,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   BAD?, 1,   BAD↓, 3,   BAD↑, 11,   Bak↑, 7,   BAX↓, 1,   BAX↑, 104,   BAX↝, 1,   Bax:Bcl2↑, 18,   Bcl-2↓, 112,   Bcl-2↑, 3,   Bcl-2↝, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 25,   Bcl-xL↑, 2,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 2,   BIM↓, 1,   BIM↑, 9,   BNIP3↑, 3,   BOK↑, 1,   Casp↓, 1,   Casp↑, 33,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 2,   Casp2↑, 1,   Casp3↓, 5,   Casp3↑, 114,   Casp3↝, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 26,   cl‑Casp3⇅, 1,   proCasp3↓, 2,   Casp6↓, 1,   Casp7↑, 10,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 26,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 66,   cl‑Casp9↓, 1,   cl‑Casp9↑, 11,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 8,   Cyt‑c↓, 1,   Cyt‑c↑, 67,   Cyt‑c↝, 1,   Diablo↑, 9,   DR5↓, 1,   DR5↑, 22,   FADD↑, 5,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 15,   FasL↑, 10,   Ferroptosis↑, 18,   GRP58↓, 1,   GSDMD↑, 1,   GSDME↑, 1,   IAP1↓, 8,   IAP2/BIRC3↓, 4,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 4,   iNOS↓, 12,   Mcl-1↓, 24,   MDM2↓, 10,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 3,   NAIP↓, 1,   Necroptosis↑, 1,   necrosis↑, 5,   oncosis↑, 2,   p38↓, 7,   p38↑, 17,   p‑p38↑, 4,   PUMA↓, 2,   PUMA↑, 3,   Pyro↑, 3,   RIP3↓, 1,   RIP3↑, 1,   survivin↓, 47,   TNFR 1↑, 2,   TRAIL↑, 6,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 13,   XIAP↓, 22,   XIAP↑, 1,   YAP/TEAD↓, 5,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 260,   Akt↑, 10,   Akt↝, 2,   p‑Akt↓, 75,   AKT1↓, 3,   AMPKα↑, 5,   CaMKII ↓, 2,   CaMKII ↑, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 2,   cSrc↓, 2,   EGFR↓, 47,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 36,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 8,   p‑ERK↑, 3,   FGFR1↓, 2,   GNAI1↓, 1,   HER2/EBBR2↓, 12,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGF-1R↓, 3,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 7,   JAK1↓, 4,   JAK2↓, 15,   p‑JAK2↓, 1,   JNK↓, 3,   JNK↑, 15,   JNK↝, 1,   p‑JNK↑, 4,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 31,   MAPK↑, 13,   MAPK↝, 3,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 7,   MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR?, 1,   mTOR↓, 353,   mTOR↑, 16,   mTOR⇅, 1,   mTOR↝, 4,   mTOR∅, 1,   p‑mTOR↓, 61,   p‑mTOR↑, 2,   mTORC2↓, 3,   mTORC2↑, 1,   p70S6↓, 5,   p70S6↑, 1,   p‑p70S6↓, 2,   P70S6K↓, 17,   P70S6K↑, 1,   p‑P70S6K↓, 7,   p‑P70S6K↑, 1,   p85S6K↓, 1,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PI3K?, 1,   PI3K↓, 192,   PI3K↑, 5,   PI3K↝, 3,   p‑PI3K↓, 13,   PI3K/Akt↓, 5,   PI3k/Akt/mTOR↓, 4,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 5,   PP2A↑, 2,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 5,   PTEN↑, 31,   PTEN↝, 1,   Raf↓, 3,   e-Raf↓, 1,   RAS↓, 13,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 2,   RIP1↑, 1,   RPS6KA1↓, 1,   S6K↓, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 8,   Src↓, 2,   p‑Src↓, 2,   STAT↓, 6,   STAT3↓, 79,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 1,   STAT6↓, 3,   p‑STAT6↓, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TSC2↑, 5,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 10,   ATF4↝, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 2,   cMyc↓, 35,   CREBBP↓, 1,   DLEU1↓, 1,   DNMT1↓, 6,   DNMT3A↓, 2,   DNMT3B↓, 2,   DNMTs↓, 5,   EZH2↓, 8,   FOXM1↓, 7,   FOXO↑, 1,   FOXO1↓, 3,   FOXO1↑, 3,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 17,   HDAC∅, 1,   HDAC1↓, 3,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 1,   HMTs↓, 1,   JPT1/HN1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-124-3p↓, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 3,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-206↑, 1,   miR-21↓, 6,   miR-21↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-340↓, 2,   miR-34a↓, 2,   miR-34a↑, 5,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 2,   miR-429↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 6,   OCT4↓, 11,   other↓, 5,   other↝, 5,   PhotoS↑, 1,   SOX2↓, 9,   SOX4↓, 4,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 2,   TFE3↑, 2,   tumCV?, 2,   tumCV↓, 59,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 23,   eIF2α↓, 3,   eIF2α↑, 4,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 37,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 12,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 6,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSP90↑, 1,   IRE1↑, 4,   PERK↑, 6,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 8,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 10,   ATG7↑, 5,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 27,   p‑Beclin-1/ATG6↑, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 7,   LC3A↑, 2,   LC3B↓, 1,   LC3B↑, 4,   LC3B-II↑, 7,   LC3I↓, 1,   LC3I↑, 1,   LC3II↑, 22,   LC3s↓, 1,   LC3s↑, 1,   lysoM↓, 1,   LysoPr↑, 1,   lysosome↓, 1,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 18,   p62↑, 6,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 3,   TumAuto↓, 4,   TumAuto↑, 92,   TumAuto⇅, 1,   ULK1/ATG1↑, 2,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↝, 1,   DFF45↓, 2,   DFF45↑, 1,   DNAdam↑, 45,   DNArepair↓, 2,   ERCC3↑, 1,   HR↓, 1,   hTERT/TERT↓, 4,   NBR2↑, 1,   p16↑, 3,   P53?, 1,   P53↓, 3,   P53↑, 74,   P53↝, 1,   p‑P53↑, 3,   p53 Wildtype↑, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 3,   PARP↑, 22,   cl‑PARP↑, 55,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 16,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 5,   TOP1?, 1,   TOP1↓, 5,   TOP2↓, 5,   TOP2↑, 1,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 3,   γH2AX↝, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 16,   CDK1↑, 3,   p‑CDK1↓, 1,   CDK2↓, 31,   CDK2↑, 2,   CDK4↓, 36,   CDK4↑, 3,   CDK4/6↓, 2,   CDK6↓, 15,   CDK6↑, 4,   CDKN1C/p57↓, 1,   CHK1↓, 1,   p‑CHK1↑, 2,   Chk2↓, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 11,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 25,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 58,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 3,   cycE/CCNE↓, 18,   cycE1↓, 2,   E2Fs↓, 3,   E2Fs↑, 1,   Ki-67↓, 25,   mitA↓, 1,   mitA↑, 1,   p19↑, 2,   P21↓, 2,   P21↑, 53,   P21↝, 1,   p27/CDKN1B↓, 4,   p27/CDKN1B↑, 25,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   Securin↓, 3,   TAp63α↑, 1,   TumCCA?, 2,   TumCCA↓, 5,   TumCCA↑, 153,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 4,   4E-BP1↑, 1,   p‑4E-BP1↓, 4,   ALDH↓, 5,   ALDH1A1↓, 1,   Axin2↑, 1,   BMI1↓, 2,   BMP7/OP1↓, 1,   BMPs↑, 2,   CD133↓, 6,   CD24↓, 3,   CD34↓, 2,   cFos↓, 9,   cFos↑, 1,   CSCs↓, 37,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 2,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 12,   HH↓, 12,   IGF-1↓, 11,   IGFBP1↑, 3,   IGFBP3↓, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 25,   Let-7↓, 1,   Let-7↑, 2,   mTORC1↓, 9,   Nanog↓, 9,   Nestin↓, 1,   NOTCH↓, 18,   NOTCH↑, 1,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 2,   OGFr↑, 2,   p300↓, 1,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 7,   Smo↓, 7,   STAT1↓, 1,   Sufu↓, 1,   TumCG↓, 81,   TumCG↑, 4,   TumCP?, 2,   TumCP↓, 150,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt?, 1,   Wnt↓, 49,   Wnt↝, 1,   Wnt/(β-catenin)↓, 8,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 11,   AP-1↝, 1,   AXL↓, 2,   CA↓, 2,   Ca+2↓, 4,   Ca+2↑, 25,   Ca+2↝, 1,   i-Ca+2?, 1,   CAFs/TAFs↓, 2,   Cal1↑, 1,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↓, 1,   Chl↑, 1,   Cofilin↓, 1,   COL1↓, 2,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 44,   EMT↓, 71,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   F-actin↑, 1,   FAK↓, 11,   p‑FAK↓, 1,   Fibronectin↓, 5,   Furin↓, 1,   GIT1↓, 1,   GLI2↓, 5,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB1↑, 1,   KRAS↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 5,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 2,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 77,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 10,   MMP7↓, 10,   MMP9↓, 83,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 26,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 33,   NCAM↑, 1,   NEDD9↓, 1,   PAK1↓, 4,   PAK1↑, 1,   PDGF↓, 3,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 3,   Rho↑, 1,   ROCK1↓, 7,   ROCK1↑, 1,   Sharpin↓, 1,   Slug↓, 11,   Smad1↓, 1,   SMAD2↓, 1,   SMAD2↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   SMAD4↓, 2,   p‑SMAD4↓, 1,   Snail↓, 29,   talin↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 18,   TGF-β↑, 2,   TIMP1↓, 2,   TIMP1↑, 4,   TIMP2↓, 3,   TIMP2↑, 3,   TSC1↑, 2,   TSP-1↑, 3,   TumCA↓, 3,   TumCI?, 2,   TumCI↓, 88,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 79,   TumCMig↑, 3,   TumMeta↓, 57,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 20,   Tyro3↓, 1,   uPA↓, 19,   uPAR↓, 3,   Vim?, 1,   Vim↓, 38,   Vim↑, 1,   vinculin↓, 1,   Zeb1↓, 13,   ZEB2↓, 1,   α-tubulin↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 52,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 78,   angioG↑, 3,   CD31/PECAM-1↓, 5,   EGR4↓, 1,   Endoglin↑, 2,   eNOS↓, 1,   HIF-1↓, 9,   Hif1a↓, 63,   Hypoxia↓, 2,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 3,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 91,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↓, 1,   BBB↑, 3,   BBB∅, 2,   CellMemb↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   GLUT1↓, 22,   GLUT2↓, 1,   GLUT4↓, 2,   MMP↓, 86,   MMP↑, 2,   MPT↑, 2,   TRPM7↓, 2,   TRPM7↑, 1,   TRPV1↑, 2,   TRPV1↝, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 14,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 57,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 13,   DCells↑, 1,   DR4↑, 2,   FOXP3↑, 2,   HMGB1↓, 1,   ICAM-1↓, 7,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 5,   IL10↓, 8,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 12,   IL2↓, 1,   IL2↑, 5,   IL33↑, 1,   IL6↓, 34,   IL6↑, 1,   IL6↝, 1,   IL8↓, 5,   Imm↑, 10,   Imm↝, 3,   Inflam↓, 20,   IRAK1↓, 2,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   NF-kB↓, 116,   NF-kB↑, 1,   NF-kB↝, 2,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 4,   p50↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 4,   PD-L1↓, 13,   PGE2↓, 16,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↑, 1,   T-Cell↑, 1,   TCF↓, 2,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR2↓, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 25,   TNF-α↑, 3,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   pH↓, 1,   pH↑, 1,   e-pH↑, 1,   i-pH↓, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   MAOA↓, 1,   PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AhR↓, 2,   AR↓, 13,   AR↝, 1,   CYP19↓, 1,   ER-α36↓, 1,   ERα/ESR1↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 2,   PPARγ↓, 3,   PPARγ↑, 7,   RANKL↓, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 33,   BioAv↑, 36,   BioAv↝, 9,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↑, 125,   CompStab↓, 3,   CompStab↑, 3,   CompStab↝, 3,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 5,   Dose↝, 43,   Dose∅, 2,   eff?, 1,   eff↓, 32,   eff↑, 57,   eff↝, 8,   eff∅, 3,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life↓, 11,   Half-Life↝, 12,   Half-Life∅, 1,   MDR1↓, 11,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 22,   P450↓, 2,   RadioS↑, 39,   selectivity↑, 58,   selectivity↝, 1,   Synergy?, 1,   Synergy↑, 83,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALP↓, 2,   AR↓, 13,   AR↝, 1,   AST↓, 1,   BG↓, 3,   BRCA1↓, 2,   BRCA1↝, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 3,   E7↓, 3,   EGFR↓, 47,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 8,   Ferritin↓, 3,   FOXM1↓, 7,   HemoG↓, 1,   HER2/EBBR2↓, 12,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 34,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 8,   LDH↑, 3,   Myc↓, 6,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 13,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 2,   TP53↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan?, 1,   AntiCan↑, 42,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↓, 1,   AntiTum↑, 18,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 2,   cardioP↑, 9,   chemoP↑, 22,   chemoPv↑, 11,   ChemoSideEff↓, 3,   fatigue↓, 3,   hepatoP↑, 3,   Mucositis↓, 1,   neuroP↑, 5,   NP/CIPN↓, 1,   OS↑, 12,   OS⇅, 1,   OS∅, 1,   Pain↓, 3,   PFS↑, 1,   PFS∅, 1,   QoL↑, 6,   QoL∅, 1,   radioP↑, 6,   RenoP↑, 7,   Risk↓, 10,   Risk↑, 1,   Sleep↑, 2,   Strength↑, 2,   toxicity↓, 23,   toxicity↝, 10,   toxicity∅, 1,   TumVol↓, 20,   TumVol∅, 1,   TumW↓, 14,   TumW∅, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 8,   GutMicro↝, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 8,  
Total Targets: 1119

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 4,   antiOx↑, 67,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 38,   GPx↑, 24,   GPx1↑, 2,   GPx4↑, 2,   GSH↑, 22,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 8,   H2O2↓, 1,   HDL↓, 1,   HO-1?, 1,   HO-1↑, 23,   hyperG↓, 1,   hyperG↝, 1,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 22,   MDA↓, 23,   MDA↑, 1,   MPO↓, 2,   NOX4↓, 1,   NQO1↑, 7,   NRF2?, 1,   NRF2↑, 47,   RNS↓, 2,   ROS?, 1,   ROS↓, 87,   mt-ROS↓, 2,   SOD↓, 1,   SOD↑, 38,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   p‑DRP1/DNM1L↝, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 4,   MFN1↝, 1,   MFN2↝, 1,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↑, 5,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   adiP↑, 1,   ALAT↓, 11,   AMPK↓, 1,   AMPK↑, 21,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↑, 5,   CRM↑, 1,   cytoP450↓, 1,   ECAR↓, 1,   FASN↓, 1,   glucose↓, 6,   glucose↝, 1,   GlucoseCon↑, 3,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↑, 1,   LDL↓, 7,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 2,   PFK↑, 1,   PKM2↑, 1,   PLA2↓, 1,   SIRT1↑, 10,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 8,   Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 7,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp12↓, 2,   Casp3↓, 12,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 2,   cl‑Casp8↓, 1,   Casp9↓, 2,   cl‑Casp9↓, 1,   Cyt‑c∅, 1,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 10,   p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 18,   Akt↝, 1,   p‑Akt↓, 6,   p‑Akt↑, 3,   CREB↑, 1,   p‑CREB↑, 1,   ERK↓, 3,   ERK↑, 3,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IKKα↑, 1,   IκB?, 1,   JAK2↑, 1,   JNK↓, 2,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 26,   mTOR↑, 19,   mTOR↝, 2,   p‑mTOR↓, 10,   p‑mTOR↑, 3,   p‑p70S6↓, 1,   P70S6K↓, 3,   p‑P70S6K↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 6,   PI3K↑, 13,   PI3K↝, 1,   p‑PI3K↓, 2,   PKA↑, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTP1B↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 8,   ATF4↓, 1,   ATF4↑, 1,   cJun↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC2↓, 1,   HOTAIR↑, 1,   miR-107↑, 1,   other↓, 4,   other↑, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 2,   HSP70/HSPA5↓, 1,   HSP90↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↑, 4,   LC3s↓, 1,   MitoP↑, 2,   p62↓, 3,   p62↑, 1,   PARK2↑, 2,   TFEB↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 3,   DNArepair↑, 1,   p16↓, 1,   P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↑, 1,   Diff↑, 1,   Diff↝, 1,   FGF↑, 1,   IGF-1↓, 1,   mTORC1↓, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 2,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 2,   MMPs↑, 1,   N-cadherin↑, 1,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TXNIP↓, 1,   Vim↓, 1,   α-SMA↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   CD31/PECAM-1↑, 1,   E-sel↓, 1,   eNOS↓, 1,   Hif1a↓, 2,   Hif1a↑, 1,   NO↓, 11,   NO↑, 1,   VEGF↓, 2,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 9,   GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 3,   MMP↑, 4,   MMP∅, 1,   MUC5AC↓, 1,   TRPA1↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 18,   HMGB1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 4,   IL10↑, 7,   IL17↓, 4,   IL18↓, 1,   IL1β↓, 24,   IL23↓, 2,   IL4↓, 2,   IL5↓, 1,   IL6↓, 30,   IL6↑, 1,   IL8↓, 6,   Imm↑, 5,   Inflam↓, 94,   Inflam↑, 1,   LPS↓, 2,   MCP1/CCL2↓, 2,   MyD88↓, 1,   NeuroI↓, 2,   NF-kB↓, 30,   p‑NF-kB↓, 1,   NLRP3↓, 10,   NLRP3↑, 1,   PGE2↓, 12,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 7,   TNF-α↓, 37,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 2,   Ach↑, 4,   AChE↓, 14,   BChE↓, 1,   BDNF↑, 14,   ChAT↑, 2,   MAOA↓, 2,   NGF↑, 3,   TPH1↓, 1,   TrkB↑, 1,   TrkB↝, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 2,   Aβ↓, 20,   Aβ42↓, 1,   BACE/β-secretase↓, 7,   tau↓, 1,   p‑tau↓, 9,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,   CYP19↓, 1,   FGF21↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 23,   BioAv↑, 18,   BioAv↝, 21,   BioEnh↑, 2,   CompStab↑, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 12,   eff↑, 10,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 12,   Half-Life∅, 2,   P-gp/ABCB1↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 11,   ALP↓, 4,   AST↓, 13,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 2,   p‑BRCA1↑, 1,   BUN↓, 2,   colonLen↑, 1,   creat↓, 3,   CRP↓, 3,   IL6↓, 30,   IL6↑, 1,   LDH↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 9,   antiAll↑, 11,   AntiArt↑, 6,   AntiCan↓, 1,   AntiCan↑, 14,   antiCG↑, 3,   antiD↓, 1,   AntiDiabetic↑, 13,   antiPs↑, 1,   AntiTum↑, 5,   cardioP↑, 31,   chemoP↑, 4,   chemoPv↑, 4,   cognitive↑, 23,   cough?, 1,   hepatoP↑, 31,   Learn↑, 3,   memory↑, 29,   motorD↑, 3,   Mucositis↓, 2,   neuroP?, 1,   neuroP↑, 67,   Obesity↓, 10,   OS↑, 4,   Pain↓, 1,   radioP↑, 3,   RenoP↑, 8,   Risk↓, 4,   SoreThr?, 1,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 11,   toxicity↓, 23,   toxicity↑, 3,   toxicity↝, 10,   toxicity∅, 2,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 5,   AntiP↑, 9,   AntiViral↑, 15,   Bacteria↓, 14,   Diar↓, 1,   GutMicro↑, 14,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 5,  
Total Targets: 403

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
22 Curcumin
19 Fisetin
15 Quercetin
14 Berberine
13 Baicalein
11 Ivermectin
9 Thymoquinone
9 Magnetic Fields
9 Resveratrol
9 Sulforaphane (mainly Broccoli)
9 itraconazole
9 Luteolin
9 Matrine
8 Apigenin (mainly Parsley)
8 EGCG (Epigallocatechin Gallate)
8 Honokiol
8 Isoliquiritigenin
8 Shikonin
7 Alpha-Lipoic-Acid
7 Artemisinin
7 Metformin
6 Chemotherapy
6 diet FMD Fasting Mimicking Diet
6 Isorhamnetin
6 Lycopene
6 Magnolol
6 Melatonin
6 Urolithin
5 Capsaicin
5 Hydrogen Gas
5 Licochalcone A
5 Piperlongumine
5 Rosmarinic acid
5 Silymarin (Milk Thistle) silibinin
4 5-fluorouracil
4 Allyl isothiocyanate
4 Benzyl isothiocyanate
4 Phenethyl isothiocyanate
4 Ashwagandha(Withaferin A)
4 Beta-Caryophyllene
4 Chlorogenic acid
4 Chrysin
4 Cinnamon
4 Citric Acid
4 Dichloroacetate
4 Diindolylmethane
4 Gambogic Acid
4 Hyperoside
4 Isovitexin
4 Vitexin
4 Kaempferol
4 L-Theanine
4 Licorice
4 Magnetic Field Rotating
4 Morin
4 doxorubicin
4 Piperine
4 Pterostilbene
3 Coenzyme Q10
3 Astragalus
3 Cisplatin
3 Isothiocyanates
3 brusatol
3 Carnosic acid
3 salinomycin
3 diet Short Term Fasting
3 Eugenol
3 Ginkgolide B
3 HydroxyTyrosol
3 isoquercitrin
3 Mangiferin
3 Naringin
2 1,8-Cineole
2 Auranofin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Anethole/trans-Anethole
2 Betulinic acid
2 Brucea javanica
2 Boswellia (frankincense)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Propolis -bee glue
2 Hydroxycinnamic-acid
2 Cranberry
2 Calorie Restriction Mimetics
2 Ursolic acid
2 CUSP9
2 Deguelin
2 Dandelion Root
2 Ellagic acid
2 Emodin
2 Ferulic acid
2 Formononetin
2 Garcinol
2 Ginkgetin
2 Juglone
2 Lasiodin
2 low dose naltrexone
2 MCT oil
2 Niclosamide (Niclocide)
2 Plumbagin
2 α-Santalol/Sandalwood oil
2 Vitamin D3
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 2-DeoxyGlucose
1 Baicalin
1 Biochanin A
1 Bufalin/Huachansu
1 Beetroot
1 Butyrate
1 Trastuzumab
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Spermidine
1 Aspirin
1 Crocetin
1 Radiotherapy/Radiation
1 Chlorella (Chlorella vulgaris)
1 diet Methionine-Restricted Diet
1 Indole-3-carbinol
1 flavonoids
1 Fucoidan
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 HydroxyCitric Acid
1 Huperzine A/Huperzia serrata
1 Inulin Prebiotic
1 phytic acid, Inositol hexakisphosphate
1 isoflavones
1 Sorafenib (brand name Nexavar)
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Lactoferrin/Talactoferrin
1 Linalool
1 Methylene blue
1 Mung Bean Sprouts
1 Magnesium
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Oleuropein
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 sericin
1 Phycocyanin
1 Parthenolide
1 Gold NanoParticles
1 Selenium
1 Selenium NanoParticles
1 acetazolamide
1 Spirulina(Arthrospira/Limnospira)
1 Selenite (Sodium)
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Usnic acid
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:209  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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