Risk Cancer Research Results

Risk, Risk: Click to Expand ⟱
Source:
Type:
Risk: by definition reduces risk of disease or cancer.
Down Target direction of risk indicates lower cancer risk.
ChemoPreventive also mean lower cancer risk. But for Chemopreventive an up arrow indicates more preventive. 
Cancer Risk Impact Score (CRIS)
CRIS scale:
–5 = very strong risk reduction
–4 = strong risk reduction
–3 = moderate risk reduction
–2 = modest risk reduction
–1 = weak / context-dependent
0 = neutral




CRIS Exposure / Compound Evidence Cancers Notes




-5 Exercise (overall)
VStrong Hum BC, CRC, Endo, PCa, Liv






-5 Aerobic + resistance VStrong Hum Broad inc + mort






-4 Aerobic exercise (mod–vig) VStrong Hum BC, CRC, Endo






-4 Resistance training (alone) Strong Hum BC, CRC






-3 High-intensity interval training Mod–Strong Hum BC, CRC






-2 NEAT / low-intensity activity Moderate Hum CRC






-5 Cruciferous vegetable pattern Strong Hum Lung, CRC, BC, PCa






-5 Sunlight exposure (physiologic) Strong Hum CRC, BC, PCa






-4 Fasting (metabolic pattern)
Strong Mech + Hum BC, CRC, PCa 






-4 Curcumin
Hum + Pre GI, BC, PCa






-4 Sulforaphane
Hum + Pre Lung, CRC, BC






-4 PEITC
Hum + Pre Lung, CRC, PCa






-4 EGCG (tea matrix)
Strong Hum GI, PCa, BC






-4 Lycopene
Strong Hum PCa






-4 Apigenin
Pre + Diet Hum BC, PCa, CRC 






-4 Luteolin
Pre + Diet Hum Lung, CRC, BC 






-4 Kaempferol
Diet Hum Ov, Panc, Lung






-4 Fisetin
Pre + Early Hum CRC, PCa, Mel






-4 Ellagic acid → Urolithin A
Hum (microbiome) CRC, PCa, BC






-3 Omega-3 (EPA/DHA)
Strong Hum CRC, BC






-3 Vitamin D3 (supp)
Obs + RCT CRC, BC






-3 Garlic (allicin)
Mod Hum GI






-3 Mushroom beta-glucans
Hum adjunct GI, BC






-3 Melatonin
Hum + Mech BC, PCa






-3 Coffee (whole)
Strong Hum Liv, Endo






-2 Quercetin
Limited Hum Lung, CRC






-2 Resveratrol
Limited Hum CRC, BC






-2 I3C / DIM
Mod Hum BC, Cerv






-2 Thymoquinone
Early Hum BC, CRC






-2 Beta-carotene (food)
Hum Lung






-1 Vitamin K2 (MK-4/7)
Limited Hum Liv, PCa






-1 Boron
Obs PCa, Lung






0 Vitamin C (oral)
Strong Hum —






0 Genistein (soy)
Strong Hum BC, PCa






0 Selenium (diet)
Mixed Hum PCa






0 Capsaicin
Mixed Gastric






+2 Vitamin E (alpha only)
Strong RCT PCa






+2 Green tea extract (high-dose)
Case reports Liv






+4 Beta-carotene (supplement)
Strong RCT Lung (smokers)






+5 Alcohol (ethanol)
Strong Hum BC, Liv, Eso







Evidence
Hum        human data
VStrong    very strong
Strong     strong
Mod        moderate
Obs        observational
Pre        preclinical
RCT        randomized controlled trial
Mech       mechanistic
Adjunct    adjunct clinical use


Scientific Papers found: Click to Expand⟱
4491- SeNPs,  Chit,  VitC,    Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
- Study, Var, NA
*ROS↓, *selenoP↑, *antiOx↑, *Inflam↓, *Risk↓, *toxicity↓, AntiTum↑, Dose↝,
4745- SeNPs,  Chemo,    Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation
- Study, NSCLC, NA
Risk↓, TumCD↑, mTOR↑, AntiTum↑, ChemoSen↑,
2164- SFN,  dietP,    Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice
- in-vitro, Pca, NA
HDAC↓, Dose↝, Risk↓, TumCP↓, H3↓,
1429- SFN,    Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
- in-vivo, Nor, NA - Human, Nor, NA
*NADPH↑, *NQO1↑, *HO-1↑, *Risk↑,
4133- Silicon,    Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study
- Study, AD, NA
*Risk↓, *Dose↑, *neuroP↑,
4136- Silicon,    Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *Risk↓, *neuroP↑,
5802- Sper,    Spermidine reduces cancer-related mortality in humans
- Review, Var, NA
EP300↓, Risk↓,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, Synergy↑,
1697- SSE,  Calc,    Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland
- Human, CRC, NA
Risk↓, Risk↓, Dose∅, AntiCan↑,
1706- SSE,    Selenium in Prostate Cancer: Prevention, Progression, and Treatment
- Review, Pca, NA
Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, Synergy↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,
4753- SSE,  Chemo,    Selenium and Lung Cancer: A Systematic Review and Meta Analysis
- Review, Lung, NA
Risk⇅, chemoP↑, radioP↑,
5082- SSE,    Rationale for the treatment of cancer with sodium selenite
- Review, Var, NA
Risk↑, antiOx↑, ROS↑, Imm↑, NK cell↑, angioG↓, toxicity↓,
4500- SSE,    Dietary selenium affects host selenoproteome expression by influencing the gut microbiota
- in-vivo, Nor, NA
*GutMicro↑, Risk↓, *GPx↑,
4498- SSE,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,
4497- SSE,    Selenium and inflammatory bowel disease
- Review, Var, NA - Review, IBD, NA
*GutMicro↑, *selenoP↑, *Inflam↓, Risk↓, *NF-kB↓, *ROS↓,
4494- SSE,    Advances in the study of selenium and human intestinal bacteria
- Review, IBD, NA - Review, Var, NA
*Risk↓, OS↑, *CRP↓, *GPx↑, *Inflam↓, *ROS↓, *GutMicro↑, *selenoP↑, *other↓,
4614- SSE,  Rad,    Updates on clinical studies of selenium supplementation in radiotherapy
- Review, Nor, NA
*toxicity∅, Risk↓, *selenoP↑, *ROS↓, *DNAdam↓, *QoL↑, *radioP↑, *Dose↝,
4739- SSE,  Chemo,  Rad,    Therapeutic Benefits of Selenium in Hematological Malignancies
- Review, Var, NA
ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
4741- SSE,    Selenium in Oncological Intervention
- Review, Var, NA
Risk↓, *other↝, Risk↓, AntiTum↑, chemoR↓, chemoP↑,
4740- SSE,    Optimising Selenium for Modulation of Cancer Treatments
- Review, Var, NA
*selenoP↑, *Dose↓, Risk↓, *toxicity↝, Dose↑, chemoP↑, radioP↑,
3963- Taur,    Past Taurine Intake Has a Positive Effect on Present Cognitive Function in the Elderly
- Human, AD, NA
*Risk↓, *other↑,
3965- Taur,    Taurine-Related Nutritional Knowledge Has a Positive Effect on Intake of Taurine and Cognitive Function in the Elderly
- Human, AD, NA
*Risk↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1/ATG6↑, *ROS↓, *GutMicro↑, *Risk↓,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *Synergy↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE/β-secretase↓,
4327- VitB1/Thiamine,    Plasma thiamine deficiency associated with Alzheimer's disease but not Parkinson's disease
- Study, AD, NA
*Risk↓, *other↝,
4056- VitB12,  VitB6,  FA,    Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis
- Review, AD, NA
*Risk∅, *cognitive↑, *cognitive∅,
4326- VitB5,    Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease
- in-vivo, HD, NA
*Risk↓, *neuroP↑, *other?, *Ach↑, *other↝, *eff↓, *other↝,
4325- VitB5,    Localized Pantothenic Acid (Vitamin B5) Reductions Present Throughout the Dementia with Lewy Bodies Brain
- Study, AD, NA - Study, Park, NA
*Risk↑, *Dose↝, *Dose↓, *other↝,
4324- VitB5,    Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson’s Disease Dementia
- Study, AD, NA - Study, Park, NA
*Risk↓, *other↝, *other↝, *Ach↑, *Aβ↑, *other?,
4323- VitB5,    Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease
- Study, AD, NA
*Risk↓, *Acetyl-CoA↑, *Ach↑, *neuroP↑,
4055- VitB6,  VitD3,    Vitamin B6 and vitamin D deficiency co-occurrence in geriatric memory patients
- Study, AD, NA
*Risk↓, *cognitive↑,
4062- VitB6,  FA,  VitB12,    Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011–2014
- Study, AD, NA
*Risk↓, *Risk↓, *Risk↓, *cognitive↑,
4057- VitB6,  VitB12,  FA,    Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory Study
- Study, AD, NA
*Risk↓, *Risk∅,
4052- VitB6,    B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study
- Study, AD, NA
*neuroP↑, *other↑, *other↑, *cognitive↑, *eff↝, *Risk↑, *other↑,
4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *Hcy/homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,
4319- VitC,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, *Inflam↓, *Risk↓, *cognitive↑,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2/PTGS2↓, ER Stress↑, IRE1↑, JNK↑, CHOP/DDIT3↑, Hif1a↓, Synergy↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, Synergy↑, TET1↑,
1740- VitD3,    Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
- Review, Var, NA
Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, Synergy↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,
1739- VitD3,    Effect of Vitamin D3 Supplements on Development of Advanced Cancer
- Trial, Var, NA
AntiCan↑, Dose↝, Risk↓, TumCP↓, Inflam↓, eff∅,
4350- VitD3,    Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines
- Review, Var, NA - Review, AD, NA
Risk↓, angioG↓, TumMeta↓, AntiCan↑, *cognitive↑, *Mood↑,
4320- VitD3,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Calcium↝, *cognitive↑, *Aβ↓, *Inflam↓, *Risk↓, *other↝,
4618- VitD3,    Vitamin D sensitizes cervical cancer to radiation-induced apoptosis by inhibiting autophagy through degradation of Ambra1
- in-vivo, Cerv, NA
Risk↓, RadioS↑, Apoptosis↑, EMT↝,
7068- VitD3,    Vitamin D Reduces GABA-Positive Astrocytes in the 5xFAD Mouse Model of Alzheimer’s Disease
- in-vivo, AD, NA
*Aβ↓, *GABA↓, Risk↓,
4087- VitE,    Vitamin E and Alzheimer's disease: what do we know so far?
- Review, AD, NA
*Risk↑, *Half-Life↑, *antiOx↑, *BioAv↑, *neuroP↑, *Inflam↑, *LDL↓, *cognitive↑,
4309- VitK2,    Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases
- Review, AD, NA
*Apoptosis↓, *ROS↓, *antiOx↑, *cognitive↑, *memory↑, *Risk↓, *p‑tau↓,
1830- VitK2,    Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study
- Study, Lung, NA
Risk↓, NF-kB↓, PKCδ↓,
1825- VitK2,    Vitamin K intake and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial
- Analysis, Pca, NA
Risk∅,

Showing Research Papers: 251 to 300 of 304
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 304

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 7,   ARE↑, 1,   Catalase↑, 2,   GPx↑, 1,   GSH↓, 3,   GSTs↑, 1,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↓, 2,   lipid-P↑, 1,   NRF2↓, 5,   NRF2↑, 2,   NRF2↝, 1,   PrxI↓, 1,   ROS↓, 9,   ROS↑, 31,   selenoP↑, 1,   SOD↑, 3,   SOD2↓, 1,   Trx↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

selm↑, 1,   selm↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   EGF↓, 1,   Insulin↓, 1,   mitResp↑, 1,   mtDam↑, 1,   OCR↓, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   OXPHOS↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 5,   ATP↓, 3,   Buty↑, 1,   cAMP↓, 1,   FASN↓, 2,   glucose↓, 2,   Glycolysis↓, 5,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HMG-CoA↓, 3,   lactateProd↑, 1,   LDL↓, 2,   PKM2↓, 1,   SCFAs↑, 1,   SIRT1↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 33,   BAX↑, 12,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   BIM↑, 1,   Casp↑, 6,   Casp3↑, 10,   cl‑Casp3↑, 4,   pro‑Casp3↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 14,   DR5↑, 2,   FADD↑, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 2,   iNOS↓, 3,   MDM2↓, 1,   MDM2↑, 1,   p‑MDM2↓, 1,   p38↑, 2,   PUMA↑, 1,   survivin↓, 4,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 1,   YAP/TEAD↓, 1,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ADCY4↑, 1,   Akt↓, 16,   Akt↑, 1,   p‑Akt↓, 4,   Akt2↓, 1,   cMET↓, 1,   EGFR↓, 4,   ERK↓, 3,   ERK↑, 3,   p‑ERK↓, 2,   HER2/EBBR2↓, 2,   IGFR↓, 1,   JAK1↓, 2,   JAK1↑, 1,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 9,   mTOR↑, 2,   PI3K↓, 9,   PI3K↑, 1,   PKCδ↓, 1,   PTEN↑, 3,   RAS↓, 1,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 2,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   H3↓, 1,   HATs↑, 1,   HDAC↓, 7,   miR-194↑, 1,   miR-21↓, 1,   miR-590-3p↑, 1,   Myc↓, 1,   MYCN↓, 1,   other↓, 5,   other↑, 8,   other↝, 14,   other∅, 1,   SUZ12↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   IRE1∅, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   NEU1↑, 1,   TumAuto↓, 2,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   BRCA1↓, 1,   BRCA2↓, 1,   DNAdam↑, 8,   DNArepair↑, 1,   hTERT/TERT↓, 1,   P53↑, 12,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 7,   PCNA↓, 5,   Telomerase↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 4,   CDK6↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   GADD34↑, 2,   GADD45A↓, 1,   Ki-67↓, 7,   P21↓, 2,   P21↑, 7,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   pRB↓, 1,   p‑RB1↓, 1,   cl‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 23,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   BMP2↓, 1,   CSCs↓, 3,   EP300↓, 1,   GH↓, 1,   HH↝, 1,   HMGCR↓, 1,   IGF-1↓, 7,   IGFBP1↑, 1,   JAG1↑, 1,   Ki-67↓, 7,   mTORC1↓, 2,   NOTCH↓, 1,   NOTCH3↑, 1,   TumCG↓, 26,   TumCG↑, 1,   TumCP↓, 35,   TumCP↑, 1,   TumCP⇅, 1,   Wnt↓, 7,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 1,   EMT↓, 4,   EMT↝, 1,   FAK↓, 2,   ITGB1↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   MMP2↓, 6,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 5,   pax↓, 2,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 2,   serineP↓, 1,   Snail↓, 1,   TET1↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 11,   TumCI↑, 1,   TumCMig↓, 12,   TumCMig↑, 1,   TumMeta↓, 21,   UroPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   ECM/TCF↓, 1,   HIF-1↓, 3,   Hif1a↓, 7,   VEGF↓, 10,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↑, 1,   GLUT1↓, 2,   GLUT2↓, 1,   IBI↑, 1,   MMP↓, 16,   MPT↑, 1,   TRPM7↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 13,   DR4↑, 3,   FOXP3↑, 1,   IL10↓, 1,   IL1β↓, 5,   IL2↑, 1,   IL6↓, 2,   Imm↑, 9,   INF-γ↑, 1,   Inflam↓, 11,   MCT1↓, 1,   Neut↑, 1,   NF-kB↓, 14,   NF-kB⇅, 1,   p‑NF-kB↓, 1,   NK cell↑, 4,   PD-L1↓, 1,   PGE2↓, 4,   PSA↓, 7,   SOCS-3↓, 1,   Th1 response↑, 1,   Th2↑, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AR↝, 1,   DHT↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARγ↑, 2,   SXR↑, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 7,   BioAv↝, 1,   chemoR↓, 1,   ChemoSen↑, 40,   ChemoSen∅, 1,   CYP1A1↓, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 2,   Dose↓, 4,   Dose↑, 7,   Dose⇅, 1,   Dose↝, 44,   Dose∅, 3,   eff↓, 4,   eff↑, 20,   eff↝, 11,   eff∅, 5,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   RadioS↑, 11,   selectivity↑, 16,   Synergy↑, 24,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   BloodF↓, 1,   BMD↑, 2,   BRCA1↓, 1,   CRP↓, 1,   EGFR↓, 4,   EZH2↓, 1,   FOXM1↓, 2,   Hcy/homoC↓, 2,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 2,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 7,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   AntiCan∅, 2,   antiNeop↑, 1,   AntiTum↑, 7,   APG↓, 1,   cardioP↑, 3,   chemoP↑, 17,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 2,   OS↓, 2,   OS↑, 17,   OS∅, 3,   Pain↓, 1,   PFS∅, 1,   QoL↑, 4,   radioP↑, 7,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 214,   Risk↑, 16,   Risk⇅, 3,   Risk↝, 7,   Risk∅, 18,   Sleep↑, 1,   toxicity↓, 9,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 8,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 2,   Ingr↝, 1,  
Total Targets: 389

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 7,   antiOx↑, 26,   Catalase↑, 6,   GPx↓, 1,   GPx↑, 10,   GPx1↑, 1,   GSH↑, 3,   GSR↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 7,   MDA↓, 4,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 6,   ROS↓, 36,   mt-ROS↓, 1,   SAM-e↑, 1,   selenoP↑, 10,   SOD↑, 9,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 2,   TrxR↑, 1,   TrxR1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   Acetyl-CoA↑, 1,   adiP↓, 1,   ALAT↓, 1,   AMPK↑, 5,   ATP↑, 2,   ATP↝, 1,   CRM↑, 2,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   glyC↓, 1,   LDL↓, 9,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↓, 1,   Casp3↑, 1,   Casp9↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   iNOS↑, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   IKKα↓, 1,   JNK↓, 1,   MAPK↓, 2,   mTOR↓, 2,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other?, 3,   other↓, 8,   other↑, 12,   other↝, 18,  

Protein Folding & ER Stress(tgid=8) ⓘ

NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   DNArepair↑, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 9,   Ca+2↝, 1,   Cartilage↑, 2,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP-10↝, 1,   MMP9↓, 1,   MUC1↑, 1,   serineP↓, 1,   TGF-β↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 3,   TXA2↓, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   BBB∅, 1,   CLDN1↑, 1,   CLDN3↑, 1,   IBI↑, 1,   MMP↑, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 7,   COX2/PTGS2↓, 5,   IFN-γ↓, 2,   IL1↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL4↑, 1,   IL6↓, 5,   Imm↑, 5,   Inflam↓, 38,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 12,   VitD↑, 4,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↑, 3,   AChE↓, 2,   ADAM10↑, 1,   BDNF↑, 1,   BrainVol↑, 1,   BrainVol↝, 1,   BrainVol∅, 1,   GABA↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 11,   Aβ↑, 1,   BACE/β-secretase↓, 2,   tau↓, 1,   p‑tau↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↑, 2,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 24,   BioAv⇅, 1,   BioAv↝, 4,   Dose?, 1,   Dose↓, 2,   Dose↑, 5,   Dose↝, 28,   eff↓, 5,   eff↑, 6,   eff↝, 3,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 5,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BG↓, 1,   BMD↑, 4,   BP↓, 7,   Calcium↑, 2,   Calcium↝, 1,   CRP↓, 8,   Hcy/homoC↓, 3,   hs-CRP↓, 2,   IL6↓, 5,   Mag↑, 2,   TC↓, 1,   TG/TAG↓, 1,   TMAO↑, 3,   VitD↑, 4,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 9,   AntiTum↓, 1,   BOLD↑, 1,   cardioP↑, 19,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 4,   cognitive↑, 41,   cognitive↝, 2,   cognitive∅, 1,   hepatoP↑, 5,   memory↑, 11,   Mood↑, 2,   motorD↓, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 28,   Obesity↓, 4,   OS↑, 3,   Pain↓, 2,   QoL↑, 2,   radioP↑, 3,   Risk↓, 75,   Risk↑, 14,   Risk↝, 1,   Risk∅, 3,   Strength↑, 3,   Stroke↓, 5,   Stroke↑, 1,   toxicity↓, 14,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 7,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 3,   AntiViral↑, 3,   Bacteria↓, 1,   GutMicro↑, 18,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 3,   Ingr↝, 5,  
Total Targets: 236

Scientific Paper Hit Count for: Risk, Risk
23 Selenium
18 Folic Acid, Vit B9
16 Boron
15 Selenite (Sodium)
14 Lycopene
13 Aspirin
10 Vitamin D3
10 Magnesium
9 Choline
8 Vitamin B6,pyridoxine
7 Vitamin K2
7 Metformin
6 Allicin (mainly Garlic)
6 Lutein
6 Vitamin C (Ascorbic Acid)
6 diet Plant based
6 Exercise
6 Vitamin B12
6 Flaxseed/Linseed
6 Kaempferol
6 Phenethyl isothiocyanate
5 Chemotherapy
5 Hormone replacement therapy
5 Calcium
5 diet Fermented Foods
5 isoflavones
5 Selenium NanoParticles
4 beta-carotene(VitA)
4 Zeaxanthin
4 Capsaicin
4 Coenzyme Q10
4 Vitamin E
4 Sulforaphane (mainly Broccoli)
4 Melatonin
4 Vitamin B5,Pantothenic Acid
3 Aluminum
3 Radiotherapy/Radiation
3 Celecoxib
3 Chlorogenic acid
3 Chocolate
3 diet FMD Fasting Mimicking Diet
3 diet Short Term Fasting
3 Silicic Acid
3 iodine
3 Urolithin
2 5-Hydroxytryptophan
2 Anti-oxidants
2 Atorvastatin
2 Genistein (soy isoflavone)
2 Bruteridin(bergamot juice)
2 Butyrate
2 EGCG (Epigallocatechin Gallate)
2 flavonoids
2 Indole-3-carbinol
2 Inulin Prebiotic
2 phytic acid, Inositol hexakisphosphate
2 Potassium
2 Quercetin
2 chitosan
2 Taurine
2 Vitamin B1/Thiamine
1 Anthocyanins
1 alpha Linolenic acid
1 Astaxanthin
1 beta-glucans
1 Bifidobacterium
1 immunotherapy
1 selenomethionine
1 Bortezomib
1 Black Rice, Oryza sativa
1 Bullatacin
1 Carvacrol
1 Catechins
1 Chyawanprash
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Vitamin A, Retinoic Acid
1 Fisetin
1 Fucoidan
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Graviola
1 Grapeseed extract
1 Inositol
1 isoquercitrin
1 Lactobacillus
1 Lecithin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Mung Bean Sprouts
1 Oleuropein
1 Broccoli
1 Rutin
1 buckwheat sprouts
1 Spermidine
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:785  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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