Half-Life Cancer Research Results

Half-Life, Half-Life: Click to Expand ⟱
Source:
Type:
For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.
Scientific Papers found: Click to Expand⟱
3321- SIL,    Silymarin (Milk thistle)
- Review, AD, NA
*neuroP↝, *Dose↝, *Half-Life?, *BioAv↝, *cognitive↑, *Aβ↓, *Inflam↓, *OS↑, *memory↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, Var, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2/PTGS2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
965- SK,    Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620
Hif1a↓, ROS↓, mTOR↓, p70S6↓, 4E-BP1↓, eIF2α↓, TumCCA↑, TumCP↓, Half-Life↝,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
5078- SSE,  Rad,    Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer
- Trial, Pca, NA
Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,
5073- SSE,    Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
- Trial, Var, NA
AntiTum↑, ChemoSen↑, Dose↑, Half-Life↝, toxicity↝, toxicity↝,
5085- SSE,    Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
- Review, Var, NA
toxicity↝, Half-Life↝, ROS↑, Thiols↓, NADPH↓, toxicity↝, other↝,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
6767- Thyme,    Thymol, thyme, and other plant sources: Health and potential uses
- Review, Nor, NA
*AntiBio↑, *Inflam↓, *Imm↑, *other↝, *Half-Life↝, *Obesity↓, *GutMicro↑,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, CompStab↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
- Review, Var, NA
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1/ATG6↑, *ROS↓, *GutMicro↑, *Risk↓,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
596- VitC,    High-Dose Vitamin C in Advanced-Stage Cancer Patients
- Review, Var, NA
ChemoSideEff↓, ROS↑, H2O2↑, Fenton↑, Hif1a↝, Dose↑, BioAv↓, Dose↝, Half-Life↝, IL1β↓, IL2↓, IL8↓, TNF-α↓,
4087- VitE,    Vitamin E and Alzheimer's disease: what do we know so far?
- Review, AD, NA
*Risk↑, *Half-Life↑, *antiOx↑, *BioAv↑, *neuroP↑, *Inflam↑, *LDL↓, *cognitive↑,

Showing Research Papers: 251 to 271 of 271
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 271

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 5,   Catalase↓, 3,   Catalase↑, 1,   Fenton↑, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 15,   GSR↓, 1,   GSSG↑, 1,   GSTs↓, 2,   H2O2↑, 3,   HO-1↓, 2,   HO-1↑, 3,   i-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 1,   lipid-P↑, 5,   MDA↓, 1,   NADH↓, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 5,   NRF2↑, 8,   Prx↑, 1,   Prx4↑, 1,   ox-PrxI↑, 1,   ROS↓, 11,   ROS↑, 78,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD?, 1,   SOD↓, 3,   mt-SOD↑, 1,   SOD2↓, 2,   Thiols↓, 1,   TrxR↓, 4,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 2,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↓, 2,   compI↓, 3,   EGF↓, 1,   ETC↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 4,   OCR↓, 2,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   PDH↑, 3,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY↓, 2,   ALDOA↓, 1,   AMPK↑, 11,   ATP↓, 6,   mt-ATP↓, 1,   ENO1↓, 1,   FASN↓, 3,   FDG↓, 1,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 12,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   HK2↓, 3,   HMG-CoA↓, 1,   IDH1↓, 1,   lactateProd↓, 5,   LDHA↓, 1,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   NADPH↓, 3,   PCK1↓, 1,   PDK1 / PDPK1↓, 7,   PDK3↑, 1,   PDKs↓, 1,   PKM2↓, 3,   PPP↓, 1,   SIRT1↓, 3,   SIRT1↑, 3,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 57,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↑, 2,   Bak↑, 6,   BAX↓, 1,   BAX↑, 25,   Bax:Bcl2↑, 5,   Bcl-2↓, 29,   Bcl-2↑, 1,   Bcl-xL↓, 8,   BIM↑, 2,   Casp↑, 14,   Casp1↓, 1,   Casp1↑, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 36,   cl‑Casp3↑, 4,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp7↑, 5,   Casp8↑, 13,   Casp9↑, 21,   cl‑Casp9↑, 1,   CellShr↑, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 23,   Diablo↑, 2,   DR5↑, 8,   FADD↑, 1,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↑, 4,   GSDME↑, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 2,   Mcl-1↓, 5,   Mcl-1↑, 1,   MDM2↓, 2,   p‑MDM2↓, 1,   MOMP↑, 2,   Necroptosis↑, 2,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 6,   p‑p38↓, 1,   p‑p38↑, 3,   PUMA↑, 2,   Pyro↑, 2,   RIP3↑, 1,   survivin↓, 16,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 4,   XIAP↓, 5,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 38,   p‑Akt↓, 7,   AKT1↓, 1,   CIP2A↓, 1,   cSrc↓, 1,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 10,   EGFR↑, 1,   ERK↓, 13,   p‑ERK↓, 5,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IKKα↓, 3,   IκB↓, 1,   IκB↑, 1,   JAK↓, 2,   JAK1↓, 3,   JAK2↓, 2,   JNK↓, 2,   JNK↑, 9,   p‑JNK↑, 3,   MAPK↓, 14,   MAPK↑, 2,   MAPK↝, 1,   mTOR↓, 34,   mTOR⇅, 1,   mTOR↝, 1,   p‑mTOR↓, 1,   mTORC2↓, 1,   p70S6↓, 2,   p‑p70S6↓, 1,   P70S6K↓, 2,   p‑PDGFR-BB↓, 1,   PI3K↓, 27,   p‑PI3K↓, 1,   PKCδ↓, 4,   PTEN↓, 1,   PTEN↑, 14,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 4,   RIP1↑, 1,   Sp1/3/4↓, 1,   Src↓, 1,   p‑Src↓, 1,   STAT3↓, 28,   STAT3↑, 2,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT6↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 4,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 2,   cJun↑, 1,   p‑cJun↑, 1,   cMyc↓, 13,   DNMTs↓, 4,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 2,   FOXO4↑, 1,   H3↓, 2,   H3↑, 1,   p‑H3↓, 1,   H4↓, 1,   H4↑, 1,   HATs↓, 1,   HATs↑, 2,   HDAC↓, 9,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-218↑, 1,   miR-30a-5p↑, 1,   miR-34a↑, 2,   miR-375↑, 1,   Myc↓, 1,   Myc↑, 1,   OCT4↓, 2,   other?, 1,   other↑, 2,   other↝, 10,   other∅, 1,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 1,   tumCV↓, 6,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 8,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 10,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 4,   IRE1↑, 1,   IRE1∅, 1,   PERK↑, 2,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↑, 3,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 2,   p62↑, 1,   SESN2↑, 1,   TumAuto↑, 11,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 1,   DNAdam↑, 14,   DNArepair↓, 2,   p16↑, 1,   P53↑, 17,   PARP↓, 1,   PARP↑, 4,   cl‑PARP↑, 23,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 7,   Telomerase↓, 5,   TOP1↓, 4,   TOP2↓, 4,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 10,   CDK4↓, 13,   CDK6↓, 3,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 7,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 17,   cycE/CCNE↓, 4,   E2Fs↓, 2,   GADD34↑, 1,   Ki-67↓, 6,   P21?, 1,   P21↓, 1,   P21↑, 14,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 9,   pRB↓, 1,   p‑RB1↓, 4,   TumCCA↓, 1,   TumCCA↑, 56,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   Axin2↑, 1,   BMP7/OP1↓, 1,   CD133↓, 1,   CD24↓, 2,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs↓, 13,   FGF↓, 1,   Gli1↓, 2,   HH↓, 4,   IGF-1?, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 6,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 4,   Nanog↓, 2,   Nestin↓, 1,   NOTCH↓, 6,   NOTCH1↓, 3,   NOTCH1↑, 2,   NOTCH3↓, 2,   OGFr↑, 1,   p300↓, 1,   PTCH1↓, 2,   Shh↓, 2,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 23,   TumCP↓, 37,   Wnt↓, 14,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 3,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 2,   Ca+2↑, 8,   Ca+2↝, 1,   Cal9↑, 1,   Cdc42↓, 1,   Cdc42↑, 1,   COL1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 10,   EMT↓, 22,   EMT↑, 1,   FAK↓, 3,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   ITGB1↓, 2,   ITGB6↓, 1,   KRAS↓, 2,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 21,   MMP7↓, 2,   MMP9↓, 30,   MMP9↑, 1,   MMPs↓, 14,   MUC4↓, 1,   N-cadherin↓, 5,   PAK1↓, 1,   PDGF↓, 3,   Rac1↓, 2,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 2,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 2,   TIMP1↑, 4,   TIMP2↑, 2,   TRIB3↑, 2,   TSC1↑, 1,   TumCI↓, 22,   TumCMig↓, 19,   TumMeta↓, 26,   TumMeta↑, 2,   Twist↓, 5,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 9,   Vim↓, 5,   Vim↑, 1,   Zeb1↓, 4,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 14,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 41,   angioG↑, 1,   EGR1↑, 1,   EGR4↓, 1,   HIF-1↓, 1,   Hif1a↓, 21,   Hif1a↝, 1,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 40,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7,   CLDN1↓, 1,   EPR↑, 7,   GLUT1↓, 4,   GLUT4↓, 1,   MMP↓, 29,   MPT↑, 4,   NHE1↓, 1,   sonoP↑, 1,   TRPV1↑, 3,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   p‑cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 22,   COX2/PTGS2↑, 1,   CXCR4↓, 3,   DR4↑, 3,   Gal-3↓, 1,   ICAM-1↓, 3,   IL1↓, 2,   IL10↓, 1,   IL1α↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 2,   IL6↓, 10,   IL6↑, 1,   IL8↓, 5,   IL8↑, 1,   Imm↑, 3,   Inflam↓, 11,   pol-M1↑, 1,   MCP1/CCL2↓, 3,   MIP-1β↑, 1,   MIP2↓, 1,   NF-kB↓, 47,   p‑NF-kB↑, 1,   NK cell↑, 1,   NK cell⇅, 1,   NLRP3↓, 1,   NLRP3↑, 2,   p65↓, 2,   p‑p65↓, 2,   PD-1↓, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 6,   PSA↓, 6,   TCF↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 1,   TLR4↝, 1,   TNF-α↓, 8,   TNF-α↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,   TAMS↓, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   AhR↓, 1,   AR↓, 7,   AR↝, 1,   CYP19↓, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 57,   BioAv↑, 54,   BioAv↝, 14,   BioEnh↑, 1,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen↑, 59,   CompStab↓, 2,   CompStab↑, 3,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP1A2↑, 2,   CYP2A3/CYP2A6↓, 1,   CYP2C9↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   DDS↑, 4,   Dose?, 1,   Dose↓, 2,   Dose↑, 7,   Dose↝, 43,   Dose∅, 5,   eff↓, 13,   eff↑, 52,   eff↝, 10,   eff∅, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life?, 1,   Half-Life↓, 38,   Half-Life↑, 22,   Half-Life↝, 65,   Half-Life∅, 6,   MDR1↓, 4,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 8,   P450↓, 1,   RadioS↑, 26,   selectivity↑, 32,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 39,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 7,   AR↝, 1,   ascitic↓, 1,   BP↓, 1,   CEA↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 10,   EGFR↑, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 10,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 1,   LDH↝, 1,   Myc↓, 1,   Myc↑, 1,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 6,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 18,   antiNeop↑, 1,   AntiTum↑, 9,   cachexia↓, 2,   cardioP↑, 2,   CardioT↓, 1,   chemoP↑, 19,   chemoPv↑, 5,   ChemoSideEff↓, 2,   fatigue↓, 1,   hepatoP↑, 4,   neuroP↑, 4,   NP/CIPN↓, 1,   NP/CIPN↑, 2,   Obesity↓, 2,   OS↑, 7,   Pain↓, 2,   QoL↑, 1,   QoL∅, 1,   radioP?, 1,   radioP↑, 5,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 7,   Risk↑, 1,   toxicity↓, 13,   toxicity↑, 3,   toxicity↝, 15,   toxicity∅, 2,   TumVol↓, 8,   TumW↓, 3,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 4,  
Total Targets: 618

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 55,   ARE↑, 3,   Bil↑, 1,   Catalase↑, 15,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 15,   GPx1↑, 1,   GSH↑, 20,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 5,   H2O2↓, 3,   H2O2↑, 1,   HDL↑, 3,   HO-1↑, 17,   Keap1↓, 1,   lipid-P↓, 17,   mt-lipid-P↓, 1,   MDA↓, 16,   MPO↓, 5,   NADH↓, 1,   NQO1↑, 4,   NQO1↝, 1,   Nrf1↑, 1,   NRF2?, 1,   NRF2↑, 25,   RNS↓, 3,   ROS?, 1,   ROS↓, 66,   ROS↑, 1,   ROS⇅, 1,   ROS∅, 1,   SOD↓, 1,   SOD↑, 28,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 2,   TBARS↓, 1,   TOS↓, 1,   TrxR↑, 1,   uricA↓, 1,   VitC↑, 4,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 6,   IronCh↝, 1,   Mets↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   Insulin↓, 1,   mitResp↑, 1,   OCR↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   adiP↓, 1,   ALAT↓, 5,   ALAT↑, 1,   ALAT∅, 1,   AMPK↑, 10,   ATP↑, 3,   cAMP↑, 1,   CRM↑, 1,   FABP4↓, 1,   FAO↑, 1,   G6PD↑, 1,   glucose↓, 1,   glucose↝, 2,   GlucoseCon↑, 1,   GlutMet↑, 1,   glyC↓, 1,   GSK‐3β↓, 6,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HMG-CoA↓, 1,   LDL↓, 4,   lipoGen↓, 1,   NADH:NAD↑, 1,   NADPH↑, 1,   SIRT1↑, 6,   SREBF2⇅, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 4,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 8,   cl‑Casp8↑, 1,   Casp9↓, 2,   Cyt‑c∅, 1,   Fas↓, 1,   FasL↓, 1,   iNOS↓, 9,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 3,   AMPKα↑, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 2,   MAPK↓, 1,   MAPK↑, 1,   p‑MAPK↓, 1,   mTOR↓, 2,   P70S6K↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT↓, 2,   STAT3↓, 1,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   p‑cMyc↑, 1,   FOXO↑, 1,   HDAC↓, 1,   HDAC↑, 1,   OCT4↓, 1,   other↓, 4,   other↑, 9,   other↝, 13,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↓, 1,   MitoP↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATR↑, 1,   p‑BRCA1↑, 1,   DNAdam↓, 2,   DNArepair↑, 1,   P53↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   Choline↑, 1,   GH↑, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   neuroG↑, 4,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 7,   AP-1↓, 2,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 2,   COL1↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 3,   N-cadherin↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   TIMP1↓, 1,   uPA↑, 1,   α-SMA↓, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   CD31/PECAM-1↑, 1,   Hypoxia↓, 1,   NO↓, 6,   TXA2↓, 1,   VCAM-1↓, 2,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 4,   BBB↑, 22,   BBB∅, 1,   GastroP↑, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 4,   OATPs↓, 1,   TRPA1↑, 1,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 3,   COX2/PTGS2↓, 20,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 3,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 19,   IL2↓, 2,   IL4↓, 2,   IL4↑, 1,   IL6↓, 19,   IL8↓, 6,   Imm↑, 5,   Imm↝, 1,   INF-γ↓, 1,   Inflam↓, 73,   Inflam↑, 2,   MCP1/CCL2↓, 3,   NeuroI↓, 1,   NF-kB↓, 17,   NF-kB↑, 2,   NLRP3↓, 3,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 8,   RANTES↓, 1,   TLR4↓, 2,   TNF-α↓, 27,   TNF-α↑, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 3,   AChE↓, 6,   BChE↓, 2,   BDNF↑, 8,   ChAT↑, 5,   GABA↓, 1,   GABA↑, 1,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 1,   NTF3/NT-3↑, 1,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 1,   Aβ↓, 14,   Aβ42↓, 1,   BACE/β-secretase↓, 5,   tau↓, 3,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 2,   PPARγ↑, 3,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 51,   BioAv↑, 78,   BioAv↝, 50,   BioAv∅, 1,   BioEnh↑, 2,   BioEnh↝, 1,   ChemoSen↑, 2,   CompStab↝, 2,   CYP2D6↓, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 4,   Dose↝, 43,   Dose∅, 2,   eff?, 1,   eff↓, 4,   eff↑, 21,   eff↝, 4,   GSTA1↑, 1,   Half-Life?, 2,   Half-Life↓, 38,   Half-Life↑, 28,   Half-Life⇅, 1,   Half-Life↝, 94,   Half-Life∅, 7,   P-gp/ABCB1↓, 2,   selectivity↑, 1,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALAT↑, 1,   ALAT∅, 1,   AST↓, 5,   AST↑, 1,   AST∅, 1,   Bil↑, 1,   BMD↑, 3,   BP↓, 7,   p‑BRCA1↑, 1,   creat↓, 2,   CRP↓, 1,   IL6↓, 19,   LDH↓, 3,   NOS2↓, 1,   TMAO↓, 1,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 3,   antiAll↑, 5,   AntiArt↑, 3,   AntiCan↑, 9,   antiCG↑, 1,   AntiDiabetic↑, 8,   AntiTum↑, 3,   BOLD↑, 1,   cardioP↓, 1,   cardioP↑, 26,   CardioT↓, 1,   chemoP↑, 6,   chemoPv↑, 5,   cognitive↑, 27,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 25,   memory↓, 1,   memory↑, 21,   Mood↑, 1,   motorD↓, 1,   motorD↑, 3,   neuroP↑, 54,   neuroP↝, 1,   Obesity↓, 5,   OS↑, 2,   Pain↓, 5,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 7,   RenoP↝, 1,   Risk↓, 4,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   Stroke↓, 2,   toxicity↓, 25,   toxicity↑, 1,   toxicity↝, 11,   toxicity∅, 5,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 3,   AntiViral↑, 6,   Bacteria↓, 8,   Diar↓, 2,   GutMicro↑, 13,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,   Phen↑, 1,  
Total Targets: 350

Scientific Paper Hit Count for: Half-Life, Half-Life
9 Curcumin
7 chitosan
7 Resveratrol
6 Boron
6 Chlorogenic acid
6 EGCG (Epigallocatechin Gallate)
6 Silymarin (Milk Thistle) silibinin
5 Auranofin
5 Artemisinin
5 Capsaicin
5 Fisetin
5 Honokiol
5 Pterostilbene
5 Sulforaphane (mainly Broccoli)
4 Alpha-Lipoic-Acid
4 Apigenin (mainly Parsley)
4 Aspirin
4 Berberine
4 Cucurbitacin
4 Dichloroacetate
4 HydroxyTyrosol
4 Isoliquiritigenin
4 Metformin
4 Shikonin
4 Selenite (Sodium)
3 Allicin (mainly Garlic)
3 Ashwagandha(Withaferin A)
3 Baicalein
3 Betulinic acid
3 Chrysin
3 Quercetin
3 Propolis -bee glue
3 Diindolylmethane
3 Luteolin
3 Lycopene
3 Magnolol
3 Mangiferin
3 Morin
3 Piperlongumine
3 Urolithin
2 1,8-Cineole
2 borneol
2 Boswellia (frankincense)
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Ferulic acid
2 Deguelin
2 Disulfiram
2 Ellagic acid
2 Eurycomanone
2 Formononetin
2 Gambogic Acid
2 Huperzine A/Huperzia serrata
2 Isovitexin
2 SDG/lignans
2 Radiotherapy/Radiation
2 Matrine
2 mebendazole
2 Phenethyl isothiocyanate
2 Rosmarinic acid
2 Thymoquinone
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Anthocyanins
1 Astragalus
1 Silver-NanoParticles
1 Acetyl-l-carnitine
1 Astaxanthin
1 Arsenic trioxide
1 Atorvastatin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bevacizumab (brand Avastin)
1 Chemotherapy
1 Bicalutamide
1 Bromelain
1 Vitamin D3
1 urea
1 Carvacrol
1 Catechins
1 Cannabichromene
1 Centella asiatica / Gotu kola → asiaticoside
1 cetuximab
1 Chocolate
1 Rutin
1 Crocetin
1 Caffeic acid
1 Dasatinib/Phyrago
1 Diclofenac
1 Indole-3-carbinol
1 Dandelion Root
1 Copper and Cu NanoParticles
1 Echinacea
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Fucoidan
1 Gallic acid
1 Gamma-aminobutyric acid
1 Garcinol
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Gossypol/AT-101
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 High-Ozonide Oil
1 Hyperoside
1 Inositol
1 isoorientin
1 isoquercitrin
1 itraconazole
1 Ivermectin
1 Vitexin
1 Juglone
1 low dose naltrexone
1 Methylene blue
1 Methyl salicylate / Sweet Birch oil
1 Melatonin
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Naringin
1 Niclosamide (Niclocide)
1 Oleuropein
1 Phenylbutyrate
1 Phycocyanin
1 Phosphatidylserine
1 immunotherapy
1 Rauwolfia serpentina/Indian Snakeroot
1 SonoDynamic Therapy UltraSound
1 Broccoli
1 Spirulina(Arthrospira/Limnospira)
1 Thyme
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1109  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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