cardioP Cancer Research Results

cardioP, cardioProtective: Click to Expand ⟱
Source:
Type:
CardioProtective


Scientific Papers found: Click to Expand⟱
3252- PBG,    Propolis Extract and Its Bioactive Compounds—From Traditional to Modern Extraction Technologies
- Review, Nor, NA
*Inflam↓, *TNF-α↓, *NF-kB↓, *MAPK↓, *ERK↓, *antiOx↑, *NRF2↑, *cardioP↑, *Glycolysis↑, *Ca+2↓, *HO-1↑, *NRF2↑, *neuroP↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
5216- PI,  doxoR,    Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells
- vitro+vivo, BC, MDA-MB-231
ChemoSen↑, necrosis↑, PTEN↓, PI3K↓, p‑Akt↓, mTOR↓, ALDH↓, TumVol↓, OS↑, cardioP↑, cl‑PARP↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31/PECAM-1↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3924- PTS,    Effect of resveratrol and pterostilbene on aging and longevity
- Review, AD, NA - Review, Stroke, NA
*antiOx↓, *ROS↑, *SOD↑, *GSH↑, *NRF2↑, *MDA↓, *HNE↓, *Inflam↓, *MAPK↓, *IL6↓, *TNF-α↓, *HO-1↑, *cardioP↑, *neuroP↑, *CRM↑, *NLRP3↓,
2303- QC,  doxoR,    Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells
- in-vitro, BC, 4T1 - in-vivo, NA, NA
cardioP↑, hepatoP↑, TumCG↓, OS↑, ChemoSen↑, chemoP↑, Hif1a↓, *Hif1a↑, selectivity↑, TumVol↓, OS↑,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
*antiOx↑, *Inflam↓, *NRF2↓, *ROS↓, *cardioP↑, *HO-1↑, *Catalase↑, *GPx↑, *NQO1↑, *SIRT1↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp/ABCB1↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP/DDIT3↑,
3601- QC,    Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid
- Review, Var, NA - Review, AD, NA
*Inflam↓, *cardioP↑, AntiCan↑, AntiTum↑, *neuroP↑, *cognitive↑, *ROS↓, *BP↓, *LDL↓,
3534- QC,  Lyco,    Synergistic protection of quercetin and lycopene against oxidative stress via SIRT1-Nox4-ROS axis in HUVEC cells
- in-vitro, Nor, HUVECs
*ROS↓, *NOX4↓, *Inflam↓, *NF-kB↓, *p65↓, *SIRT1↑, *cardioP↑, *IL6↓, *COX2/PTGS2↓,
98- QC,    Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
- in-vivo, Stroke, NA
*Bcl-2↑, *BAX↓, *Bax:Bcl2↓, *cardioP↑, *Akt↑, *PI3K↑, *LDH↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
2568- RES,    Resveratrol: A Miracle Drug for Vascular Pathologies
- Review, Var, NA
antiOx↑, Inflam↓, cardioP↑,
2567- RES,    Neuroprotective Effects of Resveratrol in Ischemic Brain Injury
- Review, Stroke, NA
*eff↑, *neuroP↑, *antiOx↑, *Inflam↓, *cardioP↑, *AntiAg↑,
2443- RES,    Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
- Review, Var, NA
*antiOx↑, *ROS↓, *PTEN↑, *Akt↓, *Catalase↑, *SOD↑, *ERK↓, *GSH↑, *AMPK↑, *FOXO1↝, *RNS↓, *Catalase↑, *cardioP↑, *PI3K↑, *eNOS↑, hepatoP↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3094- RES,    Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
CSCs↓, tumCV↓, FASN↑, BNIP3↑, *cardioP↑, *antiOx↑, NF-kB↓, COX2/PTGS2↓, MMP9↓, IGF-1↓, ERK↓, lipid-P↓, CD24↓,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2/PTGS2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
2987- RES,    Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1
- in-vivo, Nor, NA
*VEGF↑, *iNOS↑, *NF-kB↑, *Sp1/3/4↑, *cardioP↑,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑, *antiAll↑,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
7954- RT,    Rutin : therapeutic potential and recent advances in drug delivery
- Review, Nor, NA - Review, IBD, NA
*antiOx↑, *antiAll↑, *Inflam↓, *AntiTum↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *AntiArt↑, *PLA2↓, *chemoP↑, *ROS↓, *Casp3↓, *TNF-α↓, *NF-kB↓, *cardioP↑, *Stroke↓, *TG/TAG↓, *FFA/NEFA↓, *LDL↓, *HDL↑, *AntiDiabetic↑, *MPO↓, *NF-kB↓, *BioAv↓, *BioAv↝,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
4738- Se,  doxoR,    Selenium Attenuates Doxorubicin-Induced Cardiotoxicity Through Nrf2-NLRP3 Pathway
- in-vivo, Nor, NA
*NRF2↑, *NLRP3↓, *cardioP↑,
4446- SeNPs,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
3656- SFN,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA
*AntiCan↑, *cardioP↑, *NRF2↑, *Inflam↓, *NF-kB↓, *STAT3↓, *ERK↓, *MAPK↓, AP-1↑, Bcl-2↓, Casp3↑, Casp9↑,
3180- SFN,    Exploring the therapeutic effects of sulforaphane: an in-depth review on endoplasmic reticulum stress modulation across different disease contexts
- Review, Var, NA
*cardioP↑, *ER Stress↓, GRP78/BiP↑, XBP-1↑, Apoptosis↑, *NRF2↑, UPR↑,
3184- SFN,    The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical
- Review, Nor, NA
*NRF2↑, *Inflam↓, *NF-kB↓, *ROS↓, *BioAv↝, *BioAv↝, *BioAv↝, *BioAv↝, *cardioP↑, *GPx↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *NADPH↑, *NQO1↑, *LDH↓, *hepatoP↑, *ALAT↓, *AST↓, *IL6↓,
3182- SFN,    Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
- in-vitro, AML, NA
Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,
3946- Shank,    Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies
- Review, AD, NA
*neuroP↑, *cognitive↑, *AChE↓, *antiOx↑, *GSR↑, *SOD↑, *GSH↑, *Inflam↓, *ROS↓, *lipid-P↓, *cardioP↑,
3291- SIL,    Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
- Review, Nor, NA
*antiOx↑, *ROS↓, *cardioP↑, *BioAv↓, *Half-Life↝, *other↑, IronCh↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2/PTGS2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
2215- SK,  doxoR,    Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
- in-vivo, Nor, NA
*cardioP↑, *ROS↓, *Inflam↓, *Mst1↓, *NRF2↑, *eff↓, *antiOx↑, *SOD↑, *GSH↑, *TNF-α↓, BAX↓, Bcl-2↑,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2/PTGS2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
4895- Sper,    Spermidine as a target for cancer therapy
- Review, Var, NA - Review, AD, NA
TumAuto↑, Apoptosis↑, OS↑, CRM↑, TumCG⇅, cardioP↑, cognitive↑, *Dose⇅,
5782- Sper,    Cardioprotection and lifespan extension by the natural polyamine spermidine
- in-vivo, Nor, NA
cardioP↑, eff↓, AntiAge↑, BioAv↑, CRM↝,
3951- Taur,    Taurine Supplementation Alleviates Blood Pressure via Gut–Brain Communication in Spontaneously Hypertensive Rats
- in-vivo, Nor, NA
*BP↓, *Inflam↓, *ROS↓, *cardioP↑, *GutMicro↑, *BBB↑,
2134- TQ,    Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *ROS↓, *GSSG↓, *GSH↑, *VitE↑, *VitC↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *cardioP↑, *GSH/GSSG↑, *GPx↑,
2086- TQ,    Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats
- in-vivo, Nor, NA
*SOD↑, *Catalase↑, *GSH↑, *cardioP↑, *lipid-P↓,

Showing Research Papers: 251 to 300 of 321
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 321

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↓, 5,   Catalase↑, 3,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 7,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 2,   H2O2↑, 2,   HO-1↓, 3,   HO-1↑, 6,   Keap1↓, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 3,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 5,   NRF2↑, 6,   Prx↓, 1,   ROS↓, 19,   ROS↑, 63,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 4,   SOD↑, 5,   SOD1↑, 2,   SOD2↑, 2,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 2,   CDC25↓, 2,   compI↓, 1,   compIII↓, 1,   HSP60/HSPD1↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↑, 1,   OXPHOS↓, 2,   mt-OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY↓, 1,   ALAT↓, 4,   AMPK↑, 6,   AMPK↝, 1,   ATP↓, 5,   ATP↑, 1,   CRM↑, 2,   CRM↝, 1,   ECAR↓, 1,   FASN↓, 1,   FASN↑, 1,   glucose↓, 1,   GlucoseCon↓, 5,   GlutMet↓, 2,   Glycolysis↓, 8,   Glycolysis↝, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK2↓, 7,   HMG-CoA↓, 1,   lactateProd↓, 5,   lactateProd↑, 1,   LDHA↓, 2,   LDL↓, 2,   NADPH↓, 1,   PDK1 / PDPK1↓, 3,   PFK↓, 2,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 2,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 73,   Apoptosis∅, 1,   BAD↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 3,   BAX↓, 3,   BAX↑, 30,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 7,   Bcl-2↓, 36,   Bcl-2↑, 2,   Bcl-xL↓, 5,   BID↑, 2,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 1,   BNIP3↑, 3,   Casp↑, 10,   Casp1↑, 1,   Casp12↑, 2,   Casp3↑, 41,   cl‑Casp3↑, 5,   cl‑Casp3⇅, 1,   Casp7↑, 6,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 16,   Casp9↓, 1,   Casp9↑, 26,   cl‑Casp9↑, 4,   proCasp9↓, 1,   cFLIP↓, 3,   Cyt‑c↑, 26,   Diablo↑, 1,   DR5↓, 1,   DR5↑, 6,   Endon↑, 1,   Fas↑, 6,   FasL↑, 1,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 3,   Mcl-1↓, 1,   p‑Mcl-1↓, 1,   MDM2↓, 3,   MDM2↑, 1,   Necroptosis↑, 1,   necrosis↑, 3,   p38↓, 3,   p38↑, 8,   Paraptosis↑, 1,   PUMA↑, 2,   survivin↓, 10,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 2,   XIAP↓, 6,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 51,   Akt↑, 2,   p‑Akt↓, 9,   CK2↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 12,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 14,   ERK↑, 2,   p‑ERK↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IGF-1R↓, 1,   IGF-1R↑, 1,   IGF-2R↑, 1,   IKKα↓, 1,   JAK1↓, 1,   JAK1↑, 1,   JAK2↓, 3,   p‑JAK2↓, 1,   JNK↓, 1,   JNK↑, 3,   LIMK1↓, 1,   MAPK↓, 10,   MAPK↑, 5,   MAPK↝, 1,   MEK↓, 2,   mTOR↓, 25,   mTOR↝, 2,   mTORC2↓, 1,   P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 39,   p‑PI3K↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 2,   PTEN↓, 3,   PTEN↑, 8,   Raf↓, 1,   RAS↓, 2,   RAS↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 4,   cJun↓, 1,   cMyc↓, 13,   cMyc↑, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   FOXO1↓, 2,   FOXO1↑, 2,   FOXO3↑, 2,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 1,   HATs↓, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 2,   HDAC2↓, 3,   miR-106b↓, 2,   miR-124-3p↓, 1,   miR-19b↓, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-25-5p↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   Myc↓, 1,   OCT4↓, 4,   other↑, 1,   other↝, 2,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 2,   tumCV?, 1,   tumCV↓, 15,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 5,   eIF2α↑, 3,   p‑eIF2α↑, 2,   ER Stress↑, 11,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   GRP78/BiP↝, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 3,   HTRA↓, 1,   NQO2↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   UPR↑, 6,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   CTSB↓, 1,   CTSD↓, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↑, 3,   p62↓, 3,   TumAuto↓, 1,   TumAuto↑, 19,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   DNAdam↑, 15,   hTERT/TERT↓, 4,   P53↑, 27,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 9,   PCNA↓, 14,   POLD1↓, 1,   Telomerase↓, 4,   TOP1↓, 3,   TOP2↓, 4,   TP53↓, 1,   TP53↑, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 7,   CDK1↑, 1,   CDK2↓, 14,   CDK4↓, 14,   p‑CDK4↓, 1,   CDK6↓, 2,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↑, 1,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 8,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 26,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   E2Fs↓, 1,   Ki-67↓, 13,   Ki-67↑, 1,   P21↓, 2,   P21↑, 18,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 6,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   TumCCA↑, 67,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 3,   CD133↓, 1,   CD24↓, 2,   cFos↓, 2,   CSCs?, 1,   CSCs↓, 7,   Diff↑, 1,   FGF↓, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 5,   IGFBP3↑, 1,   Ki-67↓, 13,   Ki-67↑, 1,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 3,   Nestin↓, 2,   NOTCH↓, 7,   NOTCH1↓, 1,   NOTCH1↑, 3,   NOTCH3↓, 2,   Shh↓, 4,   Smo↓, 1,   TumCG↓, 32,   TumCG↑, 1,   TumCG⇅, 1,   TumCG∅, 2,   TumCP↓, 39,   Wnt↓, 6,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   AP-1↑, 1,   ASAP2↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 11,   i-Ca+2↑, 2,   p‑Cofilin↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 12,   EMT↓, 23,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 3,   Fibronectin↓, 2,   KRAS↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MMP-10↓, 1,   MMP13↓, 1,   MMP2↓, 32,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 31,   MMPs↓, 13,   MTA1↓, 1,   N-cadherin↓, 7,   PDGF↓, 2,   RECK↑, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 5,   Smad1↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 5,   TET1↑, 4,   TGF-β↓, 5,   TIMP1↑, 6,   TIMP2↓, 2,   TIMP2↑, 5,   TRIB3↑, 1,   TumCI↓, 25,   TumCI↑, 1,   TumCMig↓, 23,   TumMeta↓, 28,   TumMeta↑, 2,   Twist↓, 9,   uPA↓, 4,   Vim?, 1,   Vim↓, 6,   Zeb1↓, 2,   Zeb1↑, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 23,   NO↑, 1,   PGI2↓, 1,   VEGF↓, 32,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,   CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 2,   MMP↓, 36,   MMP↑, 3,   MPT↑, 1,   NHE1↓, 1,   TRPM7↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 4,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 2,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 2,   CXCR4↓, 2,   DR4↑, 2,   FOXP3↑, 2,   HMGB1↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 1,   IL6↓, 14,   IL8↓, 5,   Imm↑, 6,   Imm↝, 1,   Inflam↓, 15,   LRIG1↑, 1,   M2 MC↓, 1,   MCT1↓, 1,   MDSCs↓, 1,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 40,   NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 1,   NOD1↓, 1,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 10,   PSA↓, 4,   SOCS-3↓, 1,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 11,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   FGF21↓, 1,   PPARα↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 22,   BioAv↝, 5,   CBR1↓, 1,   ChemoSen↑, 66,   ChemoSen⇅, 1,   ChemoSen∅, 2,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   Dose?, 1,   Dose↑, 2,   Dose↝, 21,   eff?, 1,   eff↓, 4,   eff↑, 16,   eff↝, 6,   eff∅, 2,   Half-Life↓, 3,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 7,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 17,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 21,   Synergy↑, 41,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 2,   AR↓, 2,   AST↓, 1,   BMD↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 1,   EGFR↓, 12,   EGFR↑, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 14,   KRAS↓, 1,   LDH↓, 4,   LDH↑, 1,   LDH↝, 1,   Myc↓, 1,   PD-L1↓, 5,   PSA↓, 4,   TP53↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 3,   AntiCan↑, 36,   AntiDiabetic↑, 2,   antiNeop↑, 2,   antiNeop∅, 1,   AntiTum↑, 10,   cardioP↑, 49,   chemoP↑, 28,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 4,   hepatoP↑, 15,   memory↑, 1,   neuroP↑, 12,   NP/CIPN↓, 1,   Obesity↓, 1,   OS↓, 1,   OS↑, 10,   OS∅, 1,   Pain↓, 1,   PFS↑, 1,   PFS∅, 1,   QoL↑, 3,   radioP↑, 8,   RenoP↑, 6,   Risk↓, 17,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 9,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 2,  
Total Targets: 592

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 8,   antiOx↑, 142,   ARE↑, 2,   Catalase↑, 62,   GPx↑, 43,   GPx1↑, 1,   GPx4↑, 4,   GSH↓, 1,   GSH↑, 61,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 7,   GSSG↓, 1,   GSTs↓, 2,   GSTs↑, 17,   H2O2↓, 7,   HDL↑, 9,   HDL∅, 1,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 45,   HO-1⇅, 1,   Iron↑, 1,   Iron∅, 1,   i-Iron↓, 1,   Keap1↓, 4,   Keap1↑, 2,   lipid-P↓, 62,   MDA↓, 47,   MPO↓, 14,   NADH↓, 1,   NOX↓, 1,   NOX2↓, 1,   NOX4↓, 5,   NQO1↑, 12,   NQO1↝, 1,   Nrf1↑, 3,   NRF2?, 1,   NRF2↓, 4,   NRF2↑, 79,   PrxII↑, 1,   RNS↓, 3,   ROS?, 1,   ROS↓, 188,   ROS↑, 3,   mt-ROS↓, 1,   SOD↑, 81,   mt-SOD↑, 1,   SOD1↑, 1,   SOD2↑, 6,   TAC↑, 10,   TBARS↓, 4,   Thiols↑, 2,   Trx1↑, 1,   TrxR1↑, 1,   uricA↓, 1,   VitC↑, 5,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   Insulin↓, 3,   Insulin↑, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↑, 2,   mtDam↓, 5,   mtDam↑, 1,   OCR↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,   SIRT3↑, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 4,   ACC↓, 1,   Acetyl-CoA↑, 1,   ACLY↓, 1,   ACSL4↓, 1,   adiP↓, 1,   ALAT↓, 26,   AMPK↑, 12,   p‑AMPK↑, 2,   ATP↑, 8,   cAMP↑, 1,   CRM↑, 4,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   GAPDH↑, 1,   glucose↓, 10,   glucose↑, 2,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 9,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 3,   HMG-CoA↓, 2,   LDL↓, 28,   lipidLev↓, 4,   NAD↑, 2,   NADPH↓, 6,   NADPH↑, 4,   PFK↓, 1,   PLA2↓, 2,   SIRT1↓, 1,   SIRT1↑, 16,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   APAF1↓, 1,   Apoptosis↓, 17,   ASC↓, 1,   BAX↓, 16,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 12,   Casp↓, 2,   Casp1↓, 1,   Casp12↓, 2,   Casp3↓, 20,   cl‑Casp3↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 7,   cl‑Casp9↓, 1,   Cyt‑c↓, 6,   Fas↓, 2,   Ferroptosis↓, 6,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 21,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 15,   Akt↝, 1,   p‑Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 1,   CREB↑, 2,   ERK↓, 7,   ERK↑, 4,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB↓, 1,   JAK↓, 1,   JAK2↑, 2,   JNK↓, 5,   JNK↑, 1,   p‑JNK↓, 3,   MAPK↓, 10,   MAPK↑, 2,   MAPK↝, 1,   Mst1↓, 1,   mTOR↓, 4,   mTOR↑, 4,   p‑mTOR↓, 3,   P70S6K↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 3,   PI3K↑, 10,   PKCδ↓, 2,   PKCδ↑, 2,   PP2A↑, 1,   PROKR1↑, 1,   PROKR2↑, 1,   PTEN↓, 2,   PTEN↑, 1,   Sp1/3/4↑, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 4,   STAT3↝, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 7,   ATF2↑, 1,   ATF4↓, 3,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   FOXO1↝, 1,   FOXO3?, 1,   FOXO3↑, 2,   HDAC↓, 2,   HDAC↑, 1,   HDAC2↓, 1,   miR-34a↓, 1,   other↓, 6,   other↑, 13,   other↝, 8,   other∅, 1,   RUNX2↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   p‑eIF2α↓, 2,   ER Stress↓, 11,   GRP78/BiP↓, 5,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 3,   HSP90↓, 1,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↓, 1,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↓, 1,   MitoP↑, 1,   p62↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   DNArepair↑, 1,   p16↓, 1,   P53↓, 2,   PARP↓, 1,   PCNA↓, 2,   Telomerase↓, 2,   TOP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   CLOCK↝, 1,   FGF↑, 1,   HH↓, 1,   IGF-1↑, 2,   IGFBP1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 25,   AP-1↓, 5,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 4,   Ca+2↑, 2,   p‑Ca+2↓, 1,   mt-Ca+2↓, 1,   Cartilage↑, 3,   COL1↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   ITGB1↑, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 3,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 3,   MMPs↓, 1,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   PROK2↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 5,   TGF-β↑, 2,   TGF-β1↓, 2,   TGF-β1↑, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumMeta↓, 1,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 5,   Endoglin↑, 1,   eNOS↑, 4,   p‑eNOS↑, 2,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 15,   NO↑, 1,   TXA2↓, 3,   VCAM-1↓, 5,   VEGF↓, 3,   VEGF↑, 3,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 16,   BBB↝, 1,   GastroP↑, 10,   GLUT1↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 4,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 10,   OCLN↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 2,   TRPV1↑, 2,   TRPV3↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 7,   COX2/PTGS2↓, 54,   CXCc↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1?, 1,   IL1↓, 3,   IL10↓, 7,   IL10↑, 8,   IL12↓, 3,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 38,   IL2↓, 4,   IL22↓, 1,   IL33↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 2,   IL6?, 1,   IL6↓, 56,   IL6↑, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 15,   Imm⇅, 1,   Imm↝, 1,   INF-γ↓, 1,   Inflam↓, 180,   Inflam↑, 2,   IRF3↓, 2,   LPS↓, 2,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP‑1α/CCL3↓, 1,   MyD88↓, 3,   NeuroI↓, 1,   NF-kB↓, 68,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 13,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 16,   RAGE↓, 2,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 5,   TLR4↓, 13,   TLR4↑, 1,   TNF-α↓, 73,   TRIF↓, 2,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   Ach↑, 1,   AChE↓, 29,   AChE↑, 1,   BChE↓, 8,   BDNF↑, 14,   ChAT↑, 2,   ChE↓, 1,   GABA↑, 5,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 2,   Aβ↓, 33,   Aβ42↓, 1,   BACE/β-secretase↓, 8,   tau↓, 9,   p‑tau↓, 3,   XO↓, 1,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   END↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 6,   p‑PPARγ↓, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 46,   BioAv↑, 65,   BioAv⇅, 3,   BioAv↝, 37,   BioEnh↑, 1,   ChemoSen↑, 3,   CompStab↑, 3,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   Dose?, 1,   Dose↑, 5,   Dose⇅, 1,   Dose↝, 42,   eff↓, 5,   eff↑, 25,   eff↝, 2,   Half-Life↓, 8,   Half-Life↑, 6,   Half-Life↝, 14,   P-gp/ABCB1↓, 1,   P450↓, 2,   P450↑, 2,   selectivity↑, 1,   Synergy↑, 18,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 26,   ALP↓, 6,   AST↓, 30,   BG↓, 2,   BloodF↑, 1,   BMD↑, 4,   BP↓, 25,   BUN?, 1,   BUN↓, 3,   CK/CK-MB↓, 1,   creat↓, 9,   CRP↓, 8,   Ferritin↑, 1,   hs-CRP↓, 2,   IL6?, 1,   IL6↓, 56,   IL6↑, 1,   IRes↝, 1,   LDH↓, 19,   NOS2↓, 1,   RAGE↓, 2,   TC↓, 2,   TG/TAG↓, 4,   TMAO↓, 1,   TMAO↑, 1,   Urea↓, 2,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 13,   antiAll↑, 18,   AntiArt↑, 12,   AntiCan↓, 1,   AntiCan↑, 32,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 49,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↓, 2,   AntiTum↑, 9,   BOLD↑, 1,   cardioP?, 3,   cardioP↓, 4,   cardioP↑, 268,   cardioP⇅, 1,   cardioP∅, 1,   chemoP↑, 12,   chemoPv↑, 7,   cognitive↓, 1,   cognitive↑, 48,   cough?, 1,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 78,   Learn↑, 1,   memory↑, 43,   memory∅, 1,   motorD↓, 1,   motorD↑, 5,   Mucositis↓, 2,   MusCon↓, 1,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 149,   Obesity↓, 25,   OS↑, 8,   Pain↓, 9,   QoL↑, 2,   radioP↑, 5,   RenoP↓, 2,   RenoP↑, 29,   Risk↓, 8,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 14,   Stroke↝, 1,   toxicity↓, 27,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 3,   Weight↓, 5,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↑, 9,   AntiP↑, 1,   AntiViral↑, 13,   Bacteria↓, 31,   Diar↓, 4,   GutMicro↑, 32,   Sepsis↓, 6,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Ingr↑, 2,   Ingr↝, 13,   Phen↑, 1,   QC↑, 1,  
Total Targets: 559

Scientific Paper Hit Count for: cardioP, cardioProtective
17 doxorubicin
12 Lycopene
11 Quercetin
11 Thymoquinone
10 Resveratrol
9 Allicin (mainly Garlic)
8 Chlorogenic acid
8 EGCG (Epigallocatechin Gallate)
7 Carvacrol
7 Chrysin
6 Baicalein
6 Berberine
6 Cinnamon
6 Hydrogen Gas
6 Honokiol
6 Kaempferol
5 Alpha-Lipoic-Acid
5 Chocolate
5 Coenzyme Q10
5 Curcumin
5 Flaxseed/Linseed
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Aspirin
4 Atorvastatin
4 Centella asiatica / Gotu kola → asiaticoside
4 diet Fermented Foods
4 flavonoids
4 Hyperoside
4 Luteolin
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Thymol-Thymus vulgaris
3 Choline
3 Hydroxycinnamic-acid
3 Chemotherapy
3 Spermidine
3 Crocetin
3 Diclofenac
3 Emodin
3 Ferulic acid
3 Fisetin
3 SDG/lignans
3 Grapeseed extract
3 Metformin
3 Magnetic Fields
3 Melatonin
3 Rosmarinic acid
3 Urolithin
3 Vitamin K2
2 Baicalin
2 Beta-Caryophyllene
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Capsaicin
2 Selenium
2 Ellagic acid
2 Eugenol
2 Ginkgo biloba
2 Ginkgetin
2 iodine
2 Isoliquiritigenin
2 isoquercitrin
2 Isovitexin
2 Magnolol
2 Matrine
2 Marjoram (Origanum majorana)
2 Piperine
2 Pterostilbene
2 Rutin
2 Shikonin
2 Vitexin
1 1,8-Cineole
1 Anthocyanins
1 Astragalus
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Aloe anthraquinones
1 Berbamine
1 Biochanin A
1 bempedoic acid
1 Betulinic acid
1 Boron
1 Bruteridin(bergamot juice)
1 Carnosic acid
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Date Fruit Extract
1 Dihydrocaffeic Acid
1 diet Short Term Fasting
1 Diindolylmethane
1 Indole-3-carbinol
1 Dipyridamole
1 Dandelion Root
1 Evodiamine
1 Gallic acid
1 Gambogic Acid
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 HydroxyTyrosol
1 phytic acid, Inositol hexakisphosphate
1 isoflavones
1 isoorientin
1 Ivermectin
1 Licorice
1 Linalool
1 Mung Bean Sprouts
1 Moringa oleifera
1 Lemon Balm/Melissa officinalis
1 Morin
1 nicotinamide adenine dinucleotide
1 Naringin
1 Phenylbutyrate
1 Propolis -bee glue
1 Piperlongumine
1 Psoralidin
1 Selenium NanoParticles
1 Shankhpushpi
1 Taurine
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin E
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1188  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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