MMP2 Cancer Research Results

MMP2, metalloproteinase-2: Click to Expand ⟱
Source:
Type:
Matrix metalloproteinase-2 (MMP-2) is an enzyme that plays a significant role in the degradation of extracellular matrix components, which is crucial for various physiological processes, including tissue remodeling, wound healing, and angiogenesis.
Elevated levels of MMP-2 have been associated with poor prognosis in various cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,
4657- RES,    Resveratrol, cancer and cancer stem cells: A review on past to future
- Review, Var, NA
CSCs↓, CD133↓, Shh↓, Twist↓, Snail↓, MMP2↓, MMP9↓, Smad1↓, CD44↓, ALDH1A1↓, OCT4↓, Nanog↓, STAT3↓, survivin↓, cycD1/CCND1↓, COX2/PTGS2↓, cMyc↓,
3086- RES,    Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TET1↑, TumCMig↓, TumCI↓, TIMP2↑, TIMP3↑, MMP2↓, MMP9↓,
3078- RES,    The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment
- Review, Pca, NA
*ROS↓, ROS↑, DNAdam↑, Apoptosis↑, Hif1a↑, Casp3↑, Casp9↑, Cyt‑c↑, Dose↝, MMPs↓, MMP2↓, MMP9↓, EMT↓, E-cadherin↑, N-cadherin↓, AR↓,
3077- RES,    Resveratrol attenuates matrix metalloproteinase-9 and -2-regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways
- in-vitro, Chon, HTB94
MMP2↓, MMP9↓, SOX9↑, MMPs↓, p‑p38↑, p‑JNK↓, NF-kB↓, HO-1↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3089- RES,    The Role of Resveratrol in Cancer Therapy
- Review, Var, NA
angioG↓, VEGF↓, EGFR↓, FGF↑, TumCMig↓, TumCI↓, TIMP1↑, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, PI3K↓, Akt↓, MAPK↓, EMT↓, AR↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3095- RES,    Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk
- in-vitro, BC, NA
TumCP↓, TumCMig↓, TumCI↓, cycD1/CCND1↓, cMyc↓, MMP2↓, MMP9↓, SOX2↓, Akt↓, STAT3↓, α-SMA↓,
3010- RosA,    Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation
- in-vitro, Lung, A549 - in-vivo, NA, NA
TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, Nor, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *Synergy↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2/PTGS2↓, *mTOR↑,
3004- RosA,    Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system
- in-vitro, Nor, HSC-T6
*GSH↑, *MMP2↓, *ROS↓, *lipid-P↓, *NRF2↑,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3037- RosA,    Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation
- in-vitro, Oral, SCC9 - in-vitro, Oral, HSC3
survivin↓, AntiCan↑, Vim↓, Snail↓, SOX9↓, EMT↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, TumCG↓, ROS↑, MMP↓, GSH↓, P-gp/ABCB1↓, ATP↓,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2/PTGS2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
3188- SFN,    Sulforaphane inhibited tumor necrosis factor-α induced migration and invasion in estrogen receptor negative human breast cancer cells
- in-vitro, BC, NA
TNF-α↓, TumCI↓, TumMeta↓, MMPs↓, MMP2↓, MMP9↓, MMP13↓,
111- SFN,    Sulforaphene Interferes with Human Breast Cancer Cell Migration and Invasion through Inhibition of Hedgehog Signaling
- in-vitro, BC, SUM159
HH↓, Gli1↓, MMP2↓, MMP9↓, Smo↓, TumCMig↓, TumCI↓,
1466- SFN,    Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- vitro+vivo, Thyroid, FTC-133
TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,
1462- SFN,    Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
EMT↓, TumCI↓, TumCMig↓, E-cadherin↑, Zeb1↓, Snail↓, COX2/PTGS2↝, MMP2↝, MMP9↝,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1732- SFN,    Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
- in-vitro, BC, MCF7 - in-vitro, BC, SUM159 - in-vivo, NA, NA
TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
1729- SFN,    Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
- Review, Nor, NA
eff↑, angioG↓, VEGF↓, MMP9↓, MMP2↓,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
3332- SIL,    Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2
- in-vitro, Lung, A549
*antiOx↑, *hepatoP↑, MMP2↓, uPA↓, TIMP2↑,
2210- SK,    Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway
- in-vitro, BC, MGC803
TumCA↓, TumCI↓, TumCMig↓, MMP2↓, MMP7↓, TLR2↓, p65↓, NF-kB↓, eff↑, ROS↑,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
1062- SSE,    Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells
- in-vitro, GBM, LN229 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HDAC↓, TumCP↓, TumCCA↑, Apoptosis↑, Casp3↝, MMP2↓, *BioAv↝,
5080- SSE,    Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1
- in-vitro, GC, HGC27 - in-vitro, GC, NCI-N87
AntiTum↑, HOXB-AS1↓, TumCP↓, TumCI↓, Apoptosis↑, BAD↓, Bcl-2↓, cl‑Casp3↑, MMP2↓, E-cadherin↑, N-cadherin↓, ROS↑, NF-kB↓,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2091- TQ,    Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells
- in-vitro, BC, MCF7 - in-vitro, GC, AGS
Dose↝, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, HSP70/HSPA5↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2/PTGS2↓, MMP9↓, *antiAll↑, *Eos↓, *CD31/PECAM-1↓, *α-SMA↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
4857- Uro,    Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study
- in-vitro, ESCC, KYSE-30
tumCV↓, selectivity↑, TumCCA↑, ROS↑, Bcl-2↓, BAX↑, P21↑, MMP2↓, MMP9↓,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4851- Uro,    Urolithin A suppressed osteosarcoma cell migration and invasion via targeting MMPs and AKT1
- in-vitro, OS, MG63
TumCMig↓, TumCI↓, TumCA↑, MMP2?, MMP9?,
3129- VitC,    Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis
- in-vivo, Stroke, NA
*BBB↑, *MMP9↓, *MMPs↓, *MMP2↓, *CLDN1↝, *ZO-1↝, eff↑,
3130- VitC,    Effect of high-dose vitamin C on MMP2 expression and invasive ability in human pancreatic cancer cell line PANC-1
- in-vitro, PC, PANC1
MMP2↓, TumCI↓,
3131- VitC,    Antioxidant Vitamin C attenuates experimental abdominal aortic aneurysm development in an elastase-induced rat model
- in-vivo, Nor, NA
*MMP2↓, *MMP9↓, *TNF-α↓, *IL1β↓, *TIMP2↑, *TIMP1↓, *antiOx↑, *Inflam↓,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,

Showing Research Papers: 301 to 349 of 349
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 349

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 8,   Catalase↑, 2,   Copper↓, 1,   Copper↑, 1,   ENOX2↓, 1,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 4,   GSH↓, 21,   GSH↑, 4,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 2,   GSTs↑, 2,   H2O2↓, 2,   H2O2↑, 6,   HO-1↓, 11,   HO-1↑, 10,   HO-2↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 10,   MDA↓, 4,   MDA↑, 2,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 2,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 11,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   ROS?, 2,   ROS↓, 23,   ROS↑, 150,   ROS⇅, 6,   ROS↝, 2,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 3,   SOD2↑, 2,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 5,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Tf↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   CDC2↓, 8,   CDC25↓, 9,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 4,   ETC↓, 2,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 7,   OCR↓, 4,   OCR↑, 1,   mt-OXPHOS↓, 1,   PDH↝, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 4,   ACC↑, 2,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 19,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 11,   CAIX/CA9↑, 1,   ECAR↓, 3,   ECAR↝, 1,   FABP4↑, 1,   FASN↓, 4,   GLO-I↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 6,   GlutMet↓, 2,   Glycolysis↓, 18,   GSK‐3β↓, 10,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   HK1↓, 1,   HK2↓, 8,   lactateProd↓, 9,   LDHA↓, 6,   LDL↓, 2,   NADPH↓, 3,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PIP3↑, 1,   PKM2↓, 8,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SIRT1↓, 7,   SIRT1↑, 7,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 9,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 123,   Apoptosis↝, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 4,   BAD↑, 7,   Bak↑, 7,   BAX↓, 2,   BAX↑, 80,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 20,   Bcl-2↓, 92,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 25,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 2,   BIM↑, 4,   BNIP3↑, 2,   Casp↑, 23,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp2↑, 1,   Casp3↓, 4,   Casp3↑, 100,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 15,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 28,   Casp8∅, 1,   cl‑Casp8↑, 4,   Casp9↓, 1,   Casp9↑, 65,   cl‑Casp9↑, 9,   proCasp9↓, 1,   CellShr↑, 2,   cFLIP↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 62,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 12,   DR5↑, 21,   Endon↑, 2,   FADD↑, 3,   Fas?, 1,   Fas↓, 1,   Fas↑, 20,   FasL↓, 1,   FasL↑, 7,   FasL⇅, 1,   Ferroptosis↑, 5,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 8,   IAP2/BIRC3↓, 1,   iNOS↓, 14,   Mcl-1?, 1,   Mcl-1↓, 21,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 3,   Necroptosis↑, 1,   NOXA↑, 3,   oncosis↑, 1,   p38↓, 9,   p38↑, 8,   p‑p38↓, 5,   p‑p38↑, 3,   p‑p38↝, 1,   PUMA↓, 1,   PUMA↑, 5,   Pyro↑, 2,   survivin↓, 40,   TNFR 1↑, 3,   TRAIL↑, 3,   TRAILR↑, 3,   TumCD↑, 9,   XIAP↓, 22,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 115,   Akt↑, 3,   Akt↝, 1,   p‑Akt↓, 38,   AKT1↓, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 2,   cSrc↓, 1,   EGFR↓, 28,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 42,   ERK↑, 6,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↝, 1,   FGFR1↓, 3,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 12,   HGF/c-Met↓, 3,   Hippo↑, 1,   IGF-1R↓, 4,   IGFR↓, 2,   IKKα↓, 9,   IKKα↝, 1,   p‑IKKα↓, 2,   p‑IκB↓, 3,   JAK↓, 6,   p‑JAK↓, 1,   JAK1↓, 3,   JAK1↑, 1,   p‑JAK1↓, 1,   JAK2↓, 14,   p‑JAK2↓, 2,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   p‑JNK↝, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 31,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 2,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 60,   mTOR↝, 2,   p‑mTOR↓, 10,   mTORC2↓, 2,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   P90RSK↓, 2,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 94,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 7,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 2,   PKA↓, 1,   PKCδ↓, 11,   PTEN↓, 1,   PTEN↑, 24,   PTEN↝, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 12,   RCC1↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 9,   p‑Src↓, 2,   STAT↓, 4,   p‑STAT2↓, 1,   STAT3↓, 71,   STAT3↑, 2,   p‑STAT3↓, 9,   p‑STAT3↑, 4,   STAT4↓, 2,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 4,   CBP↓, 1,   cJun↓, 8,   cJun↑, 1,   cMyc↓, 29,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 7,   EZH2↓, 7,   FOXM1↓, 4,   FOXO↑, 4,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H3↓, 2,   H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 1,   HDAC↓, 17,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 3,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   METTL7A↑, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-126↓, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 3,   miR-155↑, 1,   miR-17↓, 1,   miR-182-5p↓, 1,   miR-194↑, 1,   miR-195↑, 1,   miR-200b↑, 2,   miR-200c↓, 1,   miR-203↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-22↑, 1,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↑, 1,   miR-27a-3p↓, 1,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 4,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 2,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 4,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 13,   other↓, 4,   other↑, 1,   other↝, 5,   other∅, 1,   PAX2↓, 1,   PhotoS↑, 1,   RASSF1A↑, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX9?, 1,   SOX9↓, 1,   SOX9↑, 1,   TCF-4↓, 1,   tumCV↓, 35,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 16,   eIF2α↓, 1,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 25,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   HSF1↓, 1,   HSP27↓, 5,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↝, 1,   HSP90↓, 6,   HSPs↓, 1,   IRE1↑, 4,   PDI↑, 1,   PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 5,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 9,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 8,   LC3s↑, 1,   p62↓, 6,   TumAuto↓, 1,   TumAuto↑, 27,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 42,   DNArepair↓, 4,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   HR↓, 1,   hTERT/TERT↓, 11,   MGMT↓, 1,   p16↑, 5,   P53?, 2,   P53↓, 2,   P53↑, 57,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 19,   cl‑PARP↑, 41,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 26,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1↓, 5,   TOP2↓, 4,   TOP2↑, 2,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 7,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 12,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 35,   CDK2↑, 2,   CDK4↓, 43,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 18,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 3,   p‑CHK1↑, 2,   Chk2↓, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 2,   Cyc↝, 1,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 16,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 67,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 18,   cycE1↓, 1,   E2Fs↓, 6,   GADD45A↓, 1,   Ki-67↓, 17,   MAD↓, 1,   P21↓, 3,   P21↑, 43,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 24,   pRB↑, 1,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 2,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 118,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 6,   ALDH1A1↓, 2,   BMP2↓, 2,   BMPs↑, 1,   CD133↓, 8,   CD24↓, 3,   CD34↓, 1,   cFos↓, 7,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 34,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   FGF↓, 3,   FGF↑, 1,   Gli↓, 2,   Gli1↓, 7,   HH↓, 7,   IGF-1↓, 6,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 17,   Let-7↑, 4,   LRP6↓, 1,   p‑LRP6↓, 1,   mTORC1↓, 3,   p‑mTORC1↓, 1,   Nanog↓, 9,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 18,   NOTCH1↓, 14,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 1,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 2,   Shh↓, 8,   Smo↓, 3,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 51,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 98,   TumCP↑, 4,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   Wnt↓, 38,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 11,   AP-1↝, 2,   ATPase↓, 1,   AXL↓, 2,   CA↓, 2,   Ca+2↑, 30,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Cdc42↑, 1,   p‑Cofilin↑, 2,   COL1↓, 3,   COL1A1↓, 1,   COL3A1↓, 2,   DLC1↑, 1,   E-cadherin↓, 14,   E-cadherin↑, 70,   EMT↓, 98,   EMT↑, 3,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 15,   FAK↑, 1,   p‑FAK↓, 3,   Fibronectin↓, 10,   GIT1↓, 1,   GLI2↓, 2,   IQGAP3↓, 1,   ITGA1∅, 1,   ITGA5↓, 1,   ITGA5∅, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB1∅, 1,   ITGB3↓, 1,   ITGB3∅, 1,   ITGB4∅, 1,   KRAS↓, 1,   LAMs↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 10,   MMP13↓, 5,   MMP14↓, 1,   MMP16↓, 3,   MMP2?, 2,   MMP2↓, 322,   MMP2↑, 3,   MMP2⇅, 1,   MMP2↝, 2,   MMP2∅, 1,   proMMP2↓, 1,   MMP3↓, 11,   MMP7↓, 15,   MMP7∅, 1,   MMP9?, 2,   MMP9↓, 263,   MMP9↑, 3,   MMP9⇅, 1,   MMP9↝, 1,   MMP9∅, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 29,   MTA1↓, 2,   N-cadherin↓, 48,   NCAM↓, 1,   NCAM↑, 1,   PAK1↓, 2,   pax↓, 1,   PDGF↓, 7,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 6,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 2,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 3,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 40,   Snail↑, 1,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 18,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 5,   TIMP1↑, 21,   TIMP2↓, 7,   TIMP2↑, 18,   TIMP3↑, 2,   TSP-1↑, 4,   TumCA↓, 5,   TumCA↑, 1,   TumCI↓, 123,   TumCI↑, 2,   TumCMig↓, 118,   TumCMig↑, 1,   TumMeta↓, 69,   TumMeta↑, 7,   TumPF↓, 1,   Twist↓, 26,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 34,   uPAR↓, 6,   Vim?, 1,   Vim↓, 53,   Vim↑, 1,   Zeb1↓, 18,   ZEB2↓, 1,   ZEB2↑, 1,   α-SMA↓, 5,   α-SMA↑, 1,   β-catenin/ZEB1↓, 44,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 74,   angioG↑, 1,   angioS↑, 1,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 2,   HIF-1↓, 7,   Hif1a↓, 50,   Hif1a↑, 1,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 8,   NO↑, 1,   PHDs↓, 1,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 115,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 3,   CLDN2↓, 1,   EPR↑, 5,   GLUT1↓, 7,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 76,   MMP↑, 1,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   TRPM7↓, 3,   TRPV1↑, 3,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 14,   CD59↑, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 79,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 13,   DR4↑, 8,   FOXP3↓, 2,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↓, 5,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 6,   IL1↑, 1,   IL10↓, 7,   IL10↑, 2,   IL12↓, 3,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 18,   IL1β↑, 2,   IL2↓, 3,   IL2↑, 4,   IL4↑, 2,   IL6↓, 47,   IL6↑, 1,   IL6↝, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 2,   Imm↝, 3,   Inflam↓, 19,   IRAK1↓, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MIP-1β↑, 1,   MIP2↓, 2,   mPGES-1↓, 2,   NF-kB?, 1,   NF-kB↓, 128,   NF-kB↑, 3,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 3,   p50↓, 3,   p65↓, 13,   p‑p65↓, 4,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 1,   PGE2↓, 24,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↓, 1,   T-Cell↑, 1,   TCF↑, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 34,   TNF-α↑, 6,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,   WFDC10A↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 1,   AR↓, 9,   AR↑, 1,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   PPARα↓, 2,   PPARα↑, 2,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 8,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B10↓, 1,   BioAv↓, 32,   BioAv↑, 30,   BioAv↝, 9,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 100,   ChemoSen∅, 1,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 2,   Dose↑, 6,   Dose↝, 29,   Dose∅, 8,   eff?, 1,   eff↓, 13,   eff↑, 41,   eff⇅, 1,   eff↝, 11,   GSTA1↑, 2,   Half-Life↓, 8,   Half-Life↑, 2,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P450↓, 2,   RadioS↑, 35,   selectivity?, 1,   selectivity↑, 47,   Synergy?, 1,   Synergy↑, 68,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 6,   ALP↓, 2,   AR↓, 9,   AR↑, 1,   AR↝, 1,   ascitic↓, 1,   AST↓, 4,   BRCA1↓, 2,   BRCA1↑, 1,   CEA↓, 1,   CRP↓, 4,   E6↓, 2,   E7↓, 2,   EGFR↓, 28,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 7,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 12,   hTERT/TERT↓, 11,   IL6↓, 47,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 4,   Myc↓, 4,   NSE↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 2,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 33,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 2,   AntiTum↑, 17,   cachexia↓, 3,   cardioP↑, 9,   chemoP?, 1,   chemoP↑, 20,   chemoPv↑, 14,   ChemoSideEff↓, 4,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 5,   OS↑, 5,   Pain↓, 1,   Pin1↓, 1,   radioP↑, 6,   RenoP↑, 6,   Risk↓, 6,   toxicity↓, 8,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 12,   TumVol∅, 1,   TumW↓, 3,   TumW∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 2,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 6,  
Total Targets: 1004

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 60,   Catalase↑, 20,   Copper↓, 1,   GPx↑, 17,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 21,   GSR↓, 1,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 10,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 2,   HO-1↑, 10,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 16,   MDA↓, 14,   MPO↓, 1,   NADH↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 23,   NRF2∅, 1,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 71,   ROS∅, 1,   SOD↑, 27,   SOD1↑, 3,   SOD2↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 1,   ALAT↓, 8,   AMPK↓, 1,   AMPK↑, 1,   DGAT1↓, 1,   FABP4↓, 1,   FASN↓, 3,   GSK‐3β↓, 2,   LDL↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 4,   Casp3?, 1,   Casp3↓, 6,   Casp3↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Ferroptosis↓, 1,   iNOS↓, 8,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   p‑Akt↓, 1,   p‑Akt↑, 1,   CREB↑, 2,   ERK↓, 1,   ERK↑, 2,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 1,   p‑LIMK1↑, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↑, 3,   PDGFR-BB↓, 1,   PI3K↑, 3,   PKCδ↑, 1,   PTEN↑, 1,   STAT3↓, 3,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   cJun↓, 2,   p‑cJun↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 2,   other↝, 3,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   p16↓, 1,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↑, 2,   Ki-67↓, 2,   P21↓, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   FGF↑, 2,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 3,   Ca+2?, 1,   Ca+2↓, 2,   Ca+2↝, 1,   p‑Cofilin↑, 1,   COL1↓, 1,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   Fibronectin↓, 1,   LAMs↑, 1,   p‑MLC2/MYL9↑, 1,   MMP1↓, 1,   MMP2↓, 14,   MMP2↑, 6,   MMP3↓, 1,   MMP9↓, 7,   MMP9↑, 2,   MMPs↓, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   PAI-1/SERPINE1↓, 1,   Rac1↑, 1,   Rho↓, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Smad1↑, 1,   Smad7↑, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   TregCell↑, 1,   TumMeta↓, 1,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 3,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 8,   NO↑, 2,   VCAM-1↓, 1,   VEGF↓, 4,   VEGF↑, 3,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 8,   CLDN1↝, 1,   CLDN5↓, 1,   GastroP↑, 2,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 4,   OCLN↓, 1,   TRPM7↓, 1,   ZO-1↓, 1,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 21,   Eos↓, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL1↓, 3,   IL10↓, 1,   IL10↑, 4,   IL12↓, 2,   IL17↓, 2,   IL1β↓, 12,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 19,   IL6↑, 1,   IL8↓, 5,   Imm↑, 11,   Inflam↓, 62,   Inflam↑, 1,   MCP1/CCL2↓, 3,   MCP1/CCL2↑, 1,   NeuroI↓, 1,   NF-kB↓, 29,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 2,   TNF-α↓, 21,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 7,   AChE↑, 1,   BChE↓, 1,   BDNF↑, 4,   GABA↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 2,   tau↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   Estro↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 24,   BioAv↑, 24,   BioAv↝, 14,   BioEnh↑, 2,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↓, 1,   eff↑, 8,   Half-Life↓, 1,   Half-Life↝, 6,   Half-Life∅, 1,   P450↓, 3,   P450↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 3,   AST↓, 11,   BMD↑, 1,   BP↓, 2,   BUN↓, 1,   creat↓, 1,   CRP↓, 1,   IL6↓, 19,   IL6↑, 1,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 11,   AntiArt↑, 6,   AntiCan↓, 1,   AntiCan↑, 12,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 14,   AntiTum↓, 1,   AntiTum↑, 4,   cardioP↑, 28,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↑, 7,   diuretic↑, 3,   hepatoP↓, 1,   hepatoP↑, 21,   Learn↑, 1,   memory↑, 11,   motorD↑, 3,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 44,   Obesity↓, 5,   Pain↓, 4,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 5,   toxicity↓, 21,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↓, 1,   AntiFungal↑, 1,   AntiViral↑, 5,   Bacteria↓, 17,   Diar↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 3,  
Total Targets: 321

Scientific Paper Hit Count for: MMP2, metalloproteinase-2
14 Fisetin
14 Quercetin
10 Baicalein
10 Berberine
10 Matrine
10 Sulforaphane (mainly Broccoli)
8 Curcumin
8 Luteolin
8 Resveratrol
7 EGCG (Epigallocatechin Gallate)
6 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Eugenol
6 Garcinol
6 Kaempferol
6 Lycopene
6 Rosmarinic acid
5 Artemisinin
5 Betulinic acid
5 Caffeic acid
5 Propolis -bee glue
5 Capsaicin
5 Dandelion Root
5 Ellagic acid
5 Thymoquinone
4 Carvacrol
4 Chrysin
4 Formononetin
4 Magnolol
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Silver-NanoParticles
3 Ashwagandha(Withaferin A)
3 Boswellia (frankincense)
3 Hydroxycinnamic-acid
3 Diindolylmethane
3 Emodin
3 Ferulic acid
3 Fucoidan
3 Gambogic Acid
3 Honokiol
3 Naringin
3 Nimbolide
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Selenite (Sodium)
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 alpha Linolenic acid
2 Andrographis
2 Radiotherapy/Radiation
2 Astaxanthin
2 Baicalin
2 Berbamine
2 Brucea javanica
2 Boron
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Cinnamon
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 CUSP9
2 Deguelin
2 Indole-3-carbinol
2 Ginkgetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 Hyperoside
2 mebendazole
2 Melatonin
2 Morin
2 Mushroom Chaga, Inonotus obliquus
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Shikonin
1 1,8-Cineole
1 Astragalus
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Cisplatin
1 Aspirin
1 Aloe anthraquinones
1 Biochanin A
1 Beta-Caryophyllene
1 Chemotherapy
1 brusatol
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 Carnosic acid
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenium NanoParticles
1 Zinc
1 Coenzyme Q10
1 Cucurbitacin
1 Ursolic acid
1 Cyclopamine
1 Cysteamine
1 D-limonene
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Sorafenib (brand name Nexavar)
1 Flaxseed/Linseed
1 5-fluorouracil
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Isoliquiritigenin
1 isoorientin
1 Ivermectin
1 Juglone
1 Lactobacillus
1 gefitinib, erlotinib
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 tamoxifen
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Oleuropein
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Propyl gallate
1 temozolomide
1 Piperlongumine
1 Polyphenols
1 Parthenolide
1 Spirulina(Arthrospira/Limnospira)
1 Aflavin-3,3′-digallate
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:201  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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