Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
Scientific Papers found: Click to Expand⟱
5732- Buty,    GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
- Study, CRC, NA
HCAR2↑, other↓, Apoptosis↑, HDAC↓, Bcl-2↓, Bcl-xL↓, cycD1/CCND1↓, DR5↑, NF-kB↓, GutMicro↑, SLC12A5↝,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
5746- CA,    Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
tumCV↓, ROS↑, TumCCA↑, Apoptosis↑, p‑MAPK↓, ERK↓, JNK↓, p38↓, IL6↓, JAK1↓, p‑STAT3↓, cycD1/CCND1↓, CDK1↓, BAX↑, Casp3↑, Bcl-2↓, TumCD↑,
5749- CA,  Z,  Rad,    Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice
- vitro+vivo, BC, MCF7 - NA, Liver, HepG2
RadioS↑, TumVol↓, Bcl-2↓, NF-kB↓, VCAM-1↓, ERK↓, DNAdam↑, TumCCA↑,
5877- CA,    Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↑, Casp9↑, Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↓, MDM2↓, ROS↑, eff↓, STAT3↓, survivin↓, cycD1/CCND1↓,
5866- CA,    Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116 - in-vitro, Colon, SW480 - in-vitro, Colon, HT29
tumCV↓, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cycD1/CCND1↓, CycD3↓, ROS↑, eff↓, Synergy↑,
5870- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen‐Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF7
ROS↑, cJun↑, p38↑, eff↓, TumCP↓, glucose↓, Apoptosis↑, BAX↑, PARP↑, Bcl-2↓, TumCG↑, Ki-67↓, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5876- CA,    Carnosic acid, a rosemary phenolic compound, induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells
- in-vitro, neuroblastoma, NA
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, PARP↑, Bcl-2↓, ROS↑, eff↓,
5874- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF10
AntiTum↓, ROS↑, cJun↑, p‑p38↑, Apoptosis↑, ROS↑, Synergy↑, TumCP↓, glucose↓, BAX↑, PARP↑, Bcl-2↓, eff↓, Ki-67↓, toxicity↝, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5836- CAP,    In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, Bxpc-3
tumCV↓, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, survivin↓, Cyt‑c↑, AIF↑, selectivity↑, JNK↑, TumCG↓,
5843- CAP,    The Effects of Capsaicin on Gastrointestinal Cancers
- Review, GC, NA
*BioAv↑, ROS↑, Apoptosis↑, Glycolysis↓, HK2↓, MMP9↓, AMPK↑, TumCP↓, Casp3↑, Bcl-2↓, P53↑, BAX↑,
5201- CAP,    Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
5199- CAP,    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
- vitro+vivo, AML, NA
STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, Synergy↑,
1262- CAP,    Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
- vitro+vivo, BC, NA
FBI-1↓, Ki-67↓, Bcl-2↓, survivin↓, BAX↑, Casp3↑, TumCP↓, Apoptosis↑,
1517- CAP,    Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
- in-vitro, Bladder, TSGH8301 - in-vitro, CRC, T24/HTB-9
ENOX2↓, TumCCA↑, ERK↓, p‑FAK↓, p‑pax↓, TumCMig↓, EMT↓, SIRT1↓, Dose∅, ROS↑, MMP↓, Bcl-2↓, Bak↑, cl‑PARP↑, Casp3↑, SIRT1↓, ac‑P53↑, BIM↑, p‑RB1↓, cycD1/CCND1↓, Dose∅, β-catenin/ZEB1↓, N-cadherin↓, E-cadherin↑,
2012- CAP,    Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways
- in-vitro, OS, MG63
AntiTum↑, Apoptosis↑, TRPV1↑, ROS↑, SOD↓, AMPK↑, P53↑, JNK↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Ca+2↑, MMP↓,
8695- CAP,    Advances in cold atmospheric plasma therapy for cancer
- Review, Var, NA
Apoptosis↑, Pyro↑, Ferroptosis↑, necrosis↑, Bacteria↓, antiCG↓, ChemoSen↑, ROS↑, RNS↑, cl‑Casp3↑, BAX↑, PARP↑, Casp8↑, P53↑, Akt↓, Bcl-2↓, GSH↓, MDA↑, Iron↑, MAPK↓, MMP9↓, TumCG↓, selectivity↑, toxicity↝,
8698- CAP,    Cold atmospheric plasma as a novel “drug” for cancer therapy
- Review, Var, NA
AntiTum↓, ChemoSen↑, selectivity↑, ROS↑, Synergy↑, mtDam↑, DNAdam↑, Cyt‑c↑, PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Ki-67↓, Ca+2↑, ER Stress↑, Synergy↑, TumCI↓, TumCCA↑, MAPK↓, Synergy↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5882- CAR,    Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
tumCV↓, TumCCA↑, pRB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, PI3K↓, p‑Akt↓, Apoptosis↑, Bcl-2↓, BAX↑,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5897- CAR,    Carvacrol Selectively Induces Mitochondria-Related Apoptotic Signaling in Primary Breast Cancer-Associated Fibroblasts
- in-vitro, BC, NA
Bax:Bcl2↑, PPARα↓, NF-kB↓, SIRT1↑, SIRT3↑, MMP3↓, selectivity↑, Bcl-2↓, BAX↑, Casp3↑, Casp6↑, Casp9↑, mt-Apoptosis↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
1287- CAR,    Bcl-2CytC_signaling_pathway">Carvacrol induces apoptosis in human breast cancer cells via Bcl-2/CytC signaling pathway
- in-vitro, BC, HCC1937
TumCP↓, TumCCA↑, Apoptosis↑, BAX↑, Cyt‑c↑, Casp3↑, Bcl-2↓,
5939- Cela,  Chemo,    Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
- in-vitro, Melanoma, U266 - in-vitro, Melanoma, RPMI-8226
TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,
6652- Cen,    AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells
- in-vitro, GC, SGC-7901 - in-vitro, GC, HGC27
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, Bcl-2↓, BAX↑, cMyc↓, Casp3↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, tumCV↓,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6012- CGA,    Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma
- in-vitro, CCA, HCC9810
TumCP↓, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, TumCCA↑, AKR1B10↓, Akt↓, mtDam↑, BAX↑, Casp9↑, Casp3↑, Bcl-2↓,
1298- CGA,    Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells
- in-vitro, Lung, A549
Bcl-2↓, BAX↑, Casp3↑, p38↑, JNK↑, Nanog↓, SOX2↓, OCT4↓,
7180- CHA,    Chaetocin: A review of its anticancer potentials and mechanisms
- Review, Var, NA
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumCMig↓, SUV39H↓, TrxR↓, Hif1a↓, HSP90↓, ox-Trx1↑, ROS↑, PI3K↓, Akt↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, DR5↑, CHOP/DDIT3↑, ATF3↑, angioG↓, VEGF↑, LDHA↓, ENO1↓,
7164- CHA,    Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo
- vitro+vivo, Melanoma, A375
TumCP↓, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, TumCG↓, PCNA↓, tumCV↓, NRF2↑, SOD2↑, Catalase↑, NRF2↓, SOD2↓, Catalase↓, TrxR↓,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
4487- Chit,  PreB,    Unravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review
- Review, Var, NA
*GutMicro↑, Apoptosis↑, BAX↑, Bcl-2↓, *Inflam↓, AntiTum↑,
6066- CHL,    The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion
- in-vitro, BC, MCF7
ERK↓, Bcl-2↓, Apoptosis↑,
6069- CHL,  PDT,    Anti-Cancer Effect of Chlorophyllin-Assisted Photodynamic Therapy to Induce Apoptosis through Oxidative Stress on Human Cervical Cancer
- in-vitro, Cerv, HeLa
eff↑, ROS↑, Casp8↓, Casp9↑, BAX↑, Cyt‑c↑, Bcl-2↓, AKT1↓,
6068- CHL,    Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis
- in-vivo, Oral, NA
NF-kB↓, IKKα↓, Apoptosis↓, Bcl-2↑, survivin↓, Casp↑, cl‑PARP↑,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
2795- CHr,    Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53
- in-vitro, Liver, HepG2
ChemoSen↑, P53↑, ERK↑, BAX↑, DR5↑, Bcl-2↓, Casp8↑, Cyt‑c↑, Casp9↑,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1 / PDPK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27/CDKN1B↑, P53↑,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
6164- Cin,    Advances in pharmacological effects and mechanism of action of cinnamaldehyde
- Review, Var, NA - Review, PSA, NA
*glucose↑, *cardioP↑, *Inflam↓, *lipid-P↓, GutMicro↑, TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, BAX↑, P53↑, Bcl-2↓, IAP1↓, PI3K↓, Akt↓, *ROS↓, *NRF2↑, *NF-kB↓, NF-kB↑,
6142- Cin,    Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, SW48 - in-vitro, CRC, HCT116
E-cadherin↑, MMP2↓, MMP9↓, PI3K↓, Akt↓, IGF-1↓, Apoptosis↑, BAX↑, cl‑PARP↑, PARP↓, Bcl-2↓, TumCI↓,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
1055- Cin,    Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
- vitro+vivo, Melanoma, NA - vitro+vivo, CRC, NA - vitro+vivo, lymphoma, NA
TumCP↓, NF-kB↓, AP-1↓, Bcl-2↓, Bcl-xL↓, survivin↓,

Showing Research Papers: 201 to 250 of 856
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 856

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 4,   antiOx↑, 9,   antiOx⇅, 2,   ARE↓, 1,   ARE↑, 1,   Catalase↓, 15,   Catalase↑, 12,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 2,   frataxin↑, 1,   GPx↓, 4,   GPx↑, 8,   GPx1↓, 1,   GPx4↓, 8,   GPx4↑, 1,   GSH↓, 51,   GSH↑, 9,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 4,   GSS↑, 1,   GSTs↓, 2,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 7,   HO-1↓, 8,   HO-1↑, 14,   HO-1↝, 1,   Iron↑, 3,   i-Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 9,   lipid-P↑, 19,   lipid-P↝, 1,   MDA↓, 6,   MDA↑, 14,   MPO↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 7,   NRF2↓, 20,   NRF2↑, 21,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx6↑, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 4,   ROS↓, 28,   ROS↑, 346,   ROS⇅, 9,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 4,   mt-ROS↑, 8,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 18,   SOD↑, 14,   SOD1↓, 2,   SOD1↑, 2,   SOD2↓, 6,   SOD2↑, 4,   TAC?, 1,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 3,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 6,   TrxR1↓, 7,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 2,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   Bfl-1↓, 1,   CDC2↓, 11,   CDC2↑, 1,   CDC25↓, 17,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   EGF↓, 5,   ETC↓, 4,   HSP60/HSPD1↓, 1,   MCU↓, 1,   mitResp↓, 3,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 27,   OCR↓, 6,   OXPHOS↓, 8,   mt-OXPHOS↓, 2,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PHB↓, 1,   PHB↑, 1,   PINK1↑, 3,   SIRT3↓, 3,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 3,   5LO↓, 3,   ACC↑, 4,   p‑ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   ALAT↓, 2,   ALAT↑, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 26,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 23,   e-ATP↑, 1,   CAIX/CA9↓, 4,   CAIX/CA9↑, 1,   i-Cer↑, 1,   ENO1↓, 4,   FAO↑, 1,   FASN↓, 10,   FBI-1↓, 1,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GAPDH↓, 3,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 3,   GlucoseCon↓, 7,   GlutaM↓, 1,   GlutMet↓, 2,   Glycolysis↓, 29,   GSK‐3β↓, 12,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 6,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 14,   HMG-CoA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDHA↓, 8,   LDL↓, 3,   lipidLev↓, 1,   MCT4↓, 1,   NAD↝, 1,   NADPH↓, 3,   NADPH↑, 1,   O-Glc↓, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 11,   PDKs↓, 1,   PFK↓, 2,   PFKFB4?, 1,   PFKP↓, 1,   PKM2↓, 12,   PLA2↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 7,   SIRT1↑, 7,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   SSAT↑, 1,   TCA?, 1,   TCA↓, 3,   TCA↑, 1,   TS↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   AIF↝, 1,   APAF1↑, 15,   Apoptosis?, 4,   Apoptosis↓, 16,   Apoptosis↑, 426,   Apoptosis↝, 1,   mt-Apoptosis↑, 6,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   p‑ASK1↑, 1,   BAD?, 1,   BAD↓, 5,   BAD↑, 25,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 22,   BAX↓, 11,   BAX↑, 505,   BAX⇅, 1,   BAX↝, 3,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2?, 1,   Bcl-2↓, 764,   Bcl-2↑, 18,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 116,   Bcl-xL↑, 3,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 17,   BIM↓, 1,   BIM↑, 17,   BNIP3?, 2,   BNIP3↑, 5,   BOK↑, 2,   Casp↓, 1,   Casp↑, 56,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp1↑, 4,   Casp10↑, 2,   Casp12?, 1,   Casp12↑, 6,   Casp12↝, 1,   cl‑Casp12↑, 2,   Casp2↑, 3,   Casp3?, 3,   Casp3↓, 6,   Casp3↑, 331,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 93,   proCasp3↓, 3,   proCasp3↑, 3,   Casp6↑, 2,   Casp7?, 1,   Casp7↑, 32,   cl‑Casp7↑, 8,   Casp8↓, 1,   Casp8↑, 67,   cl‑Casp8↑, 14,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 194,   Casp9∅, 1,   p‑Casp9↑, 2,   cl‑Casp9↑, 37,   proCasp9↓, 1,   proCasp9↑, 3,   CellShr↑, 1,   cFLIP↓, 10,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 180,   Cyt‑c↝, 4,   Cyt‑c?, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 8,   DIDO1/DIO-1↑, 1,   DR5↑, 34,   FADD↑, 12,   Fas↓, 2,   Fas↑, 35,   FasL↓, 1,   FasL↑, 18,   Ferroptosis↑, 9,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME↑, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 1,   HEY1↓, 2,   IAP1↓, 21,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 17,   iNOS↑, 2,   Mcl-1↓, 64,   MDM2↓, 16,   MDM2↑, 1,   p‑MDM2↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 8,   NAIP↓, 2,   Necroptosis↑, 3,   necrosis↑, 4,   NOXA↑, 8,   p38↓, 7,   p38↑, 32,   p‑p38↓, 7,   p‑p38↑, 13,   Paraptosis↑, 2,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 118,   survivin↑, 1,   survivin↝, 1,   TNFR 1↑, 4,   TRAIL↑, 9,   TRAILR↑, 2,   TumCD↓, 2,   TumCD↑, 29,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 56,   XIAP↑, 1,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 182,   Akt↑, 6,   Akt↝, 1,   p‑Akt↓, 70,   p‑Akt↑, 1,   AKT1↓, 6,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 2,   Cavin3↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 2,   p‑cMET↑, 2,   cSrc↓, 4,   EGFR↓, 31,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 60,   ERK↑, 17,   p‑ERK↓, 27,   p‑ERK↑, 6,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↓, 1,   HRAS↓, 1,   IGF-1R↓, 3,   IGFR↓, 1,   IKKα↓, 10,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 2,   JAK↓, 5,   JAK1↓, 8,   JAK1↑, 1,   JAK2↓, 23,   p‑JAK2↓, 2,   JNK↓, 5,   JNK↑, 33,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 10,   cl‑JNK↑, 1,   LATS1↓, 1,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 40,   MAPK↑, 20,   MAPK↝, 1,   p‑MAPK↓, 3,   p‑MAPK↑, 4,   MARK4↓, 2,   MEK↓, 6,   p‑MEK↓, 2,   p‑MEK↑, 1,   MKK4↓, 1,   Mst1↑, 1,   mTOR↓, 91,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 22,   mTORC2↓, 4,   p‑p42↓, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 6,   p‑P70S6K↓, 2,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 3,   PI3K↓, 130,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 16,   p‑PI3K↑, 1,   PI3K/Akt↓, 9,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 2,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 3,   PTEN↑, 33,   PTEN↝, 2,   PTPN6↑, 1,   Raf↓, 8,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   RIP1↑, 1,   RTK-RAS↓, 1,   p‑S6K↓, 2,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 13,   Src↓, 5,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 6,   STAT3↓, 88,   STAT3↑, 4,   p‑STAT3↓, 22,   p‑STAT3↑, 1,   STAT4↑, 1,   STAT5↓, 2,   STAT6↓, 2,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 4,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   ATF3↑, 3,   ATF4↓, 1,   ATF4↑, 16,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 1,   cMyc↓, 56,   cMyc↑, 2,   DNMT1↓, 8,   DNMT3A↓, 3,   DNMTs↓, 7,   EZH2↓, 5,   FOXM1↓, 7,   FOXO↑, 2,   FOXO1↓, 1,   FOXO1↑, 4,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 3,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 26,   HDAC1↓, 9,   HDAC10↑, 1,   HDAC2↓, 6,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC6↓, 2,   HES1↓, 1,   HOXB-AS1↓, 1,   IRF1↑, 1,   KCNQ1OT1↓, 1,   miR-106b↓, 2,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-125b↓, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-17↓, 1,   miR-195↑, 1,   miR-21↓, 7,   miR-21↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 3,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 10,   miR-375↓, 1,   miR-375↝, 1,   miR-384↑, 1,   miR-409-3p↑, 1,   miR-422a↑, 1,   miR-497↑, 1,   miR-548ah-5p↑, 1,   miR-590-3p↑, 1,   Myc↓, 7,   n-MYC↓, 2,   NR1D2↓, 1,   OCT4↓, 15,   OCT4↑, 1,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 9,   PhotoS↑, 3,   Set9↑, 1,   sonoS↑, 2,   SOX2↓, 9,   SOX4↑, 1,   SOX9?, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TET3↑, 1,   TFE3↑, 1,   tumCV?, 3,   tumCV↓, 112,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 36,   CRT↑, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 10,   p‑eIF2α↓, 1,   p‑eIF2α↑, 6,   ER Stress↓, 1,   ER Stress↑, 48,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 13,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 5,   HSP27↑, 2,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP90↓, 11,   HSP90↑, 3,   HSPs↓, 1,   IRE1↑, 4,   PERK↑, 10,   p‑PERK↑, 2,   SERPINH1/HSP47↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↑, 10,   ATG7↑, 4,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 29,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 5,   LC3A↑, 2,   LC3B↑, 2,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 1,   LC3II↓, 3,   LC3II↑, 19,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 11,   p62↑, 5,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto?, 1,   TumAuto↑, 55,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 4,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 3,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 76,   mt-DNAdam↑, 1,   DNArepair↓, 4,   DNArepair↑, 1,   ERCC1↓, 2,   ERCC3↑, 1,   hTERT/TERT↓, 10,   MGMT↓, 1,   p16↑, 3,   P53↓, 9,   P53↑, 177,   P53↝, 1,   p‑P53↓, 2,   p‑P53↑, 10,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   PARP↓, 10,   PARP↑, 35,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↓, 3,   cl‑PARP↑, 134,   cl‑PARP∅, 1,   PARP1↓, 2,   PARP1↑, 2,   cl‑PARP1↑, 5,   PCNA↓, 51,   PCNA↑, 1,   POLD1↓, 1,   RAD51↓, 1,   RAD51↑, 1,   SIRT6↓, 1,   Telomerase↓, 11,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 5,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 12,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 29,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 44,   CDK2↑, 5,   CDK4↓, 51,   CDK4↑, 2,   CDK4/6↓, 3,   CDK6↓, 21,   CDK6↑, 1,   CHK1↓, 4,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 1,   ChrCon↑, 3,   Cyc↓, 5,   Cyc↝, 1,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 43,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 143,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 2,   CycD3↓, 5,   cycE/CCNE↓, 24,   cycE/CCNE↑, 2,   cycE1↓, 3,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 3,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 44,   MAD↓, 1,   mitA↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 8,   P21↑, 92,   P21↝, 2,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 40,   PLK1↓, 1,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 3,   RB1↓, 2,   RB1↑, 3,   p‑RB1↓, 2,   cl‑RB1↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA↓, 8,   TumCCA↑, 289,   WEE1↑, 3,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 3,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 9,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   CEBPA↑, 1,   cFos↓, 8,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 37,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli↓, 2,   Gli1↓, 20,   HH↓, 17,   HMGCR↓, 1,   IGF-1↓, 9,   IGF-2↓, 1,   IGFBP3↑, 5,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 44,   Let-7↑, 2,   MCM2↓, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nanog↑, 1,   Nestin↓, 3,   NOTCH↓, 13,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 15,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 1,   PCLAF↓, 1,   PTCH1↓, 9,   PTCH2↓, 1,   SAL↑, 1,   Shh↓, 13,   Smo↓, 9,   p‑STAT1↓, 1,   Sufu↑, 1,   TumCG?, 3,   TumCG↓, 147,   TumCG↑, 4,   TumCP?, 1,   TumCP↓, 229,   TumCP↑, 4,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 34,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↑, 3,   AP-1↓, 9,   AP-1↑, 1,   AP-1↝, 2,   ATPase↓, 2,   AXL↓, 4,   Ca+2↓, 4,   Ca+2↑, 40,   Ca+2↝, 3,   i-Ca+2↑, 1,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↑, 4,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   COL1↓, 2,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 3,   E-cadherin↓, 8,   E-cadherin↑, 57,   EMT↓, 72,   EMT↑, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 18,   p‑FAK↓, 3,   Fibronectin↓, 6,   GIT1↓, 1,   GLI2↓, 9,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   LAMs↓, 2,   LEF1↓, 3,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 4,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 5,   MMP16↓, 1,   MMP2↓, 99,   MMP2↝, 1,   MMP3↓, 9,   MMP7↓, 10,   MMP9↓, 117,   MMPs↓, 32,   MRGPRF↓, 1,   MTA1↓, 2,   MUC4↓, 3,   N-cadherin↓, 37,   NFAT↑, 1,   p44↓, 1,   p‑p44↓, 2,   PAI-1/SERPINE1↑, 1,   PAK1↓, 1,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 4,   Rac1↓, 4,   RECK↑, 2,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 19,   SMAD2↓, 2,   p‑SMAD2↓, 2,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↑, 1,   Snail?, 1,   Snail↓, 31,   TET1↑, 2,   TGF-β↓, 16,   TGF-β↑, 3,   TIMP1↓, 3,   TIMP1↑, 10,   TIMP2↓, 2,   TIMP2↑, 13,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 3,   TumCA↑, 1,   TumCI?, 2,   TumCI↓, 102,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 105,   TumCMig↑, 1,   TumMeta↓, 68,   TumMeta↑, 5,   TumPF↓, 1,   Twist↓, 21,   TXNIP↑, 1,   Tyro3↓, 2,   uPA↓, 21,   uPAR↓, 2,   Vim?, 1,   Vim↓, 41,   Vim↑, 1,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 83,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 9,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 57,   LOX1↓, 2,   NO↓, 4,   NO↑, 5,   VCAM-1↓, 5,   VEGF↓, 125,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 17,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CellMemb↓, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 3,   GLUT1↓, 12,   GLUT1↑, 1,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT4↓, 2,   KCNH2/hERG↓, 1,   MMP↓, 198,   MMP↑, 1,   MPT↑, 5,   NHE1↓, 1,   SLC12A5↝, 1,   TRPM7↓, 1,   TRPV1↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 2,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 12,   CD8+↑, 4,   cDC2↓, 5,   COX2/PTGS2↓, 80,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR2↓, 2,   CXCR4↓, 17,   CXCR4↑, 1,   DR4↑, 12,   FOXP3↓, 2,   FOXP3↑, 1,   HCAR2↑, 1,   HLA↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 1,   HMGB1↑, 1,   ICAM-1↓, 13,   IFN-γ↓, 4,   IFN-γ↑, 5,   IL1↓, 7,   IL1↑, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 16,   IL1β↑, 3,   IL2↓, 2,   IL2↑, 7,   IL33↑, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 50,   IL6↑, 2,   IL6↝, 1,   IL7↓, 1,   IL8↓, 13,   Imm↑, 12,   Imm↝, 1,   Inflam↓, 38,   Inflam↝, 1,   LTA/TNF-β↓, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 175,   NF-kB↑, 11,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 2,   NLRP3↑, 2,   p65↓, 10,   p‑p65↓, 5,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 13,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↑, 1,   SOCS1↑, 2,   T-Cell↑, 3,   TCF↓, 2,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR4↓, 6,   TLR4↝, 1,   TNF-α↓, 42,   TNF-α↑, 11,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 2,   TRAF1↓, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AhR↑, 1,   AR↓, 16,   AR↝, 1,   ER-α36↓, 2,   ERα/ESR1↓, 2,   ERβ/ESR2↑, 1,   GR↝, 1,   PPARα↓, 1,   PPARγ↓, 5,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 30,   BioAv↑, 33,   BioAv↝, 8,   BioEnh↑, 1,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 144,   ChemoSen↝, 1,   CompStab↑, 3,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 3,   Dose↑, 8,   Dose↝, 65,   Dose∅, 8,   eff↓, 88,   eff↑, 89,   eff↝, 8,   GSTA1↑, 1,   GSTM1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 7,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MDR1↑, 1,   MRP↓, 1,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 18,   P450↓, 2,   RadioS↑, 43,   selectivity↓, 1,   selectivity↑, 108,   Synergy?, 1,   Synergy↑, 99,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 2,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 16,   AR↝, 1,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   AST∅, 1,   BRAF↝, 1,   BRCA1↓, 2,   BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 4,   E6↓, 3,   E7↓, 3,   EGFR↓, 31,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 2,   EZH2↓, 5,   FOXM1↓, 7,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 50,   IL6↑, 2,   IL6↝, 1,   LDH?, 1,   LDH↓, 13,   LDH↑, 6,   LDH↝, 2,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 7,   NSE↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 9,   PSA↝, 1,   PSADT↑, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 3,   AntiCan↑, 61,   AntiCan?, 1,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 2,   AntiTum↑, 34,   cachexia↓, 2,   cardioP↑, 11,   CardioT↓, 1,   chemoP?, 1,   chemoP↑, 33,   chemoPv↑, 19,   ChemoSideEff↓, 7,   ChemoSideEff∅, 1,   hepatoP↑, 15,   K17↓, 1,   neuroP↑, 8,   NKG2D↑, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 9,   Pain↓, 2,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 3,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 12,   Risk↓, 13,   Symptoms↓, 1,   toxicity?, 1,   toxicity↓, 23,   toxicity↑, 1,   toxicity↝, 12,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 43,   TumVol↑, 2,   TumW↓, 22,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   Bacteria↓, 5,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 4,   Ingr↝, 11,  
Total Targets: 1240

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 90,   ARE↑, 1,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 52,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 38,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 49,   GSH/GSSG↑, 1,   GSR↑, 5,   GSTs↓, 1,   GSTs↑, 13,   H2O2↓, 5,   HDL↑, 2,   HO-1?, 2,   HO-1↓, 1,   HO-1↑, 26,   HO-2↓, 1,   Iron↓, 2,   Keap1↓, 5,   Keap1↑, 1,   lipid-P↓, 38,   MDA?, 1,   MDA↓, 39,   MDA↑, 1,   MPO↓, 6,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 6,   Nrf1↑, 3,   NRF2?, 1,   NRF2↑, 50,   Prx↑, 1,   RNS↓, 5,   ROS?, 1,   ROS↓, 118,   ROS↑, 3,   ROS∅, 3,   SOD?, 1,   SOD↓, 2,   SOD↑, 69,   SOD1↑, 2,   SOD2↑, 4,   TAC↑, 6,   TBARS↓, 4,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↑, 1,   PGC-1α↓, 2,   PGC-1α↑, 2,   PINK1↑, 2,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1,   ACSL4↓, 1,   ALAT↓, 15,   AMPK↓, 2,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↓, 2,   ATP↑, 4,   mt-ATP↑, 1,   GAPDH↑, 1,   glucose↓, 5,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 3,   H2S↑, 2,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 3,   NH3↓, 1,   PFK↓, 1,   PLA2↓, 1,   SIRT1↑, 7,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 2,   Apoptosis↓, 31,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 48,   BAX↑, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 12,   Bcl-2↑, 58,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↑, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 35,   Casp3↑, 2,   cl‑Casp3↓, 9,   Casp8↓, 1,   Casp9↓, 10,   cl‑Casp9↓, 4,   Cyt‑c↓, 8,   Cyt‑c↑, 2,   Fas↓, 3,   FasL↓, 1,   Ferroptosis↓, 4,   GSDMD↓, 1,   iNOS↓, 20,   MLKL↓, 1,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 9,   p‑Akt↓, 1,   p‑Akt↑, 7,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 1,   p‑CREB↑, 4,   EGFR↓, 1,   ERK↓, 3,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK↓, 2,   JAK2↑, 3,   JNK↓, 6,   JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   Mst1↓, 2,   mTOR↓, 1,   mTOR↑, 5,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   p‑p70S6↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 3,   PI3K↑, 9,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 2,   p‑PTEN↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↓, 2,   STAT3↑, 6,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF4↓, 2,   cJun↓, 1,   p‑cJun↓, 1,   FOXO3↑, 1,   HDAC↓, 2,   HDAC2↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 2,   other↑, 4,   other↝, 3,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   CHOP/DDIT3↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 2,   IRE1↓, 2,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 3,   p62↑, 2,   PARK2↑, 3,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 6,   p16↓, 1,   P53↓, 4,   P53↑, 2,   PARP↓, 1,   cl‑PARP↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↑, 1,   P21↓, 2,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 5,   cal2↓, 2,   Cartilage↑, 1,   E-cadherin↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP9↓, 2,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 2,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 1,   Zeb1↓, 1,   α-SMA↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↓, 1,   E-sel↓, 2,   eNOS↑, 1,   Hif1a↓, 1,   NO?, 1,   NO↓, 15,   NO↑, 3,   VCAM-1↓, 3,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 9,   BBB↝, 2,   BBB∅, 2,   CLDN4↑, 1,   GastroP↑, 5,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↓, 2,   MMP↑, 12,   MMP∅, 1,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↑, 2,   OCLN↝, 1,   TJ↑, 3,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 26,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 7,   IL10↑, 5,   IL13↑, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 31,   IL1β↑, 1,   IL2↓, 1,   IL22↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 38,   IL6↑, 1,   IL8↓, 8,   Imm↓, 1,   Imm↑, 6,   Inflam↓, 108,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 6,   NF-kB↓, 39,   NF-kB↑, 3,   NK cell↑, 1,   NLRP3↓, 7,   PGE2↓, 9,   PGE2↑, 1,   PSA∅, 1,   RAGE↓, 4,   RANTES↓, 1,   TLR4↓, 6,   TNF-α↓, 55,   TNF-α↑, 1,   TRAF1↓, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 4,   AChE↓, 21,   ADAM10↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 16,   BDNF⇅, 1,   ChAT↑, 3,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 2,   SYP↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 3,   Aβ↓, 18,   Aβ42↓, 3,   BACE/β-secretase↓, 7,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 3,   p‑tau↓, 6,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   Estro↓, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↑, 3,   p‑PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 27,   BioAv↑, 34,   BioAv↝, 20,   BioAv∅, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↑, 1,   CYP2D6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 13,   Dose∅, 1,   eff↓, 4,   eff↑, 9,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 14,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 4,   AST↓, 17,   Bil↓, 1,   BMD↑, 2,   BP↓, 4,   BUN?, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 4,   CRP↓, 4,   EGFR↓, 1,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6↓, 38,   IL6↑, 1,   LDH↓, 8,   NOS2↓, 1,   PSA∅, 1,   RAGE↓, 4,   SpO2↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 1,   antiAll↑, 12,   AntiArt↑, 8,   AntiCan↑, 18,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 20,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 6,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 5,   cognitive↑, 22,   diuretic↑, 3,   hepatoP↓, 2,   hepatoP↑, 33,   Learn↑, 4,   memory↑, 22,   motorD↑, 5,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 70,   Obesity↓, 8,   OS↑, 1,   Pain↓, 3,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 11,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 10,   toxicity?, 1,   toxicity↓, 21,   toxicity↑, 3,   toxicity↝, 6,   toxicity∅, 9,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13,   AntiFungal↓, 1,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 12,   Bacteria↓, 20,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 12,   Inf↓, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 489

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
36 Curcumin
32 Silver-NanoParticles
29 Thymoquinone
25 Quercetin
18 Luteolin
17 Apigenin (mainly Parsley)
15 Baicalein
15 EGCG (Epigallocatechin Gallate)
13 Allicin (mainly Garlic)
13 Sulforaphane (mainly Broccoli)
13 Betulinic acid
12 Fisetin
12 Shikonin
11 Berberine
11 Emodin
11 Honokiol
11 Silymarin (Milk Thistle) silibinin
10 Cisplatin
10 Melatonin
10 Resveratrol
10 Gambogic Acid
10 Garcinol
10 Licochalcone A
10 Matrine
9 Eugenol
9 Gossypol/AT-101
9 Lycopene
8 Capsaicin
8 Graviola
8 Magnolol
8 Morin
7 Magnetic Fields
7 Ashwagandha(Withaferin A)
7 D-limonene
7 Radiotherapy/Radiation
7 Beta-Caryophyllene
7 Carvacrol
7 Isoliquiritigenin
7 Juglone
7 Nimbolide
7 Piperlongumine
6 5-fluorouracil
6 Paclitaxel/Taxol
6 Phenethyl isothiocyanate
6 Boron
6 Cinnamon
6 Ursolic acid
6 Dandelion Root
6 Ferulic acid
6 Formononetin
6 Ginkgetin
6 Hibiscus sabdariffa
6 Hyperoside
6 isoorientin
6 Kaempferol
6 lambertianic acid
6 Licorice
5 Astragalus
5 Artemisinin
5 Astaxanthin
5 doxorubicin
5 Benzyl isothiocyanate
5 Boswellia (frankincense)
5 Carnosic acid
5 Cynaropicrin
5 Isobavachalcone
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Rosmarinic acid
5 Urolithin
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Photodynamic Therapy
4 Alpha-Lipoic-Acid
4 Isovitexin
4 Metformin
4 Aloe anthraquinones
4 Biochanin A
4 Chemotherapy
4 Bufalin/Huachansu
4 α-Bisabolol / Chamomile oil
4 Crocetin
4 Ellagic acid
4 Eurycomanone
4 Geraniol
4 Ginkgolide B
4 HydroxyTyrosol
4 Indole-3-carbinol
4 Isorhamnetin
4 isoquercitrin
4 Ivermectin
4 Moringa oleifera
4 Propolis -bee glue
3 3-bromopyruvate
3 Açaí, Euterpe oleracea
3 Gemcitabine (Gemzar)
3 Allyl isothiocyanate
3 immunotherapy
3 Berbamine
3 Caffeic acid
3 Chlorogenic acid
3 chaetocin
3 chitosan
3 Chlorophyllin
3 Chrysin
3 Docetaxel
3 Evodiamine
3 Gallic acid
3 Ginkgolic acids
3 Ginger/6-Shogaol/Gingerol
3 Vitexin
3 L-Theanine
3 Laetrile B17 Amygdalin
3 Oleuropein
3 Patchouli Oil (Pogostemon cablin)
3 Phenylbutyrate
3 Selenite (Sodium)
3 VitK3,menadione
2 tamoxifen
2 Ajoene (compound of Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 DTS(dibenzyl trisulphide) from Anamu
2 Andrographis
2 beta-glucans
2 Baicalin
2 Brucea javanica
2 brusatol
2 Bromelain
2 borneol
2 Genistein (soy isoflavone)
2 Butyrate
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Citric Acid
2 Carvone
2 Polyphenols
2 Cucurbitacin
2 Electrical Pulses
2 Chlorella (Chlorella vulgaris)
2 Flaxseed/Linseed
2 carboplatin
2 Hydrogen Gas
2 iodine
2 itraconazole
2 Lactobacillus
2 low dose naltrexone
2 Lemongrass Extract/Citral
2 SDG/lignans
2 Linalool
2 Lutein
2 Mangiferin
2 Methylglyoxal
2 Marjoram (Origanum majorana)
2 Propyl gallate
2 Phycocyanin
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Taurine
2 Vitamin K2
1 Coenzyme Q10
1 Acoschimperoside P, 2’-acetate
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 epirubicin
1 Isothiocyanates
1 selenomethionine
1 Black turtle bean
1 Zinc
1 Celastrol
1 Prebiotic
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Hydroxycinnamic-acid
1 Citicoline, CDP-Choline
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dichloroacetate
1 Deguelin
1 Date Fruit Extract
1 Diindolylmethane
1 Fenbendazole
1 olaparib/LYNPARZA
1 Galloflavin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Grapeseed extract
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 Huperzine A/Huperzia serrata
1 Rutin
1 Butein
1 Scopoletin
1 Vitamin C (Ascorbic Acid)
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Methylene blue
1 mebendazole
1 MCT, metronomic chemo
1 methylseleninic acid
1 Magnetic Field Rotating
1 Moringin
1 Zeolite
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Shiitake, AHCC
1 Naringin
1 Neem
1 Oleocanthal
1 Orlistat
1 sericin
1 Physalin F & B
1 Piperine
1 Plumbagin
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 isoflavones
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Selenium NanoParticles
1 Sesamin
1 Auranofin
1 Salvia miltiorrhiza
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 Terpinen-4-ol / Tea Tree Oil
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Tomatine
1 Vitamin D3
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:27  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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