GSH Cancer Research Results

GSH, Glutathione: Click to Expand ⟱
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Glutathione (GSH) is a thiol antioxidant that scavenges reactive oxygen species (ROS), resulting in the formation of oxidized glutathione (GSSG). Decreased amounts of GSH and a decreased GSH/GSSG ratio in tissues are biomarkers of oxidative stress.
Glutathione is a powerful antioxidant found in every cell of the body, composed of three amino acids: cysteine, glutamine, and glycine. It plays a crucial role in protecting cells from oxidative stress, detoxifying harmful substances, and supporting the immune system.
cancer cells can have elevated levels of glutathione, which may help them survive in the oxidative environment created by the immune response and chemotherapy. This can make cancer cells more resistant to treatment.
While glutathione can be obtained from certain foods (like fruits, vegetables, and meats), its absorption from supplements is debated. Some people take N-acetylcysteine (NAC) or other precursors to boost glutathione levels, but the effects on cancer prevention or treatment are still being studied.
Depleting glutathione (GSH) to raise reactive oxygen species (ROS) is a strategy that has been explored in cancer research and therapy.
Many cancer cells have altered redox states and may rely on GSH to survive. Increasing ROS levels can induce stress in these cells, potentially leading to cell death.
Certain drugs and compounds can deplete GSH levels. For example, agents like buthionine sulfoximine (BSO) inhibit the synthesis of GSH, leading to its depletion.
Cancer cells tend to exhibit higher levels of intracellular GSH, possibly as an adaptive response to a higher metabolism and thus higher steady-state levels of reactive oxygen species (ROS).

"...intracellular glutathione (GSH) exhibits an astounding antioxidant activity in scavenging reactive oxygen species (ROS)..."
"Cancer cells have a high level of GSH compared to normal cells."
"...cancer cells are affluent with high antioxidant levels, especially with GSH, whose appearance at an elevated concentration of ∼10 mM (10 times less in normal cells) detoxifies the cancer cells." "Therefore, GSH depletion can be assumed to be the key strategy to amplify the oxidative stress in cancer cells, enhancing the destruction of cancer cells by fruitful cancer therapy."

The loss of GSH is broadly known to be directly related to the apoptosis progression.
Scientific Papers found: Click to Expand⟱
7561- HYP,    Hyperoside Exerts Therapeutic Effects on Parkinson's Disease by Mitigating Oxidative Stress through Activation of Nrf2/HO-1 Pathway
- in-vivo, Park, NA
*motorD↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *BAX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *MDA↓, *Apoptosis↓,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7803- IBC,    Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response
- in-vivo, Nor, NA - in-vitro, NA, HepG2
*hepatoP↓, *ALAT↑, *AST↑, *ROS↑, *MDA↑, *Catalase↓, *GSH↓, *GPx↓, *i-Iron↑,
7759- ISL,  Rad,    Isoliquiritigenin, a Bioactive Blood Component Derived from Licorice, Activates Nrf2 Enzymes to Confer Protection Against Radiation-Induced Nerve Injury
- vitro+vivo, Nor, PC12
*radioP↑, *LDH↓, *ROS↓, *SOD1↑, *GSH↑, *TAC↑, *NRF2↓, *cognitive↑, *Learn↑, *memory↑,
7789- ISL,    Cancer Chemopreventive Activity and Metabolism of Isoliquiritigenin, a Compound Found in Licorice
- Review, Nor, NA
*GSH↑, *GSTs↑, *chemoPv↑,
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,
7878- isoO,  Cisplatin,    Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *chemoP↑, *SIRT1↑, *SIRT6↑, *NRF2↑, *HO-1↑, *NQO1↑, *NOX4↓, *ROS↓, *MPO↓, *MDA↓, *SOD↑, *GSH↑,
7871- isoO,  Cisplatin,    Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
- vitro+vivo, Lung, NA
ChemoSen↑, i-Iron↑, i-MDA↑, *i-ROS↑, GSH↓, Ferroptosis↑, NRF2↓, GPx4↓, SIRT6↓,
7813- ISQ,    Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress
- in-vivo, Stroke, NA
*Apoptosis↓, *ROS↓, *SOD↑, *GSH↑, *Catalase↑, *NRF2↑, *HO-1↑, *MDA↓, *NGB↑, *neuroP↑,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,
8153- JG,    Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes
- in-vitro, Nor, HaCaT
*tumCV↓, *GSH↓, *ROS↑,
5113- JG,    Juglone in Oxidative Stress and Cell Signaling
- Review, Var, NA - Review, AD, NA
ROS↑, Pin1↓, antiOx⇅, *ROS↓, SMAD2↓, GSH↓, lipid-P↑, TumCCA↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Ca+2↑, Cyt‑c↑, AntiFungal↑, Bacteria↓, Akt↓,
5114- JG,    Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism
- in-vitro, AML, HL-60
ROS↑, GSH↓, eff↓, cl‑PARP↑, proCasp3↑, proCasp9↑, MMP↓, Cyt‑c↑, Diablo↑,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
5098- JG,    Effects of Juglone on Antioxidant Status in Pancreatic Cancer Cell Lines
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
tumCV↓, ROS↑, GSH⇅,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
5116- JG,    Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells
- in-vitro, Melanoma, B16-BL6
GSH↓, ROS↑, chemoPv↑,
1921- JG,    Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis
- in-vitro, PC, NA - vitro+vivo, PC, NA
TumCG↓, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, FOSL1↑, HO-1↑,
8086- KAE,    Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety
- Review, Nor, NA
*hepatoP↑, *BioAv↝, *CYP2E1↓, *antiOx↑, *AST↓, *ALAT↓, *ROS↓, *lipid-P↓, *SIRT1↑, *GSH↑, *SOD↑, *p‑SMAD2↓, *p‑SMAD3↓, *COL1↓, *other↝,
8069- KAE,    Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *Learn↑, *memory↑, *SOD↑, *GSH↑, *TNF-α↓, *MDA↓,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8054- KAE,    Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway
- vitro+vivo, AD, NA
*AKR1B10↝, *MDA↓, *ROS↓, *GSH↑, *SOD↑, *GPx4↑, *NQO1↑, *xCT/SLC7A11↑, *NRF2↑, *HO-1↑, *cognitive↑, *Aβ↓, *p‑tau↓, *Ferroptosis↓, *AKR1C3/17β-HSD5/PGF Synthase↑, *AKR1B1/ALR2↑,
8169- Lap,    Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells
- in-vitro, Liver, HepG2
toxicity↑, mtDam↑, ROS↑, NRF2↑, GSH↑, GSSG↑, SOD2↑,
8167- LapC,    Characterization of lapachol cytotoxicity: contribution of glutathione depletion for oxidative stress in Saccharomyces cerevisiae
- in-vitro, Nor, NA
*GSH↓, *SOD1↓, *lipid-P↑, *ROS↑,
8254- LCA,  Geld,    Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation
- in-vitro, Ovarian, NA
MMP↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, ROS↑, GSH↓, eff↓,
8256- LCA,    Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice
- in-vivo, Colon, CT26
TumVol?, TumCP↓, *RenoP↑, *creat↓, BUN↓, hepatoP↑, *ALAT↓, *AST↓, *NO↓, *lipid-P↓, *GSH↑, chemoP↑, Dose↝,
8223- LCA,    Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells
- in-vitro, Nor, RAW264.7
*Apoptosis↓, *ROS↓, *GSH↑, *GCLM↑, *GCLC↑, *HO-1↑, *NRF2↑, *Keap1↓, *ARE↑, *Akt↑, *ERK↑, *PI3K↑,
8129- LF,    Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy
- Trial, CRC, NA
Dose↝, toxicity↓, INF-γ↝, other↑, *ROS↓, Imm↑, WBC↑, Neut↑, T-Cell↑, *antiOx↑, *GSH↑, *chemoP↑, *RenoP↑, *hepatoP↑, BUN↓, creat↓, ALAT↓, AST↓, RBC↑, PC↑, Mucositis↓, *AntiBio↑, *AntiViral↑, *AntiFungal↑, *Inflam↓,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8183- LGE,    Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCG↓, selectivity↑, MMP↓, ROS↑, GSH↓, eff↓, p‑P53↑, BAX↑, Bcl-2↓, Bcl-xL↓, cl‑Casp3↑,
8295- lign,    Distribution, biosynthesis and therapeutic potential of lignans
- Review, Var, NA
*Ingr?, *BioAv↝, *antiOx↑, *AntiCan↑, *Inflam↓, *other?, Dose↝, AntiTum↑, pS2/TFF1↓, Bcl-2↓, IGF-1R↓, *radioP↑, *HO-1↑, GSTM1↑, NQO1↑, ChemoSen↑, *AntiDiabetic↑, *glucose↓, *GSH↑, *SOD↑, *MDA↓, *NO↓, *Bacteria↓, *AntiFungal↑,
8332- LIN,    Linalool decreases HepG2 viability by inhibiting mitochondrial complexes I and II, increasing reactive oxygen species and decreasing ATP and GSH levels
- in-vitro, Liver, HepG2 - in-vitro, Colon, Caco-2 - in-vitro, NA, NIH-3T3 - in-vitro, BC, MCF7 - in-vitro, Nor, HEK293
compI↓, compII↓, ATP↓, GSH↓, ROS↑,
8327- LIN,    Recent updates on bioactive properties of linalool
- Review, Var, NA
*AntiCan↑, *AntiBio↑, *neuroP↑, *Stress↓, *hepatoP↑, *RenoP↑, *ROS↓, ROS↑, *Inflam↓, *toxicity↓, TumCP↓, TumCCA↑, mtDam↑, MMP↓, compI↓, compII↓, ETC↓, ATP↓, angioG↓, ChemoSen↑, *GSH↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ALAT↓, *AST↓, chemoP↑,
8326- LIN,    Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development
- Review, Var, NA
Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,
8320- LIN,    Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways
- in-vivo, Nor, NA
RenoP↑, Dose↝, *TLR4↓, *MyD88↓, *TRIF↓, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *chemoP↑, *Casp3↓, *Casp9↓, *BAX↓, *Bcl-2↑, ChemoSen↑, *cardioP?, *hepatoP↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *ROS↓, *BUN?, *creat↓, *GSH↑, *SOD↑, *Catalase↑, *MDA↓, *NADPH↓, *NRF2↑, *HO-1↑,
8382- LT,    Luteolin as a dietary flavonoid for brain health: modulating neuroinflammation and cognitive decline in neurodegenerative disorders
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *NF-kB↓, *NRF2↑, *BDNF↑, *cognitive↑, *motorD↑, *BBB↑, *BioAv↓, *NO↓, *ROS↓, *NRF2↑, *ARE↑, *MMP↑, *BDNF↑, *Learn↑, *memory↑, *cognitive↑, *p‑JNK↓, *GFAP↓, *AIF1/Iba-1↓, *TNF-α↓, *IL1β↓, *BAX↓, *COX2/PTGS2↓, *BACE/β-secretase↓, *Aβ42↓, *PSD95↑, *SNAP25↑, *lipid-P↓, *GSTs↓, *GSH↑, *SOD↓, *Catalase↓, *AChE↓, *Casp3↓, *Casp9↓,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8370- LT,    Luteolin Induces GPX4-dependent Ferroptosis and Enhances Immune Activation in Colon Cancer
- vitro+vivo, Colon, NA
TumCP↓, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, Ferroptosis↑, pol-M1↑, CD8+↑, Imm↑,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8403- LT,    Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
- in-vitro, CRC, HT-29
tumCV↓, selectivity↑, Apoptosis↑, Casp↑, MMP↓, Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, ROS↓, SOD↑, Catalase↑, GSH↑, antiOx↑, MAPK↑,
8399- LT,    Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *cognitive↑, *neuroP↑, *Aβ↓, *mtDam↓, *Apoptosis↓, *PPARγ↑, *ROS↓, *SOD↑, *GSH↑, *NRF2↑, *MFN2↑, *DRP1/DNM1L↓, *FIS1↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *cl‑Casp9↓, *cl‑Casp3↓, *IDE↑, *BACE/β-secretase↓, *Aβ42↓,
2588- LT,  Chemo,    Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway
- in-vitro, CRC, HCT116
NRF2↓, NQO1↓, HO-1↓, GSH↓, ChemoSen↑,
2587- LT,    Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
- in-vitro, Lung, A549
NRF2↓, GSH↓, ChemoSen↑, HO-1↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2904- LT,    Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons
- in-vitro, Park, SK-N-SH - in-vitro, AD, NA
*ROS↓, *neuroP↑, *MMP↑, *Catalase↑, *GSH↑, selectivity↑, *eff↑, *Cyt‑c↓,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,

Showing Research Papers: 301 to 350 of 640
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 640

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 5,   antiOx↑, 13,   antiOx⇅, 1,   Catalase↓, 26,   Catalase↑, 15,   Copper↑, 1,   cystine↓, 1,   Fenton↑, 11,   GCLM↑, 2,   GPx↓, 11,   GPx↑, 16,   GPx1↓, 1,   GPx1⇅, 1,   GPx4↓, 46,   GPx4↑, 1,   GSH?, 1,   GSH↓, 272,   GSH↑, 38,   GSH⇅, 2,   GSH↝, 2,   GSH∅, 3,   i-GSH↓, 1,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 8,   GSR↓, 3,   GSR↑, 5,   GSSG↓, 1,   GSSG↑, 7,   GSTs↓, 2,   GSTs↑, 8,   H2O2↓, 3,   H2O2↑, 16,   mt-H2O2↑, 1,   HO-1↓, 9,   HO-1↑, 18,   HO-1⇅, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 31,   Iron↝, 2,   i-Iron↑, 4,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 8,   lipid-P↑, 43,   lipid-P↝, 1,   MDA?, 1,   MDA↓, 12,   MDA↑, 41,   i-MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 3,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 26,   NRF2↑, 28,   NRF2⇅, 1,   NRF2∅, 1,   Prx4↑, 1,   PYCR1↓, 1,   RNS↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 29,   ROS↑, 267,   ROS⇅, 6,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 20,   SOD1↑, 3,   SOD2↓, 3,   SOD2↑, 3,   T-SOD↓, 1,   TAC↓, 3,   TBARS↓, 1,   TBARS↑, 4,   Thiols↓, 7,   i-Thiols↓, 1,   TOS↑, 1,   Trx↓, 6,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 11,   TrxR1?, 1,   TrxR1↓, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 21,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 5,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 4,   Mets↑, 1,   NCOA4↑, 3,   Zn2+↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↝, 1,   compI↓, 5,   compII↓, 3,   compIII↓, 2,   compV↓, 1,   EGF↓, 2,   ETC↓, 6,   Insulin↓, 3,   mitResp↓, 6,   mtDam↓, 1,   mtDam↑, 20,   OCR↓, 2,   OCR↑, 2,   OXPHOS↓, 3,   OXPHOS↑, 1,   mt-OXPHOS↓, 2,   PDH↓, 1,   PDH↑, 1,   SDH↓, 1,   SIRT3↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↑, 4,   ALAT↓, 7,   AMP↑, 1,   AMPK↑, 12,   p‑AMPK↑, 1,   ATP↓, 25,   ATP↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 3,   FDG↓, 1,   G6PD↓, 3,   GAPDH↓, 4,   GLO-I↓, 1,   GLS↓, 2,   glucose↓, 3,   GlucoseCon↓, 5,   GlucoseCon∅, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 26,   GSK‐3β↓, 5,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 14,   lactateProd↓, 7,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 2,   LDL↓, 2,   MethCyc↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 2,   PDK1 / PDPK1↓, 2,   PFKP↓, 2,   PKM2↓, 7,   polyA↓, 1,   PPP↓, 1,   PPP↑, 1,   Pyruv↓, 1,   RNR↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 5,   SIRT2↑, 1,   SREBP2↓, 1,   TCA↓, 4,   TCA↑, 1,   TS↓, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 3,   Apoptosis↓, 5,   Apoptosis↑, 138,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 7,   Bak↓, 1,   Bak↑, 5,   BAX↓, 4,   BAX↑, 78,   Bax:Bcl2↑, 14,   Bcl-2↓, 78,   Bcl-2↑, 3,   Bcl-xL↓, 15,   Bcl-xL↑, 1,   BID↑, 4,   BIM↓, 1,   BIM↑, 3,   BNIP3↝, 1,   BOK↑, 1,   Casp↑, 15,   Casp↝, 1,   Casp1↓, 1,   Casp10↑, 1,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 100,   cl‑Casp3↓, 1,   cl‑Casp3↑, 12,   cl‑Casp3∅, 1,   proCasp3↑, 3,   Casp6↑, 1,   Casp7↑, 16,   cl‑Casp7↑, 1,   Casp8↑, 26,   cl‑Casp8↑, 2,   Casp9↓, 2,   Casp9↑, 57,   cl‑Casp9↓, 1,   cl‑Casp9↑, 7,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 58,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 12,   FADD↑, 3,   Fas↑, 15,   FasL↑, 3,   Ferroptosis↓, 2,   Ferroptosis↑, 57,   GranB/GZMB↝, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 9,   Mcl-1↓, 7,   MDM2↓, 3,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 5,   p38↑, 14,   p‑p38↑, 3,   Paraptosis↑, 1,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 4,   Pyro↑, 2,   RIP1↑, 3,   RIP3↑, 3,   survivin↓, 19,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 16,   XIAP↓, 18,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 65,   Akt↑, 4,   p‑Akt↓, 13,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 3,   BRAF↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 12,   EGFR↑, 2,   ERK↓, 29,   ERK↑, 4,   p‑ERK↓, 3,   p‑ERK↑, 1,   FGFR1↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 4,   IKKα↓, 5,   IKKα↑, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 5,   JNK↓, 3,   JNK↑, 13,   p‑JNK↓, 1,   p‑JNK↑, 3,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 15,   MAPK↑, 15,   MAPK↝, 2,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   MEK↓, 1,   p‑MEK↓, 2,   mTOR↓, 36,   p‑mTOR↓, 4,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 41,   PI3K↑, 2,   PI3K↝, 1,   p‑PI3K↓, 4,   PI3K/Akt↓, 1,   PI3K/Akt⇅, 1,   PI3K/Akt↝, 1,   PKCδ↓, 4,   PTEN↓, 2,   PTEN↑, 7,   PTEN↝, 1,   Raf↓, 6,   RAS↓, 6,   RAS↑, 1,   RET↓, 1,   Sp1/3/4↓, 8,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 35,   p‑STAT3↓, 7,   STAT6↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF3↑, 2,   ATF4↑, 9,   ATF4↝, 1,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 25,   DNMT1↓, 4,   DNMT1↑, 1,   DNMT3B↓, 1,   DNMTs↓, 3,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 3,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   ac‑H3↓, 1,   H4↓, 1,   ac‑H4↓, 1,   HATs↑, 1,   HDAC↓, 14,   HDAC1↓, 5,   HDAC2↓, 4,   HDAC3↓, 3,   HDAC8↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-22↑, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 3,   miR-384↑, 1,   miR-422a↑, 1,   Myc↓, 1,   MYCN↓, 1,   OCT4↓, 5,   other↓, 7,   other↑, 8,   other⇅, 1,   other↝, 6,   PAX2↓, 1,   PhotoS↑, 3,   SALL4↓, 1,   sonoS↑, 3,   SOX2↓, 6,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 1,   tumCV?, 1,   tumCV↓, 40,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↑, 17,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 3,   ER Stress↑, 29,   GRP78/BiP↑, 8,   HSP27↓, 3,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP90↓, 6,   HSPs↑, 1,   IRE1↑, 2,   PERK↑, 6,   p‑PERK↑, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 10,   p‑Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 8,   LC3s↑, 1,   p62↓, 5,   p62↑, 2,   TumAuto↑, 17,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 46,   mt-DNAdam↑, 1,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 2,   p16↑, 1,   P53↓, 4,   P53↑, 66,   P53↝, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 2,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 32,   cl‑PARP∅, 1,   PARP1↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 21,   SIRT6↓, 2,   Telomerase↓, 5,   TOP1↓, 1,   TOP1∅, 1,   TOP2↓, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK1↑, 4,   CDK1↝, 1,   CDK2↓, 16,   CDK2↑, 2,   CDK4↓, 21,   CDK4↑, 1,   CDK6↓, 7,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 2,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 15,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 35,   cycE/CCNE↓, 9,   GADD45A↑, 2,   Ki-67↓, 21,   mitA↑, 2,   P21↓, 3,   P21↑, 41,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 15,   pRB↓, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 108,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 3,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 15,   Diff↑, 2,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   FGF↓, 2,   FOSL1↑, 1,   GDF15↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGFBP3↑, 2,   Ki-67↓, 21,   mTORC1↓, 2,   Nanog↓, 6,   Nestin↓, 1,   NOTCH↓, 3,   NOTCH1↓, 8,   SCF↓, 1,   Shh↓, 3,   STAT1↓, 1,   TumCG↓, 68,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 94,   Wnt↓, 12,   Wnt↝, 1,   Zn2+↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 6,   ASAP2↓, 1,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 3,   Ca+2↑, 15,   Ca+2↝, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   CD11b↑, 1,   Cdc42↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 16,   EMT↓, 35,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 2,   FAK↓, 4,   p‑FAK↓, 1,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB6↓, 1,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 2,   LRP1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 38,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 40,   MMP9↑, 1,   MMPs↓, 17,   MTA1↓, 1,   MUC1-C↓, 1,   MUC4↓, 1,   N-cadherin↓, 15,   PCBP1↓, 1,   PDGF↓, 1,   proline↓, 1,   Rac1↓, 1,   Rho↓, 1,   Rho↝, 1,   ROCK1↓, 1,   Slug↓, 5,   Smad1↑, 1,   SMAD2↓, 1,   Snail↓, 8,   TET1↑, 1,   TGF-β↓, 3,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   TIMP3↑, 1,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↑, 1,   TumCI↓, 38,   TumCMig↓, 39,   TumCMig↑, 1,   TumMeta↓, 29,   TumMeta↑, 4,   TumPF↓, 1,   Twist↓, 8,   Tyro3↓, 1,   uPA↓, 6,   uPAR↓, 2,   Vim↓, 16,   Vim↑, 1,   Zeb1↓, 4,   ZEB2↓, 1,   β-catenin/ZEB1↓, 21,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 42,   CD31/PECAM-1↓, 3,   EGR1↑, 1,   EGR4↓, 1,   HIF-1↓, 1,   HIF-1↑, 1,   Hif1a↓, 27,   LOX1↓, 1,   NO↓, 4,   NO↑, 10,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 43,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CTR1↑, 1,   EPR↑, 1,   GLUT1↓, 5,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   MMP?, 1,   MMP↓, 93,   MMP↑, 2,   MPT↑, 1,   OCLN↑, 1,   SLC12A5↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↝, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↑, 1,   CD44↓, 8,   CD8+↑, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 44,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 9,   DR4↑, 3,   FOXP3↓, 1,   HMGB1↓, 4,   ICAM-1↓, 4,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 2,   IL10↑, 2,   IL12↓, 1,   IL12↑, 1,   IL1β↓, 10,   IL1β↑, 2,   IL2↓, 3,   IL2↑, 4,   IL4↓, 1,   IL4↑, 2,   IL6↓, 27,   IL8↓, 10,   Imm↑, 8,   INF-γ↝, 1,   Inflam↓, 22,   LRIG1↑, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   Neut↑, 1,   NF-kB↓, 77,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NK cell↑, 7,   NLRP3↓, 4,   NLRP3↑, 1,   p50↓, 2,   p65↓, 4,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 8,   PGE1↓, 1,   PGE2↓, 11,   PSA↓, 8,   PSA∅, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR1↑, 1,   TLR4↓, 4,   TLR4↝, 1,   TNF-α↓, 26,   TNF-α↑, 6,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↝, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 2,   AR↓, 9,   ER-α36↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 1,   BioAv↓, 19,   BioAv↑, 13,   BioAv↝, 10,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 108,   CompStab↓, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 36,   Dose∅, 4,   eff?, 1,   eff↓, 51,   eff↑, 65,   eff↝, 5,   GSTA1↓, 1,   GSTA1↑, 1,   GSTM1↑, 1,   GSTP1/GSTπ↓, 2,   Half-Life?, 1,   Half-Life↓, 4,   Half-Life↝, 7,   Half-Life∅, 1,   MDR1↓, 4,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 13,   P-gp/ABCB1↑, 1,   P450↓, 3,   RadioS↓, 1,   RadioS↑, 38,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 71,   Synergy↑, 50,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 7,   ALP↓, 2,   AR↓, 9,   AST↓, 4,   BMD↑, 1,   BP↓, 1,   BRAF↑, 1,   BRAF↝, 1,   BRCA1↑, 1,   BUN↓, 3,   CEA↓, 2,   creat↓, 3,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 12,   EGFR↑, 2,   ERα/ESR1↓, 1,   EZH2↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 27,   KRAS↓, 2,   LDH↓, 8,   LDH↑, 4,   LDH↝, 1,   Myc↓, 1,   NSE↓, 1,   PC↑, 1,   PD-L1↓, 8,   PSA↓, 8,   PSA∅, 1,   RAGE↓, 1,   RBC↑, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   Urea↓, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 43,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↑, 9,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 9,   CardioT↓, 1,   chemoP↑, 29,   chemoPv↑, 14,   ChemoSideEff↓, 7,   cognitive↑, 5,   fatigue↓, 1,   fatigue∅, 1,   hepatoP↑, 15,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 11,   NP/CIPN↓, 1,   OS↓, 1,   OS↑, 15,   Pain↓, 2,   Pin1↓, 2,   QoL↑, 4,   QoL∅, 1,   radioP↑, 8,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 3,   toxicity↓, 6,   toxicity↑, 4,   toxicity↝, 2,   TumVol?, 1,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 3,   GutMicro↑, 2,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 889

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 1,   antiOx↓, 9,   antiOx↑, 162,   ARE↑, 4,   Bil↓, 1,   Catalase↓, 7,   Catalase↑, 132,   Catalase↝, 1,   Copper↓, 2,   Fenton↓, 3,   GCLC↑, 3,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 84,   GPx↝, 1,   GPx∅, 1,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 7,   GSH↓, 17,   GSH↑, 321,   GSH⇅, 1,   GSH∅, 2,   GSH/GSSG↓, 1,   GSH/GSSG↑, 2,   GSR↓, 3,   GSR↑, 19,   GSS↑, 1,   GSSG↓, 5,   GSSG∅, 1,   GSTs↓, 4,   GSTs↑, 28,   H2O2↓, 12,   H2O2↑, 1,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 6,   HNE↓, 1,   HO-1↓, 4,   HO-1↑, 87,   HO-1⇅, 1,   HO-2↓, 1,   Iron↓, 3,   Iron↝, 1,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 7,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 97,   lipid-P↑, 3,   MDA↓, 136,   MDA↑, 7,   MPO↓, 15,   MPO↑, 1,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 3,   NQO1↑, 21,   Nrf1↑, 3,   NRF2↓, 6,   NRF2↑, 144,   NRF2⇅, 1,   Prx↑, 5,   RNS↓, 3,   ROS?, 2,   ROS↓, 263,   ROS↑, 13,   ROS⇅, 2,   ROS∅, 5,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD?, 1,   SOD↓, 9,   SOD↑, 190,   SOD↝, 1,   SOD1↓, 2,   SOD1↑, 4,   SOD2↑, 4,   TAC↑, 16,   TBARS↓, 9,   TBARS↑, 1,   Thiols↑, 1,   TOS↓, 2,   Trx↑, 7,   Trx1↑, 3,   TrxR↑, 3,   TrxR1↑, 1,   uricA↓, 2,   VitC↑, 11,   VitE↑, 8,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 2,   FPN↑, 1,   FTH1↓, 1,   IronCh↓, 1,   IronCh↑, 19,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 6,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 5,   ACC↓, 1,   ACC↑, 1,   Acetyl-CoA↑, 2,   ACSL4↓, 1,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 49,   ALAT↑, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 15,   AMPK⇅, 1,   ATP↓, 2,   ATP↑, 14,   cAMP↑, 1,   CRM↑, 2,   FAO↑, 1,   FASN↓, 3,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 7,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 12,   GlutMet↑, 1,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 5,   H2S↑, 4,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 2,   IDH1↑, 1,   lactateProd↓, 1,   LDHA↓, 1,   LDHA↑, 1,   LDL↓, 16,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 7,   NADPH↑, 6,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PFK2↓, 1,   PGC1A↑, 1,   PIP3↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PLA2↓, 1,   PONs↑, 1,   PPP↓, 1,   SIRT1↓, 1,   SIRT1↑, 18,   SIRT2↑, 1,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 27,   ASC↓, 1,   BAD↓, 1,   BAX↓, 20,   BAX↑, 3,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 18,   Bcl-2↝, 1,   Casp↓, 1,   Casp1↓, 3,   Casp3↓, 38,   Casp3↑, 1,   cl‑Casp3↓, 5,   proCasp3↓, 1,   Casp7↓, 1,   Casp8↓, 2,   Casp9↓, 14,   cl‑Casp9↓, 1,   Cyt‑c↓, 10,   Cyt‑c↑, 1,   Fas↓, 1,   Ferroptosis↓, 8,   Ferroptosis↑, 2,   GSDMD↓, 1,   iNOS↓, 43,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 5,   p38↑, 2,   p‑p38↓, 3,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 7,   Akt↑, 19,   p‑Akt↓, 1,   p‑Akt↑, 1,   AMPKα↑, 1,   CREB↑, 2,   p‑CREB↑, 3,   ERK↓, 7,   ERK↑, 7,   p‑ERK↓, 2,   p‑ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK2↓, 1,   p‑JAK2↓, 1,   JNK↓, 10,   JNK↑, 1,   p‑JNK↓, 4,   MAPK?, 1,   MAPK↓, 15,   MAPK↑, 6,   MAPK↝, 1,   p‑MAPK↓, 1,   Mst1↓, 1,   mTOR↓, 1,   mTOR↑, 4,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 17,   PKA↑, 1,   PKCδ?, 1,   PKCδ↑, 4,   PP2A↑, 3,   PTEN↓, 4,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 5,   STAT3↑, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 3,   ATF4↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO1↝, 1,   FOXO3↑, 2,   HDAC↓, 3,   HDAC2↓, 1,   OCT4↓, 1,   other?, 3,   other↓, 4,   other↑, 10,   other↝, 14,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   ER Stress↓, 4,   GRP78/BiP↓, 3,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSPs↓, 1,   HSPs↑, 3,   IRE1↓, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 2,   LC3II↓, 1,   LC3II↑, 2,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 16,   P53↓, 3,   P53↑, 1,   PARP↓, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP11↑, 1,   MMP13↓, 2,   MMP2↓, 5,   MMP2↑, 1,   MMP3↓, 1,   MMP3↑, 1,   MMP9↓, 12,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 2,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 8,   TGF-β↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 3,   Vim↓, 2,   α-SMA↓, 9,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   E-sel↓, 1,   eNOS↓, 1,   eNOS↑, 3,   p‑eNOS↑, 1,   Hif1a↓, 2,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 39,   NO↑, 4,   VCAM-1↓, 10,   VEGF↓, 2,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 37,   BBB↝, 1,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 1,   GastroP↑, 8,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 2,   MMP↑, 20,   MMP↝, 1,   NHE3↑, 1,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 1,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   ZO-1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 54,   COX2/PTGS2↑, 2,   HCAR2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 8,   IFN-γ↓, 11,   IFN-γ↑, 1,   IL1↓, 4,   IL10↓, 11,   IL10↑, 12,   IL12↓, 3,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 78,   IL1β↑, 1,   IL2↓, 4,   IL22↓, 1,   IL23↓, 2,   IL33↓, 1,   IL4↓, 7,   IL4↑, 4,   IL5↓, 2,   IL5↑, 1,   IL6↓, 67,   IL6↑, 4,   IL8↓, 9,   Imm↓, 1,   Imm↑, 8,   Imm⇅, 1,   INF-γ↓, 1,   Inflam↓, 163,   Inflam↑, 4,   IP-10/CXCL-10↓, 1,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 5,   NeuroI↓, 5,   NF-kB↓, 95,   NF-kB↑, 2,   NLRP3↓, 14,   p65↓, 4,   PGE2↓, 16,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 1,   SOCS-3↓, 1,   TLR1↓, 1,   TLR2↓, 4,   TLR4↓, 21,   TNF-α↓, 103,   TNF-α↑, 3,   TRAF1↓, 1,   TRAF6↓, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 9,   Ach↑, 10,   AChE↓, 46,   AChE↑, 1,   AChE∅, 1,   ADAM10↑, 3,   BChE↓, 10,   BDNF↓, 1,   BDNF↑, 28,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 7,   ChE↓, 1,   EndoR↑, 1,   GABA↑, 2,   MAOA↓, 5,   MAOB↓, 3,   monoA↑, 1,   NGF↑, 5,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 3,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 6,   Aβ↓, 44,   Aβ42↓, 4,   BACE/β-secretase↓, 17,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 9,   p‑tau↓, 16,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   ER(estro)↑, 1,   FGF21↑, 2,   GR↑, 4,   GR↝, 1,   PPARα↑, 3,   PPARα↝, 1,   PPARγ↑, 8,   RAAS↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 36,   BioAv↑, 51,   BioAv⇅, 1,   BioAv↝, 22,   BioEnh↑, 3,   ChemoSen↑, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 36,   eff↓, 8,   eff↑, 31,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↑, 5,   Half-Life↝, 8,   P-gp/ABCB1↓, 4,   P450↓, 3,   P450↑, 2,   P450↝, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 49,   ALAT↑, 1,   ALB↑, 1,   ALB↝, 1,   ALP↓, 12,   anemia↓, 1,   AST↓, 49,   AST↑, 1,   BG↓, 2,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 2,   BP↓, 8,   BP↝, 1,   BUN?, 1,   BUN↓, 4,   CEA↓, 2,   CK/CK-MB↓, 1,   creat↓, 10,   CRP↓, 9,   Ferritin↓, 1,   Ferritin↑, 2,   HemoG↑, 1,   IL6↓, 67,   IL6↑, 4,   IRes↝, 1,   LDH↓, 15,   LDH↑, 1,   NOS2↓, 3,   RAGE↓, 3,   RBC↑, 1,   TG/TAG↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 8,   antiAll?, 1,   antiAll↑, 11,   AntiArt↑, 10,   AntiCan↑, 17,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 26,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 59,   CardioT↓, 2,   chemoP↑, 14,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 66,   cognitive∅, 1,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 82,   Learn↑, 7,   memory↑, 63,   Mood?, 1,   motorD↓, 1,   motorD↑, 9,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 139,   NP/CIPN↓, 2,   Obesity↓, 11,   OS↑, 3,   Pain↓, 6,   radioP↑, 12,   RenoP↓, 1,   RenoP↑, 32,   RenoP↝, 1,   Risk↓, 4,   Sleep↑, 2,   Strength↑, 2,   Stress↓, 2,   Stroke↓, 12,   toxicity?, 2,   toxicity↓, 31,   toxicity↑, 3,   toxicity↝, 8,   toxicity∅, 11,   Weight↓, 3,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,   Wound Healing↑, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 9,   AntiFungal↑, 6,   AntiViral↑, 9,   Bacteria↓, 17,   Diar↓, 3,   GutMicro↑, 25,   Inf↓, 1,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 658

Scientific Paper Hit Count for: GSH, Glutathione
32 Thymoquinone
28 Curcumin
22 Silver-NanoParticles
21 Quercetin
20 Piperlongumine
19 Silymarin (Milk Thistle) silibinin
18 Alpha-Lipoic-Acid
17 Shikonin
15 Radiotherapy/Radiation
15 Luteolin
13 Sulforaphane (mainly Broccoli)
12 Resveratrol
12 Phenethyl isothiocyanate
11 Sulfasalazine
11 Lycopene
11 Selenite (Sodium)
10 Cisplatin
10 Allicin (mainly Garlic)
10 Artemisinin
10 Boron
10 Chrysin
10 Rosmarinic acid
9 Selenium
8 Melatonin
8 Chemotherapy
8 diet Methionine-Restricted Diet
8 Juglone
7 3-bromopyruvate
7 Ashwagandha(Withaferin A)
7 doxorubicin
7 Matrine
7 Propolis -bee glue
7 Selenium NanoParticles
6 Betulinic acid
6 Chlorogenic acid
6 Carvone
6 Copper and Cu NanoParticles
6 Eugenol
6 Gallic acid
6 Propyl gallate
5 Apigenin (mainly Parsley)
5 Baicalein
5 erastin
5 Rutin
5 Carvacrol
5 Crocetin
5 D-limonene
5 Ferulic acid
5 Hyperoside
5 Magnetic Fields
5 Vitamin C (Ascorbic Acid)
4 Berberine
4 Carnosic acid
4 Emodin
4 Fisetin
4 Honokiol
4 Kaempferol
4 Linalool
4 Morin
4 Parthenolide
3 2-DeoxyGlucose
3 Auranofin
3 chitosan
3 Cysteamine
3 Isoliquiritigenin
3 Licochalcone A
3 methylseleninic acid
3 Magnetic Field Rotating
3 Piperine
3 Pterostilbene
3 Aflavin-3,3′-digallate
3 Turmerones
2 Anethole/trans-Anethole
2 Ascorbyl Palmitate
2 Beta-Caryophyllene
2 Bromelain
2 brusatol
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Caffeic acid
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Gemcitabine (Gemzar)
2 Chocolate
2 Cichoric acid / Chicoric acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Date Fruit Extract
2 Docetaxel
2 Dandelion Root
2 Ellagic acid
2 EGCG (Epigallocatechin Gallate)
2 Sesame seeds and Oil
2 Formononetin
2 Fucoidan
2 Ginkgo biloba
2 Lemon Balm/Melissa officinalis
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Hydrogen Gas
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 isoorientin
2 Isovitexin
2 Lactoferrin/Talactoferrin
2 Methylsulfonylmethane
2 salinomycin
2 Vitexin
1 1,8-Cineole
1 cetuximab
1 Anthocyanins
1 Astragalus
1 Photodynamic Therapy
1 Camptothecin
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Aloe anthraquinones
1 Baicalin
1 Ras-selective lethal 3
1 Boswellia (frankincense)
1 Butyrate
1 Capsaicin
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 chemodynamic therapy
1 chaetocin
1 Chlorophyllin
1 Zinc
1 Chyawanprash
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Black phosphorus
1 SonoDynamic Therapy UltraSound
1 Cucurbitacin
1 Galantamine
1 Cynaropicrin
1 Diindolylmethane
1 Exercise
1 Shilajit/Fulvic Acid
1 Gambogic Acid
1 Garcinol
1 Salvia officinalis
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Hydroxycinnamic-acid
1 Hyperthermia
1 Isobavachalcone
1 Butein
1 Scopoletin
1 isoquercitrin
1 Lapatinib
1 Lapachol
1 Geldanamycin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Magnolol
1 Methyl Jasmonate
1 Metformin
1 Moringa oleifera
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 N-Acetyl-Cysteine
1 Naringin
1 Nimbolide
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Phenylbutyrate
1 Plumbagin
1 Orlistat
1 Scoulerine
1 polyethylene glycol
1 Anti-oxidants
1 Shankhpushpi
1 Squalene
1 Glutathione
1 Taurine
1 methotrexate
1 Ursolic acid
1 Urolithin
1 Vitamin B12
1 Folic Acid, Vit B9
1 VitK3,menadione
1 immunotherapy
1 Vitamin K2
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:137  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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