MMP9 Cancer Research Results

MMP9, MMP9: Click to Expand ⟱
Source: HalifaxProj(suppress)
Type:
Matrix metalloproteinase-9 (MMP-9) is an enzyme that plays a significant role in the degradation of extracellular matrix components.
MMP-9 facilitates the breakdown of the extracellular matrix, which can enable cancer cells to invade surrounding tissues and spread to distant sites (metastasis).
Elevated levels of MMP-9 have been associated with poor prognosis in several cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
7541- HT,    Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer
- Trial, BC, NA
Dose↝, MMP9↓, TIMP1↓,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
7548- HYP,    Mechanistic evaluation of hyperoside against non-small cell lung cancer: a combined approach of network pharmacology and in vitro experimental validation
- in-vitro, NSCLC, A549
MMP9↓, cl‑Casp3↑, MAPK↑, EGFR↓, TumCP↓, p38↑, Apoptosis↑, BAX↑, ERK↓, FOXO1↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7808- IBC,    Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells
- in-vitro, Tong, Tca8113
TumCP↓, Apoptosis↑, Bcl-2↓, BAX↑, Casp↑, p‑Akt↓, ERK↓, MMP2↓, MMP9↓,
7639- Ins,    Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells
- in-vitro, Nor, MCF10
EMT↓, E-cadherin↑, AntiCan↑, MMP9↓,
7695- IP6,    The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells
- in-vitro, Colon, Caco-2
AntiCan↑, TumCA↓, TumCMig↓, MMP13↓, MMP3↓, MMP2↓, TIMP1↓, MMP1↓, MMP9↓, TIMP2↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, Synergy↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7693- IP6,    Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: I. In vitro studies of adhesion, migration and invasion of MDA-MB 231 human breast cancer cells
- in-vitro, BC, MDA-MB-231
TumCA↓, MMP9↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
8029- IVM,    Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
- Review, Var, NA
TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, Akt↓, mTOR↓, BBB∅, ROS↑, MMP↓, Casp3↓, Casp9↑, TumCCA↑, P53↑, cMyc↓, MMP9↓, HSP27↓, ICD↑, Synergy↑, *AntiP↑,
8043- IVM,    Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma
- vitro+vivo, ESCC, KYSE-30 - in-vitro, ESCC, KYSE70 - in-vitro, ESCC, KYSE150
tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, PAK1↓, ChemoSen↑, cl‑PARP↑, Casp3↑, TumMeta↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
1920- JG,  TQ,  PLB,    Natural quinones induce ROS-mediated apoptosis and inhibit cell migration in PANC-1 human pancreatic cancer cell line
- in-vitro, PC, PANC1
ROS↑, TumCMig↓, MMP9↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MMP2↓, MMP9↓, miR-34a↑, miR-25-5p↑, miR-195↑, miR-27a-3p↑, Let-7↑, miR-106b↓, miR-17↓, miR-21↓, miR-155↓, miR-221↓, TumPF↓,
8255- LCA,    Antitumor and antimetastatic effects of licochalcone A in mouse models
- in-vivo, Colon, NA
COX2/PTGS2↓, iNOS↓, NF-kB↓, AP-1↓, AntiTum↑, β-catenin/ZEB1↓, OS↑, TumMeta↓, MMP9↓,
8290- LE,    Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells
- vitro+vivo, Pca, DU145
*toxicity↝, Apoptosis↑, TumCCA↑, TumCMig↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, COX2/PTGS2↓, VEGF↓, MMP9↓, ICAM-1↓, VCAM-1↓,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8393- LT,    Progress, pharmacokinetics and future perspectives of luteolin modulating signaling pathways to exert anticancer effects: A review
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, EMT↓, Imm↝, ChemoSen↑, *Inflam↓, *COX2/PTGS2↓, *NF-kB↓, MMP2↓, MMP9↓, p‑Akt↓, p‑PI3K↓, IGF-2↓, IGF-1R↓, CXCL16↓, NOTCH1↓, HES1↓, VEGF↓, ROS↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
2927- LT,    Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
- in-vitro, Cerv, HeLa
TumCMig↓, DNMTs↓, HDAC↓, HATs↓, ac‑H3↓, ac‑H4↓, MMP2↓, MMP9↓, HO-1↓, E-cadherin↑, EZH2↓, HER2/EBBR2↓, IL18↓, IL8↓, IL2↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
3262- Lyco,    Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1
- in-vitro, adrenal, SK-HEP-1
TumCI↓, MMP9↓, NF-kB↓, Sp1/3/4↓, IGF-1R↓, i-ROS↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
1714- Lyco,    Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
- in-vitro, Ovarian, OV-MZ-6 - in-vivo, NA, NA
ChemoSen↑, CA125↓, ITGA5↓, ITGB1↓, MMP9↓, FAK↓, EMT↓, MAPK↓, MMP9↓, antiOx↑, Ki-67↓, MAPK↓,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4784- Lyco,    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
- Review, Diabetic, NA - Review, CardioV, NA
*antiOx↑, *IL8↓, *IL6↓, *IL1↓, *NF-kB↓, Inflam↓, cycD1/CCND1↓, MMP2↓, MMP9↓, Bcl-2↓, NF-kB↓, *Nrf1↑, *antiOx↑, *BDNF↑, *neuroP↑, *cardioP↑, ROS↑, Dose↝,
4788- Lyco,    Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)
- Review, Var, NA
AntiCan↑, ChemoSen↑, chemoP↑, Dose↝, BioAv↑, BioAv↑, BioAv↓, cardioP↑, AntiDiabetic↑, hepatoP↑, neuroP↑, MAPK↓, MMP2↓, MMP9↓, TIMP1↑, TIMP2↑,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
4792- Lyco,    A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy
- Review, Var, NA
*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2/PTGS2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, Synergy↑,
8520- MAG,    The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy
- in-vitro, BC, MDA-MB-231
TumCI↓, MMP9↓, NF-kB↓, *toxicity↓,
8518- MAG,    Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway
- in-vitro, CCA, NA
TumCG↓, TumCMig↓, TumCI↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, p‑IκB↓, p‑p65↓, NF-kB↓,
4518- MAG,  Cisplatin,    Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells
- in-vitro, GC, MKN45
ChemoSen↑, tumCV↓, BAX↑, Bcl-2↓, P21↑, P53↑, MMP9↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
8566- Matr,    Matrine suppresses lung metastasis of human hepatocellular carcinoma by directly targeting matrix metalloproteinase-9
- vitro+vivo, HCC, MHCC-97H
TumCMig↓, TumCI↓, Dose↓, MMP9↓, TumMeta↓,

Showing Research Papers: 251 to 300 of 448
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 448

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   Catalase↓, 5,   Catalase↑, 3,   Copper↓, 1,   Copper↑, 1,   frataxin↑, 1,   GPx↓, 2,   GPx↑, 4,   GPx4↓, 6,   GSH↓, 23,   GSH↑, 5,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 5,   HO-1↓, 9,   HO-1↑, 14,   HO-2↓, 1,   Iron↑, 3,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 4,   lipid-P↑, 13,   MDA↓, 5,   MDA↑, 5,   MPO↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 13,   NRF2↑, 16,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   RNS↑, 1,   ROS?, 2,   ROS↓, 26,   ROS↑, 170,   ROS⇅, 7,   ROS∅, 1,   i-ROS↓, 2,   i-ROS↑, 2,   mt-ROS↑, 1,   SOD↓, 6,   SOD↑, 7,   SOD1↓, 1,   SOD1↑, 2,   SOD2↓, 1,   SOD2↑, 3,   TBARS↑, 1,   Thiols↓, 1,   Trx1↑, 1,   TrxR↓, 7,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 2,   Tf↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   Bfl-1↓, 1,   CDC2↓, 7,   CDC25↓, 10,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 5,   ETC↓, 3,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 8,   OCR↓, 3,   mt-OXPHOS↓, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 6,   ACADS/SCAD↓, 1,   ACC↑, 1,   ALAT↓, 6,   ALAT↝, 1,   AMPK↓, 2,   AMPK↑, 20,   AMPK↝, 1,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 13,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FABP4↑, 1,   FASN↓, 3,   FASN↑, 1,   GAPDH↓, 2,   GLO-I↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 9,   GlutMet↓, 2,   Glycolysis↓, 23,   GSK‐3β↓, 11,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   HK1↓, 1,   HK2↓, 11,   lactateProd↓, 9,   LDHA↓, 6,   LDL↓, 1,   lipidLev↓, 1,   NADPH↓, 3,   NADPH↑, 3,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 7,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 1,   PIP3↑, 1,   PKM2↓, 8,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SIRT1↓, 6,   SIRT1↑, 9,   SIRT2↑, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 143,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 5,   Bak↑, 5,   BAX↓, 2,   BAX↑, 94,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 22,   Bcl-2↓, 104,   Bcl-2↑, 3,   Bcl-xL↓, 35,   BID↓, 2,   BID↑, 6,   p‑BID↓, 1,   BIM↑, 5,   BNIP3↑, 3,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 25,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp2↑, 1,   Casp3↓, 5,   Casp3↑, 114,   Casp3∅, 1,   cl‑Casp3↑, 15,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 12,   cl‑Casp7↑, 1,   Casp8↑, 29,   Casp8∅, 1,   cl‑Casp8↑, 4,   proCasp8↑, 2,   Casp9↓, 1,   Casp9↑, 76,   p‑Casp9↑, 1,   cl‑Casp9↑, 8,   proCasp9↓, 1,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 62,   mt-Cyt‑c↓, 1,   Diablo↑, 12,   DR5↑, 22,   Endon↑, 2,   FADD↑, 4,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 20,   FasL↓, 1,   FasL↑, 8,   FasL⇅, 1,   Ferroptosis↑, 7,   GranB/GZMB↝, 1,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 16,   IAP2/BIRC3↓, 6,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 19,   Mcl-1?, 1,   Mcl-1↓, 27,   p‑Mcl-1↓, 1,   MDM2↓, 9,   MDM2↑, 1,   MOMP↑, 2,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 3,   p38↓, 13,   p38↑, 13,   p‑p38↓, 4,   p‑p38↑, 4,   p‑p38↝, 1,   Perforin↝, 1,   PUMA↓, 1,   PUMA↑, 6,   Pyro↑, 4,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 53,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 7,   XIAP↓, 26,   XIAP↑, 1,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 134,   Akt↑, 4,   p‑Akt↓, 43,   AKT1↓, 2,   Akt2↓, 1,   CaMKII ↓, 1,   CIP2A↓, 2,   CK2↓, 4,   cMET↓, 2,   p‑cMET↓, 1,   cSrc↓, 3,   EGFR↓, 34,   p‑EGFR↓, 3,   ERK↓, 53,   ERK↑, 8,   p‑ERK↓, 23,   p‑ERK↑, 1,   p‑ERK↝, 1,   FGFR1↓, 3,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↑, 1,   IGF-1R↓, 6,   IGFR↓, 1,   IKKα↓, 10,   IKKα↝, 1,   p‑IKKα↓, 2,   IκB↓, 1,   p‑IκB↓, 3,   p‑IκB↑, 1,   JAK↓, 6,   p‑JAK↓, 1,   JAK1↓, 4,   p‑JAK1↓, 1,   JAK2↓, 17,   p‑JAK2↓, 3,   p‑JAK3↓, 1,   JNK↓, 12,   JNK↑, 18,   p‑JNK↓, 5,   p‑JNK↑, 2,   p‑JNK↝, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 35,   MAPK↑, 13,   p‑MAPK↓, 2,   MARK4↓, 2,   MEK↓, 5,   p‑MEK↓, 2,   MKK4↓, 1,   mTOR↓, 67,   mTOR↝, 1,   p‑mTOR↓, 11,   mTORC2↓, 2,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 106,   PI3K↑, 1,   p‑PI3K↓, 8,   p‑PI3K↑, 1,   PI3K/Akt↓, 4,   PKA↓, 2,   PKCδ↓, 14,   p‑PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 29,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 12,   p‑S6K↓, 1,   SHP1↑, 2,   Sp1/3/4↓, 12,   Sp1/3/4↑, 1,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 4,   p‑STAT2↓, 1,   STAT3↓, 76,   STAT3↑, 3,   p‑STAT3↓, 13,   p‑STAT3↑, 3,   STAT5↓, 3,   STAT6↓, 2,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 6,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 8,   cJun↑, 1,   p‑cJun↓, 1,   cMyc↓, 40,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 6,   DNMTs↓, 7,   EZH2↓, 6,   FOXM1↓, 4,   FOXO↑, 3,   FOXO1↓, 3,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 8,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 7,   HATs↑, 1,   HDAC↓, 18,   HDAC1↓, 5,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 3,   JPT1/HN1↓, 1,   LINC01116↓, 1,   Matr↓, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-126↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 5,   miR-155↑, 1,   miR-17↓, 1,   miR-182-5p↓, 1,   miR-194↑, 1,   miR-195↑, 1,   miR-200b↑, 2,   miR-200c↓, 1,   miR-203↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↑, 1,   miR-27a-3p↓, 1,   miR-27a-3p↑, 1,   miR-301a-3p↓, 1,   miR-340↓, 2,   miR-34a↑, 5,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 2,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 5,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 15,   other↓, 3,   other↑, 1,   other↝, 4,   other∅, 1,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 11,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 2,   SOX9↑, 1,   TCF-4↓, 2,   tumCV↓, 28,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 17,   eIF2α↓, 1,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 33,   Erlin1↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 12,   GRP78/BiP↝, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 7,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSPs↓, 1,   IRE1↑, 5,   PDI↑, 1,   PERK↑, 3,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 4,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 5,   Beclin-1/ATG6↑, 10,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B-II↓, 1,   LC3B-II↑, 4,   LC3II↓, 3,   LC3II↑, 8,   LC3s↓, 1,   LC3s↑, 1,   p62↓, 6,   p62↑, 2,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 31,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 2,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↑, 1,   DFF45↓, 2,   DNAdam↓, 3,   DNAdam↑, 40,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 11,   MGMT↓, 1,   p16↑, 4,   P53?, 2,   P53↓, 2,   P53↑, 75,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 16,   cl‑PARP↓, 1,   cl‑PARP↑, 50,   PARP1↑, 1,   PCNA↓, 24,   POLD1↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 14,   TOP1↓, 7,   TOP2↓, 6,   TOP2↑, 2,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 8,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 11,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 40,   CDK2↑, 3,   CDK4↓, 51,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 24,   CDK6↑, 1,   CDK8↓, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 3,   p‑CHK1↑, 1,   Chk2↓, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 19,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 85,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 23,   E2Fs↓, 5,   GADD45A↑, 1,   Ki-67↓, 28,   MAD↓, 1,   P21↓, 4,   P21↑, 55,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 21,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 10,   TumCCA↑, 148,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 6,   ALDH1A1↓, 3,   BMP2↓, 2,   BMPs↑, 1,   CD133↓, 10,   CD133↑, 1,   CD24↓, 4,   CD34↓, 1,   cFos↓, 8,   p‑cFos↓, 1,   cMYB↓, 1,   CSCs↓, 38,   CSCs↑, 1,   Diff↓, 1,   Diff↑, 3,   EIF4E↓, 1,   FGF↓, 3,   FGF↑, 1,   Gli↓, 2,   Gli1↓, 9,   HH↓, 8,   IGF-1↓, 9,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 28,   Let-7↑, 6,   LRP6↓, 1,   p‑LRP6↓, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 11,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 19,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 2,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 2,   Shh↓, 7,   Smo↓, 3,   STAT1↓, 1,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 67,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 127,   TumCP↑, 2,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 42,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 20,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 2,   CA↓, 3,   Ca+2↓, 1,   Ca+2↑, 32,   Ca+2↝, 1,   i-Ca+2?, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↓, 1,   CCN2/CTGF↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1A1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 13,   E-cadherin↑, 69,   EMMPRIN↓, 1,   EMT↓, 101,   EMT↑, 3,   EpCAM↓, 4,   F-actin↓, 2,   FAK↓, 22,   FAK↑, 2,   p‑FAK↓, 5,   fascin↓, 1,   Fibronectin↓, 8,   GIT1↓, 1,   GLI2↓, 2,   IQGAP3↓, 1,   ITGA1∅, 1,   ITGA5↓, 3,   ITGA5∅, 1,   ITGB1↓, 4,   ITGB1∅, 1,   ITGB3↓, 1,   ITGB3∅, 1,   ITGB4∅, 1,   KAI1/CD82↑, 1,   LAMs↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP-10↓, 2,   MMP1↓, 13,   MMP11↓, 1,   MMP13↓, 8,   MMP14↓, 1,   MMP16↓, 3,   MMP2?, 2,   MMP2↓, 260,   MMP2↑, 2,   MMP2⇅, 1,   MMP2↝, 1,   MMP2∅, 1,   MMP3↓, 15,   MMP7↓, 16,   MMP7∅, 1,   MMP9?, 2,   MMP9↓, 399,   MMP9↑, 9,   MMP9⇅, 1,   MMP9↝, 1,   MMP9∅, 1,   pro‑MMP9↓, 1,   MMPs↓, 27,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 46,   NCAM↓, 1,   PAI-1/SERPINE1↓, 1,   PAK1↓, 2,   PDGF↓, 7,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 6,   ROCK1↓, 7,   ROCK1↑, 1,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 2,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 2,   Snail?, 2,   Snail↓, 37,   Snail↑, 1,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 21,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 7,   TIMP1↑, 23,   TIMP2↓, 5,   TIMP2↑, 17,   TIMP3↑, 2,   TSP-1↑, 3,   TumCA↓, 7,   TumCA↑, 1,   TumCI↓, 135,   TumCI↑, 2,   TumCMig↓, 126,   TumCMig↑, 1,   TumMeta↓, 94,   TumMeta↑, 6,   TumPF↓, 1,   Twist↓, 28,   Twist↑, 1,   uPA↓, 40,   uPAR↓, 7,   Vim?, 1,   Vim↓, 59,   Zeb1↓, 18,   ZEB2↓, 3,   ZEB2↑, 1,   α-SMA↓, 4,   α-SMA↑, 1,   α-tubulin↑, 3,   β-catenin/ZEB1↓, 49,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 97,   angioG↑, 1,   angioS↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 3,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 3,   HIF-1↓, 4,   Hif1a↓, 57,   Hif1a↑, 2,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 7,   NO↑, 1,   PHDs↓, 1,   TXA2↓, 1,   VCAM-1↓, 4,   VEGF↓, 148,   VEGF↑, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 19,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB∅, 1,   CLDN1↓, 2,   CLDN2↓, 1,   EPR↑, 5,   EPR↝, 1,   GLUT1↓, 9,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 75,   MMP↑, 1,   MMP∅, 1,   MPT↑, 5,   NHE1↓, 2,   TRPM7↓, 1,   TRPV1↑, 3,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 15,   CD8+↑, 1,   p‑cDC2↓, 1,   COX1↓, 5,   COX2/PTGS2↓, 107,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR2↓, 2,   CXCR4↓, 23,   CXCR4↑, 1,   DR4↑, 8,   FOXP3↓, 2,   FOXP3↑, 1,   Gal-3↓, 1,   HMGB1↓, 4,   ICAM-1↓, 12,   IFN-γ↓, 2,   IFN-γ↑, 2,   Igs↑, 1,   IL-1Ra↑, 1,   IL1↓, 7,   IL1↑, 2,   IL10↓, 6,   IL10↑, 3,   IL12↓, 4,   IL12↑, 1,   IL17↓, 1,   IL18↓, 2,   IL18↑, 1,   IL1R2↑, 1,   IL1RL1/ST2↑, 1,   IL1α↓, 2,   IL1β↓, 15,   IL1β↑, 2,   IL2↓, 4,   IL2↑, 4,   IL22↓, 1,   IL23↓, 1,   IL33↑, 1,   IL4↓, 2,   IL4↑, 2,   IL6↓, 53,   IL6↑, 1,   IL8↓, 13,   IL8↑, 2,   Imm↑, 2,   Imm↝, 3,   Inflam↓, 27,   IRAK1↓, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 7,   MIP2↓, 1,   mPGES-1↓, 2,   NF-kB?, 1,   NF-kB↓, 168,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 3,   NLRP3↑, 2,   p50↓, 3,   p65↓, 11,   p65↑, 1,   p‑p65↓, 3,   PD-1↓, 2,   PD-L1↓, 8,   PD-L1↑, 1,   PGE2↓, 25,   PSA↓, 5,   PSA∅, 1,   RAGE↓, 1,   T-Cell↑, 1,   Th1 response↑, 2,   TLR2↓, 1,   TLR4↓, 3,   TLR4↝, 1,   TNF-α↓, 34,   TNF-α↑, 7,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 1,   AhR↓, 1,   AR↓, 12,   AR↑, 1,   CYP19↓, 1,   ER-α36↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   GR↑, 1,   PPARα↓, 2,   PPARα↑, 1,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 8,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 40,   BioAv↑, 41,   BioAv↝, 10,   BioEnh↑, 2,   CBR1↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 122,   CompStab↓, 1,   CompStab↝, 2,   CYP1A1↓, 3,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   DDS↑, 1,   Dose?, 3,   Dose↓, 3,   Dose↑, 6,   Dose↝, 36,   Dose∅, 9,   eff?, 1,   eff↓, 17,   eff↑, 62,   eff↝, 10,   GSTA1↑, 1,   Half-Life↓, 9,   Half-Life↑, 4,   Half-Life↝, 9,   Half-Life∅, 1,   MDR1↓, 7,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 17,   P-gp/ABCB1⇅, 1,   P450↓, 1,   RadioS↑, 37,   selectivity?, 2,   selectivity↑, 45,   selectivity∅, 1,   Synergy↑, 88,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 6,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 12,   AR↑, 1,   ascitic↓, 2,   AST↓, 4,   AST↝, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   CRP↓, 3,   E6↓, 2,   E7↓, 2,   EGFR↓, 34,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 6,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 11,   IL6↓, 53,   IL6↑, 1,   LDH↓, 3,   LDH↑, 4,   Myc↓, 5,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 5,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 40,   AntiCan?, 1,   antiCG↓, 1,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 3,   AntiTum↓, 1,   AntiTum↑, 19,   cachexia↓, 2,   cardioP↑, 8,   CardioT↑, 2,   chemoP?, 1,   chemoP↑, 16,   chemoPv↑, 18,   ChemoSideEff↓, 4,   cognitive↑, 2,   hepatoP↓, 1,   hepatoP↑, 8,   neuroP↑, 5,   OS↑, 7,   Pin1↓, 1,   QoL↑, 2,   radioP↑, 7,   Remission↑, 1,   RenoP↑, 5,   Risk↓, 4,   toxicity↓, 13,   toxicity↑, 5,   toxicity↝, 6,   toxicity∅, 1,   TumVol↓, 16,   TumVol∅, 1,   TumW↓, 5,   TumW∅, 1,   Weight↑, 1,   Weight∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 3,   GutMicro↝, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 1037

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 77,   ARE↑, 1,   Catalase↑, 31,   Copper↓, 1,   GPx↓, 1,   GPx↑, 25,   GPx1↑, 1,   GPx3↑, 1,   GPx4↑, 1,   GSH↑, 28,   GSR↓, 1,   GSR↑, 6,   GSTs↑, 11,   H2O2↓, 5,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 2,   HO-1↑, 20,   hyperG↝, 1,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 18,   mt-lipid-P↓, 1,   MDA↓, 22,   MPO↓, 3,   MPO↑, 1,   NADH↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2?, 1,   NRF2↑, 30,   Prx↑, 2,   RNS↓, 4,   ROS?, 2,   ROS↓, 86,   SOD↑, 40,   SOD1↑, 6,   SOD2↑, 3,   TAC↑, 1,   TrxR↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   mtDam↓, 1,   PGC-1α↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↑, 1,   5LO↓, 3,   ALAT↓, 8,   AMPK↑, 8,   ATP↑, 1,   cAMP↑, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   glucose↑, 1,   GlucoseCon↑, 2,   GlutMet↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   LDL↓, 3,   NAD↑, 1,   NADH:NAD↑, 1,   SIRT1↑, 11,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   ASC?, 1,   BAD↓, 1,   BAX↓, 7,   Bcl-2↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 7,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 2,   Cyt‑c↓, 3,   Cyt‑c∅, 2,   Ferroptosis↓, 1,   iNOS↓, 14,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 2,   Pyro?, 1,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 5,   p‑Akt↓, 2,   p‑Akt↑, 2,   AKT1↓, 1,   CREB↑, 1,   p‑CREB↑, 1,   ERK↓, 1,   ERK↑, 4,   p‑ERK↑, 1,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 3,   JNK↑, 1,   p‑JNK↓, 1,   p‑LIMK1↑, 1,   MAPK↓, 9,   MAPK↑, 4,   mTOR↓, 1,   mTOR↑, 2,   PDGFR-BB↓, 1,   PI3K↓, 1,   PI3K↑, 5,   PKA↑, 1,   PKCδ↑, 3,   PP2A↑, 1,   PTEN↓, 2,   PTEN↑, 1,   Src↓, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   other↓, 4,   other↑, 5,   other↝, 7,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSP70/HSPA5↝, 1,   HSPs↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 2,   p16↓, 1,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 2,   P21↓, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↑, 1,   Diff↑, 1,   IGF-1↑, 2,   neuroG↑, 3,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 10,   AP-1↓, 4,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   p‑Cofilin↑, 1,   COL1↑, 1,   EMT↑, 1,   LAMs↑, 1,   p‑MLC2/MYL9↑, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP2↓, 7,   MMP2↑, 2,   MMP3↓, 3,   MMP9↓, 32,   MMP9↑, 6,   MMPs↓, 2,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   ROCK1↑, 1,   Smad1↑, 1,   SMAD3↓, 1,   TGF-β↓, 4,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 2,   TIMP2↑, 2,   TregCell↑, 1,   TumCI↓, 1,   TumMeta↓, 1,   α-SMA↓, 5,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 3,   CD31/PECAM-1↓, 1,   eNOS↑, 2,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 15,   NO↑, 4,   VCAM-1↓, 5,   VEGF↓, 3,   VEGF↑, 6,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 14,   BBB∅, 2,   CLDN1↝, 1,   GastroP↑, 2,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 3,   MMP↑, 10,   MMP∅, 1,   MUC19↓, 1,   MUC2↓, 1,   TJ↑, 1,   TRPM7↓, 1,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 34,   CXCR4↓, 1,   Eos↓, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 3,   IL10↓, 1,   IL10↑, 5,   IL12↓, 3,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 25,   IL2↑, 2,   IL23↓, 1,   IL4↓, 2,   IL4↑, 2,   IL5↓, 2,   IL6↓, 31,   IL8↓, 7,   Imm↑, 12,   Inflam↓, 85,   Inflam↑, 2,   IRF3↓, 1,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 45,   NK cell↑, 1,   NLRP3↓, 6,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 14,   PGE2↑, 3,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR4↓, 6,   TNF-α↓, 32,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   AChE↑, 1,   BChE↓, 1,   BDNF↑, 9,   GABA↑, 3,   NGF↑, 2,   PSD95↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   Aβ↓, 15,   BACE/β-secretase↓, 5,   tau↓, 1,   p‑tau↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 28,   BioAv↑, 25,   BioAv↝, 19,   BioEnh↑, 1,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose⇅, 1,   Dose↝, 8,   eff↓, 2,   eff↑, 17,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↝, 6,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 3,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 3,   AST↓, 11,   BMD↑, 1,   BP↓, 2,   BP↝, 1,   p‑BRCA1↑, 1,   CRP↓, 5,   Hcy/homoC↓, 1,   IL6↓, 31,   LDH↓, 4,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 4,   antiAll↑, 14,   AntiArt↑, 7,   AntiCan↓, 1,   AntiCan↑, 16,   antiCG↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 15,   antiPs↑, 1,   AntiTum↑, 5,   cardioP↑, 27,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 17,   diuretic↑, 3,   hepatoP↓, 1,   hepatoP↑, 24,   Learn↑, 2,   memory↑, 18,   motorD↑, 4,   Mucositis↓, 1,   neuroP↓, 2,   neuroP↑, 61,   Obesity↓, 4,   OS↑, 1,   Pain↓, 6,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 5,   Risk↓, 1,   Stroke↓, 5,   toxicity↓, 20,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 3,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 7,   Bacteria↓, 19,   Diar↓, 1,   GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 379

Scientific Paper Hit Count for: MMP9, MMP9
19 Resveratrol
15 Fisetin
13 Curcumin
12 Thymoquinone
11 Matrine
11 Sulforaphane (mainly Broccoli)
9 Apigenin (mainly Parsley)
9 Baicalein
9 Berberine
9 Quercetin
9 Luteolin
9 Lycopene
8 Garcinol
8 Magnetic Fields
7 Boswellia (frankincense)
7 Propolis -bee glue
7 Capsaicin
7 Magnolol
7 Morin
6 Silver-NanoParticles
6 Alpha-Lipoic-Acid
6 Artemisinin
6 Caffeic acid
6 Chrysin
6 Diindolylmethane
6 Dandelion Root
6 EGCG (Epigallocatechin Gallate)
6 Eugenol
6 Honokiol
6 Kaempferol
6 Rosmarinic acid
5 Melatonin
5 Betulinic acid
5 Ellagic acid
5 Ferulic acid
5 Formononetin
5 Gambogic Acid
5 Nimbolide
5 Piperine
4 Cisplatin
4 Cucurbitacin
4 Pterostilbene
4 Silymarin (Milk Thistle) silibinin
4 Shikonin
4 Urolithin
3 Ascorbyl Palmitate
3 Celastrol
3 Hydroxycinnamic-acid
3 D-limonene
3 Emodin
3 phytic acid, Inositol hexakisphosphate
3 Magnetic Field Rotating
3 Phenethyl isothiocyanate
3 Piperlongumine
2 1,8-Cineole
2 Sorafenib (brand name Nexavar)
2 Astragalus
2 Paclitaxel/Taxol
2 alpha Linolenic acid
2 Radiotherapy/Radiation
2 Ashwagandha(Withaferin A)
2 Baicalin
2 Berbamine
2 Biochanin A
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Chlorogenic acid
2 chitosan
2 Cinnamon
2 Crocetin
2 CUSP9
2 Deguelin
2 Indole-3-carbinol
2 Evodiamine
2 tamoxifen
2 Fucoidan
2 Ginkgolic acids
2 Genistein (soy isoflavone)
2 Ginger/6-Shogaol/Gingerol
2 Graviola
2 Grapeseed extract
2 Proanthocyanidins
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 Inositol
2 Ivermectin
2 Juglone
2 Licorice
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Naringin
2 Marjoram (Origanum majorana)
2 Selenite (Sodium)
2 Vitamin C (Ascorbic Acid)
1 2-DeoxyGlucose
1 3-bromopyruvate
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Isovitexin
1 Aspirin
1 Astaxanthin
1 Beta-Caryophyllene
1 Chemotherapy
1 Brucea javanica
1 brusatol
1 Bacopa monnieri
1 borneol
1 Carnosic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Centella asiatica / Gotu kola → asiaticoside
1 Selenium NanoParticles
1 Carvone
1 Cyclopamine
1 Cysteamine
1 Vitamin A, Retinoic Acid
1 Folic Acid, Vit B9
1 Bortezomib
1 Flaxseed/Linseed
1 Gallic acid
1 Ginkgo biloba
1 Geraniol
1 Ginkgetin
1 Hops (Humulus lupulus)
1 Hyperoside
1 Isobavachalcone
1 Isoliquiritigenin
1 isoorientin
1 Plumbagin
1 Lactobacillus
1 Licochalcone A
1 Methylglyoxal
1 Methylsulfonylmethane
1 Myricetin
1 Niclosamide (Niclocide)
1 Propyl gallate
1 temozolomide
1 Polyphenols
1 Parthenolide
1 Sanguinarine
1 Sesame seeds and Oil
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Turmerones
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:203  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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