COX2/PTGS2 Cancer Research Results

COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Cyclooxygenase-2 (COX-2) is an enzyme that plays a critical role in the conversion of arachidonic acid to prostaglandins, which are lipid compounds involved in various physiological processes, including inflammation, pain, and fever. COX-2 is an inducible enzyme, meaning its expression is typically low in normal tissues but can be upregulated in response to inflammatory stimuli, growth factors, and certain oncogenic signals.
-Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis.
-COX-2 is an inducible enzyme that is upregulated in response to pro-inflammatory signals, including cytokines (e.g., IL-1β, TNF-α) and growth factors.

COX-2 is often overexpressed in various tumors, including colorectal, breast, lung, and prostate cancers.
The prostaglandins produced by COX-2, particularly prostaglandin E2 (PGE2), have several effects that can facilitate cancer progression:
Cell Proliferation: PGE2 can promote the proliferation of cancer cells by activating signaling pathways such as the PI3K/Akt and MAPK pathways.
Nonselective NSAIDs, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. Epidemiological studies have suggested that regular use of NSAIDs may reduce the risk of certain cancers, particularly colorectal cancer.
Drugs specifically targeting COX-2, such as celecoxib, have been developed.

COX-2 and xanthine oxidase are ROS-producing pro-oxidant enzymes that contribute to inflammation. Elevated COX‑2 levels, often found in inflammatory conditions or certain types of cancers, can contribute to increased production of ROS.
Scientific Papers found: Click to Expand⟱
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6923- Flav,    Flavonoids: an overview
- Review, Nor, NA
*antiOx↑, AntiCan↑, *cardioP↑, *XO↓, *COX2/PTGS2↓, *5LO↓, *PI3K↓, *AChE↓, *Imm⇅, *BP↓, TumCCA↑, *Aβ↓, *BACE/β-secretase↓, *NF-kB↓, *ROS↓, *neuroP↑, *AntiAg↑, *AntiThr↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
6995- Form,    Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia
- Review, Nor, BV2
*TNF-α↓, *IL6↓, *IL1β↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *neuroP↑, *Inflam↓,
6967- Form,  BTZ,    Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model
- in-vivo, Melanoma, U266 - in-vivo, Melanoma, RPMI-8226
Synergy↑, NF-kB↓, PI3K↓, Akt↓, AP-1↓, COX2/PTGS2↓, MMP9↓, Casp3↑, cl‑PARP↑, Dose↝, Ki-67↓, VEGF↓,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
4030- FulvicA,    Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes
- Review, Nor, NA
*Inflam↓, TNF-α↓, *COX2/PTGS2↓, *PGE2↓, *ROS↓, *GutMicro↑, *BioEnh↑, *BioEnh↑, *SOD↑, *Catalase↑, *GPx↑,
7080- GABA,    The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention
- Review, AD, NA
*BBB↝, *cognitive↑, *Dose↝, *toxicity↓, *Stress↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL1β↓, *TNF-α↓, *Sleep↑, *Pain↓, *neuroP↑, *eff↑, *Ach↑, *AST↓, *ALAT↓, *BP↓, *other↝,
5150- GamB,    Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
- in-vitro, CLL, KBM-5 - in-vitro, Nor, HEK293
Apoptosis↑, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, TRAF1↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, MMP9↓, angioG↓, VEGF↓, NF-kB↓, eff↓,
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓, CompStab↝,
7088- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC4
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, selectivity↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, Var, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2/PTGS2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓, antiNeop↑,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
7238- GBE,    Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells
- in-vitro, Nor, RAW264.7
*NO↓, *PGE2↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓,
7107- GEN,    Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients
- Trial, Pca, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
COX2/PTGS2↓, P21↑, PGE2↓, other↑, Dose↝,
7108- GEN,    Genistein: A Review on its Anti-Inflammatory Properties
- Review, Nor, NA
*cardioP↑, *Inflam↓, *NF-kB↓, *PGE2↓, *iNOS↓, *ROS↓, *COX2/PTGS2↓, *toxicity↑,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
7141- GI,    Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
- Study, Nor, BV2
*eff↑, *CompStab↓, *NRF2↑, *Inflam↓, *eff↑, *antiOx↑, *neuroP↑, *COX2/PTGS2↓, *NF-kB↓, *eff↓, *BioAv↝, *CompStab↑,
7142- GI,    Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
- Trial, Nor, NA
COX2/PTGS2↓, *PGE2↓, *5-HETE↓, *12-HETE↓, *Eic↓, *AntiCan↑, *antiOx↑, *Inflam↓, 5LO↓, eff↝,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7151- GI,    A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, RAW264.7
MMP9↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, Synergy↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
4508- GLA,  aLinA,    α-Linolenic and γ-linolenic acids exercise differential antitumor effects on HT-29 human colorectal cancer cells
- in-vitro, Colon, HT29
Apoptosis↑, *Inflam↓, AntiCan↑, lipid-P↑, COX2/PTGS2↝, MKP1↝,
1240- GSE,  PACs,    Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, Hs294T
TumCMig↓, TumCI↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7111- GSL,    In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens
- in-vitro, Nor, NA
*NO↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓, *Inflam↓,
2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, OS↑, Dose↝, Dose↝, CEA↓, CA125↓, CYFRA21-1↓, SIRT1↓, COX2/PTGS2↓, IL1β↓, IL6↓, TNF-α↓, HMGB1↓, NF-kB↓, EP2↓,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
1649- HCAs,    Anticancer Properties of Hydroxycinnamic Acids -A Review
- Review, Var, NA
*antiOx↑, MMP2↓, MMP9↓, VEGF↓, TGF-β↓, Bax:Bcl2↑, TumCCA↑, COX2/PTGS2↓, NF-kB↓,
7462- HNK,    Neuroprotective effects of honokiol: from chemistry to medicine
- Study, AD, NA
*ATR↑, *neuroP↑, *antiOx↑, *Inflam↓, *Half-Life↝, *ROS↓, *Ca+2↓, *GABA↓, *COX2/PTGS2↓, *memory↑,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
- Review, Var, NA
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2897- HNK,    Honokiol Inhibits Proliferation, Invasion and Induces Apoptosis Through Targeting Lyn Kinase in Human Lung Adenocarcinoma Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, A549
TumCP↓, Apoptosis↑, EGFR↓, PI3K↓, Akt↓, STAT3↓, TumCI↓, TNF-α↑, NF-kB↓, VEGF↓, MMP9↓, COX2/PTGS2↓,
1087- HNK,    Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of β-Catenin Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, H226
TumCMig↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, p65↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓,
7471- Hops,    Spent hops (Humulus Lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated RAW 264.7 macrophages
- in-vitro, Nor, RAW264.7
*IL6↓, *COX2/PTGS2↓, *iNOS↓, *NO↓, *NF-kB↓, *Inflam↓,
7563- HYP,    Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury
- vitro+vivo, Nor, NA
*Inflam↓, *antiOx↑, *Dose↝, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NOX4↓, *NOX2↓, *NOX1↓, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *neuroP↑,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7688- iod,  CEL,    Iodine prevents the increase of testosterone-induced oxidative stress in a model of rat prostatic hyperplasia
- in-vivo, Pca, NA
TumCP↓, ROS↓, NOS2↓, COX2/PTGS2↓,
1088- IP6,    Preventive Inositol Hexaphosphate Extracted from Rice Bran Inhibits Colorectal Cancer through Involvement of Wnt/β-Catenin and COX-2 Pathways
- in-vivo, CRC, NA
AntiTum↑, β-catenin/ZEB1↓, COX2/PTGS2↓,

Showing Research Papers: 251 to 300 of 547
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 547

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 12,   Catalase↓, 5,   Catalase↑, 4,   Copper↓, 1,   GPx↓, 1,   GPx↑, 6,   GPx4↓, 5,   GSH↓, 21,   GSH↑, 10,   GSR↑, 2,   GSTs↓, 2,   GSTs↑, 3,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 4,   HO-1↑, 16,   HO-2↓, 1,   Iron↑, 2,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 7,   lipid-P↑, 14,   MDA↓, 5,   MDA↑, 5,   MPO↓, 5,   NADH↓, 1,   NQO1↑, 3,   NRF2↓, 11,   NRF2↑, 31,   NRF2↝, 1,   Prx↑, 1,   Prx4↑, 1,   ROS↓, 36,   ROS↑, 162,   ROS⇅, 10,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 4,   SOD↓, 7,   SOD↑, 8,   SOD2↓, 4,   TBARS↑, 1,   Thiols↓, 2,   TrxR↓, 4,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 2,   Tf↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   Bfl-1↓, 1,   CDC2↓, 5,   CDC25↓, 9,   EGF↓, 4,   ETC↓, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 3,   mitResp↑, 2,   MKK7↓, 2,   MKP5↑, 1,   mtDam?, 1,   mtDam↑, 11,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   SIRT3↓, 2,   SIRT3↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5-HETE↓, 1,   5LO↓, 18,   AApath↓, 1,   ACC↑, 4,   p‑ACC↑, 1,   ACSL4↑, 1,   ALAT↓, 9,   ALAT↝, 1,   AMPK↓, 2,   AMPK↑, 26,   AMPK↝, 1,   p‑AMPK↑, 2,   ARG↓, 1,   ATP↓, 9,   ATP↑, 2,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 1,   ECAR↝, 1,   FASN↓, 4,   FASN↑, 1,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 9,   GlutMet↓, 1,   Glycolysis↓, 19,   GSK‐3β↓, 11,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 7,   HK2↓, 10,   HMG-CoA↓, 1,   lactateProd↓, 13,   lactateProd↑, 1,   LDHA↓, 5,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NADPH↓, 3,   NADPH↑, 3,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 9,   PDK3↑, 1,   PKM2↓, 9,   PLA2↓, 1,   SCD1↓, 1,   SHARP↑, 1,   SIRT1↓, 6,   SIRT1↑, 10,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   TCA↓, 1,   TumCM/A↓, 1,   Warburg↓, 8,  

Cell Death(tgid=5) ⓘ

AIF↑, 8,   APAF1↑, 6,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 138,   Apoptosis↝, 1,   mt-Apoptosis↑, 1,   ASC↑, 1,   BAD↓, 1,   BAD↑, 4,   Bak↓, 1,   Bak↑, 5,   BAX↓, 5,   BAX↑, 74,   BAX⇅, 1,   BAX↝, 2,   Bax:Bcl2↑, 26,   Bcl-2↓, 95,   Bcl-2↑, 3,   Bcl-2↝, 2,   Bcl-xL↓, 32,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 4,   BNIP3↑, 3,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 25,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↑, 1,   Casp12↑, 2,   Casp3↓, 5,   Casp3↑, 106,   Casp3↝, 2,   cl‑Casp3↑, 17,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 15,   cl‑Casp7↑, 2,   Casp8↑, 31,   Casp8∅, 1,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 67,   cl‑Casp9↑, 9,   proCasp9↑, 1,   CellShr↑, 2,   cFLIP↓, 7,   Cyt‑c↓, 4,   Cyt‑c↑, 70,   Cyt‑c↝, 2,   Diablo↑, 10,   DR5↓, 1,   DR5↑, 18,   Endon↑, 1,   FADD↑, 4,   Fap1↓, 1,   Fas?, 1,   Fas↑, 15,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 6,   GranB/GZMB↝, 1,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 18,   IAP2/BIRC3↓, 8,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 46,   JWA↑, 1,   Mcl-1↓, 21,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 8,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 2,   necrosis↑, 1,   NOXA↑, 2,   p38↓, 8,   p38↑, 19,   p‑p38↓, 2,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 5,   Pyro↑, 1,   RIP3↑, 1,   survivin↓, 57,   TNFR 1↑, 2,   TRAIL↑, 7,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 7,   TumCD∅, 1,   XIAP?, 1,   XIAP↓, 27,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 123,   Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 33,   AKT1↓, 1,   CK2↓, 4,   cMET↓, 3,   p‑cMET↑, 1,   CREB2↓, 1,   cSrc↓, 4,   EF-1α↓, 1,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 51,   ERK↑, 4,   ERK↝, 1,   p‑ERK↓, 14,   p‑ERK↑, 1,   FGFR1↓, 3,   FGFR2↓, 1,   GRB2↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 14,   HGF/c-Met↓, 1,   IGF-1R↓, 3,   IGF-2R↑, 1,   IGFR↓, 1,   IKKα↓, 8,   p‑IKKα↓, 1,   IR↓, 1,   IκB↓, 3,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 6,   JAK1↓, 3,   JAK1↑, 1,   JAK2↓, 12,   p‑JAK2↓, 1,   JAK3↓, 1,   JNK↓, 8,   JNK↑, 18,   JNK↝, 1,   p‑JNK↓, 4,   MAP2K1/MEK1↓, 1,   MAPK↓, 28,   MAPK↑, 13,   MAPK↝, 3,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 7,   MKK4↓, 2,   MKP1↝, 1,   mTOR↓, 64,   mTOR↑, 1,   mTOR↝, 3,   p‑mTOR↓, 5,   mTORC2↓, 3,   p70S6↓, 2,   P70S6K↓, 2,   P90RSK↓, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 96,   PI3K↑, 1,   PI3K↝, 2,   p‑PI3K↓, 5,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PKA↓, 2,   PKCδ↓, 11,   p‑PKCδ↓, 1,   PTEN↑, 28,   PTEN↝, 1,   p‑PTEN↓, 1,   Raf↓, 6,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 15,   RAS↑, 1,   RIP1↑, 1,   RTK-RAS↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 6,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 5,   STAT3↓, 70,   STAT3↑, 3,   p‑STAT3↓, 14,   p‑STAT3↑, 1,   STAT4↓, 2,   STAT5↓, 2,   STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 2,   ATF4↑, 6,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 10,   cJun↑, 1,   p‑cJun↓, 1,   cMyc↓, 43,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 11,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 5,   FOXO↑, 4,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 4,   FOXO3↑, 4,   FOXO3↝, 1,   H3↑, 2,   ac‑H3↓, 1,   ac‑H3↑, 3,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 3,   HATs↓, 9,   HATs↑, 2,   HDAC↓, 28,   HDAC1↓, 6,   HDAC2↓, 4,   HDAC3↓, 2,   HDAC6↓, 1,   HDAC8↓, 2,   HES1↓, 1,   Matr↓, 1,   miR-106b↓, 1,   miR-134↑, 1,   miR-145↑, 1,   miR-194↑, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-21↑, 1,   miR-210↓, 1,   miR-34a↑, 2,   miR-375↑, 1,   Myc↓, 7,   MYCN↓, 1,   n-MYC↓, 1,   NEAT1↓, 1,   OCT4↓, 8,   other↓, 6,   other↑, 3,   other⇅, 1,   other↝, 10,   other∅, 3,   PCAF↓, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 4,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 2,   TFAP2A↓, 1,   tumCV↓, 29,   tumCV∅, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 12,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 31,   GRP78/BiP↓, 2,   GRP78/BiP↑, 11,   HSF1↓, 1,   HSP27↓, 5,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 10,   HSP90↑, 1,   HSPs↓, 2,   HSPs↑, 1,   HTRA↓, 1,   IRE1↑, 4,   NQO2↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 2,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 8,   p62↓, 3,   p62↑, 1,   TumAuto↑, 26,   TumAuto↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 2,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 2,   DFF45↑, 2,   DNAdam↓, 3,   DNAdam↑, 47,   DNArepair↓, 1,   DNArepair↑, 1,   ERCC1↓, 1,   hTERT/TERT↓, 7,   p16↑, 4,   P53?, 1,   P53↓, 4,   P53↑, 85,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 3,   p73↑, 1,   PARP↓, 5,   PARP↑, 13,   PARP↝, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 55,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 28,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1↓, 5,   TOP2↓, 6,   TOP2↑, 2,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 2,   CDK1↓, 8,   CDK1↑, 4,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 44,   CDK2↑, 3,   CDK4↓, 48,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 18,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 3,   Chk2↓, 2,   ChrCon↑, 1,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 8,   CycB/CCNB1↓, 21,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 88,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 2,   cycE/CCNE↓, 23,   cycE/CCNE↑, 2,   cycE1↓, 1,   E2Fs↓, 6,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 22,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 5,   P21↑, 62,   P21↝, 2,   p‑P21↑, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 20,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 3,   RB1↑, 2,   p‑RB1↓, 7,   Securin↓, 2,   TumCCA?, 3,   TumCCA↓, 5,   TumCCA↑, 146,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7,   ALDH1A1↓, 2,   BMP2↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 6,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   cFos↓, 8,   CSCs↓, 29,   Diff↓, 2,   Diff↑, 2,   EP2↓, 2,   EP4/PTGER4↓, 1,   FGF↓, 4,   Gli↓, 2,   Gli1↓, 5,   HH↓, 6,   Id1↓, 1,   IGF-1?, 1,   IGF-1↓, 8,   IGF-2↓, 1,   IGFBP3↑, 3,   Jun↓, 1,   Ki-67↓, 22,   Let-7↑, 3,   mTORC1↓, 5,   p‑mTORC1↓, 1,   Nanog↓, 9,   Nestin↓, 4,   NICD↓, 1,   NOTCH↓, 13,   NOTCH1↓, 14,   NOTCH1↑, 2,   NOTCH3↓, 2,   p300↓, 2,   Piezo1↑, 1,   SCF↓, 1,   Shh↓, 9,   Smo↓, 3,   STAT1↓, 2,   TAZ↓, 1,   TumCG↓, 43,   TumCG↑, 3,   TumCG∅, 1,   TumCP↓, 106,   tyrosinase↓, 1,   Wnt↓, 40,   Wnt↑, 1,   Wnt↝, 1,   Wnt/(β-catenin)↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 16,   AP-1↝, 1,   ARG1/2↑, 1,   ASAP2↓, 1,   ATPase↓, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 6,   Ca+2↓, 2,   Ca+2↑, 23,   Ca+2↝, 2,   i-Ca+2?, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   Cal9↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 3,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 39,   EFEMP↓, 1,   EMT↓, 62,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 15,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 7,   GIT1↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MALAT1↓, 2,   MET↓, 1,   MMP-10↓, 2,   MMP1↓, 6,   MMP13↓, 3,   MMP2↓, 93,   MMP2↑, 1,   MMP2↝, 2,   MMP3↓, 5,   MMP7↓, 18,   MMP9↓, 134,   MMP9↑, 2,   MMP9↝, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 38,   MUC4↓, 4,   N-cadherin↓, 23,   p44↓, 1,   pax↓, 1,   PDGF↓, 8,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 5,   ROCK1↓, 6,   ROCK1↑, 1,   serineP↓, 1,   Slug?, 1,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD3↓, 2,   Snail?, 2,   Snail↓, 24,   SPARC↓, 1,   TET1↑, 3,   TGF-β↓, 20,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 9,   TIMP2↓, 2,   TIMP2↑, 12,   TIMP3↑, 1,   TSP-1↑, 3,   TumCA↓, 4,   TumCA↑, 1,   TumCI↓, 57,   TumCMig↓, 57,   TumMeta↓, 62,   TumMeta↑, 4,   Twist↓, 20,   uPA↓, 27,   uPAR↓, 2,   Vim↓, 30,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 2,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 51,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 90,   angioG↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 6,   Hif1a↓, 60,   Hypoxia↓, 1,   LOX1↓, 4,   NO↓, 13,   NO↑, 3,   NO↝, 1,   PGI2↓, 1,   PHDs↓, 1,   VCAM-1↓, 4,   VEGF↓, 134,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 14,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 3,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↑, 1,   GLUT1↓, 11,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 71,   MMP↑, 3,   MPT↑, 3,   NHE1↓, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↓, 1,   CD4+↓, 2,   CD4+↑, 1,   CD44↓, 9,   CD59↑, 1,   COX1?, 1,   COX1↓, 10,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 321,   COX2/PTGS2↑, 10,   COX2/PTGS2↝, 5,   COX2/PTGS2∅, 2,   CXCc↓, 2,   CXCL1↓, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 20,   CXCR4↑, 1,   DR4↑, 5,   Eos↑, 1,   FOXP3↓, 3,   FOXP3↑, 1,   FoxP3+↓, 1,   GM-CSF↓, 2,   HCAR2↑, 1,   HLA↑, 1,   HMGB1↓, 2,   ICAM-1↓, 12,   IFN-γ↓, 7,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 11,   IL1↑, 1,   IL10↓, 10,   IL10↑, 2,   IL12↓, 4,   IL12↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 33,   IL1β↑, 2,   IL1β∅, 1,   IL2↓, 6,   IL2↑, 4,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 3,   IL5↓, 1,   IL6↓, 71,   IL6↑, 2,   IL6↝, 1,   IL8↓, 18,   IL8↑, 2,   Imm↑, 10,   Imm↝, 1,   Inflam↓, 54,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 9,   MCT1↓, 2,   MDSCs↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   mPGES-1↓, 2,   MyD88↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 207,   NF-kB↑, 6,   NF-kB↝, 1,   p‑NF-kB↓, 4,   p‑NF-kB↑, 2,   NK cell↑, 8,   NK cell⇅, 1,   NLRP3↓, 6,   p50↓, 2,   p65↓, 10,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 8,   PGD2↓, 1,   PGE1↓, 2,   PGE2↓, 56,   PGE2↑, 1,   PSA↓, 8,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 1,   TCF↓, 2,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR2↓, 1,   TLR4↓, 8,   TNF-α↓, 67,   TNF-α↑, 6,   TNF-α↝, 1,   TNF-α∅, 1,   TRADD↑, 1,   TRAF1↓, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10?, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ADRB2↓, 1,   AhR↓, 2,   AR↓, 14,   AR↝, 1,   AR-V7?, 1,   CYP19?, 1,   CYP19↓, 1,   ER-α36↓, 2,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARα↓, 2,   PPARα↑, 3,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 13,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   AKR1B10↓, 1,   BioAv↓, 32,   BioAv↑, 28,   BioAv↝, 15,   BioEnh?, 1,   BioEnh↑, 4,   ChemoSen↓, 2,   ChemoSen↑, 124,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 3,   CYP1A1↓, 4,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 5,   Dose↓, 1,   Dose↑, 11,   Dose⇅, 1,   Dose↝, 42,   Dose∅, 13,   eff↓, 18,   eff↑, 52,   eff↝, 11,   eff∅, 2,   GSTA1↑, 1,   GSTZ1↓, 1,   Half-Life↓, 12,   Half-Life↑, 2,   Half-Life↝, 11,   MDR1↓, 10,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 14,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 4,   P450↝, 1,   RadioS↑, 49,   selectivity?, 1,   selectivity↑, 53,   Synergy?, 1,   Synergy↓, 1,   Synergy↑, 94,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 9,   ALAT↝, 1,   ALP↓, 3,   ALP↝, 1,   AR↓, 14,   AR↝, 1,   ascitic↓, 2,   AST↓, 7,   AST↝, 1,   BloodF⇅, 1,   BMD↑, 1,   BP↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 7,   CYFRA21-1↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 3,   Ferritin↓, 2,   FOXM1↓, 5,   HER2/EBBR2↓, 14,   hTERT/TERT↓, 7,   IL6↓, 71,   IL6↑, 2,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 1,   LDH↝, 2,   i-LDH↓, 1,   Myc↓, 7,   NOS2↓, 3,   PD-L1↓, 8,   PSA↓, 8,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 2,   Tumccf↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↓, 3,   AntiCan↑, 41,   antiNeop↑, 3,   AntiTum↑, 12,   AntiTum⇅, 1,   BowelM↑, 1,   cachexia↓, 1,   cardioP↑, 12,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 36,   chemoPv↑, 22,   chemoPv⇅, 1,   ChemoSideEff↓, 5,   cognitive?, 1,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 13,   neuroP↑, 4,   NP/CIPN↓, 1,   Obesity↓, 1,   OS?, 1,   OS↑, 11,   Pain↓, 1,   QoL↑, 5,   radioP↑, 10,   RenoP↑, 9,   Risk↓, 18,   Symptoms∅, 1,   toxicity↓, 12,   toxicity↑, 1,   toxicity↝, 9,   toxicity∅, 1,   TumVol↓, 17,   TumW↓, 6,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 1,   Ingr↝, 9,  
Total Targets: 1039

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 2,   antiOx↓, 9,   antiOx↑, 122,   ARE↑, 4,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 83,   Fenton↓, 2,   GCLC↑, 3,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 59,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 73,   GSR↓, 1,   GSR↑, 11,   GSSG↓, 2,   GSTs↓, 3,   GSTs↑, 23,   H2O2↓, 6,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 61,   HO-1⇅, 1,   Keap1↓, 5,   Keap1↑, 1,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 66,   MDA↓, 60,   MDA↑, 1,   MPO↓, 13,   MPO↑, 1,   NADH↓, 1,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 11,   Nrf1↑, 1,   NRF2↓, 2,   NRF2↑, 92,   ONOO↓, 1,   Prx↑, 2,   RNS↓, 7,   ROS?, 1,   ROS↓, 206,   ROS↑, 2,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   SOD↓, 2,   SOD↑, 109,   SOD1↑, 3,   SOD2↑, 3,   TAC↑, 8,   TBARS↓, 4,   Thiols↑, 2,   TOS↓, 1,   TrxR↑, 2,   uricA↓, 2,   VitC↑, 3,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2,   mitResp↑, 1,   mtDam↓, 3,   OCR↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,   PINK1↑, 2,   SIRT3↑, 1,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   12LOX↓, 3,   12LOX↑, 1,   15-LOX/ALOX15↓, 1,   5-HETE↓, 1,   5LO↓, 17,   5LO↝, 1,   Acetyl-CoA↓, 1,   ACSL4↓, 1,   adiP↑, 1,   ALAT?, 1,   ALAT↓, 19,   AMPK↑, 11,   p‑AMPK↑, 1,   ATP↑, 6,   cAMP↑, 3,   cPLA2↓, 1,   cytoP450↓, 1,   DGAT1↓, 1,   ECAR↓, 1,   Eic↓, 1,   FAO↑, 2,   FASN↓, 3,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   GlutMet↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 13,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK2↑, 1,   HMG-CoA↓, 2,   LDHA↓, 1,   LDL↓, 11,   lipidLev↓, 3,   LTC4↓, 1,   NAD↑, 2,   NADPH↓, 3,   NADPH↑, 3,   PGM1?, 1,   PKM2↓, 3,   SIRT1↑, 16,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 15,   ASC↓, 1,   BAX↓, 17,   Bcl-2↓, 3,   Bcl-2↑, 6,   Casp↓, 2,   Casp1↓, 3,   Casp3?, 1,   Casp3↓, 23,   Casp3∅, 1,   cl‑Casp3↓, 2,   Casp6↓, 1,   Casp8↓, 2,   Casp9↓, 12,   cl‑Casp9↓, 1,   Cyt‑c↓, 4,   Cyt‑c∅, 1,   Fas↓, 3,   Ferroptosis↓, 3,   iNOS↓, 90,   iNOS↑, 2,   necrosis↓, 2,   p38↓, 8,   p‑p38↓, 4,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 7,   p‑Akt↓, 1,   p‑Akt↑, 1,   AKT1↓, 1,   Akt2↓, 1,   CREB↑, 2,   p‑CREB↑, 1,   EGFR↓, 2,   ERK↓, 6,   ERK↑, 4,   p‑ERK↓, 3,   p‑ERK↑, 2,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 1,   JNK↓, 8,   JNK↑, 1,   p‑JNK↓, 6,   MAPK?, 1,   MAPK↓, 19,   MAPK↑, 3,   MAPK↝, 1,   p‑MAPK?, 1,   p‑MAPK↓, 2,   p‑MKK4↑, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 7,   PI3K↑, 4,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 2,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 4,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   MEF2D↑, 1,   miR-34a↓, 1,   other↓, 6,   other↑, 13,   other↝, 10,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   ER Stress↓, 4,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 5,   HSPs↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↑, 2,   LC3B↑, 1,   LC3II↑, 1,   MitoP↓, 1,   p62↓, 1,   p62↑, 2,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATR↑, 1,   p‑BRCA1↑, 1,   DNAdam↓, 4,   p16↓, 1,   P53↓, 4,   P53↑, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 2,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   Ki-67↓, 1,   P21↓, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 1,   EP2↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   neuroG↑, 4,   p300↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 22,   AP-1↓, 11,   BACH1↓, 1,   Ca+2↓, 8,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 3,   COL1↓, 1,   COL1↑, 1,   MLC2/MYL9↝, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 6,   MMP2↓, 6,   MMP3↓, 5,   MMP3↑, 1,   MMP9↓, 11,   MMP9↑, 1,   MMPs↓, 5,   MMPs↑, 1,   MUC1↑, 2,   p‑Rac1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β1↑, 1,   TIMP1↓, 2,   TIMP1↑, 2,   TumCI↓, 1,   TXNIP↓, 1,   α-SMA↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   CD31/PECAM-1↓, 1,   E-sel↓, 2,   eNOS↓, 1,   Hif1a↓, 4,   LOX1↓, 2,   NO↓, 49,   NO↑, 2,   TXA2↓, 3,   VCAM-1↓, 7,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 23,   BBB↝, 3,   BBB∅, 2,   CLDN1↑, 3,   CLDN3↑, 1,   GastroP↑, 7,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 3,   MMP↓, 2,   MMP↑, 12,   MMP∅, 1,   MUC2↑, 1,   OCLN↑, 3,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 2,   TRPV3↑, 2,   VGSC↓, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   CB2 / CNR2↑, 3,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 15,   COX2/PTGS2?, 2,   COX2/PTGS2↓, 219,   COX2/PTGS2↑, 2,   COX2/PTGS2∅, 1,   CXCc↓, 1,   CXCR4↓, 2,   Eos↓, 2,   HCAR2↑, 1,   HMGB1↓, 2,   ICAM-1↓, 7,   IFN-γ↓, 8,   IFN-γ↑, 3,   IL1↓, 6,   IL10↓, 6,   IL10↑, 15,   IL12↓, 6,   IL17↓, 8,   IL18↓, 3,   IL1β↓, 89,   IL2↓, 7,   IL2↑, 1,   IL23↓, 1,   IL4↓, 6,   IL4↑, 4,   IL5↓, 2,   IL5↑, 1,   IL6↓, 96,   IL6↑, 2,   IL8↓, 19,   IL8↑, 1,   Imm↑, 13,   Imm⇅, 1,   INF-γ↓, 2,   Inflam?, 1,   Inflam↓, 201,   IRF3↓, 2,   LTA/TNF-β↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 2,   NeuroI↓, 7,   Neut↑, 1,   NF-kB↓, 128,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NK cell↑, 3,   NLRP3↓, 20,   p65↓, 2,   PGD2↓, 2,   PGE2↓, 55,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 1,   RANTES↓, 2,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 4,   TLR4↓, 20,   TLR4↑, 1,   TNF-α↓, 125,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,   β-HEX↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 4,   Ach↑, 5,   AChE↓, 30,   AChE↑, 1,   AChE∅, 1,   ADAM10↑, 1,   BChE↓, 7,   BChE∅, 1,   BDNF↑, 20,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 3,   EndoR↑, 1,   GABA↓, 1,   GABA↑, 1,   GDNF↑, 1,   MAOA↓, 3,   MAOA↑, 1,   monoA↑, 1,   NGF↑, 4,   PSD95↑, 3,   SNAP25↑, 2,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 1,   Aβ↓, 39,   Aβ42↓, 2,   BACE/β-secretase↓, 13,   tau↓, 10,   p‑tau↓, 6,   XO↓, 3,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   DHT↓, 1,   Estro↓, 1,   GR↓, 1,   GR↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 7,   testos↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 45,   BioAv↑, 59,   BioAv⇅, 1,   BioAv↝, 26,   BioEnh↑, 6,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP2E1↓, 2,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 33,   eff↓, 2,   eff↑, 19,   eff↝, 1,   GSTA1↑, 3,   Half-Life↓, 4,   Half-Life↑, 3,   Half-Life↝, 15,   P-gp/ABCB1↓, 2,   P450↓, 2,   P450↑, 1,   P450↝, 1,   Synergy↑, 19,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 19,   ALB↑, 1,   ALP↓, 2,   AST↓, 24,   BG↓, 1,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 2,   BP↓, 10,   p‑BRCA1↑, 1,   Calcium↑, 1,   CEA↓, 1,   CK/CK-MB↓, 1,   creat↓, 4,   CRP↓, 9,   EGFR↓, 2,   hs-CRP↓, 1,   IL6↓, 96,   IL6↑, 2,   LDH↓, 11,   LDH↑, 1,   Mag↑, 1,   NOS2↓, 5,   PSA↓, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 25,   AntiArt↑, 6,   AntiCan↑, 19,   antiCG↑, 1,   AntiDiabetic↑, 18,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 65,   cardioP⇅, 1,   chemoP↑, 9,   chemoPv↑, 10,   cognitive↓, 2,   cognitive↑, 51,   cognitive↝, 1,   cough?, 1,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 51,   Learn↑, 5,   memory↑, 50,   Mood↑, 2,   motorD↓, 1,   motorD↑, 6,   Mucositis↓, 1,   neuroP↑, 131,   NP/CIPN↓, 2,   Obesity↓, 12,   OS↑, 5,   Pain↓, 14,   QoL↑, 1,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 20,   Risk↓, 1,   Sleep↑, 3,   SoreThr?, 1,   Strength↑, 2,   Stress↓, 2,   Stroke↓, 8,   toxicity↓, 38,   toxicity↑, 2,   toxicity↝, 11,   toxicity∅, 5,   Weight↓, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13,   AntiFungal↓, 1,   AntiFungal↑, 3,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 11,   Bacteria↑, 1,   Diar↓, 2,   GutMicro↑, 21,   GutMicro↝, 1,   Inf↓, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 1,   Ingr↝, 11,   Phen↑, 1,   QC↑, 1,  
Total Targets: 562

Scientific Paper Hit Count for: COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein
29 Curcumin
25 Thymoquinone
19 Quercetin
18 Resveratrol
15 Fisetin
13 Lycopene
11 Celecoxib
11 Chrysin
11 Silymarin (Milk Thistle) silibinin
10 Apigenin (mainly Parsley)
10 Propolis -bee glue
10 Eugenol
9 Boswellia (frankincense)
9 Carvacrol
9 isoorientin
9 Sulforaphane (mainly Broccoli)
8 Berberine
8 Beta-Caryophyllene
8 Diclofenac
8 Honokiol
7 Artemisinin
7 EGCG (Epigallocatechin Gallate)
7 Kaempferol
7 Licorice
7 Luteolin
7 Rosmarinic acid
6 Chlorogenic acid
6 Ginger/6-Shogaol/Gingerol
5 Radiotherapy/Radiation
5 Baicalein
5 Echinacea
5 Ellagic acid
5 Ferulic acid
5 Garcinol
5 Magnetic Fields
5 Piperine
4 Aspirin
4 Ashwagandha(Withaferin A)
4 Capsaicin
4 Cisplatin
4 lambertianic acid
4 Melatonin
4 Phycocyanin
4 Shikonin
4 Urolithin
4 Zyflamend
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Isovitexin
3 Betulinic acid
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cichoric acid / Chicoric acid
3 Chemotherapy
3 D-limonene
3 Dandelion Root
3 Formononetin
3 Gambogic Acid
3 Grapeseed extract
3 Isoliquiritigenin
3 Morin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Rutin
2 acetaminophen
2 Allicin (mainly Garlic)
2 alpha Linolenic acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Baicalin
2 xanthohumol
2 Cannabidiol
2 Boron
2 buckwheat sprouts
2 Carnosic acid
2 Caffeic acid
2 Thymol-Thymus vulgaris
2 Chocolate
2 Crocetin
2 Ursolic acid
2 CUSP9
2 Docosahexaenoic Acid
2 Diindolylmethane
2 Emodin
2 Flaxseed/Linseed
2 Genistein (soy isoflavone)
2 Geraniol
2 Hydroxycinnamic-acid
2 Hyperoside
2 phytic acid, Inositol hexakisphosphate
2 Isorhamnetin
2 Vitexin
2 L-Theanine
2 Lemongrass Extract/Citral
2 Magnolol
2 Lemon Balm/Melissa officinalis
2 doxorubicin
2 Naringin
2 Nimbolide
2 Oleuropein
2 Oleocanthal
2 Piperlongumine
2 Sesamin
2 Vitamin C (Ascorbic Acid)
2 Vitamin K2
1 1,8-Cineole
1 3-bromopyruvate
1 Açaí, Euterpe oleracea
1 Auranofin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 Benzyl isothiocyanate
1 Brucea javanica
1 brusatol
1 Beetroot
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 cannabidiolic acid
1 Celastrol
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Galantamine
1 Docetaxel
1 Oxygen, Hyperbaric
1 Lecithin
1 Dichloroacetate
1 Date Fruit Extract
1 eicosapentaenoic acid
1 Evodiamine
1 Exercise
1 flavonoids
1 Bortezomib
1 Shilajit/Fulvic Acid
1 Gamma-aminobutyric acid
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Proanthocyanidins
1 Siegesbeckia glabrescens
1 Hydrogen Gas
1 Hops (Humulus lupulus)
1 Inositol
1 iodine
1 Laetrile B17 Amygdalin
1 Lasiodin
1 Licochalcone A
1 Linalool
1 Lutein
1 5-fluorouracil
1 MBE, Maqui berry
1 mebendazole
1 Sulindac
1 Metformin
1 Magnetic Field Rotating
1 Moringa oleifera
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 Neem
1 Marjoram (Origanum majorana)
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Protocatechuic acid
1 Mung Bean Sprouts
1 Polyphenols
1 Propranolol
1 Perilla
1 Germacranolide sesquiterpene lactone
1 Salvia officinalis
1 Sanguinarine
1 Lignans
1 Sesame seeds and Oil
1 Spirulina(Arthrospira/Limnospira)
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B1/Thiamine
1 Whole Body Vibration
1 Wogonin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:66  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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