MMP2 Cancer Research Results

MMP2, metalloproteinase-2: Click to Expand ⟱
Source:
Type:
Matrix metalloproteinase-2 (MMP-2) is an enzyme that plays a significant role in the degradation of extracellular matrix components, which is crucial for various physiological processes, including tissue remodeling, wound healing, and angiogenesis.
Elevated levels of MMP-2 have been associated with poor prognosis in various cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4851- Uro,    Urolithin A suppressed osteosarcoma cell migration and invasion via targeting MMPs and AKT1
- in-vitro, OS, MG63
TumCMig↓, TumCI↓, TumCA↑, MMP2?, MMP9?,
3129- VitC,    Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis
- in-vivo, Stroke, NA
*BBB↑, *MMP9↓, *MMPs↓, *MMP2↓, *CLDN1↝, *ZO-1↝, eff↑,
3130- VitC,    Effect of high-dose vitamin C on MMP2 expression and invasive ability in human pancreatic cancer cell line PANC-1
- in-vitro, PC, PANC1
MMP2↓, TumCI↓,
3131- VitC,    Antioxidant Vitamin C attenuates experimental abdominal aortic aneurysm development in an elastase-induced rat model
- in-vivo, Nor, NA
*MMP2↓, *MMP9↓, *TNF-α↓, *IL1β↓, *TIMP2↑, *TIMP1↓, *antiOx↑, *Inflam↓,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,

Showing Research Papers: 301 to 306 of 306
Prev Page 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 306

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   cl‑Casp3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   p300↓, 1,   TOPflash↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 2,   MMP2?, 1,   MMP2↓, 3,   MMP9?, 1,   MMP9↓, 2,   N-cadherin↓, 2,   Snail↓, 1,   TumCA↑, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 1,   Vim↓, 2,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,   eff↑, 1,   selectivity↑, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Migration(tgid=13) ⓘ

CLDN1↝, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   TIMP1↓, 1,   TIMP2↑, 1,   ZO-1↝, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  
Total Targets: 12

Scientific Paper Hit Count for: MMP2, metalloproteinase-2
14 Fisetin
13 Quercetin
10 Baicalein
10 Berberine
10 Sulforaphane (mainly Broccoli)
8 Curcumin
8 Resveratrol
7 EGCG (Epigallocatechin Gallate)
6 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Eugenol
6 Garcinol
6 Lycopene
6 Rosmarinic acid
5 Artemisinin
5 Betulinic acid
5 Caffeic acid
5 Propolis -bee glue
5 Capsaicin
5 Dandelion Root
5 Ellagic acid
5 Thymoquinone
4 Carvacrol
4 Chrysin
4 Formononetin
4 Luteolin
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Ashwagandha(Withaferin A)
3 Boswellia (frankincense)
3 Hydroxycinnamic-acid
3 Emodin
3 Ferulic acid
3 Fucoidan
3 Gambogic Acid
3 Honokiol
3 Magnolol
3 Naringin
3 Nimbolide
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Selenite (Sodium)
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Silver-NanoParticles
2 Alpha-Lipoic-Acid
2 alpha Linolenic acid
2 Andrographis
2 Radiotherapy/Radiation
2 Astaxanthin
2 Baicalin
2 Berbamine
2 Brucea javanica
2 Boron
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Cinnamon
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 CUSP9
2 Deguelin
2 Ginkgetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 Hyperoside
2 Shikonin
1 1,8-Cineole
1 Astragalus
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Cisplatin
1 Aspirin
1 Aloe anthraquinones
1 Biochanin A
1 Beta-Caryophyllene
1 Chemotherapy
1 brusatol
1 Bacopa monnieri
1 Carnosic acid
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenium NanoParticles
1 Zinc
1 Coenzyme Q10
1 Cucurbitacin
1 Ursolic acid
1 Cyclopamine
1 Cysteamine
1 D-limonene
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Sorafenib (brand name Nexavar)
1 5-fluorouracil
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
1 Isobavachalcone
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Isoliquiritigenin
1 isoorientin
1 Juglone
1 Melatonin
1 Magnetic Field Rotating
1 Myricetin
1 Oleuropein
1 Phenylbutyrate
1 Propyl gallate
1 temozolomide
1 Piperlongumine
1 Polyphenols
1 Parthenolide
1 Kaempferol
1 Aflavin-3,3′-digallate
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:201  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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