TumCI Cancer Research Results

TumCI, Tumor Cell invasion: Click to Expand ⟱
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Tumor cell invasion is a critical process in cancer progression and metastasis, where cancer cells spread from the primary tumor to surrounding tissues and distant organs. This process involves several key steps and mechanisms:

1.Epithelial-Mesenchymal Transition (EMT): Many tumors originate from epithelial cells, which are typically organized in layers. During EMT, these cells lose their epithelial characteristics (such as cell-cell adhesion) and gain mesenchymal traits (such as increased motility). This transition is crucial for invasion.

2.Degradation of Extracellular Matrix (ECM): Tumor cells secrete enzymes, such as matrix metalloproteinases (MMPs), that degrade the ECM, allowing cancer cells to invade surrounding tissues. This degradation facilitates the movement of cancer cells through the tissue.

3.Cell Migration: Once the ECM is degraded, cancer cells can migrate. They often use various mechanisms, including amoeboid movement and mesenchymal migration, to move through the tissue. This migration is influenced by various signaling pathways and the tumor microenvironment.

4.Angiogenesis: As tumors grow, they require a blood supply to provide nutrients and oxygen. Tumor cells can stimulate the formation of new blood vessels (angiogenesis) through the release of growth factors like vascular endothelial growth factor (VEGF). This not only supports tumor growth but also provides a route for cancer cells to enter the bloodstream.

5.Invasion into Blood Vessels (Intravasation): Cancer cells can invade nearby blood vessels, allowing them to enter the circulatory system. This step is crucial for metastasis, as it enables cancer cells to travel to distant sites in the body.

6.Survival in Circulation: Once in the bloodstream, cancer cells must survive the immune response and the shear stress of blood flow. They can form clusters with platelets or other cells to evade detection.

7.Extravasation and Colonization: After traveling through the bloodstream, cancer cells can exit the circulation (extravasation) and invade new tissues. They may then establish secondary tumors (metastases) in distant organs.

8.Tumor Microenvironment: The surrounding microenvironment plays a significant role in tumor invasion. Factors such as immune cells, fibroblasts, and signaling molecules can either promote or inhibit invasion and metastasis.
Scientific Papers found: Click to Expand⟱
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3083- RES,    Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
YAP/TEAD↓, Rho↓, FAK↓, MMP9↓, ChemoSen↑, RAS↓, ROCK1↓, TumCI↓, TumMeta↓,
3082- RES,    Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vivo, NA, NA
VEGF↓, CXCL12↓, IL6↓, α-SMA↓, Hif1a↓, TumCI↓, EMT↓,
3086- RES,    Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TET1↑, TumCMig↓, TumCI↓, TIMP2↑, TIMP3↑, MMP2↓, MMP9↓,
3089- RES,    The Role of Resveratrol in Cancer Therapy
- Review, Var, NA
angioG↓, VEGF↓, EGFR↓, FGF↑, TumCMig↓, TumCI↓, TIMP1↑, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, PI3K↓, Akt↓, MAPK↓, EMT↓, AR↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF-7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3095- RES,    Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk
- in-vitro, BC, NA
TumCP↓, TumCMig↓, TumCI↓, cycD1/CCND1↓, cMyc↓, MMP2↓, MMP9↓, SOX2↓, Akt↓, STAT3↓, α-SMA↓,
3070- RES,    Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma
- in-vitro, RCC, ACHN - in-vitro, RCC, 786-O - in-vivo, NA, NA
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, NLRP3↓,
2988- RES,    The Antimetastatic Effects of Resveratrol on Hepatocellular Carcinoma through the Downregulation of a Metastasis-Associated Protease by SP-1 Modulation
- in-vitro, HCC, HUH7
TumCMig↓, TumCI↓, uPA↓, Sp1/3/4↓,
101- RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, Snail↓, N-cadherin↓, E-cadherin↑, TumCI↓, TumMeta↓,
877- RES,    Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, HCT116
MALAT1↓, Wnt/(β-catenin)↓, TumCI↓, TumMeta↓,
1048- RosA,  Ger,    Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis
- in-vivo, Colon, MC38
TumCMig↓, TumCI↓, PD-1↓, COX2↓, PD-L1↓,
3027- RosA,    Rosmarinic acid inhibits proliferation and invasion of hepatocellular carcinoma cells SMMC 7721 via PI3K/AKT/mTOR signal pathway
- in-vitro, HCC, SMMC-7721 cell
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, TumCMig↓, MMPs↓, Vim↓,
3010- RosA,    Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation
- in-vitro, Lung, A549 - in-vivo, NA, NA
TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
5127- Sal,    Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
- in-vitro, Ovarian, NA
TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Wnt↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, EMT↓,
5042- SAS,    xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling
- Review, Var, NA
xCT↓, GSH↓, TumCG↓, TumCI↓, ROS↑, RadioS↑, eff↓,
5035- SAS,    Sulfasalazine, a potent suppressor of gastric cancer proliferation and metastasis by inhibition of xCT: Conventional drug in new use
- Human, GC, NA - in-vitro, GC, NCI-N87 - in-vitro, GC, SGC-7901
other?, TumCP↓, TumMeta↓, TumCI↓, xCT↓, OS↑,
3188- SFN,    Sulforaphane inhibited tumor necrosis factor-α induced migration and invasion in estrogen receptor negative human breast cancer cells
- in-vitro, BC, NA
TNF-α↓, TumCI↓, TumMeta↓, MMPs↓, MMP2↓, MMP9↓, MMP13↓,
111- SFN,    Sulforaphene Interferes with Human Breast Cancer Cell Migration and Invasion through Inhibition of Hedgehog Signaling
- in-vitro, BC, SUM159
HH↓, Gli1↓, MMP2↓, MMP9↓, Smo↓, TumCMig↓, TumCI↓,
2166- SFN,    Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction
- in-vitro, Oral, NA - in-vivo, NA, NA
CSCs↓, selectivity↑, TumCMig↓, TumCI↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1466- SFN,    Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- vitro+vivo, Thyroid, FTC-133
TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,
1462- SFN,    Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
EMT↓, TumCI↓, TumCMig↓, E-cadherin↑, Zeb1↓, Snail↓, COX2↝, MMP2↝, MMP9↝,
1457- SFN,    Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells
- in-vitro, CRC, HT-29
IL6↓, ROS↓, TumCP↓, TumCI↓, p38↓, AP-1↓,
1452- SFN,    Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells
- in-vitro, GC, AGS
MMP9↓, p38↓, ERK↓, AP-1↓, ROS↓, NF-kB↓, TumCI↓, MMP9↓, HDAC↓, Glycolysis↓, Hif1a↓, *memory↑, *cognitive↑,
1434- SFN,  GEM,    Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
- in-vitro, CCA, HuCCT1 - in-vitro, CCA, HuH28 - in-vivo, NA, NA
HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,
1499- SFN,    Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway
- in-vitro, BC, NA
TumCMig↓, TumCI↓, FAK↓, p‑MEK↓, p‑ERK↓,
3326- SIL,    Silymarin suppresses proliferation of human hepatocellular carcinoma cells under hypoxia through downregulation of the HIF-1α/VEGF pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B
*hepatoP↑, chemoPv↑, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓, angioG↓,
3306- SIL,  Rad,    Radioprotective and radiosensitizing properties of silymarin/silibinin in response to ionizing radiation
- Review, Var, NA
radioP↑, RadioS↑, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, DNAdam↓, ROS↑, *ROS↓, *Inflam↓,
3296- SIL,    Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway
- in-vitro, Oral, Ca9-22 - in-vivo, Oral, YD10B
TumCP↓, TumCCA↑, ROS↑, SOD1↓, SOD2↓, *JNK↑, toxicity?, TumCMig↓, TumCI↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, P53↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, SOD↓,
1127- SIL,    Silibinin suppresses epithelial–mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1
- in-vitro, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, EMT↓, RHBDD1↓,
2417- SK,    Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H446
TumCP↓, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, PFKFB2↓, Warburg↓, GLUT1∅, LDHA∅, PKM2∅, GLUT3∅, PDH∅,
2360- SK,    Shikonin inhibits growth, invasion and glycolysis of nasopharyngeal carcinoma cells through inactivating the phosphatidylinositol 3 kinase/AKT signal pathway
- in-vitro, NPC, HONE1 - in-vitro, NPC, SUNE-1
TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, ATP↓, PKM2↓, PI3K↓, Akt↓, MMP3↓, MMP9↓, TIMP1↑,
2234- SK,    Shikonin Suppresses Cell Tumorigenesis in Gastric Cancer Associated with the Inhibition of c-Myc and Yap-1
- in-vitro, GC, NA
TumCP↓, TumCI↓, TumCMig↓, cMyc↓, YAP/TEAD↓,
2232- SK,    Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis
- in-vitro, ESCC, EC9706
tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,
2190- SK,    Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway
- in-vitro, HCC, HCCLM3
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↓, ROS↑, OCR↓, ATP↓, PKM2↓,
2183- SK,    Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1
- in-vitro, Thyroid, TPC-1
TumCMig↓, TumCI↓, PTEN↑, DNMT1↓,
2182- SK,  Cisplatin,    Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway
- in-vitro, Lung, A549 - in-vitro, Lung, PC9 - in-vivo, NA, NA
tumCV↓, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, PKM2↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, ChemoSen↑, TumVol↓, TumW↓, GLUT1↓,
2203- SK,    Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
- in-vitro, Lung, NA
TumCP↓, Apoptosis↓, TumCMig↓, TumCI↓, Ferroptosis↑, ERK↓, GPx4↓, 4-HNE↑, ROS↑, GSH↓, ATF3↑, HDAC1↓, ac‑Histones↑,
2210- SK,    Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway
- in-vitro, BC, MGC803
TumCA↓, TumCI↓, TumCMig↓, MMP2↓, MMP7↓, TLR2↓, p65↓, NF-kB↓, eff↑, ROS↑,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
3046- SK,    Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway
- in-vitro, Lung, A549
TumCP↓, TumCI↓, TumCMig↓, p‑ERK↓, ITGB1↓,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
1191- SM,    Salvia miltiorrhiza extract inhibits TPA‑induced MMP‑9 expression and invasion through the MAPK/AP‑1 signaling pathw
- in-vitro, BC, MCF-7
Inflam↓, MMP9↓, TumCI↓, AP-1↓, lipidLev↓,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
5080- SSE,    Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1
- in-vitro, GC, HGC27 - in-vitro, GC, NCI-N87
AntiTum↑, HOXB-AS1↓, TumCP↓, TumCI↓, Apoptosis↑, BAD↓, Bcl-2↓, cl‑Casp3↑, MMP2↓, E-cadherin↑, N-cadherin↓, ROS↑, NF-kB↓,
5334- TFdiG,    Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
- in-vitro, Thyroid, 8505C
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, survivin↓, SREBP1↓, toxicity↑,
5337- TFdiG,    Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,

Showing Research Papers: 251 to 300 of 325
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 325

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

4-HNE↑, 1,   ATF3↑, 1,   Ferroptosis↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 3,   HO-1↑, 2,   NQO1?, 1,   NRF2↑, 2,   mt-OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 15,   ROS↝, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD1↓, 1,   SOD2↓, 1,   TrxR↓, 1,   xCT↓, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 5,   CDC25↓, 1,   p‑MEK↓, 1,   MMP↓, 7,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   AMPK↑, 1,   cMyc↓, 4,   FABP4↑, 1,   glucoNG↓, 1,   GlucoseCon↓, 4,   GlutMet↓, 1,   Glycolysis↓, 5,   ac‑Histones↑, 1,   HK2↓, 2,   lactateProd↓, 4,   LDHA∅, 1,   lipidLev↓, 1,   PDH∅, 1,   PFK↓, 1,   PFKFB2↓, 1,   PKM2↓, 4,   PKM2∅, 1,   POLD1↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 1,   SIRT2↑, 1,   SREBP1↓, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 16,   BAD↓, 1,   BAX↑, 3,   Bcl-2↓, 5,   Casp↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 4,   Casp7↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 1,   p‑Chk2↑, 1,   CK2↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   MAPK↓, 1,   Myc↓, 1,   necrosis↑, 1,   p27↑, 2,   p38↓, 2,   p38↑, 1,   survivin↓, 4,   TUNEL↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   HATs↓, 1,   other?, 1,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   LC3I↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 2,   DNMT1↓, 1,   P53↑, 1,   p‑P53↑, 1,   cl‑PARP↑, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 5,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 2,   CD44↓, 1,   CSCs↓, 4,   EMT?, 1,   EMT↓, 13,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 2,   FGF↑, 1,   FOXO4↓, 1,   Gli1↓, 6,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC↓, 3,   HDAC1↓, 1,   HH↓, 2,   HOXB-AS1↓, 1,   IGF-1↓, 1,   IGFBP3↓, 1,   mTOR↓, 4,   mTOR↑, 1,   PI3K↓, 6,   PTCH1↓, 1,   PTEN↑, 2,   RAS↓, 1,   Shh↓, 1,   Smo↓, 3,   SOX2↓, 1,   STAT3↓, 1,   TumCG↓, 7,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AP-1↓, 3,   Ca+2↑, 1,   CXCL12↓, 1,   E-cadherin↑, 7,   FAK↓, 2,   Fibronectin↓, 1,   GLI2↓, 1,   ITGB1↓, 1,   Ki-67↓, 3,   MALAT1↓, 1,   MMP13↓, 2,   MMP2↓, 13,   MMP2↝, 1,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 16,   MMP9↝, 1,   MMPs↓, 4,   N-cadherin↓, 5,   RHBDD1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 6,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↑, 2,   TIMP2↑, 1,   TIMP3↑, 1,   TumCA↓, 1,   TumCI↓, 50,   TumCMig↓, 33,   TumCP↓, 24,   TumMeta↓, 11,   Twist↓, 1,   uPA↓, 1,   Vim?, 1,   Vim↓, 4,   Zeb1↓, 3,   α-SMA↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 3,   eNOS↓, 1,   Hif1a↓, 9,   TAMS↝, 1,   VEGF↓, 6,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 2,   GLUT1∅, 1,   GLUT3∅, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   COX2↝, 1,   CRP↓, 1,   CXCR4↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 1,   NF-kB↓, 6,   p65↓, 1,   PD-1↓, 2,   PD-L1↓, 1,   Th1 response↑, 1,   TLR2↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,  

Drug Metabolism & Resistance ⓘ

ABCG2↓, 1,   BioAv↓, 1,   BioAv↝, 2,   BioEnh?, 1,   ChemoSen↑, 7,   Dose↑, 1,   Dose↝, 1,   eff↓, 2,   eff↑, 4,   Half-Life↝, 1,   RadioS↑, 3,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 2,   CRP↓, 1,   EGFR↓, 3,   HER2/EBBR2↓, 1,   IL6↓, 2,   Ki-67↓, 3,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   OS↑, 2,   radioP↑, 2,   Risk↓, 1,   toxicity?, 1,   toxicity↑, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 233

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   Keap1↓, 1,   NRF2↑, 1,   ROS↓, 4,   ROS↑, 1,  

Cell Death ⓘ

JNK↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Migration ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Imm↑, 1,   Inflam↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose↝, 1,   Half-Life↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 2,   Pain↓, 1,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 24

Scientific Paper Hit Count for: TumCI, Tumor Cell invasion
14 Curcumin
13 Resveratrol
13 Quercetin
12 Shikonin
11 Berberine
10 Apigenin (mainly Parsley)
10 Honokiol
10 Sulforaphane (mainly Broccoli)
9 EGCG (Epigallocatechin Gallate)
9 Thymoquinone
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Chlorogenic acid
7 Magnetic Fields
6 Fisetin
6 Garcinol
6 Magnolol
6 Piperlongumine
5 Astragalus
5 Lycopene
5 Metformin
5 Pterostilbene
4 Artemisinin
4 Baicalein
4 Carvacrol
4 Celastrol
4 Gemcitabine (Gemzar)
4 Chrysin
4 Phenethyl isothiocyanate
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
4 Urolithin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Berbamine
3 Brucea javanica
3 brusatol
3 Capsaicin
3 Propolis -bee glue
3 Gambogic Acid
3 Juglone
3 Magnetic Field Rotating
3 Bicarbonate(Sodium)
3 Piperine
3 Whole Body Vibration
2 alpha Linolenic acid
2 Astaxanthin
2 Boswellia (frankincense)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Celecoxib
2 Disulfiram
2 Copper and Cu NanoParticles
2 Ellagic acid
2 Emodin
2 Ginkgo biloba
2 Genistein (soy isoflavone)
2 Graviola
2 Grapeseed extract
2 HydroxyTyrosol
2 Nimbolide
2 Cisplatin
2 salinomycin
2 Sulfasalazine
2 Selenite (Sodium)
2 Aflavin-3,3′-digallate
2 Vitamin C (Ascorbic Acid)
2 Zinc
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 Andrographis
1 Aspirin -acetylsalicylic acid
1 Ascorbyl Palmitate
1 Melatonin
1 Aloe anthraquinones
1 Biochanin A
1 Atorvastatin
1 bempedoic acid
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Boron
1 Butyrate
1 Carnosic acid
1 chitosan
1 Selenium NanoParticles
1 Chlorophyllin
1 Cinnamon
1 Cyclopamine
1 Deguelin
1 Evodiamine
1 Ferulic acid
1 Paclitaxel
1 γ-linolenic acid (Borage Oil)
1 Proanthocyanidins
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Luteolin
1 5-fluorouracil
1 doxorubicin
1 immunotherapy
1 Noscapine
1 Oroxylin A
1 Oleuropein
1 Orlistat
1 Psoralidin
1 isoflavones
1 Docetaxel
1 Hyperoside
1 Germacranolide
1 Radiotherapy/Radiation
1 Salvia miltiorrhiza
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Arsenic trioxide
1 Vitamin K2
1 VitK3,menadione
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:324  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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