OS Cancer Research Results

OS, overall survival: Click to Expand ⟱
Source:
Type:
Overall survival
Scientific Papers found: Click to Expand⟱
4963- PEITC,    Sensory Acceptable Equivalent Doses of β - Phenylethyl isothiocyanate (PEITC) Induce Cell Cycle Arrest and Retard Growth of p53 Mutated Oral Cancer In Vitro and In Vivo
- vitro+vivo, Oral, CAL27 - vitro+vivo, Oral, FaDu - vitro+vivo, Oral, SCC4 - vitro+vivo, Oral, SCC9
Dose↝, selectivity↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,
4924- PEITC,    Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial
- Trial, Oral, NA
QoL↑, P53↑, OS↑, Cyt‑c↝, other↝, ROS↑, selectivity↑, P21↑, TumCCA↑, Dose↝, BioAv↑, Weight↑, chemoP↑,
5216- PI,  doxoR,    Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells
- vitro+vivo, BC, MDA-MB-231
ChemoSen↑, necrosis↑, PTEN↓, PI3K↓, p‑Akt↓, mTOR↓, ALDH↓, TumVol↓, OS↑, cardioP↑, cl‑PARP↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
2942- PL,    Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems
- in-vitro, CRC, CT26 - in-vitro, CRC, DLD1 - in-vivo, CRC, CT26
ROS↑, GSH↓, TrxR↓, RadioS↑, DNAdam↑, TumCCA↑, mitResp↓, GSTs↓, OS↑,
3352- QC,    A review of quercetin: Antioxidant and anticancer properties
- Review, Var, NA
*antiOx↑, *lipid-P↓, *TNF-α↓, *NF-kB↓, *COX2/PTGS2↓, *IronCh↑, P53↓, TumCCA↑, HSPs↓, P21↓, RAS↓, ER(estro)↑, OS?,
2303- QC,  doxoR,    Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells
- in-vitro, BC, 4T1 - in-vivo, NA, NA
cardioP↑, hepatoP↑, TumCG↓, OS↑, ChemoSen↑, chemoP↑, Hif1a↓, *Hif1a↑, selectivity↑, TumVol↓, OS↑,
5969- Rad,  CET,    Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
- Trial, HNSCC, NA
Dose↝, radioP↑, OS↑,
5971- Rad,  CET,    Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
- Trial, HNSCC, NA
OS↑,
5286- Ramu,    Ramucirumab efficacy in first-line gastric and esophageal cancer treatment
- Review, GC, NA
VEGFR2/KDR/Flk1↓, OS↑, toxicity↝,
5284- Ramu,    https://pmc.ncbi.nlm.nih.gov/articles/PMC4131847/
- Review, Var, NA
VEGFR2/KDR/Flk1↓, OS↑, angioG↓, toxicity↝, ChemoSen↑, Dose↝,
5285- Ramu,  docx,    A randomized, double-blind, phase II study of ramucirumab plus docetaxel vs placebo plus docetaxel in Japanese patients with stage IV non-small cell lung cancer after disease progression on platinum-based therapy
- Trial, NSCLC, NA
OS↑,
5287- Ramu,    Real-Life Use of Ramucirumab in Gastric Cancer in Spain: the RAMIS Study
- in-vivo, GC, NA
VEGFR2/KDR/Flk1↓, OS↑, OS↑,
2990- RES,    Resveratrol reduces cerebral edema through inhibition of de novo SUR1 expression induced after focal ischemia
- in-vivo, Stroke, NA
*OS↑, *antiOx↑, Sp1/3/4↓,
3490- RF,    Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases
- Review, AD, NA - Review, Park, NA
*OS↑, *memory↑, *cognitive↑, *memory↑, *Aβ↓, *eff↑, *HSF1↑, *HSP70/HSPA5↑,
6810- RF,    SUMMARY OF SAFETY AND PROBABLE BENEFIT (SSPB)
- Trial, HCC, NA
Dose↝, Dose↝, Dose↝, OS↑,
6808- RF,    Safety and Efficacy of amplitude-modulated radiofrequency electromagnetic fields in advanced hepatocellular carcinoma
- Trial, HCC, NA
OS↑, *toxicity↓, Dose↝, TumCG↓, Dose↝, Dose↝, Dose↝, eff↑,
5138- SAS,  Rad,    Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion
- vitro+vivo, GBM, NA
cystine↓, GSH↓, ROS↑, RadioS↑, eff↓, DNAdam↑, OS↑,
5036- SAS,    Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
xCT/SLC7A11↓, GSH↓, OS↑, Myc↓, CDK1↓, CD44↓, Synergy↑, TumCG↓,
5035- SAS,    Sulfasalazine, a potent suppressor of gastric cancer proliferation and metastasis by inhibition of xCT: Conventional drug in new use
- Human, GC, NA - in-vitro, GC, NCI-N87 - in-vitro, GC, SGC-7901
other?, TumCP↓, TumMeta↓, TumCI↓, xCT/SLC7A11↓, OS↑,
1705- Se,    Serum Selenium Level and 10-Year Survival after Melanoma
- Study, Melanoma, NA
OS↑,
1696- Se,    Selenium dietary intake and survival among CRC patients
- Human, CRC, NA
OS↑,
1689- Se,    Selenium and breast cancer - An update of clinical and epidemiological data
- Analysis, BC, NA
OS↑, eff↑, Dose∅, *toxicity↝, eff↑,
4492- Se,    Selenium in cancer prevention: a review of the evidence and mechanism of action
- Review, Var, NA
Risk↓, AntiCan↑, *selenoP↑, TumMeta↓, *DNAdam↓, OS↑, *ROS↓,
4496- Se,    Selenium status and survival from colorectal cancer in the European prospective investigation of cancer and nutrition
- Analysis, CRC, NA
Risk↝, OS↑,
4722- Se,    The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis
- Review, Var, NA
Risk↓, *NRF2↓, NRF2↑, *NRF2↓, OS↑, eff↝, eff↝, NRF2↝,
3947- Shank,    Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer's disease Drosophila model
- in-vivo, AD, NA
*OS↑, *antiOx↑, *ROS↓, *AChE↑, *neuroP↑, *memory↑,
3292- SIL,  Fe,    Anti-tumor activity of silymarin nanoliposomes in combination with iron: In vitro and in vivo study
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
*antiOx↑, ROS↑, OS↑, Weight↑, TumVol↓, eff↑, Fenton↑,
4204- SIL,    Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels
- in-vivo, Stroke, NA
*OS↑, *BDNF↑, *IGF-1↑,
3321- SIL,    Silymarin (Milk thistle)
- Review, AD, NA
*neuroP↝, *Dose↝, *Half-Life?, *BioAv↝, *cognitive↑, *Aβ↓, *Inflam↓, *OS↑, *memory↑,
2232- SK,    Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis
- in-vitro, ESCC, EC9706
tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,
2233- SK,    Clinical trial on the effects of shikonin mixture on later stage lung cancer
- Trial, Lung, NA
TumVol↓, Remission↑, OS↑, QoL↑, Weight↑, *toxicity∅,
2222- SK,    The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis
- in-vitro, OS, U2OS - in-vitro, OS, 143B - in-vivo, NA, NA
Necroptosis↑, RIP1↑, RIP3↑, OS↑, P53↑,
1068- SM,    Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA - Human, BC, NA
TumCG↓, Ferroptosis↑, GPx4↓, TumVol↓, OS↑, GSH/GSSG↓,
9043- SP,    Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis
- in-vivo, HCC, NA
Dose↝, OS↑, AFP↓, TAC↑, BAX↑, P53↑, MDA↓, VEGF↓, ROS↓, angioG↓,
9040- SP,    Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19: a randomized controlled trial
- Trial, Covid, NA
*Dose↝, *OS↑, *IL6↓, *TNF-α↓, *IL10↓, *IP-10/CXCL-10↓, *MIP‑1α/CCL3?, *IFN-γ↑, *toxicity↓,
4895- Sper,    Spermidine as a target for cancer therapy
- Review, Var, NA - Review, AD, NA
TumAuto↑, Apoptosis↑, OS↑, CRM↑, TumCG⇅, cardioP↑, cognitive↑, *Dose⇅,
1707- SSE,    A Diet Lacking Selenium, but Not Zinc, Copper or Manganese, Induces Anticancer Activity in Mice with Metastatic Cancers
- in-vivo, Ovarian, NA - in-vivo, BC, NA
OS↓,
5078- SSE,  Rad,    Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer
- Trial, Pca, NA
Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,
5084- SSE,  GEM,    The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study
- in-vitro, PC, PANC1 - vitro+vivo, PC, Panc02
tumCV↓, ChemoSen↑, TumCG↓, OS↑, MMP↓, AIF↑, GSH↓, Trx↓, ROS↑, AntiTum↑,
4494- SSE,    Advances in the study of selenium and human intestinal bacteria
- Review, IBD, NA - Review, Var, NA
*Risk↓, OS↑, *CRP↓, *GPx↑, *Inflam↓, *ROS↓, *GutMicro↑, *selenoP↑, *other↓,
6174- TM,    Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse
- Trial, BC, NA
OS↑, toxicity↓, AntiTum↑, Copper↓, angioG↓,
2131- TQ,    Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway
- in-vitro, Stroke, NA - in-vivo, Nor, NA
*eff↑, *OS↑, *Inflam↓, *ROS↓, *NRF2↑, *HO-1↑,
3420- TQ,    Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway
- in-vitro, Nor, HUVECs - in-vitro, NA, NA
*NF-kB↓, *NLRP3↓, *angioG↑, *MMP9↑, *VEGF↑, *OS↑, *Pyro?, *ROS↓, *Apoptosis↓, *SIRT1↑, *SOD1↑, *HO-1↑, *eNOS↑, *ASC?, *Casp1↓, *IL1β↓, *IL18↓,
2412- TTT,    A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights
- Review, GBM, NA
TumCG↓, eff↝, OS↑,
6453- TUR,    Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Dose↝, *BioEnh↑, *BBB↑, *ROS↓, *GSH↑, *SOD↑, *GSR↑, *NO↓, *P450↓, OS↑, TumCG↓, *GutMicro↑, *Pain↓, *neuroP↑, *AChE↓, *BDNF↑, *Bacteria↓, *AntiFungal↑, *toxicity↓,
4863- Uro,    Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *Aβ↓, *OS↑, *cognitive↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,

Showing Research Papers: 301 to 350 of 364
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 364

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 2,   Copper↓, 1,   CoQ10↑, 1,   cystine↓, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 3,   GPx4↓, 2,   GSH↓, 10,   GSH↑, 1,   GSH/GSSG↓, 2,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 4,   HO-1↑, 4,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 3,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 5,   NRF2↝, 1,   RNS↑, 1,   ROS↓, 3,   ROS↑, 69,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 5,   SOD2↑, 1,   TAC↓, 1,   TAC↑, 1,   TKT↓, 1,   Trx↓, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   compI↓, 2,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 2,   mitResp↓, 2,   mtDam↑, 7,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 3,   PINK1↑, 1,   PleEff↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   adiP↑, 1,   ALAT↓, 2,   ALAT↑, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↑, 1,   CRM↑, 2,   ECAR↓, 1,   FAO↑, 1,   GAPDH↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 2,   Glycolysis↓, 10,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK2?, 1,   HK2↓, 3,   HMG-CoA↓, 2,   KeyT↑, 1,   lactateProd↓, 3,   lactateProd↑, 2,   LDHA↓, 1,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   MethCyc↓, 1,   NAD↓, 1,   PDK1 / PDPK1↓, 2,   PDKs↓, 2,   PFK↓, 2,   PFK1↓, 1,   PKM2↓, 5,   Pyruv↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   TCA?, 1,   TS↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 36,   Bak↑, 2,   BAX↓, 1,   BAX↑, 9,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-xL↑, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↓, 1,   Casp3↑, 18,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 3,   cl‑Casp8↑, 1,   Casp9↑, 7,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   Ferroptosis↑, 3,   ICD↑, 1,   iNOS↓, 1,   iNOS↑, 1,   Mcl-1↑, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 3,   p38↑, 2,   p‑p38↑, 1,   Pyro↑, 1,   RIP3↑, 1,   survivin↓, 1,   TumCD↑, 9,   XIAP↓, 2,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   p‑Akt↓, 3,   p‑Akt↑, 1,   BRAF↓, 2,   CaMKII ?, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 5,   ERK↓, 5,   ERK↑, 1,   p‑ERK↓, 1,   ERK5↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JNK↑, 3,   MAPK↓, 5,   MAPK↑, 1,   MEK↓, 1,   p‑MEK↓, 1,   mTOR↓, 12,   mTOR↑, 1,   OR13G1?, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 12,   PI3K↑, 1,   p‑PI3K↓, 1,   PKA↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 2,   c-Raf↓, 1,   RAS↓, 3,   RIP1↑, 1,   Sp1/3/4↓, 1,   STAT3↓, 7,   p‑STAT3↑, 1,   TK1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 2,   cJun↑, 1,   cMyc↓, 5,   FOXM1↓, 1,   FOXO1↑, 1,   FOXO3↓, 1,   GATA3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H3K9↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↑, 1,   HDAC↓, 7,   HDAC8↓, 1,   KISS1↑, 1,   miR-34a↑, 1,   Myc↓, 1,   MYCN↑, 1,   OCT4↓, 1,   OLIG2↓, 1,   other?, 1,   other↓, 2,   other↑, 2,   other⇅, 1,   other↝, 17,   other∅, 2,   OV6↓, 1,   SD↑, 1,   SOX2↓, 1,   SOX4↓, 1,   SOX9↓, 1,   SUV39H↓, 2,   tumCV↓, 8,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 3,   HSPs↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   LC3B↑, 1,   LC3I↑, 1,   LC3II↑, 2,   LC3s↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   TumAuto↓, 1,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATR↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 13,   DNArepair↓, 3,   DNArepair↑, 2,   hTERT/TERT↓, 2,   P53?, 1,   P53↓, 1,   P53↑, 16,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 9,   PCNA↓, 6,   Telomerase↓, 1,   TOP2↑, 1,   TP53↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 6,   CDKN1C/p57↑, 1,   CHK1↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 10,   E2Fs↓, 1,   Ki-67↓, 11,   mitA↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 10,   p27/CDKN1B↑, 3,   p‑pRB↓, 1,   p‑RB1↓, 1,   TubPol↓, 2,   TumCCA↑, 31,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   AXIN1↑, 2,   CD133↓, 3,   CSCs↓, 6,   Diff↑, 1,   EP2↓, 1,   GH↓, 1,   Gli1↓, 5,   HH↓, 9,   HMGCR↓, 1,   IGF-1↓, 9,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 11,   mTORC1↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   PTCH2↓, 1,   Shh↓, 2,   Smo↓, 1,   TumCG↓, 64,   TumCG↑, 1,   TumCG⇅, 1,   TumCG↝, 1,   TumCP↓, 32,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   BACH1↑, 1,   Ca+2↑, 4,   Cofilin↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 9,   EMT↓, 11,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 2,   fascin↓, 1,   GLI2↓, 1,   GLI3↑, 1,   KRAS↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 7,   MMPs↓, 5,   N-cadherin↓, 6,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TSP-1↑, 1,   TumCA↓, 2,   TumCI↓, 11,   TumCMig↓, 17,   TumMeta?, 1,   TumMeta↓, 22,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 1,   Vim↓, 4,   Zeb1↓, 2,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   CD31/PECAM-1↓, 1,   E-sel↓, 1,   E-sel↑, 1,   eNOS↑, 1,   Hif1a↓, 10,   Hif1a↝, 1,   Hypoxia↓, 2,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 19,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CellMemb↑, 1,   CLDN1↓, 1,   EPR↑, 2,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   IBI↑, 1,   MMP↓, 15,   MMP↑, 2,   MPT↑, 1,   SVCT-2∅, 1,   TRPM7↓, 1,   TRPV1↓, 1,   VGSC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 7,   CD44↓, 1,   CD8+↑, 8,   COX2/PTGS2↓, 11,   CXCc↓, 1,   CXCL12↓, 1,   CXCL9↓, 1,   DCells↓, 1,   DCells↑, 3,   FOXP3↓, 1,   FOXP3↑, 1,   GM-CSF↓, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↑, 1,   IL10↓, 2,   IL10↑, 2,   IL12↑, 2,   IL17↑, 1,   IL18↑, 1,   IL1β↓, 5,   IL1β↑, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 14,   IL6↑, 1,   IL8↓, 3,   IL8↑, 1,   Imm↑, 17,   Imm↝, 2,   Inflam↓, 12,   pol-M1↝, 1,   Macrophages↑, 1,   NF-kB↓, 14,   NF-kB↑, 1,   NK cell↑, 6,   NLRP3↑, 1,   p65↓, 2,   p65↑, 1,   PD-L1↓, 4,   PDT+↓, 1,   PGE1↓, 1,   PGE2↓, 4,   PSA↓, 4,   PSA∅, 1,   Resistin↓, 1,   T-Cell↑, 2,   TCF7/TCF1↓, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 12,   TNF-α↑, 3,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↑, 1,   pH↝, 3,   e-pH↑, 3,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   EstroRS/ERS↑, 1,   FGF21↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 2,   PPARγ↑, 1,   RANKL↓, 1,   testos∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 10,   BioAv↝, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 53,   ChemoSen∅, 1,   Dose?, 1,   Dose↓, 3,   Dose↑, 12,   Dose↝, 85,   Dose∅, 15,   eff↓, 13,   eff↑, 58,   eff⇅, 1,   eff↝, 15,   Half-Life↓, 2,   Half-Life↑, 2,   Half-Life↝, 3,   Half-Life∅, 1,   MDR1↓, 2,   P-gp/ABCB1↓, 4,   RadioS?, 1,   RadioS↑, 21,   selectivity↑, 36,   Synergy↑, 39,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 7,   ALAT↓, 2,   ALAT↑, 1,   AR↓, 1,   ascitic↓, 1,   AST↓, 1,   AST↑, 1,   BG↓, 2,   BloodF↑, 2,   BMD↑, 5,   BRAF↓, 2,   BRCA1↑, 1,   CA125↓, 2,   CA19-9↓, 1,   CEA↓, 1,   CRP↓, 1,   CYFRA21-1↓, 1,   EGFR↓, 5,   EstroRS/ERS↑, 1,   Ferritin↓, 2,   FOXM1↓, 1,   hTERT/TERT↓, 2,   IL6↓, 14,   IL6↑, 1,   KeyT↑, 1,   KRAS↓, 1,   LDH↓, 4,   Myc↓, 1,   PD-L1↓, 4,   PSA↓, 4,   PSA∅, 1,   TP53↓, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AEs∅, 1,   AntiAge↑, 2,   AntiCan↓, 1,   AntiCan↑, 12,   antiNeop↑, 3,   AntiTum↓, 1,   AntiTum↑, 15,   Appetite↑, 2,   BowelM↑, 3,   breath↑, 2,   cachexia↓, 2,   cardioP↑, 5,   chemoP↑, 16,   chemoPv↑, 2,   ChemoSideEff↓, 5,   cognitive↑, 2,   CR↑, 3,   DCR↑, 3,   EFS↑, 1,   fatigue↓, 4,   hepatoP↑, 4,   LC↑, 4,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 4,   ORR↑, 2,   ORR∅, 1,   OS?, 4,   OS↓, 5,   OS↑, 294,   OS⇅, 1,   OS↝, 2,   OS∅, 16,   Pain↓, 8,   PFS?, 1,   PFS↓, 1,   PFS↑, 3,   PFS∅, 2,   QoL↑, 31,   QoL∅, 3,   radioP↑, 13,   Remission↓, 1,   Remission↑, 9,   RFS↑, 1,   Risk↓, 18,   Risk↑, 1,   Risk↝, 1,   Risk∅, 3,   Sleep↑, 2,   Strength↑, 4,   toxicity↓, 24,   toxicity↑, 4,   toxicity↝, 10,   toxicity∅, 4,   TR↑, 1,   TTP↑, 1,   TumVol↓, 32,   TumVol↑, 2,   TumW↓, 5,   Weight↓, 4,   Weight↑, 13,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 6,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 1,  
Total Targets: 582

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 21,   Catalase↑, 9,   Fenton↓, 1,   GPx↑, 7,   GSH↑, 9,   GSR↑, 3,   GSTs↑, 1,   HDL↑, 1,   HO-1↑, 6,   Iron↝, 1,   lipid-P↓, 7,   MDA↓, 5,   MDA↑, 1,   MPO↓, 2,   NFE2L2↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 2,   NRF2↑, 12,   RNS↓, 1,   ROS↓, 36,   mt-ROS↓, 2,   selenoP↑, 2,   SOD↑, 13,   SOD1↑, 1,   TBARS↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   EGF↓, 1,   Insulin↓, 1,   mtDam↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 2,   ALAT∅, 1,   AMPK↑, 7,   CRM↑, 1,   glucose↓, 4,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 3,   H2S↑, 1,   HK2↑, 1,   LDL↓, 3,   NADPH↓, 2,   PFK↑, 1,   PKM2↑, 1,   SIRT1↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   ASC?, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 1,   Casp3↓, 3,   Casp9↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   AMPKα↑, 1,   CREB↑, 1,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 1,   mTOR↓, 4,   PI3K↑, 1,   PTEN↑, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↑, 1,   other↓, 1,   other↑, 4,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 3,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSF1↑, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↓, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 2,   IGF-1↑, 1,   neuroG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 2,   MMP9↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 2,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GLUT4↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 6,   FOXP3↑, 1,   GM-CSF↑, 1,   HMGB1↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL17↑, 1,   IL18↓, 1,   IL1β↓, 5,   IL23↓, 2,   IL4↑, 1,   IL6↓, 6,   Imm↑, 1,   Inflam↓, 27,   IP-10/CXCL-10↓, 1,   IP-10/CXCL-10↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3?, 1,   mPGES-1↓, 1,   Neut↑, 1,   NF-kB↓, 11,   NLRP3↓, 3,   NLRP3↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 11,   Treg lymp↝, 1,   TREM-1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 4,   EndoR↑, 1,   monoA↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 7,   Aβ42↓, 1,   BACE/β-secretase↓, 2,   p‑tau↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 2,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 4,   BioEnh↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 9,   eff↑, 10,   Half-Life?, 1,   Half-Life↑, 1,   Half-Life↝, 1,   P450↓, 3,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT∅, 1,   ALP↓, 2,   AST↓, 3,   AST∅, 1,   BG↓, 1,   BMD↑, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 1,   IL6↓, 6,   IRes↓, 1,   LDH↓, 2,   SpO2↑, 1,   TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 7,   antiAll↑, 2,   AntiDiabetic↑, 4,   cachexia↓, 1,   cardioP↑, 15,   chemoP↑, 1,   cognitive↑, 13,   hepatoP↑, 6,   memory↑, 12,   memory∅, 1,   Mood↑, 1,   motorD↑, 2,   neuroP↑, 20,   neuroP↝, 1,   Obesity↓, 2,   OS↓, 1,   OS↑, 46,   Pain↓, 2,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 4,   Strength↑, 2,   Stroke↓, 3,   toxicity?, 1,   toxicity↓, 12,   toxicity↝, 5,   toxicity∅, 5,   Weight↓, 2,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 3,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↓, 1,   GutMicro↑, 8,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,  
Total Targets: 235

Scientific Paper Hit Count for: OS, overall survival
18 Chemotherapy
18 Magnetic Fields
18 Magnetic Field Rotating
14 Vitamin C (Ascorbic Acid)
14 Hydrogen Gas
13 Radiotherapy/Radiation
9 diet Methionine-Restricted Diet
8 Silver-NanoParticles
8 Hyperthermia
8 immunotherapy
8 beta-glucans
8 Dichloroacetate
8 Selenium
8 MCT, metronomic chemo
7 Alpha-Lipoic-Acid
7 capecitabine
7 Curcumin
7 diet Plant based
7 itraconazole
7 Melatonin
5 HydroxyCitric Acid
5 cetuximab
5 diet FMD Fasting Mimicking Diet
5 mebendazole
5 Metformin
5 Bicarbonate(Sodium)
5 Phenylbutyrate
4 Bevacizumab (brand Avastin)
4 EGCG (Epigallocatechin Gallate)
4 Gemcitabine (Gemzar)
4 Fucoidan
4 Phenethyl isothiocyanate
4 Ramucirumab (CYRAMZA)
4 Selenite (Sodium)
3 3-bromopyruvate
3 Lycopene
3 low dose naltrexone
3 almonertinib
3 Anti-oxidants
3 Aspirin
3 Arsenic trioxide
3 Atorvastatin
3 Carvacrol
3 Cimetidine
3 Oxygen, Hyperbaric
3 Quercetin
3 Exercise
3 diet Short Term Fasting
3 Honokiol
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 iodine
3 Juglone
3 nivolumab
3 Mistletoe/Viscum album Extracts
3 nicotinamide adenine dinucleotide
3 Sulfasalazine
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
3 Urolithin
2 Acetyl-l-carnitine
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Bufalin/Huachansu
2 Bifidobacterium
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Docetaxel
2 Chlorogenic acid
2 chaetocin
2 Choline
2 Citric Acid
2 Calorie Restriction Mimetics
2 Resveratrol
2 Spermidine
2 diet Fermented Foods
2 Sulforaphane (mainly Broccoli)
2 Disulfiram
2 eicosapentaenoic acid
2 Flaxseed/Linseed
2 Orlistat
2 hydroxychloroquine
2 imatinib
2 isoflavones
2 Lapatinib
2 Lactoferrin/Talactoferrin
2 ipilimumab
2 Patchouli Oil (Pogostemon cablin)
2 Propolis -bee glue
2 Piperine
2 doxorubicin
2 EMF
2 Spirulina(Arthrospira/Limnospira)
2 Thymoquinone
2 VitK3,menadione
1 2-DeoxyGlucose
1 Auranofin
1 Astragalus
1 Akkermansia
1 Baicalein
1 Berberine
1 Brucea javanica
1 Bacopa monnieri
1 Boron
1 Black Rice, Oryza sativa
1 Butyrate
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Sorafenib (brand name Nexavar)
1 Cannabidiol
1 Celastrol
1 chitosan
1 Chocolate
1 Chrysin
1 Coenzyme Q10
1 Hydroxycinnamic-acid
1 Artemisinin
1 Dasatinib/Phyrago
1 Cisplatin
1 salinomycin
1 Deguelin
1 Bortezomib
1 diet Ketogenic
1 D-limonene
1 Copper and Cu NanoParticles
1 Echinacea
1 Emodin
1 Electrical Pulses
1 Folic Acid, Vit B9
1 Formononetin
1 Garcinol
1 Geraniol
1 5-fluorouracil
1 Ginkgolide B
1 Gossypol/AT-101
1 Paclitaxel/Taxol
1 Isoliquiritigenin
1 Isovitexin
1 Vitexin
1 Trastuzumab
1 Licochalcone A
1 SDG/lignans
1 Luteolin
1 Mung Bean Sprouts
1 Lutein
1 Magnolol
1 Magnesium
1 Mangiferin
1 Helleborus niger extracts – Christmas Rose
1 Naringin
1 Noscapine
1 Piperlongumine
1 Radio Frequency
1 Shankhpushpi
1 Iron
1 Salvia miltiorrhiza
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitamin K2
1 Xylitol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:229  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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