DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
4513- GLA,    Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines
- in-vitro, Liver, HUH7
TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,
4511- GLA,    Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study
- vitro+vivo, Nor, RAW264.7
*radioP↑, *ROS↓, *DNAdam↓, *IL6↓, *TNF-α↓, *IL10↓, *NF-kB↓, *SOD↑, *Catalase↑, *GSH↑,
7332- GSE,    The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials
- Review, Nor, NA
*BP↓, *eff↑, *ROS↓, *DNAdam↓, *cardioP↑, *eff↝,
7330- GSE,    Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
- Review, Var, NA
*BioAv↑, *ROS↓, AntiCan↑, selectivity↑, RenoP↑, *hepatoP↑, *DNAdam↓, *Stroke↓, *Bcl-2↑, cMyc↓,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓, *antiAll↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
292- HCA,    Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway
- in-vitro, AML, K562
ACLY↓, TumCG↓, AMPK↑, mTOR↑, UPR↑, eIF2α↑, ATF4↑, TumCCA↑, DNAdam↑,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
602- HCAs,    Prooxidant activity of hydroxycinnamic acids on DNA damage in the presence of Cu(II) ions: mechanism and structure-activity relationship
- Analysis, Var, NA
ROS↑, DNAdam↑,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7351- HibSad,    Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression
- in-vitro, AML, HL-60
tumCV↓, DNAdam↑, RB1↓, Bcl-2↓, BAX↑,
7350- HibSad,    Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway
- in-vitro, GC, AGS
TumCD↑, DNAdam↑, P53↑, Bcl-2↓, Mcl-1↓, Cyt‑c↑, FasL↑, Fas↑, p38↑, BAX↑, Dose↝, TumCCA↑,
7339- Hne,    Apoptosis-inducing activity of Helleborus niger in ALL and AML
- in-vitro, AML, NA
TumCP↓, DNAdam↓, Casp3↑, MMP↓, eff↑, Apoptosis↑,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
- Review, Var, NA
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
7622- HPT,    A Review of the Current Clinical Evidence for Loco-Regional Moderate Hyperthermia in the Adjunct Management of Cancers
- Review, Var, NA
LC↑, OS↑, QoL↑, toxicity↓, Dose↝, Dose↝, ROS↑, DNArepair↓, EPR↑, DNAdam↑, HSP70/HSPA5↑, BloodF↑, Hypoxia↓,
4644- HT,    The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells
- in-vitro, Melanoma, NA
tumCV↓, Apoptosis↑, P53↑, γH2AX↑, Akt↓, ROS↑, DNAdam↑,
7818- IBC,    Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma
- in-vitro, neuroblastoma, NA
TumCD↑, selectivity↑, Apoptosis↑, DNAdam↑, pro‑Casp3↑, pro‑Casp9↑, cl‑Casp3↑, cl‑Casp9↑, NA↑, BAX?,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7795- ISQ,    The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Nor, HaCaT
BioAv↑, TumCP↓, selectivity↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bcl-2↓, cl‑PARP↑, BAX↑, AIF↑, Endoglin↑, PI3K↓, Akt↓, mTOR↓,
7962- JG,    Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide
- in-vitro, Var, NA
Synergy↑, Pin1↓, *DNAdam↓,
5118- JG,    Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
m-ROS↑, DNAdam↑, Apoptosis↑, TumAuto↑, p38↑, MAPK↑, JNK↑, MMP↓, LC3II↑, Beclin-1/ATG6↑,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8060- KAE,    Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
TumCCA↑, DNAdam↑, ChrCon↑, cl‑Casp9↑, cl‑Casp3↑, cl‑Casp7↑, cl‑PARP↑, MPT↑, Cyt‑c↑, Bcl-xL↓, Bak↑, Akt↓, BAD↑, Casp↑, MMP↓,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8164- LapC,    Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II
- vitro+vivo, GBM, NA
TumCP↓, Apoptosis↑, DNAdam↑, TOP1↓, TOP2↓,
8176- Las,    In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model
- vitro+vivo, BC, NA
TumCCA↑, Apoptosis↑, DNAdam↑, TumMeta↓, PI3K↓, Akt↓, mTOR↓, STAT3↓, TumVol↓, toxicity↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8265- LE,    Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response
- vitro+vivo, CRC, NA
TumCG↓, Inflam↓, tumCV↓, DNAdam↑, Apoptosis↑, Casp3↑, TumCCA↑, cycD1/CCND1↓, HMGB1↓, NHEJ↓, TumCP↓,
8268- LE,    Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer
- vitro+vivo, CRC, NA
AntiTum↑, IL6↓, CCN2/CTGF↓, Inflam↓, HMGB1↓, DNAdam↓, CSCs↓, TLR4↓, NF-kB↓,
1787- LE,    Licorice and cancer
- Review, Var, NA
Inflam↓, AntiCan↓, DNAdam↓, LOX1↓, COX2/PTGS2↓, PKCδ↓, EGFR↓,
8199- LGE,    Citral is a new inducer of caspase-3 in tumor cell lines
- in-vitro, Var, NA
Dose↑, Apoptosis↑, DNAdam↑, Casp3↑,
8193- LGE,    Targets and pathways involved in the antitumor activity of citral and its stereo-isomers
- Review, Var, NA
TumCP↓, Apoptosis↑, ROS↑, DNAdam↑, MARK4↓, ALDH1A3↓, CSCs↓, chemoR↓, BioAv↓, selectivity↝,
8184- LGE,    Cytotoxicity of citral against melanoma cells: The involvement of oxidative stress generation and cell growth protein reduction
- in-vitro, Melanoma, B16-BL6 - in-vitro, Nor, HaCaT
TumCP↓, ROS↑, DNAdam↑, P53↝, NO↓, NF-kB↓, ERK↓, Akt↓, selectivity↑,
8317- LIN,    Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways
- in-vitro, Liver, HepG2
TumCP↓, TumCCA↑, CDK4↓, cycA1/CCNA1↓, P21↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, cl‑PARP↑, DNAdam↑, RAS↓, Akt↓, mTOR↓, ROS↑, MAPK↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
8346- Lut,    Lutein inhibits tumor progression through the ATR/Chk1/p53 signaling pathway in non-small cell lung cancer
- vitro+vivo, NSCLC, A549
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, DNAdam↑, ATR↑, CHK1↑, TumCG↓, OS↑,
8342- Lut,  Cisplatin,    Lutein Influences Cisplatin Sensitivity Through Differential Regulation of DNA Damage Response Genes in Breast Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
tumCV↓, DNAdam↑, selectivity↑, ROS↑, Casp3↑, BRCA1↓, Ku70/XRCC6↓, XRCC1↓, ChemoSen↑, NA↓,
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, Synergy↑,
1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
4777- Lyco,    Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells
- in-vitro, GC, AGS
*antiOx↑, tumCV↓, DNAdam↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, ROS↓, NF-kB↓, COX2/PTGS2↓, EGFR↓, p38↓,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
4794- Lyco,    Anticancer Effect of Lycopene in Gastric Carcinogenesis
- Review, GC, NA
*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,

Showing Research Papers: 251 to 300 of 452
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 452

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 7,   Catalase↑, 3,   Catalase∅, 1,   cystine↓, 1,   Fenton↑, 8,   GPx↓, 2,   GPx↑, 4,   GPx4↓, 5,   GSH↓, 30,   GSH↑, 5,   GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 2,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs∅, 1,   H2O2↓, 1,   H2O2↑, 14,   HO-1↓, 7,   HO-1↑, 7,   HO-2↓, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 4,   c-Iron↑, 1,   lipid-P↓, 4,   lipid-P↑, 19,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 3,   i-MDA↑, 1,   mt-NADH↓, 1,   NADPH/NADP+↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 12,   Prx4↑, 1,   PrxII↓, 1,   ROS↓, 22,   ROS↑, 253,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   i-ROS↑, 3,   m-ROS↑, 1,   mt-ROS↑, 6,   SOD↓, 6,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC?, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx↓, 4,   Trx↑, 1,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 10,   TrxR1↓, 2,   TrxR1⇅, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   NCOA4↑, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   ADP:ATP↑, 1,   BCR↓, 1,   CDC2↓, 3,   CDC25↓, 10,   CDC25↝, 1,   compI↓, 2,   EGF↓, 3,   ETC↓, 2,   ETC↝, 1,   Insulin↓, 2,   mitResp↓, 2,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 19,   OCR↓, 1,   mt-OCR↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 2,   PDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 2,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 3,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 17,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 22,   ATP↑, 1,   CRM↑, 1,   ECAR↓, 1,   ECAR↝, 1,   p‑ENO1↓, 1,   FASN↓, 2,   G6PD∅, 1,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlucoseCon∅, 1,   Glycolysis↓, 21,   GSK‐3β↓, 6,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   H2S↑, 1,   Histones↑, 2,   HK2↓, 8,   lactateProd↓, 9,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 6,   LDL↓, 2,   MCT4↓, 1,   NAD↓, 5,   NADPH↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 7,   PPP↓, 1,   Pyruv↓, 2,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 4,   SIRT1↑, 6,   SIRT2↓, 1,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 17,   APAF1↑, 6,   Apoptosis↓, 6,   Apoptosis↑, 208,   mt-Apoptosis↑, 4,   BAD↓, 1,   BAD↑, 8,   Bak↑, 4,   BAX?, 1,   BAX↓, 2,   BAX↑, 74,   Bax:Bcl2↑, 26,   Bcl-2↓, 74,   Bcl-2↑, 2,   Bcl-xL↓, 13,   Bcl-xL↑, 1,   BID↑, 3,   p‑BID↓, 1,   cl‑BID↑, 2,   BIM↑, 5,   Casp↓, 2,   Casp↑, 33,   Casp3↓, 3,   Casp3↑, 129,   cl‑Casp3↑, 19,   proCasp3↑, 1,   pro‑Casp3↑, 2,   Casp6↑, 1,   Casp7↑, 20,   cl‑Casp7↑, 2,   Casp8↑, 28,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 71,   cl‑Casp9↑, 11,   proCasp9↑, 1,   pro‑Casp9↑, 1,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 64,   Diablo↑, 8,   DR5↑, 6,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 13,   FasL↑, 5,   Ferroptosis↑, 8,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 8,   JWA↑, 1,   Mcl-1↓, 8,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 4,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 4,   Necroptosis↑, 5,   necrosis↑, 6,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 4,   p38↑, 13,   p‑p38↑, 2,   Paraptosis↑, 2,   PUMA↑, 4,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 23,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 32,   XIAP↓, 11,   YAP/TEAD↓, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 81,   Akt↑, 2,   p‑Akt↓, 17,   p‑Akt↑, 2,   Akt2↓, 1,   CK2↓, 2,   cMET↓, 1,   cSrc↓, 1,   DDIT4↑, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   ERK↓, 31,   ERK↑, 4,   p‑ERK↓, 5,   p‑ERK↑, 2,   FGFR1↓, 2,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   HRAS↓, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   JAK↓, 5,   p‑JAK↓, 1,   JAK1↓, 4,   JAK1↑, 1,   JAK2↓, 7,   JNK↓, 4,   JNK↑, 13,   p‑JNK↑, 2,   MAPK↓, 23,   MAPK↑, 10,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 3,   MKK4↓, 1,   mTOR↓, 41,   mTOR↑, 2,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC2↓, 2,   NRAS↓, 1,   p70S6↓, 2,   p‑p70S6↑, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 47,   PI3K↑, 4,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PIK3CA↓, 1,   PKCδ↓, 9,   cl‑PKCδ↑, 1,   PTEN↓, 1,   PTEN↑, 13,   Raf↓, 4,   RAS↓, 6,   RIP1↑, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 6,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 34,   STAT3↑, 2,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT5↓, 4,   STAT6↓, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 1,   cMyc↓, 23,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   FOXM1↓, 3,   FOXO↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   FOXO3↝, 1,   FOXO4↑, 2,   ac‑H3↑, 3,   H3K18↓, 1,   ac‑H4↑, 2,   HATs↓, 2,   HDAC↓, 7,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC8↓, 1,   miR-21↓, 2,   miR-210↓, 1,   miR-218↑, 1,   miR-27a-3p↓, 1,   miR-590-3p↑, 1,   Myc↓, 4,   n-MYC↓, 1,   OCT4↓, 7,   other↓, 1,   other↑, 9,   other↝, 9,   OV6↓, 1,   PhotoS↑, 2,   SOX2↓, 5,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   TCF-4↓, 2,   tumCV?, 1,   tumCV↓, 58,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 12,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 35,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 12,   HSF1↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   IRE1↑, 4,   NPL4↓, 1,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 10,   XBP-1↓, 1,   XBP-1↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2,   ATG5↑, 2,   ATG7↑, 1,   autoF↓, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 3,   LC3s↝, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 3,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 6,   p‑ATM↑, 1,   ATR↑, 3,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↓, 14,   DNAdam↑, 377,   mt-DNAdam↑, 2,   DNArepair↓, 3,   FEN1↓, 2,   HR↓, 1,   hTERT/TERT↓, 6,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   NHEJ↓, 1,   p16↑, 2,   P53↓, 3,   P53↑, 67,   P53↝, 3,   p‑P53↑, 5,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 13,   p‑PARP↑, 1,   cl‑PARP↓, 3,   cl‑PARP↑, 56,   cl‑PARP↝, 1,   PARP1↑, 3,   PCNA↓, 21,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 10,   TOP1↓, 6,   TOP1∅, 1,   TOP2↓, 8,   TP53↑, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 25,   p‑γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 3,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 24,   CDK2↑, 1,   CDK4↓, 26,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 11,   CDK6↑, 2,   CDK8↓, 1,   CHK1↓, 4,   CHK1↑, 2,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 5,   p‑Chk2↑, 1,   ChrCon↑, 3,   Cyc↓, 1,   cycA1/CCNA1↓, 6,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 54,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 19,   cycE1↓, 2,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↑, 2,   Ki-67↓, 12,   mitA↑, 3,   P21↓, 3,   P21↑, 55,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 20,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 3,   TumCCA↑, 166,   TumCCA∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7,   ALDH1A1↓, 2,   ALDH1A3↓, 1,   CD133↓, 7,   CD133↑, 1,   cFos↓, 7,   CSCs↓, 34,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 4,   FGF↓, 1,   Gli1↓, 4,   HH↓, 2,   IGF-1↓, 5,   IGF-2↓, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   Ki-67↓, 12,   mTORC1↓, 3,   p‑mTORC1↓, 1,   Nanog↓, 7,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 5,   NOTCH⇅, 1,   NOTCH1↓, 7,   NOTCH1↑, 2,   NOTCH2↓, 1,   p300↓, 1,   PTCH1↓, 3,   SCF↓, 1,   Shh↓, 2,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 63,   TumCG↑, 1,   TumCP↓, 97,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 20,   Wnt/(β-catenin)↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 6,   APC↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 26,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   CD11b↑, 1,   Cdc42↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 17,   EMT↓, 33,   EMT↑, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 3,   GLI2↓, 2,   ITGB1↑, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 42,   MMP3↓, 4,   MMP7↓, 6,   MMP9↓, 43,   MMPs↓, 10,   MUC4↓, 1,   N-cadherin↓, 11,   NCAM↑, 1,   NEDD9↓, 1,   PDGF↓, 1,   RECK↑, 1,   Slug?, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 7,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β↑, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 7,   TRIB3↑, 1,   TSC1↑, 1,   TumCA↓, 2,   TumCI↓, 34,   TumCMig↓, 37,   TumMeta↓, 42,   TumMeta↑, 1,   Twist↓, 5,   TXNIP↑, 1,   uPA↓, 8,   Vim↓, 14,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54,   angioG↑, 2,   CD31/PECAM-1↓, 1,   Endoglin↑, 2,   eNOS↓, 2,   HIF-1↓, 4,   Hif1a↓, 29,   Hif1a↑, 1,   Hypoxia↓, 2,   LOX1↓, 2,   NO↓, 4,   NO↑, 5,   VCAM-1↓, 3,   VEGF↓, 51,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   CellMemb↑, 4,   CLDN1↓, 1,   CTR1↑, 2,   EPR↑, 11,   GLUT1↓, 5,   GLUT2↓, 1,   MMP↓, 115,   MMP↑, 2,   MMP↝, 1,   MPT↓, 1,   MPT↑, 4,   NHE1↓, 1,   SVCT-2↝, 1,   SVCT-2∅, 1,   TRPM7↓, 2,   TRPV1↓, 1,   TRPV1↑, 1,   TRPV1↝, 1,   VGCC↑, 1,   VGSC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 34,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 7,   DR4↑, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 8,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 2,   IL4↓, 2,   IL4↑, 1,   IL6↓, 22,   IL8↓, 3,   Imm↑, 13,   Inflam↓, 19,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 65,   NF-kB↑, 7,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 3,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 14,   PSA↓, 2,   TCF↓, 1,   TCF↑, 1,   TLR4↓, 3,   TNF-α↓, 17,   TNF-α↑, 4,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↑, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 7,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PRL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 20,   BioAv↑, 24,   BioAv↝, 5,   BioEnh↑, 3,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen↓, 2,   ChemoSen↑, 114,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   DDS↑, 1,   Dose?, 6,   Dose↓, 5,   Dose↑, 7,   Dose↝, 34,   Dose∅, 10,   DrugR↓, 1,   eff↓, 48,   eff↑, 88,   eff⇅, 1,   eff↝, 12,   GSTA1↑, 2,   Half-Life↓, 5,   Half-Life↝, 5,   MDR1↓, 8,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 13,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 59,   selectivity?, 2,   selectivity↓, 2,   selectivity↑, 99,   selectivity↝, 1,   Synergy↑, 62,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 1,   AR↓, 7,   AST↓, 1,   BG↓, 2,   BloodF↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↓, 2,   FOXM1↓, 3,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 6,   IL6↓, 22,   KRAS↓, 1,   LDH↓, 6,   LDH↑, 2,   LDH↝, 1,   Myc↓, 4,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 2,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 42,   AntiCan∅, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 11,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 6,   ChemoSideEff↓, 5,   hepatoP↑, 4,   K17↓, 1,   LC↑, 1,   neuroP↑, 3,   NKG2D↑, 1,   NP/CIPN↓, 1,   NP/CIPN↝, 1,   OS↑, 13,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 7,   RenoP↑, 4,   Risk↓, 10,   Strength↑, 1,   toxicity↓, 11,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 13,   TumW↓, 4,   Weight↑, 2,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,   Sepsis↓, 2,  
Total Targets: 831

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 57,   Bil↓, 1,   Catalase↑, 28,   DPPH↓, 1,   Fenton↓, 1,   GPx↑, 21,   GPx1↑, 2,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 24,   GSR↑, 2,   GSTs↑, 9,   H2O2↓, 1,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 4,   HO-1↑, 17,   Keap1↓, 1,   lipid-P↓, 22,   lipid-P↑, 1,   MDA↓, 20,   MPO↓, 3,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 20,   p‑NRF2↑, 1,   Prx↑, 1,   RNS↓, 3,   ROS?, 1,   ROS↓, 75,   ROS↑, 3,   ROS∅, 4,   selenoP↑, 5,   SOD↓, 2,   SOD↑, 31,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 2,   Trx1↑, 1,   uricA↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   FIS1↓, 1,   mtDam↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 4,   ACC↓, 1,   ALAT↓, 7,   AMPK↑, 2,   Buty↑, 1,   DGAT1↓, 1,   FASN↓, 2,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 2,   HMG-CoA↓, 1,   LDL↓, 6,   lipidLev↓, 1,   NADPH↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   BAX↓, 7,   Bax:Bcl2↓, 1,   Bcl-2↑, 5,   Bcl-xL↑, 1,   Casp↓, 1,   Casp3↓, 7,   cl‑Casp3↓, 1,   Casp9↓, 2,   Cyt‑c↓, 2,   iNOS↓, 10,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,   p38↑, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   ERK↓, 2,   ERK↑, 3,   IκB?, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↑, 1,   STAT3↓, 2,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   p‑cJun↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 4,   other↑, 4,   other↝, 3,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

CTSZ↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 63,   DNAdam↑, 3,   DNAdam∅, 1,   DNArepair↑, 2,   SIRT6↑, 2,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↓, 1,   Ki-67↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   FGF↑, 1,   Ki-67↓, 2,   TumCG↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 3,   Ca+2↝, 1,   COL1↓, 1,   COL1↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 1,   MUC1↑, 1,   ROCK1↓, 2,   Snail↑, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↑, 1,   Vim↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 5,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↑, 3,   MUC19↓, 1,   MUC2↓, 1,   TJ↑, 1,   VGCC↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD25+↑, 1,   CD4+↑, 2,   cGAS–STING↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 16,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 5,   IL17↓, 3,   IL1α↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL22↓, 2,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 19,   IL6↑, 1,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 70,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 4,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 19,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 4,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 2,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR1↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 23,   TNF-α↑, 1,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 6,   AChE↑, 1,   AChE↝, 1,   BChE↓, 2,   BDNF↑, 6,   GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   Aβ↓, 7,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GLP-1R↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 25,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 2,   CompStab↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose?, 2,   Dose↓, 2,   Dose↑, 2,   Dose↝, 19,   Dose∅, 1,   eff↓, 1,   eff↑, 16,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 2,   Half-Life∅, 1,   P450↓, 1,   P450↑, 1,   RadioS↑, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALB↑, 1,   ALB↝, 1,   ALP↓, 3,   AST↓, 8,   BG↓, 1,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 5,   BUN↓, 2,   creat↓, 3,   CRP↓, 4,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 19,   IL6↑, 1,   LDH↓, 2,   NOS2↓, 1,   RAGE↓, 2,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 6,   AntiArt↑, 4,   AntiCan↑, 13,   AntiDiabetic↑, 16,   AntiTum↑, 1,   Bone Healing↑, 1,   cardioP↑, 19,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 10,   diuretic↑, 2,   hepatoP↑, 20,   memory↑, 11,   Mood↑, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 27,   Obesity↓, 4,   OS↑, 3,   Pain↓, 3,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 11,   RenoP↑, 7,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity?, 2,   toxicity↓, 27,   toxicity↝, 6,   toxicity∅, 6,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 4,   AntiViral↑, 5,   Bacteria↓, 15,   Diar↓, 1,   GutMicro↑, 8,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 4,  
Total Targets: 339

Scientific Paper Hit Count for: DNAdam, DNA damage
33 Silver-NanoParticles
19 Radiotherapy/Radiation
17 Vitamin C (Ascorbic Acid)
14 Magnetic Fields
12 Curcumin
11 Fisetin
9 Cisplatin
8 Quercetin
8 Lycopene
7 Chemotherapy
7 Ashwagandha(Withaferin A)
7 doxorubicin
7 Chrysin
7 salinomycin
7 Selenium NanoParticles
7 Sulforaphane (mainly Broccoli)
6 Artemisinin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 Gallic acid
5 Kaempferol
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Ferulic acid
4 Garcinol
4 Licorice
4 Magnolol
4 Magnetic Field Rotating
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 chitosan
3 Moringa oleifera
3 Anethole/trans-Anethole
3 Melatonin
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Cat’s Claw
3 Cynaropicrin
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Hibiscus sabdariffa
3 Juglone
3 Lemongrass Extract/Citral
3 Lutein
3 mebendazole
3 Nimbolide
3 Marjoram (Origanum majorana)
3 Phenethyl isothiocyanate
3 Phycocyanin
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Metformin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Fucoidan
2 Gambogic Acid
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Hydrogen Gas
2 Hydroxycinnamic-acid
2 isoorientin
2 methylseleninic acid
2 Morin
2 Mucuna pruriens/Velvet Bean
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 buckwheat sprouts
1 Rutin
1 Zinc
1 carboplatin
1 Catechins
1 chaetocin
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Sesame seeds and Oil
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Germanium inorganic
1 Ginkgetin
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 Hyperthermia
1 HydroxyTyrosol
1 Isobavachalcone
1 isoquercitrin
1 Lapachol
1 Lasiodin
1 Linalool
1 Luteolin
1 MCT, metronomic chemo
1 Methyl salicylate / Sweet Birch oil
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Aromatherapy
1 5-fluorouracil
1 Piperine
1 Plumbagin
1 Rauwolfia serpentina/Indian Snakeroot
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 triptolide
1 Urolithin
1 Iron
1 Magnesium
1 Vitexin
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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