BioAv Cancer Research Results

BioAv, bioavailability: Click to Expand ⟱
Source:
Type: measurement
Bioavailability (usually in %) absorbed by the body.
Scientific Papers found: Click to Expand⟱
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, eff↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, eff↑, Ca+2↑,
6145- Cin,    Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice
- in-vivo, Nor, NA
BioAv↑, GutMicro↑,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, eff↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
3997- CoQ10,    Coenzyme Q and Its Role in the Dietary Therapy against Aging
- Review, AD, NA
*AntiAge↑, *Inflam↓, *antiOx↑, *Apoptosis↓, *BioAv↑, *other↝, *cognitive↑, *DNAdam↓, *ER Stress↓,
6159- CoQ10,    Increased Bioavailability of Ubiquinol Compared to That of Ubiquinone Is Due to More Efficient Micellarization during Digestion and Greater GSH-Dependent Uptake and Basolateral Secretion by Caco-2 Cells
- in-vitro, Colon, Caco-2
BioAv↑,
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,
5810- CPT,  CPT-11,    Camptothein-Based Anti-Cancer Therapies and Strategies to Improve Their Therapeutic Index
- Review, NA, NA
AntiCan↑, BioAv↓, toxicity⇅, TOP1↓, Apoptosis↑, TumCP↓, other↝, BioAv↑, other↝, eff↑,
5809- CPT,    Cancer Therapies Utilizing the Camptothecins: A Review of in Vivo Literature
- Review, Var, NA
BioAv↓, TOP1↓, BioAv↑,
6181- Cro,    Crocetin: A Systematic Review
- Review, Var, NA - Review, AD, NA
cardioP↑, hepatoP↑, *neuroP↑, AntiCan↑, *AntiDiabetic↑, *memory↑, *BioAv↓, *ROS↓, Apoptosis↑, *lipid-P↓, *SOD↑, SOD↓, ERα/ESR1↓, HDAC2↓, TumCCA↑, Bax:Bcl2↑, IL6↓, IL8↓, Shh↓, COX2↑, *GSK‐3β↓, *ERK↓, *tau↓, *ROS↓, *GSTs↑, *Catalase↑, *SOD↑, *BioAv↑,
6180- Cro,    New findings in the metabolism of the saffron apocarotenoids, crocins and crocetin, by the human gut microbiota
- Study, Nor, NA
*BioAv↑,
6311- Cro,    Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model
- in-vivo, Nor, NA
*BioAv↝, *BioAv↑,
6310- Cro,    Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption
- in-vivo, Nor, NA
BioAv↓, BioAv↑, BioAv↑, eff↑,
6307- Cro,    Effects of Intestinal Microbiota on Pharmacokinetics of Crocin and Crocetin in Male Sprague-Dawley Rats
- in-vivo, Nor, NA
*BioAv↝,
6296- Cro,    Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats
- in-vivo, Nor, NA
*BioAv↓,
6295- Cro,    Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract
- Human, Nor, NA
*BioAv↑, *Dose↝, Half-Life↓, Dose↝,
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, NA, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
1602- Cu,    A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy†
- in-vitro, BC, MCF7 - in-vitro, BC, 4T1 - in-vitro, Lung, A549 - in-vitro, Liver, HepG2
eff↑, GSH↓, H2O2↑, ROS↑, *BioAv↑, selectivity↑, TumCCA↑, Apoptosis↑, Fenton↑, *toxicity?,
6194- Cuc,    Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats
- in-vivo, Nor, NA
*BioAv↓, *Half-Life↝, *AST∅, *ALAT∅, *RenoP↝, *Half-Life↝,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
6198- Cuc,    Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS
- in-vivo, Nor, NA
*BioAv↑, *Half-Life↑,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
6205- CUR,    Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: critical analysis
- Review, Var, NA
BioAv↓, Half-Life↓, COX2↓, ChemoSen↑, cachexia↓, NF-kB↓,
6206- CUR,    Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological Study
- Review, Nor, NA
*BioAv↓, *Half-Life↓, *BioAv↑,
6207- CUR,    Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment
- Review, Var, NA - Review, AD, NA
*AntiCan↑, *Obesity↓, *Inflam↓, *lipid-P↓, *BioAv↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *ROS↓, *mt-SOD↑, *MDA↓, *BBB↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroG↑, *memory↑, cardioP↑,
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑,
6211- CUR,    The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer
- Review, Var, NA
HIF-1↓, VEGF↓, angioG↓, RadioS↑, ChemoSen↑, other↝, Apoptosis↑, TumCG↓, TumMeta↓, BioAv↓, COX2↓, CD31↓, IL8↓, TGF-β↓, NF-kB↓, JAK2↓, STAT3↓,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, eff↑, PhotoS↑, eff↑, ROS↑, GSH↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6230- CUR,    Dual redox effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC) on human liver cancer cells, HepG2 via ROS, glutathione and Nrf2/Keap1 pathway
- in-vitro, Liver, HepG2
chemoP↑, selectivity↑, *BioAv↓, *BioAv↑, ROS↑, ROS↓, ROS↑,
6228- CUR,    A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability
- Study, Nor, NA
*BioAv↓, *other↓,
6222- CUR,    Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials
- Review, Var, NA
RadioS↑, ChemoSen↑, MMPs↓, TumMeta↓, TumCI↓, Inflam↓, NF-kB↓, BioAv↓, BioAv↑, MAPK↓, PI3K↓, Akt↓, *ROS↓, *MDA↓, *lipid-P↓, *Half-Life↓, mTOR↓,
6221- CUR,    Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer
- Review, Var, NA
NF-kB↓, Imm↑, *TAC↑, *MDA↓, ROS↑, TumAuto↑, TumCCA↑, Keap1↑, ChemoSen↑, ER Stress↑, eff↓, TrxR↓, STAT3↓, *BioAv↓,
6219- CUR,    Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action
- Review, Var, NA
PI3K↓, Akt↓, NF-kB↓, BioAv↑, GSK‐3β↓, Slug↓, Cyt‑c↑, Casp3↑, Casp9↑,
6218- CUR,    Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications
- Review, Var, NA
NF-kB↓, TrxR↓, ROS↑, TumMeta↓, TumCD↑, RadioS↑, BioAv↝, BioAv↑,
6209- CUR,    Curcumin as a complementary treatment in oncological therapy: a systematic review
other↝, eff↓, *BioAv↓, ChemoSen↓,
6770- CUR,    A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin
- Review, Nor, NA
*AntiBio↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *Half-Life↓,
2305- CUR,    Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN
- in-vitro, BC, MCF7
BioAv↑, PKM2↓, FASN↓, Glycolysis↓,
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
GlucoseCon↓, lactateProd↓, ECAR↓, NO↓, ROS↑, HK2↓, PFK1↓, GAPDH↓, PKM2↓, LDHA↓, FASN↓, GLUT1↓, MCT1↓, MCT4↓, HCAR1↓, SDH↑, ChemoSen↑, ROS↑, BioAv↑, P53↑, NF-kB↓, pH↑,
2654- CUR,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, Catalase↓, SOD1↓, GLO-I↓, NADPH↓, TumCCA↑, Apoptosis↑, Akt↓, ER Stress↑, JNK↑, STAT3↓, BioAv↑,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
2817- CUR,    Neuroprotection by curcumin: A review on brain delivery strategies
- Review, Nor, NA
*BioAv↝, neuroP↑,
2809- CUR,    Comparative absorption of curcumin formulations
- in-vivo, Nor, NA
BioAv↑, BioAv↑, BioAv↑, BioAv↑, BioAv↑, BioAv↓, Half-Life↝,
2814- CUR,    Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management
- Review, Var, NA
*BioAv↓, *Inflam↓, *antiOx↑, AntiCan↑, CK2↓, GSK‐3β↓, EGFR↓, TOP1↓, TOP2↓, NF-kB↓, COX2↓, CRP↓,
2816- CUR,    NEUROPROTECTIVE EFFECTS OF CURCUMIN
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *AP-1↓, *NF-kB↓, *HATs↓, *HDAC↑, Dose↑, *ROS↓, *cognitive↑, *Aβ↓,
4829- CUR,    Dual Action of Curcumin as an Anti- and Pro-Oxidant from a Biophysical Perspective
- Review, Var, NA
*antiOx↑, ROS↑, *lipid-P↓, *iNOS↓, *BioAv↓,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
4655- CUR,    Inhibition of Cancer Stem-like Cells by Curcumin and Other Polyphenol Derivatives in MDA-MB-231 TNBC Cells
- in-vitro, BC, NA
CSCs↓, *BioAv↓,

Showing Research Papers: 251 to 300 of 635
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 635

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Fenton↑, 1,   Ferroptosis↑, 1,   GSH↓, 3,   H2O2↑, 1,   HO-1↑, 1,   Keap1↑, 1,   NQO1↑, 1,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 22,   SOD↓, 1,   SOD1↓, 1,   TrxR↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   MMP↓, 3,   mtDam↑, 1,   SDH↑, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 3,   ECAR↓, 1,   FASN↓, 2,   GAPDH↓, 1,   GLO-I↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   MCT4↓, 1,   NADPH↓, 1,   PFK1↓, 1,   PKM2↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 10,   Akt↑, 1,   Apoptosis↑, 16,   Bak↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Bcl-xL↓, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↑, 6,   Casp9↓, 1,   Casp9↑, 2,   CK2↓, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   iNOS↓, 1,   JNK↑, 2,   MAPK↓, 3,   Mcl-1↓, 1,   MCT1↓, 1,   NOXA↑, 1,   p27↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 3,   TRAIL↑, 1,   TumCD↓, 1,   TumCD↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

SOX9?, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   EZH2↓, 1,   HATs↓, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other↝, 4,   PhotoS↑, 2,   sonoS↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 5,   GRP78/BiP↝, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DNAdam↑, 2,   DNMT1↓, 1,   DNMTs↓, 3,   p16↑, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 2,   P21↑, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   Axin2↑, 1,   CD133↑, 1,   cFos↓, 2,   CIP2A↓, 1,   CSCs↓, 3,   EMT↓, 3,   ERK↓, 1,   FOXO1↓, 1,   GSK‐3β↓, 4,   HDAC↓, 2,   HDAC2↓, 1,   mTOR↓, 5,   Nanog↓, 1,   NOTCH↓, 3,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 8,   PTEN↑, 2,   Shh↓, 1,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 8,   STAT3↑, 1,   TOP1↓, 4,   TOP2↓, 1,   TumCG↓, 6,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AP-1↓, 1,   Ca+2↑, 1,   CD31↓, 1,   CXCL12↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   FAK↑, 1,   p‑FAK↓, 1,   LAMs↓, 1,   MMP2↓, 4,   MMP9↓, 7,   MMPs↓, 5,   PKCδ↓, 1,   Slug↓, 1,   TGF-β↓, 2,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 6,   TumCMig↓, 2,   TumCP↓, 6,   TumMeta↓, 7,   TumMeta↑, 2,   VCAM-1↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   EGFR↓, 2,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   NO↓, 1,   VEGF↓, 8,   VEGFR2↓, 2,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 5,   COX2↑, 1,   CRP↓, 1,   HCAR1↓, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL12↓, 1,   IL2↓, 2,   IL6↓, 3,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 2,   JAK↓, 2,   JAK2↓, 2,   MCP1↓, 1,   NF-kB↓, 15,   PGE2↓, 1,   TLR4↝, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 22,   BioAv↝, 2,   ChemoSen↓, 1,   ChemoSen↑, 13,   Dose?, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 2,   eff↑, 13,   Half-Life↓, 4,   Half-Life↝, 3,   RadioS↑, 4,   selectivity↑, 2,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↓, 1,   CRP↓, 1,   EGFR↓, 2,   ERα/ESR1↓, 1,   EZH2↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↑, 2,   neuroP↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 1,  
Total Targets: 221

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 12,   ARE↑, 1,   Catalase↑, 2,   GSTs↑, 2,   HO-1↑, 4,   lipid-P↓, 5,   MDA↓, 5,   NRF2↑, 3,   ROS↓, 15,   SOD↑, 5,   mt-SOD↑, 1,   SOD1↑, 1,   TAC↑, 1,   Thiols↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT∅, 1,   AMPK↑, 1,   cytoP450↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   iNOS↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 1,   HATs↓, 1,   other↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   GSK‐3β↓, 2,   HDAC↑, 1,   neuroG↑, 2,   STAT↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   CRP↓, 1,   IL1↓, 2,   IL6↓, 2,   Inflam↓, 12,   Inflam↑, 1,   NF-kB↓, 6,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   GABA↑, 1,   MAOA↝, 1,   tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   NLRP3↓, 1,   NLRP3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 19,   BioAv↝, 4,   Dose↝, 1,   eff↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT∅, 1,   AST∅, 1,   BMD↑, 1,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 2,   AntiDiabetic↑, 2,   AntiTum↓, 1,   cardioP↑, 2,   cognitive↑, 4,   hepatoP↑, 3,   memory↑, 6,   neuroP↓, 1,   neuroP↑, 7,   Obesity↓, 1,   radioP↑, 2,   RenoP↝, 1,   toxicity?, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 2,  
Total Targets: 93

Scientific Paper Hit Count for: BioAv, bioavailability
49 Curcumin
21 EGCG (Epigallocatechin Gallate)
20 chitosan
18 Baicalein
17 Quercetin
17 Chlorogenic acid
16 Selenium NanoParticles
16 Resveratrol
16 Sulforaphane (mainly Broccoli)
15 Apigenin (mainly Parsley)
15 Berberine
15 Chrysin
14 Pterostilbene
13 Thymoquinone
11 Silymarin (Milk Thistle) silibinin
11 Lycopene
10 Alpha-Lipoic-Acid
10 Carvacrol
9 Astaxanthin
9 borneol
9 Honokiol
9 Rosmarinic acid
8 Capsaicin
8 Crocetin
8 Piperlongumine
8 Urolithin
7 Allicin (mainly Garlic)
7 Artemisinin
7 Betulinic acid
7 Luteolin
7 Phenethyl isothiocyanate
6 Silver-NanoParticles
6 Ashwagandha(Withaferin A)
6 Biochanin A
6 Thymol-Thymus vulgaris
6 Propolis -bee glue
6 Ellagic acid
6 Emodin
6 Eugenol
5 beta-glucans
5 Baicalin
5 Boswellia (frankincense)
5 Centella asiatica / Gotu kola → asiaticoside
5 Cucurbitacin
5 Piperine
5 Fisetin
5 Magnolol
5 Naringin
5 Selenite (Sodium)
4 1,8-Cineole
4 5-Hydroxytryptophan
4 Beta-Caryophyllene
4 Boron
4 Celastrol
4 Phenylbutyrate
4 Vitamin C (Ascorbic Acid)
4 Shikonin
4 Aflavin-3,3′-digallate
3 Ascorbyl Palmitate
3 Gold NanoParticles
3 Berbamine
3 Caffeic acid
3 Folic Acid, Vit B9
3 Chocolate
3 Rutin
3 Cinnamon
3 Hydroxycinnamic-acid
3 Coenzyme Q10
3 Copper and Cu NanoParticles
3 Diclofenac
3 Disulfiram
3 Ferulic acid
3 HydroxyTyrosol
3 Lecithin
3 Magnetic Fields
3 Niclosamide (Niclocide)
3 Selenium
3 Silicic Acid
3 Spermidine
3 Terpinen-4-ol / Tea Tree Oil
2 3-bromopyruvate
2 Auranofin
2 Astragalus
2 Citric Acid
2 Chemotherapy
2 Aspirin
2 Paclitaxel
2 Atorvastatin
2 immunotherapy
2 Radiotherapy/Radiation
2 Butyrate
2 Melatonin
2 Cynanbungeigenin C (CBC) and D (CBD)
2 Chlorophyllin
2 Choline
2 Camptothecin
2 Dasatinib/Phyrago
2 Dichloroacetate
2 Deguelin
2 D-limonene
2 Shilajit/Fulvic Acid
2 Gallic acid
2 Geraniol
2 Methyl salicylate / Sweet Birch oil
2 magnetic nanoparticles
2 nicotinamide adenine dinucleotide
2 Oleuropein
2 Turmerones
2 Ursolic acid
1 Aluminum
1 Anethole/trans-Anethole
1 Aromatherapy
1 Gemcitabine (Gemzar)
1 Aloe anthraquinones
1 doxorubicin
1 Docetaxel
1 xanthohumol
1 beta-carotene(VitA)
1 Bicalutamide
1 Bacopa monnieri
1 α-Bisabolol / Chamomile oil
1 Carnosic acid
1 urea
1 capecitabine
1 Catechins
1 Cat’s Claw
1 Cannabidiol
1 Zinc
1 irinotecan
1 Cyclopamine
1 Dichloroacetophenone(2,2-)
1 Dandelion Root
1 Echinacea
1 Electrical Pulses
1 Eurycomanone
1 Fenbendazole
1 flavonoids
1 Kaempferol
1 MCToil
1 Gambogic Acid
1 Genistein (soy isoflavone)
1 Germacranolide
1 Hydrogen Gas
1 HydroxyCitric Acid
1 itraconazole
1 Methylene blue
1 Metformin
1 Magnesium
1 Bicarbonate(Sodium)
1 Oleocanthal
1 Oxygen, Hyperbaric
1 Cisplatin
1 Psoralidin
1 Parthenolide
1 enzalutamide
1 salinomycin
1 Date Fruit Extract
1 cetuximab
1 Tomatine
1 Vitamin B3,Niacin
1 Vitamin D3
1 Vitamin E
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:792  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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