lipid-P Cancer Research Results

lipid-P, lipid peroxidation: Click to Expand ⟱
Source:
Type:
Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products.
Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis.
The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer.
Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases.

Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy.
Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes.
Scientific Papers found: Click to Expand⟱
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4927- PEITC,    Targeting ferroptosis in osteosarcoma
- Review, OS, NA
AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,
5016- PEITC,    Phenethyl Isothiocyanate (PEITC) interaction with Keap1 activates the Nrf2 pathway and inhibits lipid accumulation in adipocytes
- in-vitro, Nor, NA
*NRF2↑, *Diff↓, *Weight↓, *lipid-P↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
3599- PI,    Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *neuroP↑, *lipid-P↓, *AChE↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
2958- PL,    Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity
- in-vitro, Oral, HSC3
TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,
1947- PL,    Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, NA
TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,
1944- PL,    Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress
- in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
ER Stress↑, TrxR1↓, ROS↑, eff↓, Bcl-2↓, proCasp3↓, BAX↓, cl‑Casp3↑, TumCCA↑, p‑PERK↑, ATF4↑, TumCG↓, lipid-P↑, selectivity↑,
1951- PL,    Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation
- in-vitro, Lung, A549
ROS↑, lipid-P↑, MMP↓, TumCCA↑, TrxR↓, eff↑,
3914- PS,    Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints
- Trial, AD, NA
*memory↑, *cognitive↑, *lipid-P↓, *antiOx↑, *Inflam↓,
3931- PTS,    Pterostilbene Protects against Osteoarthritis through NLRP3 Inflammasome Inactivation and Improves Gut Microbiota as Evidenced by In Vivo and In Vitro Studies
- in-vivo, Arthritis, NA
*Inflam↓, *NLRP3↓, *GutMicro↑, *lipid-P↓, *ROS↓, *Cartilage↑, *IL6↓, *MMP13↓, *Dose↝,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2/PTGS2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1/CCL2↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2/PTGS2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3352- QC,    A review of quercetin: Antioxidant and anticancer properties
- Review, Var, NA
*antiOx↑, *lipid-P↓, *TNF-α↓, *NF-kB↓, *COX2/PTGS2↓, *IronCh↑, P53↓, TumCCA↑, HSPs↓, P21↓, RAS↓, ER(estro)↑, OS?,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, Var, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *Synergy↑, *ROS↓, *cognitive↑, *Synergy↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
3605- QC,    Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease
- Review, AD, NA
*Aβ↓, *ROS↓, *lipid-P↓, *Apoptosis↓,
3602- QC,    The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
- in-vivo, AD, NA
*BACE/β-secretase↓, *cognitive↑, *ROS↓, *lipid-P↓, *iNOS↓, *COX2/PTGS2↓, *BBB↑, *neuroP↑, *other↓, *memory↑,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,
4787- QC,    Quercetin: A Phytochemical with Pro-Apoptotic Effects in Colon Cancer Cells
- Review, CRC, NA
Inflam↓, AntiCan↑, Apoptosis↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, NF-kB↓, IL6↓, IL1β↓, *antiOx↑, *lipid-P↓, *ROS↓, MAPK↓, JAK↓, STAT↓, PI3K↓, Akt↓, chemoP↑, ROS⇅, DNAdam↑, ChemoSen↝,
6422- QC,    Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells
- in-vitro, Alcohol, L02
*mt-ROS↓, *lipid-P↓, *MMP↑, *mtDam↓, *NLRP3↓, *ASC↓, *cl‑Casp1↓, *IL18↓, *IL1β↓, *GSDMD↓, *Pyro↓, *CYP2E1↓, *MFN1↓, *MFN2↓, *OPA1↓, *DRP1/DNM1L↑,
6051- RES,  SeNPs,  Chit,    Resveratrol-loaded selenium/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer's disease
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *GutMicro↑, *lipid-P↓, *Aβ↓, *tau↓, *cognitive↑,
1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
RadioS↑, ChemoSen↑, *BioAv↓, *BioAv↑, Ferroptosis↑, lipid-P↑, xCT/SLC7A11↓, GPx4↓, *BioAv↑, COX2/PTGS2↓, cycD1/CCND1↓, FasL↓, FOXP3↓, HLA↑, p‑NF-kB↓, BAX↑, Bcl-2↓, MALAT1↓,
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
*other↑, *Aβ↓, *Inflam↓, *NF-kB↓, *neuroP↑, *HO-1↑, *lipid-P↓, *COX2/PTGS2↓, *AMPK↑, *Catalase↑, *SOD↑, *GSR↑, *ROS↓, *MMP9↓, *cognitive↑, *SIRT1↑, *IL1β↓, *IL6↓,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3080- RES,    Resveratrol: A miraculous natural compound for diseases treatment
- Review, Var, NA
SIRT1↑, ROCK1↓, AMPK↑, *lipid-P↓, Aβ↓, COX2/PTGS2↓, angioG↓, Hif1a↓, VEGF↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, Synergy↑, Synergy↑, Synergy↑,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3094- RES,    Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
CSCs↓, tumCV↓, FASN↑, BNIP3↑, *cardioP↑, *antiOx↑, NF-kB↓, COX2/PTGS2↓, MMP9↓, IGF-1↓, ERK↓, lipid-P↓, CD24↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE/β-secretase↓,
1749- RosA,    Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer
- Review, Var, NA
antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,
3618- RosA,    Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review
- Review, AD, NA
*hepatoP↑, *antiOx↑, *angioG↓, *other↓, *Inflam↓, *ROS↓, *IronCh↑, *lipid-P↓, *antiOx↑,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2/PTGS2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
3622- RosA,    Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats
- in-vivo, Diabetic, NA
*lipid-P↓, *AChE↓,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, Nor, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *Synergy↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2/PTGS2↓, *mTOR↑,
3004- RosA,    Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system
- in-vitro, Nor, HSC-T6
*GSH↑, *MMP2↓, *ROS↓, *lipid-P↓, *NRF2↑,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
3934- RT,    Rutin: A Potential Therapeutic Agent for Alzheimer Disease
- Review, AD, NA
*ROS↓, *Aβ↓, *neuroP↑, *memory↑, *GSH↑, *SOD↑, *lipid-P↓, *MDA↓, *IL1β↓, *IL6↓, *cognitive↑, *BBB↑, *MAPK↑, *IL8↓, *COX2/PTGS2↓, *NF-kB↓, *iNOS↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
- in-vitro, Var, NA
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, Synergy↑,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,

Showing Research Papers: 301 to 350 of 415
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 415

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 1,   antiOx↑, 6,   antiOx⇅, 1,   Catalase↓, 11,   Catalase↑, 5,   Fenton↑, 9,   GPx↓, 9,   GPx↑, 7,   GPx4↓, 35,   GPx4↑, 1,   GPx4∅, 1,   GSH↓, 54,   GSH↑, 10,   GSH/GSSG↓, 5,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 7,   HNE↑, 1,   HO-1↓, 7,   HO-1↑, 14,   HO-1↝, 1,   Iron↓, 2,   Iron↑, 28,   i-Iron↓, 1,   i-Iron↑, 5,   c-Iron↑, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 30,   lipid-P↑, 116,   lipid-P↝, 2,   MDA?, 1,   MDA↓, 6,   MDA↑, 23,   i-MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NQO1↓, 2,   NQO1↑, 4,   NRF2↓, 14,   NRF2↑, 17,   ROS?, 1,   ROS↓, 16,   ROS↑, 151,   ROS⇅, 5,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 4,   selenoP↑, 1,   SOD?, 1,   SOD↓, 11,   SOD↑, 9,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 11,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FPN↝, 1,   FTH1↓, 2,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 2,   LIP↑, 1,   NCOA4↑, 2,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC2↑, 1,   CDC25↓, 2,   CDC25↝, 1,   compI↓, 1,   compII↓, 1,   EGF↓, 1,   ETC↓, 4,   Insulin↓, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 14,   OCR↑, 1,   OXPHOS↓, 1,   PDH↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↑, 1,   ACSL4↑, 3,   ACSL4↝, 1,   ALAT↓, 5,   AMPK↑, 14,   ATP↓, 9,   ATP↑, 1,   mt-ATP↓, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 3,   FASN↑, 1,   FDG↓, 1,   G6PD↓, 2,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 4,   Glycolysis↓, 11,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   HK2↓, 8,   HMG-CoA↓, 1,   KeyT↑, 1,   lactateProd↓, 5,   lactateProd↑, 1,   LDHA↓, 4,   LDL↓, 2,   lipoGen↓, 1,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 2,   PDK1 / PDPK1↓, 4,   PDK3↑, 1,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 2,   Pyruv↓, 1,   RNR↓, 1,   SCD1↓, 2,   SIRT1↓, 2,   SIRT1↑, 6,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 6,   APAF1↑, 5,   Apoptosis↓, 1,   Apoptosis↑, 86,   ASC↓, 1,   BAD↓, 1,   Bak↓, 1,   BAX↓, 2,   BAX↑, 48,   Bax:Bcl2↑, 6,   Bcl-2↓, 50,   Bcl-2↑, 4,   Bcl-xL↓, 5,   Bcl-xL↑, 1,   BID↑, 2,   BIM↓, 1,   BIM↑, 3,   BNIP3↑, 3,   Casp↑, 14,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 53,   cl‑Casp3↑, 9,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 9,   cl‑Casp7↑, 2,   Casp8↑, 15,   cl‑Casp8↑, 2,   pro‑Casp8↑, 1,   Casp9↑, 34,   cl‑Casp9↑, 5,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 36,   DR5↓, 1,   DR5↑, 10,   Endon↑, 1,   FADD↑, 4,   Fas↑, 8,   FasL↓, 1,   FasL↑, 3,   Ferroptosis↓, 1,   Ferroptosis↑, 57,   GranB/GZMB↝, 1,   HEY1↓, 1,   IAP1↓, 2,   iNOS↓, 8,   Mcl-1↓, 7,   MDM2↓, 3,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 6,   Necroptosis↑, 1,   necrosis↑, 3,   NOXA↑, 1,   p38↓, 2,   p38↑, 8,   p‑p38↑, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 3,   survivin↓, 14,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 12,   XIAP↓, 6,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 53,   Akt↑, 2,   p‑Akt↓, 9,   AMPKα↑, 1,   CaMKII ↓, 1,   CK2↓, 1,   cMET↓, 1,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 16,   ERK↑, 3,   p‑ERK↓, 5,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   HRAS↓, 1,   IGF-1R↓, 2,   IKKα↓, 3,   JAK↓, 3,   JAK1↓, 1,   JAK2↓, 4,   JNK↓, 4,   JNK↑, 5,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 13,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↑, 1,   MEK↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   MKP1↝, 1,   mTOR↓, 29,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 3,   P70S6K↑, 1,   p‑P70S6K↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 39,   PI3K↑, 1,   p‑PI3K↓, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 6,   Raf↓, 2,   e-Raf↓, 1,   RAS↓, 4,   RIP1↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 6,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 22,   p‑STAT3↓, 5,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF3↑, 1,   ATF4↑, 7,   ATFs↑, 1,   cJun↓, 2,   p‑cJun↑, 1,   cMyc↓, 11,   cMyc↑, 1,   DLEU1↓, 1,   DNMT1↑, 1,   DNMTs↓, 1,   FOXM1↓, 1,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   H3↓, 2,   H3↑, 1,   H4↓, 1,   HATs↑, 1,   HDAC↓, 6,   HDAC1↓, 2,   HDAC2↓, 2,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-182-5p↓, 1,   miR-200b↑, 1,   miR-21↓, 2,   miR-22↑, 1,   miR-34a↓, 2,   miR-592↑, 1,   Myc↓, 1,   OCT4↓, 4,   other?, 1,   other↓, 2,   other↑, 5,   other↝, 11,   other∅, 1,   PhotoS↑, 1,   SOX2↓, 3,   TCF-4↓, 1,   tumCV↓, 26,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   eIF2α↑, 4,   p‑eIF2α↑, 3,   ER Stress↑, 21,   Erlin1↑, 1,   GRP78/BiP↑, 6,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 5,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 5,   p‑PERK↑, 1,   UPR↑, 8,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   autoF↓, 1,   autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 2,   LC3s↑, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 1,   p‑p62↑, 1,   TumAuto↑, 16,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 37,   hTERT/TERT↓, 3,   P53↓, 3,   P53↑, 47,   P53↝, 1,   PARP↑, 7,   cl‑PARP↓, 1,   cl‑PARP↑, 16,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 16,   Telomerase↓, 2,   TOP1↓, 4,   TOP2↓, 1,   TOP2↑, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 9,   CDK1↑, 3,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 13,   CDK2↑, 1,   CDK4↓, 15,   CDK4↑, 2,   CDK6↓, 3,   CDK6↑, 1,   CDK7↓, 1,   CHK1↓, 2,   CHK1↝, 1,   Chk2↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 4,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 19,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 9,   cycE/CCNE↑, 1,   E2Fs↓, 2,   Ki-67↓, 12,   mitA↑, 1,   P21↓, 2,   P21↑, 20,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 4,   pRB↑, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 85,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 1,   CD24↓, 1,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs↓, 8,   Diff↑, 2,   FGF↓, 2,   FOSL1↑, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 2,   Ki-67↓, 12,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 2,   NOTCH↓, 2,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 2,   Piezo1↑, 2,   Shh↓, 1,   TumCG↓, 37,   TumCP↓, 73,   TumCP↑, 2,   TumCP⇅, 1,   tyrosinase↓, 1,   Wnt↓, 12,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 5,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 2,   BACH1↑, 1,   Ca+2↓, 3,   Ca+2↑, 12,   i-Ca+2↑, 2,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 13,   EMT↓, 23,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 2,   fascin↓, 2,   Fibronectin↓, 2,   ITGB1↓, 1,   KRAS↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 2,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 27,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 30,   MMP9↑, 2,   MMPs↓, 20,   N-cadherin↓, 12,   PDGF↓, 2,   PGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 2,   Rho↝, 1,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 5,   SMAD2↓, 1,   Snail↓, 9,   T-cadherin↑, 1,   TET1↑, 2,   TGF-β↓, 2,   TIMP1↓, 1,   TIMP1↑, 6,   TIMP2↑, 7,   TIMP3↑, 1,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 29,   TumCI↑, 1,   TumCMig↓, 30,   TumCMig↑, 1,   TumMeta↓, 28,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 5,   Tyro3↓, 1,   uPA↓, 7,   uPAR↓, 1,   Vim↓, 12,   Vim↑, 1,   Zeb1↓, 1,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 17,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 40,   angioG↑, 1,   CD31/PECAM-1↓, 2,   EGR4↓, 1,   HIF-1↓, 2,   HIF-1↑, 1,   Hif1a↓, 19,   Hypoxia↓, 1,   LOX1↓, 2,   NO↓, 3,   NO↑, 4,   REL↑, 1,   VCAM-1↓, 2,   VEGF↓, 36,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN2↓, 1,   EPR↑, 3,   GLUT1↓, 4,   MMP↓, 52,   MMP↑, 1,   MPT↑, 3,   SLC12A5↓, 1,   TRPM7↓, 1,   TRPV1↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD44↓, 5,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 36,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 5,   DR4↑, 5,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HLA↑, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 4,   IFN-γ↑, 2,   Igs↓, 1,   Igs↑, 1,   IL1↓, 2,   IL10↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 4,   IL4↓, 2,   IL6↓, 13,   IL8↓, 4,   Imm↑, 11,   Imm↝, 1,   Inflam↓, 11,   LRIG1↑, 1,   pol-M1↑, 2,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   Neut↑, 1,   NF-kB↓, 50,   NF-kB↑, 4,   p‑NF-kB↓, 1,   NK cell↑, 6,   NLRP3↓, 2,   NLRP3↑, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 6,   PGE2↓, 6,   PSA↓, 3,   T-Cell↑, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR1↑, 1,   TLR4↓, 3,   TNF-α↓, 15,   TNF-α↑, 2,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   AR↑, 1,   CYP24A1↓, 1,   ER-α36↓, 3,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   PPARα↓, 2,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 12,   BioAv↑, 15,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 73,   ChemoSen↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   DDS↑, 2,   Dose?, 2,   Dose↑, 6,   Dose↝, 20,   Dose∅, 2,   eff↓, 25,   eff↑, 43,   eff↝, 5,   Half-Life↓, 4,   Half-Life↑, 1,   MDR1↓, 4,   P-gp/ABCB1↓, 6,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 22,   selectivity↑, 40,   Synergy?, 1,   Synergy↑, 40,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 5,   ALP↓, 1,   AR↓, 6,   AR↑, 1,   ascitic↓, 1,   AST↓, 3,   BG↓, 1,   BP↓, 1,   BUN↓, 1,   CEA↓, 2,   CIT↓, 1,   creat↓, 2,   CRP↓, 1,   E6↓, 4,   E7↓, 4,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   Ferritin↓, 3,   FOXM1↓, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 13,   KeyT↑, 1,   KRAS↓, 1,   LDH↓, 4,   LDH↑, 2,   Myc↓, 1,   NSE↓, 1,   PD-L1↓, 6,   PSA↓, 3,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 32,   antiNeop↑, 1,   AntiTum↑, 12,   cachexia↓, 2,   cardioP↑, 8,   chemoP↑, 23,   chemoPv↑, 8,   ChemoSideEff↓, 1,   cognitive↑, 3,   hepatoP↑, 11,   memory↑, 1,   neuroP↑, 4,   OS?, 1,   OS↑, 5,   Pain↓, 2,   Pin1↓, 1,   QoL↑, 3,   radioP↑, 6,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 7,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol?, 1,   TumVol↓, 7,   TumW↓, 4,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 1,   GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 8,  
Total Targets: 749

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 150,   ARE↑, 3,   Bil↓, 2,   Bil↑, 2,   Catalase↓, 3,   Catalase↑, 88,   Fenton↓, 4,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 61,   GPx1↑, 3,   GPx4↓, 3,   GPx4↑, 3,   GPx4∅, 1,   GSH↓, 3,   GSH↑, 98,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 19,   GSSG↓, 3,   GSTs↓, 3,   GSTs↑, 24,   H2O2↓, 11,   HDL↓, 1,   HDL↑, 6,   HDL∅, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 49,   HO-1↝, 1,   HO-1∅, 1,   Iron↓, 2,   Iron↝, 1,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   lipid-P?, 3,   lipid-P↓, 260,   lipid-P↑, 7,   mt-lipid-P↓, 1,   MDA↓, 59,   MDA↑, 1,   MPO↓, 7,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 3,   NQO1↑, 11,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 79,   NRF2∅, 1,   ONOO↓, 1,   Prx↑, 2,   RNS↓, 3,   ROS?, 2,   ROS↓, 210,   ROS↑, 6,   mt-ROS↓, 2,   selenoP↑, 2,   SOD?, 1,   SOD↓, 3,   SOD↑, 126,   mt-SOD↑, 1,   SOD1↓, 1,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 14,   TBARS↓, 5,   Thiols↑, 2,   TOS↓, 3,   Trx↑, 2,   UCPs↑, 1,   uricA↓, 2,   VitC↑, 7,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 18,   IronCh↝, 1,   Mets↝, 1,   NCOA4↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   DRP1/DNM1L↑, 1,   ETC↑, 1,   FIS1↓, 2,   MFN1↓, 1,   MFN2↓, 1,   mitResp↑, 3,   mtDam↓, 11,   OCR↑, 1,   OPA1↓, 1,   PGC-1α↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 8,   ACC↑, 1,   Acetyl-CoA↑, 3,   ACSL4↓, 2,   ACSL4∅, 1,   adiP↑, 2,   ALAT↓, 34,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 16,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 15,   ATP∅, 1,   mt-ATP↑, 1,   Buty↑, 1,   CPT1A↑, 1,   CRM↑, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   G6PD↑, 1,   glucose↓, 3,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 5,   GSK‐3β↓, 14,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↑, 1,   HMG-CoA↓, 1,   IDH1↑, 1,   LDL↓, 18,   lipidLev↓, 1,   NAD↓, 1,   NADH:NAD↑, 1,   NADPH↓, 5,   NADPH↑, 3,   PGC1A↑, 1,   PLA2↓, 1,   PONs↑, 1,   SCD1↓, 1,   SCFAs↑, 2,   SIRT1↑, 18,   SREBP1/SREBF1↓, 2,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 23,   ASC↓, 1,   BAX↓, 17,   BAX↑, 2,   Bax:Bcl2↓, 1,   Bcl-2↓, 4,   Bcl-2↑, 11,   Bcl-xL↑, 1,   Casp↓, 2,   cl‑Casp1↓, 1,   Casp3?, 1,   Casp3↓, 25,   Casp3↑, 1,   cl‑Casp3↓, 2,   proCasp3↓, 1,   Casp9↓, 11,   Cyt‑c↓, 6,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 9,   Ferroptosis↑, 2,   GSDMD↓, 1,   iNOS↓, 35,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 8,   p‑Akt↓, 1,   p‑Akt↑, 1,   Akt2↓, 1,   CREB↑, 3,   p‑CREB↑, 2,   EGFR↓, 1,   ERK↓, 5,   ERK↑, 1,   p‑ERK↓, 2,   IKKα↓, 2,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 1,   JAK2↓, 2,   JAK2↑, 1,   JNK↓, 6,   JNK↑, 2,   p‑JNK↓, 3,   MAPK↓, 10,   MAPK↑, 4,   MAPK↝, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   mTOR↓, 2,   mTOR↑, 3,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 8,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 1,   STAT↓, 1,   STAT3↓, 5,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 2,   cJun↓, 2,   cMyc↓, 1,   FOXO↑, 2,   FOXO3↑, 1,   HDAC↓, 1,   OCT4↓, 1,   other?, 2,   other↓, 7,   other↑, 10,   other↝, 17,   other∅, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 4,   GRP78/BiP↑, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   IRE1↓, 1,   PERK↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 1,   LC3B↑, 1,   LC3II↓, 1,   MitoP↑, 4,   p62↓, 2,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 14,   DNArepair↑, 1,   P53↓, 1,   P53↑, 1,   PCNA↑, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   GADD34↓, 1,   P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1,   Diff↑, 1,   Diff↝, 1,   IGF-1↑, 2,   IGFBP1↑, 1,   neuroG↑, 4,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 11,   AP-1↓, 3,   ATPase↑, 1,   Ca+2↓, 9,   Ca+2↑, 1,   Ca+2↝, 2,   Cartilage↑, 3,   COL1↓, 2,   COL1↑, 1,   Fibrosis↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 6,   MMPs↓, 2,   MUC1↑, 1,   N-cadherin↑, 1,   Na+↑, 1,   PDGF↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 1,   Tyro3↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 4,   CD31/PECAM-1↑, 1,   E-sel↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   p‑eNOS↑, 1,   LOX1↓, 1,   NO↓, 21,   NO↑, 1,   VCAM-1↓, 6,   VEGF↓, 2,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 4,   BBB↑, 28,   BBB↝, 3,   BBB∅, 2,   GastroP↑, 7,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 3,   MMP↓, 3,   MMP↑, 18,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   Na+↑, 1,   OATPs↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPM7↓, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 7,   IFN-γ↓, 9,   IFN-γ↑, 2,   IL1↓, 3,   IL10↓, 5,   IL10↑, 7,   IL12↓, 1,   IL17↓, 6,   IL18↓, 1,   IL1β↓, 52,   IL2↓, 4,   IL23↓, 2,   IL33↓, 1,   IL4↓, 7,   IL4↑, 1,   IL5↓, 1,   IL6↓, 53,   IL6↑, 2,   IL8↓, 8,   IL8↑, 1,   Imm↓, 1,   Imm↑, 10,   INF-γ↓, 1,   Inflam?, 1,   Inflam↓, 154,   Inflam↑, 3,   IRF3↓, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 7,   MyD88↓, 2,   NeuroI↓, 6,   NF-kB↓, 78,   NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 17,   p65↓, 1,   PGE2↓, 18,   RAGE↓, 1,   RANTES↓, 1,   TLR1↓, 2,   TLR2↓, 3,   TLR4↓, 11,   TLR4↑, 1,   TNF-α↓, 78,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 5,   Ach↑, 9,   AChE↓, 49,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 9,   BDNF↓, 2,   BDNF↑, 23,   ChAT↑, 9,   ChE↓, 1,   DA↑, 1,   GABA↑, 2,   GABA↝, 1,   GDNF↑, 1,   MAOA↓, 5,   MAOA↑, 1,   MAOA↝, 1,   MAOB↓, 3,   monoA↓, 1,   monoA↑, 1,   NGF↑, 3,   PSD95↑, 5,   RELN↑, 1,   SNAP25↑, 3,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 4,   Aβ↓, 55,   Aβ42↓, 3,   BACE/β-secretase↓, 16,   PSEN1/PS1↓, 1,   tau↓, 11,   p‑tau↓, 13,   XO↓, 1,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   CYP19↓, 1,   END↑, 1,   ER(estro)↓, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 4,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 8,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 32,   BioAv↑, 57,   BioAv⇅, 1,   BioAv↝, 13,   BioEnh↑, 1,   ChemoSen↑, 2,   CompStab↑, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 21,   eff↓, 1,   eff↑, 32,   eff↝, 2,   GSTA1↓, 1,   Half-Life↓, 4,   Half-Life↑, 3,   Half-Life↝, 14,   P-gp/ABCB1↓, 1,   P450↓, 2,   P450↑, 1,   Synergy↑, 18,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 34,   ALB↝, 1,   ALP↓, 12,   AST↓, 35,   BG↓, 3,   Bil↓, 2,   Bil↑, 2,   BloodF↑, 4,   BMD↑, 3,   BP↓, 11,   BP↝, 1,   BP∅, 1,   BUN↓, 4,   CEA↓, 1,   CK/CK-MB↓, 1,   creat↓, 9,   CRP↓, 9,   EGFR↓, 1,   hs-CRP↓, 1,   IL6↓, 53,   IL6↑, 2,   LDH↓, 14,   LDH↑, 1,   NOS2↓, 4,   RAGE↓, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 5,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 9,   antiAll↑, 9,   AntiArt↑, 5,   AntiCan↑, 14,   antiCG↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 21,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↑, 4,   Bone Healing↑, 1,   cardioP↑, 63,   CardioT↓, 1,   chemoP↑, 7,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 64,   cognitive∅, 2,   diuretic↑, 3,   hepatoP↓, 1,   hepatoP↑, 63,   Learn↑, 7,   memory?, 1,   memory↓, 1,   memory↑, 66,   memory∅, 1,   Mood↑, 1,   motorD↓, 1,   motorD↑, 8,   Mucositis↓, 2,   neuroP↑, 118,   NP/CIPN↓, 1,   Obesity↓, 7,   OS↑, 3,   Pain↓, 4,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 26,   Risk↓, 3,   Sleep↑, 2,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 7,   toxicity↓, 36,   toxicity↑, 2,   toxicity↝, 10,   toxicity∅, 5,   Weight↓, 2,   Weight↑, 1,   Weight∅, 2,   Wound Healing↑, 8,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 8,   AntiP↑, 1,   AntiViral↑, 8,   Bacteria↓, 17,   Diar↓, 2,   GutMicro↑, 22,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 2,   Ingr↝, 10,  
Total Targets: 572

Scientific Paper Hit Count for: lipid-P, lipid peroxidation
17 Curcumin
14 Thymoquinone
13 Quercetin
12 Silymarin (Milk Thistle) silibinin
11 Luteolin
11 Resveratrol
10 Silver-NanoParticles
10 Alpha-Lipoic-Acid
9 Eugenol
7 Artemisinin
7 Chrysin
7 Ferulic acid
7 Lycopene
7 Rosmarinic acid
7 Urolithin
6 Ashwagandha(Withaferin A)
6 Berberine
6 Carvacrol
6 Crocetin
6 Copper and Cu NanoParticles
6 Cisplatin
6 Shikonin
5 doxorubicin
5 Cinnamon
5 Matrine
5 Piperlongumine
5 Selenium NanoParticles
5 Selenite (Sodium)
4 Vitamin C (Ascorbic Acid)
4 Bacopa monnieri
4 Boron
4 Boswellia (frankincense)
4 Caffeic acid
4 Propolis -bee glue
4 Centella asiatica / Gotu kola → asiaticoside
4 Chemotherapy
4 Radiotherapy/Radiation
4 isoquercitrin
4 Phenethyl isothiocyanate
4 Licochalcone A
3 Allicin (mainly Garlic)
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Beta-Caryophyllene
3 α-Bisabolol / Chamomile oil
3 chitosan
3 Coenzyme Q10
3 Selenium
3 Docosahexaenoic Acid
3 Dandelion Root
3 EGCG (Epigallocatechin Gallate)
3 erastin
3 Fisetin
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Hydrogen Gas
3 Juglone
3 Melatonin
3 Moringa oleifera
3 Pterostilbene
3 salinomycin
2 1,8-Cineole
2 alpha Linolenic acid
2 Astaxanthin
2 Baicalein
2 Biochanin A
2 beta-carotene(VitA)
2 buckwheat sprouts
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Carnosine
2 Citicoline, CDP-Choline
2 Citric Acid
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Spirulina(Arthrospira/Limnospira)
2 Disulfiram
2 Emodin
2 Flaxseed/Linseed
2 phytic acid, Inositol hexakisphosphate
2 Flaxseed Oil
2 Ginkgo biloba
2 Ginkgetin
2 Graviola
2 Hyperoside
2 Inositol
2 Isoliquiritigenin
2 Sulforaphane (mainly Broccoli)
2 Kaempferol
2 Licorice
2 Linalool
2 Magnetic Fields
2 Mangiferin
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Piperine
2 Rutin
2 Vitexin
1 Astragalus
1 Glucose
1 Apigenin (mainly Parsley)
1 Atorvastatin
1 Aloe anthraquinones
1 Betulinic acid
1 Bromelain
1 Bruteridin(bergamot juice)
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 Cichoric acid / Chicoric acid
1 methotrexate
1 immunotherapy
1 Carica papaya leaf extract
1 Cranberry
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Diclofenac
1 diet Fermented Foods
1 diet Ketogenic
1 Oxygen, Hyperbaric
1 D-limonene
1 eicosapentaenoic acid
1 ferumoxytol
1 Formononetin
1 Fucoidan
1 Gallic acid
1 Gambogic Acid
1 Ginkgolide B
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 HydroxyTyrosol
1 Inulin Prebiotic
1 Isorhamnetin
1 isoflavones
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Lactobacillus
1 Lapachol
1 SDG/lignans
1 Methylene blue
1 MBE, Maqui berry
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 methylseleninic acid
1 Magnetic Field Rotating
1 Lemon Balm/Melissa officinalis
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Phosphatidylserine
1 Sulfasalazine
1 Shankhpushpi
1 Spermidine
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Vitamin B5,Pantothenic Acid
1 VitK3,menadione
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:453  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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