MDA Cancer Research Results

MDA, Serum malondialdehyde: Click to Expand ⟱
Source:
Type:
MDA : malondialdehyde. The level of oxidative stress can be measured by assessing the MDA levels.
Since MDA is highly cytotoxic and carcinogenic agent it is frequently used as a biomarker of oxidative stress during major health problems such as cancer, etc.
Malondialdehyde (MDA) is the most widely used agent to estimate the extent of lipid peroxidation. Timely diagnosis of the condition followed by supplementation with antioxidants like beta-carotene, pro-vitamin A, vitamin A, vitamin C, vitamin E, lipoic acid, zinc, selenium, and spirulina can prevent potentially malignant disorders.
MDA is a lipid peroxidation marker
Scientific Papers found: Click to Expand⟱
8455- Mg,    Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis
- in-vivo, AD, NA
*Learn↑, *memory↑, *cognitive↑, *ROS↓, *Inflam↓, *GutMicro↑, *IBI↑, *MDA↓, *SOD↑, *Catalase↑, *TNF-α↓, *IL1β↓, *IL10↑,
8670- MLT,    Antitumor Effects of Melatonin in Luminal and Triple-Negative Breast Cancer Cells: Metabolic Reprogramming, Redox Regulation, and Cellular Dynamics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, TumCMig↓, TumCI↓, GAPDH↓, Hif1a↓, citrate↓, ROS↑, lipid-P↑, LDH↓, G6PD↓, MDA?, Catalase↓, GPx↑, GSH↑, *ROS↓,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
3841- MO,    Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion
- in-vivo, Stroke, NA
*MDA↓, *SOD↑, *neuroP↑, *ROS↓, *Inflam↓, *eff↝,
3840- MO,    Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
- in-vivo, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *cognitive↑, *ROS↓, *Ach↑,
3838- MO,    Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves
- in-vitro, AD, PC12 - Review, Stroke, NA
*Inflam↓, *neuroP↑, *antiOx↑, *ROS↓, *memory↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *eff↑,
3834- MO,    Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *cal2↓, *p‑tau↓, *ROS↓, *SOD↑, *MDA↓, *cognitive↑, *memory↑,
4226- MO,    The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model
- in-vivo, AD, NA
*neuroP↑, *Mood↑, *BDNF↑, *AChE↓, *MDA↓,
8619- MO,  doxoR,    Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells
- vitro+vivo, BC, MCF7
*Dose↝, *cardioP↑, *ROS↓, *lipid-P↓, *antiOx↑, *Inflam↓, *NF-kB↓, *TNF-α↓, *COX2/PTGS2↓, *MPO↓, ChemoSen↑, *Dose↝, *AST↓, *CK/CK-MB↓, *SOD↑, Synergy↑, MDA↑, NO↑, GSH↓, ROS↑,
8613- MO,    Unraveling the Effects of Melissa officinalis L. on Cognition and Sleep Quality: A Narrative Review
- Review, AD, NA
*Sleep↑, *Mood↑, *Synergy↑, *QoL↑, *cognitive↑, *ROS↓, *NRF2↑, *HO-1↑, *NF-kB↓, *TNF-α↓, *COX2/PTGS2↓, *MDA↓, *Catalase↑, *SOD↑, *BDNF↑, *Dose↝,
8875- MOR,    Neuroprotective Effect of Morin Against Chemical-Induced Neurotoxicities and Neurodegenerative Disease Models
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *chemoP↑, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *ROS↓, *MDA↓, *NO↓, *TLR4↓, *NF-kB↓, *ERK↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓,
8872- MOR,    Morin attenuates memory deficits in a rat model of Alzheimer's disease by ameliorating oxidative stress and neuroinflammation
- in-vivo, AD, NA
*Dose↝, *MDA↓, *NO↓, *GSH↑, *Catalase↑, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *BDNF↑, *antiOx↑, *NeuroI↓, *memory↑,
8884- MOR,    Morin Reactivates Nrf2 by Targeting Inhibition of Keap1 to Alleviate Deoxynivalenol-Induced Intestinal Oxidative Damage
- in-vivo, Nor, NA
*other↑, *other↑, *TAC↑, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *Keap1↓, *NRF2↑, *Dose↝,
8882- MOR,  Cisplatin,    Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose?, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑, *MDA↓, *other↑, *Ferroptosis↓, *Iron↓, *ROS↓, *other↓, ChemoSen↑, *chemoP↑, *selectivity↑,
8879- MOR,  doxoR,    Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models
- vitro+vivo, Ovarian, OVCAR-3 - NA, Melanoma, A2780S
Dose↝, ChemoSen↑, cycA1/CCNA1↓, cycD1/CCND1↓, TumVol↓, Apoptosis↑, TumCCA↑, ROS↝, chemoP↑, TumAuto↑, ROS↓, SOD↑, Catalase↑, GSH↑, MDA↓, cardioP↑, mTOR↓, PI3K↓, Akt↓, Bcl-2↓, Casp3↑, Casp9↑, LC3A↑, ATG5↑, Beclin-1/ATG6↑,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
3811- mushLions,    Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment
- in-vitro, AD, NA
*memory↑, *BBB↑, *GSH↑, *AChE↓, *MDA↓,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
8453- OM,    Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress
- in-vivo, Nor, NA
Dose↝, creat↓, Urea↓, uricA↓, BUN↓, MDA↓, GSH↑, SOD↑, Catalase↑, RenoP↑, *ROS↓,
8435- OM,  Aroma,    Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study
- in-vivo, AD, NA
*Dose?, *antiOx↑, *BDNF↑, *cognitive↑, *AntiViral↑, *AChE↝, *TumMeta↓, *TumCG↓, *Ingr↝, *DNAdam↓, *ROS↓, *MDA↓, *memory↑,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, Nor, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2/PTGS2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓, *antiAll↑,
3251- PBG,    The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways
- Review, AD, NA - Review, Diabetic, NA - Review, Var, NA - in-vitro, Nor, H9c2
*antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *Catalase↑, *HO-1↑, *NO↓, *NOS2↓, *NF-kB↓, *NRF2↑, *hepatoP↑, *MDA↓, *mtDam↓, *GSH↑, *p65↓, *TNF-α↓, *IL1β↓, *NRF2↑, *NRF2↓, *ROS⇅, *BioAv↓, *BioAv↑,
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
1670- PBG,    Lung response to propolis treatment during experimentally induced lung adenocarcinoma
- in-vivo, Lung, NA
GSH↑, SOD↑, MDA↓, selectivity↑, Inflam↓, TumW↓,
4927- PEITC,    Targeting ferroptosis in osteosarcoma
- Review, OS, NA
AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
2958- PL,    Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity
- in-vitro, Oral, HSC3
TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,
1237- PTS,    Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade
- in-vitro, Ovarian, SKOV3
TumCMig↓, TumCI↓, MDA↑, ROS↑, BAX↑, Casp3↑, Bcl-2↓, SREBP1/SREBF1↓, FASN↓, AMPK↓, p‑AMPK↑, p‑P53↑, p‑TSC2↑, p‑Akt↓, p‑mTOR↓, p‑S6K↓, p‑4E-BP1↓,
3924- PTS,    Effect of resveratrol and pterostilbene on aging and longevity
- Review, AD, NA - Review, Stroke, NA
*antiOx↓, *ROS↑, *SOD↑, *GSH↑, *NRF2↑, *MDA↓, *HNE↓, *Inflam↓, *MAPK↓, *IL6↓, *TNF-α↓, *HO-1↑, *cardioP↑, *neuroP↑, *CRM↑, *NLRP3↓,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3361- QC,    Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
- in-vivo, Nor, NA - in-vitro, NA, NA
*BG↓, *ROS↓, *SOD↑, *MDA↓, *ER Stress↓, *iNOS↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *antiOx↓, *Inflam↓, *JAK2↑, *STAT3?,
3364- QC,    Quercetin Protects Human Thyroid Cells against Cadmium Toxicity
- in-vitro, Nor, NA
*MDA↓, *GRP78/BiP↓,
3365- QC,    Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- in-vivo, Sepsis, NA
*ER Stress↓, *PDI↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *ATF6↓, *PERK↓, *IRE1↓, *MMP↑, *SOD↑, *ROS↓, *MDA↓, *SIRT1↑, *AMPK↑, *Sepsis↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
897- QC,    Anti- and prooxidant effects of chronic quercetin administration in rats
- in-vivo, Nor, NA
*MDA↓, *GSH⇅, *ROS⇅,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
*AntiCan↑, *Inflam↓, *Bacteria↓, *AntiDiabetic↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *NRF2↑, *Trx↑, *IronCh↑, *MDA↑, cycD1/CCND1↓, PI3K↓, Casp3↑, BAX↑, ChemoSen↑, ROS↑, Synergy↑, MMP↓, Cyt‑c↑, Akt↓, ERK↓,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
2338- QC,    Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury
- Review, Nor, NA
*SIRT1↑, *NLRP3↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *PKM2↓, *HO-1↑, *ROS↓, *NO↓, *MDA↓, *antiOx↑, *COX2/PTGS2↓, *HMGB1↓, *iNOS↓, *NF-kB↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2/PTGS2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
4288- RES,    Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β
- in-vivo, AD, NA
*memory↑, *GSH↑, *ROS↓, *MDA↓, *p‑tau↓, *PI3K↑, *Akt↑, *AMPK↑, *PP2A↑, *GSK‐3β↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, Synergy↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
3021- RosA,    Rosmarinic acid ameliorates septic-associated mortality and lung injury in mice via GRP78/IRE1α/JNK pathway
- in-vivo, Sepsis, NA
*eff↑, *SOD↑, *MDA↓, *GRP78/BiP↓, *IRE1↓, *JNK↓, *Sepsis↓,

Showing Research Papers: 251 to 300 of 363
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 363

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↓, 11,   Catalase↑, 12,   Fenton↑, 2,   GCLM↓, 1,   GPx↓, 3,   GPx↑, 7,   GPx4↓, 30,   GPx4↑, 1,   GSH↓, 50,   GSH↑, 10,   GSH/GSSG↓, 2,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 3,   HO-1↓, 6,   HO-1↑, 11,   Iron↑, 25,   Iron↝, 1,   i-Iron↑, 3,   Keap1↑, 3,   lipid-P↓, 3,   lipid-P↑, 23,   MDA?, 1,   MDA↓, 23,   MDA↑, 63,   i-MDA↑, 4,   MPO↓, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 14,   NRF2↑, 11,   OSI↑, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 14,   ROS↑, 94,   ROS⇅, 1,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 14,   SOD↑, 17,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   T-SOD↓, 1,   TAC↓, 2,   TAC↑, 1,   TBARS↓, 1,   TOS↑, 2,   TrxR↓, 2,   uricA↓, 1,   xCT/SLC7A11↓, 8,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 6,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   NCOA4↑, 3,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compI↓, 1,   compII↓, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 11,   OXPHOS↓, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↑, 3,   ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 8,   p‑AMPK↑, 2,   ATP↓, 7,   mt-ATP↓, 1,   citrate↓, 1,   FASN↓, 3,   G6PD↓, 2,   GAPDH↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 9,   GSK‐3β↓, 1,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   HK2↓, 6,   lactateProd↓, 4,   lactateProd↑, 1,   LDHA↓, 3,   NAD↝, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFKP↓, 1,   PKM2↓, 2,   PKM2↑, 1,   Pyruv↓, 1,   SCD1↓, 2,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis↓, 3,   Apoptosis↑, 56,   mt-Apoptosis↑, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 34,   Bax:Bcl2↑, 10,   Bcl-2↓, 36,   Bcl-xL↓, 3,   BID↑, 3,   BIM↑, 1,   Casp↑, 5,   cl‑Casp↑, 1,   Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 46,   cl‑Casp3↑, 6,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 7,   Casp8↑, 14,   Casp9↑, 25,   cl‑Casp9↑, 2,   CellShr↑, 1,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 22,   mt-Cyt‑c↓, 1,   DR5↓, 1,   DR5↑, 5,   Endon↑, 1,   FADD↑, 3,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 35,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 4,   Mcl-1↓, 1,   MDM2↓, 2,   MOMP↑, 2,   necrosis↑, 2,   p38↑, 5,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 1,   Pyro↑, 2,   survivin↓, 6,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 6,   XIAP↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 37,   Akt↑, 4,   p‑Akt↓, 6,   AMPKα↑, 1,   BRAF↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   cMET↓, 2,   cSrc↓, 1,   EGFR↓, 5,   EGFR↑, 1,   ERK↓, 9,   ERK↑, 3,   p‑ERK↓, 1,   ERK5↓, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 2,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 5,   JNK↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 10,   MAPK↑, 4,   MAPK↝, 2,   p‑MEK↓, 1,   mTOR↓, 23,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 4,   P70S6K↓, 1,   PI3K↓, 31,   PI3K↑, 1,   PI3K/Akt↝, 1,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 3,   PTEN↝, 1,   Raf↓, 2,   RAS↓, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 4,   STAT↓, 2,   STAT3↓, 22,   p‑STAT3↓, 3,   TSC2↑, 1,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 5,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 10,   DLEU1↓, 1,   DNMT1↓, 3,   DNMT1↑, 1,   DNMTs↓, 1,   EZH2↓, 3,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   HDAC↓, 2,   HDAC1↓, 2,   HDAC2↓, 2,   HDAC3↓, 2,   miR-124-3p↓, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-27a-3p↓, 1,   miR-34a↓, 1,   MYCN↓, 1,   OCT4↓, 4,   other↓, 1,   other↑, 2,   other↝, 2,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 2,   SOX9?, 1,   tumCV?, 1,   tumCV↓, 15,   USF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 6,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 11,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 5,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 10,   p‑Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 1,   p62↓, 1,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↑, 12,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 18,   p16↑, 1,   P53↓, 1,   P53↑, 29,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 6,   cl‑PARP↑, 7,   cl‑PARP1↑, 1,   PCNA↓, 8,   SIRT6↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TOP2↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 9,   CDK2↑, 2,   CDK4↓, 11,   CDK6↓, 3,   CDK6↑, 1,   CHK1↓, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 16,   cycE/CCNE↓, 1,   Ki-67↓, 10,   mitA↑, 1,   P21↓, 1,   P21↑, 16,   p27/CDKN1B↑, 3,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   TumCCA↑, 51,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 1,   BMP7/OP1↓, 2,   CD133↑, 1,   cFos↓, 2,   CSCs↓, 7,   EIF4E↓, 1,   FGF↓, 2,   FOSL1↑, 1,   GDF15↓, 1,   Gli↓, 1,   HH↓, 2,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 10,   Nanog↓, 4,   NOTCH↓, 2,   NOTCH↑, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   Shh↓, 1,   STAT1↓, 1,   TumCG↓, 21,   TumCP↓, 42,   Wnt↓, 8,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 4,   i-Ca+2↑, 1,   COL1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 6,   EMT↓, 19,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   LAMs↓, 2,   LRP1↑, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP2↓, 16,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 23,   MMP9↑, 2,   MMPs↓, 4,   N-cadherin↓, 6,   NeuroT↓, 1,   PCBP1↓, 1,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug?, 1,   Slug↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 3,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP2↓, 2,   TIMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 20,   TumCMig↓, 20,   TumMeta↓, 10,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 7,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 10,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   EGR1↓, 1,   Hif1a↓, 16,   Hypoxia↓, 1,   NO↓, 2,   NO↑, 3,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 25,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   BBB∅, 1,   GLUT1↓, 4,   MMP↓, 24,   MPT↑, 1,   SLC12A5↓, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD47↓, 1,   CD8+↑, 3,   COX2/PTGS2↓, 17,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL12↓, 1,   CXCR2↓, 1,   CXCR4↓, 3,   DR4↑, 3,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL1β↓, 4,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 13,   IL8↓, 3,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 5,   pol-M1↑, 2,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   NF-kB?, 1,   NF-kB↓, 25,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 4,   PGE2↓, 4,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 3,   TNF-α↓, 10,   TNF-α↑, 3,   TRADD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 4,   BNP↓, 1,   ER-α36↓, 1,   GR↑, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 6,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen↑, 40,   CompStab↓, 1,   CompStab↝, 1,   Dose↑, 1,   Dose↝, 17,   eff↓, 13,   eff↑, 12,   eff↝, 1,   eff∅, 1,   GSTA1↓, 1,   GSTM1↑, 1,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 4,   P-gp/ABCB1⇅, 1,   RadioS↑, 10,   selectivity↑, 22,   Synergy?, 1,   Synergy↑, 24,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 4,   ALAT↓, 4,   AR↓, 4,   AST↓, 2,   BMD↑, 1,   BRAF↑, 1,   BRAF↝, 1,   BUN↓, 1,   CA19-9↓, 1,   CEA↓, 2,   creat↓, 2,   CRP↓, 2,   EGFR↓, 5,   EGFR↑, 1,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IL6↓, 13,   LDH↓, 6,   LDH↑, 1,   NOS2↑, 1,   PD-L1↓, 4,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 18,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↑, 5,   cachexia↓, 1,   cardioP↑, 7,   chemoP↑, 13,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 8,   memory↑, 1,   neuroP↑, 1,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 5,   Pain↓, 1,   PFS↑, 1,   QoL↑, 3,   radioP↑, 8,   RenoP↑, 8,   Risk↓, 3,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 602

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 2,   antiOx↓, 6,   antiOx↑, 113,   ARE↑, 2,   Bil↑, 2,   Catalase↓, 5,   Catalase↑, 108,   Catalase↝, 1,   Copper↓, 1,   Fenton↓, 3,   GCLC↑, 3,   GCLM↑, 3,   GPx↓, 5,   GPx↑, 81,   GPx∅, 1,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 6,   GPx4∅, 1,   GSH↓, 6,   GSH↑, 136,   GSH⇅, 1,   GSH∅, 2,   GSH/GSSG↑, 2,   GSR↓, 3,   GSR↑, 9,   GSSG↓, 6,   GSTs↓, 2,   GSTs↑, 13,   H2O2↓, 9,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 5,   HDL∅, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 5,   HO-1↑, 79,   HO-1⇅, 1,   HO-1∅, 1,   Iron↓, 4,   Iron↝, 1,   i-Iron↓, 3,   i-Iron↑, 1,   Keap1↓, 7,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 61,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA?, 1,   MDA↓, 269,   MDA↑, 12,   MDA∅, 1,   MPO↓, 17,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 3,   NQO1↑, 21,   NQO1↝, 1,   Nrf1↑, 1,   NRF2↓, 5,   NRF2↑, 119,   NRF2∅, 1,   p‑NRF2↑, 1,   ONOO↓, 1,   Prx↑, 3,   RNS↓, 3,   ROMO1↑, 1,   ROS?, 2,   ROS↓, 217,   ROS↑, 7,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 1,   SOD?, 2,   SOD↓, 9,   SOD↑, 183,   SOD↝, 1,   mt-SOD↑, 1,   SOD1↑, 4,   SOD2↑, 2,   TAC↑, 24,   TBARS↓, 5,   Thiols↑, 2,   TOS↓, 2,   Trx↑, 2,   Trx1↑, 2,   TrxR↑, 1,   uricA↓, 3,   VitC↑, 3,   VitE↓, 1,   VitE↑, 1,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 1,   FTH1↑, 1,   FTL↓, 1,   IronCh↓, 1,   IronCh↑, 7,   Mets↝, 1,   TfR1/CD71↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↓, 1,   Insulin↑, 2,   mtDam↓, 7,   NGB↑, 1,   OCR↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACC↓, 1,   ACSL4↓, 2,   ACSL4∅, 1,   adiP↓, 1,   ALAT↓, 38,   ALAT↑, 1,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 13,   ATP↓, 1,   ATP↑, 8,   Buty↑, 1,   cAMP↑, 2,   CRM↑, 2,   DGAT1↓, 1,   FASN↓, 4,   glucose↓, 8,   glucose↝, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 15,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 3,   HK2↑, 1,   HMG-CoA↓, 2,   LDL↓, 10,   lipidLev↓, 2,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 4,   NADPH↑, 3,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PLA2↓, 1,   SCFAs↑, 2,   SIRT1↓, 1,   SIRT1↑, 17,   SREBP1/SREBF1↓, 3,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 3,   APAF1↓, 1,   Apoptosis↓, 30,   Apoptosis∅, 1,   ASC↓, 1,   BAX↓, 22,   BAX↑, 2,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 19,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 36,   Casp3↑, 2,   cl‑Casp3↓, 5,   proCasp3↓, 1,   Casp8↓, 2,   Casp9↓, 12,   Casp9↑, 1,   Cyt‑c↓, 6,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 10,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   iNOS↓, 42,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 2,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 12,   p‑Akt↓, 4,   p‑Akt↑, 2,   CREB↑, 3,   p‑CREB↑, 2,   ERK↓, 6,   ERK↑, 3,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   JAK2↓, 3,   JAK2↑, 3,   p‑JAK2↓, 1,   JNK↓, 12,   JNK↑, 1,   p‑JNK↓, 3,   MAPK?, 1,   MAPK↓, 15,   MAPK↑, 4,   p‑MAPK?, 1,   p‑MAPK↓, 2,   mTOR↓, 3,   mTOR↑, 3,   p‑mTOR↓, 4,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 13,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ↑, 1,   PP2A↑, 2,   PTEN↓, 1,   STAT↓, 1,   STAT3?, 1,   STAT3↓, 5,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   ATF4↑, 1,   cJun↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 2,   HDAC↓, 1,   other?, 3,   other↓, 7,   other↑, 14,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 11,   GRP78/BiP↓, 10,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 6,   HSP70/HSPA5↝, 1,   IRE1↓, 3,   PDI↓, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG5↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 1,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   P53↓, 2,   PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 2,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↝, 1,   IGF-1↓, 1,   Ki-67↓, 2,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 1,   BACH1↓, 1,   Ca+2↓, 9,   cal2↓, 1,   COL1↓, 3,   COL1↑, 2,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 2,   MMP13↓, 1,   MMP2↓, 2,   MMP2↑, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 1,   MUC1↑, 1,   ROCK1↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 3,   TGF-β1↑, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 3,   Vim↓, 2,   α-SMA↓, 7,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   eNOS↓, 1,   Hif1a↓, 5,   LOX1↓, 1,   NO?, 1,   NO↓, 43,   NO↑, 3,   VCAM-1↓, 8,   VEGF↓, 4,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 17,   BBB↝, 1,   BBB∅, 2,   GastroP↑, 4,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 5,   MMP↓, 1,   MMP↑, 15,   NHE3↑, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 2,   BALF-Lym↓, 1,   CD25+↑, 1,   CD4+↑, 3,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 2,   CXCL15↓, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 9,   IFN-γ↓, 6,   IFN-γ↑, 2,   IgE↓, 2,   IL1↓, 3,   IL10↓, 7,   IL10↑, 17,   IL12↓, 4,   IL13↓, 2,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 73,   IL1β↑, 1,   IL2↓, 4,   IL22↓, 1,   IL23↓, 2,   IL33↓, 1,   IL4↓, 8,   IL4↑, 5,   IL5↓, 3,   IL5↑, 1,   IL6?, 1,   IL6↓, 72,   IL6↑, 3,   IL8↓, 11,   Imm↑, 10,   INF-γ↓, 3,   Inflam↓, 147,   Inflam↑, 5,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 4,   NeuroI↓, 7,   Neut↓, 1,   NF-kB↓, 77,   NK cell↑, 1,   NLRP3↓, 18,   p65↓, 4,   PGE2↓, 18,   PGE2↑, 2,   RAGE↓, 3,   RANTES↓, 2,   SOCS-3↓, 1,   Th2↓, 1,   TLR2↓, 3,   TLR4↓, 25,   TNF-α↓, 104,   TNF-α↑, 3,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GFAP↓, 3,   GGT/CD224↓, 1,   MGlio↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   Ach↑, 6,   AChE↓, 42,   AChE↝, 1,   ADAM10↑, 1,   BChE↓, 7,   BDNF↑, 30,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 8,   ChE↓, 1,   GABA↑, 2,   GDNF↑, 1,   MAOA↓, 4,   MAOB↓, 2,   monoA↑, 1,   NGF↑, 6,   PSD95↑, 5,   RELN↑, 1,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 5,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APOE4↓, 1,   APP↓, 7,   cl‑APP↑, 1,   Aβ↓, 42,   Aβ42↓, 2,   BACE/β-secretase↓, 19,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 11,   p‑tau↓, 10,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   BNP↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 25,   BioAv↑, 38,   BioAv⇅, 1,   BioAv↝, 12,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 3,   Dose?, 5,   Dose↓, 1,   Dose↑, 5,   Dose↝, 37,   eff↓, 4,   eff↑, 29,   eff↝, 3,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↑, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 38,   ALAT↑, 1,   ALB↑, 1,   ALP↓, 6,   AST↓, 39,   AST↑, 1,   BG↓, 1,   Bil↑, 2,   BloodF↑, 1,   BMD↑, 3,   BP↓, 6,   BP↝, 1,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 2,   CK/CK-MB↓, 1,   creat↓, 13,   CRP↓, 13,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 72,   IL6↑, 3,   LDH↓, 14,   LDH↑, 2,   LDH∅, 1,   NOS2↓, 3,   RAGE↓, 3,   SpO2↑, 1,   TC↓, 2,   TG/TAG↓, 3,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 3,   AirwayM↓, 1,   AntiAge↑, 3,   antiAll?, 1,   antiAll↑, 18,   AntiArt↑, 5,   AntiCan↑, 14,   antiCG↑, 1,   AntiDiabetic↑, 23,   antiPs↑, 3,   AntiTum↑, 1,   ANXi↓, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 40,   CardioT↓, 1,   chemoP↑, 13,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 56,   cognitive∅, 1,   diuretic↑, 1,   hepatoP↓, 3,   hepatoP↑, 63,   Learn↑, 10,   memory↑, 63,   Mood↑, 4,   motorD↑, 6,   Mucositis↓, 1,   neuroP↑, 109,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 4,   Pain↓, 5,   QoL↑, 2,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 28,   Risk↓, 5,   Sleep↑, 3,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 13,   toxicity↓, 27,   toxicity↑, 2,   toxicity↝, 7,   toxicity∅, 5,   Weight↓, 1,   Weight↑, 3,   Weight∅, 1,   Wound Healing↑, 8,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 4,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 11,   Diar↓, 3,   GutMicro↑, 28,   Inf↓, 1,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 3,   Ingr↝, 4,  
Total Targets: 611

Scientific Paper Hit Count for: MDA, Serum malondialdehyde
17 Curcumin
14 Thymoquinone
12 Hydrogen Gas
11 Silver-NanoParticles
11 Boron
11 Lycopene
11 Quercetin
10 Silymarin (Milk Thistle) silibinin
9 Luteolin
8 Magnetic Fields
7 Propolis -bee glue
6 doxorubicin
6 Betulinic acid
6 Carvacrol
6 Chlorogenic acid
6 Ferulic acid
5 Cisplatin
5 Baicalein
5 Crocetin
5 isoorientin
5 Sulforaphane (mainly Broccoli)
5 Kaempferol
5 L-Theanine
5 Matrine
5 Moringa oleifera
5 Morin
5 Shikonin
4 Resveratrol
4 Alpha-Lipoic-Acid
4 Astaxanthin
4 Berberine
4 Vitamin C (Ascorbic Acid)
4 Chrysin
4 Hyperoside
4 Rosmarinic acid
4 Rutin
3 Allicin (mainly Garlic)
3 Apigenin (mainly Parsley)
3 Melatonin
3 Radiotherapy/Radiation
3 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 α-Bisabolol / Chamomile oil
3 Centella asiatica / Gotu kola → asiaticoside
3 Chemotherapy
3 Spirulina(Arthrospira/Limnospira)
3 EGCG (Epigallocatechin Gallate)
3 Selenium NanoParticles
3 Selenite (Sodium)
3 Vitexin
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Allyl isothiocyanate
2 borneol
2 Selenium
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Carvone
2 Copper and Cu NanoParticles
2 Chlorella (Chlorella vulgaris)
2 Dandelion Root
2 Emodin
2 Sesame seeds and Oil
2 Gallic acid
2 Graviola
2 HydroxyCitric Acid
2 Isoliquiritigenin
2 Isovitexin
2 Juglone
2 Licochalcone A
2 Licorice
2 Linalool
2 Magnolol
2 Lemon Balm/Melissa officinalis
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Piperlongumine
2 Pterostilbene
1 3-bromopyruvate
1 cetuximab
1 5-Hydroxytryptophan
1 Anthocyanins
1 Paclitaxel/Taxol
1 Baicalin
1 Biochanin A
1 Bromelain
1 Boswellia (frankincense)
1 Caffeic acid
1 Carnosic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 chitosan
1 Chlorophyllin
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Galantamine
1 Diclofenac
1 Docosahexaenoic Acid
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 D-limonene
1 Ellagic acid
1 Eurycomanone
1 Eugenol
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Fucoidan
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Huperzine A/Huperzia serrata
1 Isobavachalcone
1 isoquercitrin
1 Isothiocyanates
1 Ivermectin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Vitamin E
1 Metformin
1 Magnetic Field Rotating
1 Magnesium
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Oleuropein
1 HydroxyTyrosol
1 Aromatherapy
1 buckwheat sprouts
1 Orlistat
1 salinomycin
1 Sulfasalazine
1 Anti-oxidants
1 Date Fruit Extract
1 Sesamin
1 Lignans
1 Shankhpushpi
1 Silicic Acid
1 Safflower yellow
1 Taurine
1 5-fluorouracil
1 Urolithin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:570  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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