TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱

Source:

Type:

Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.

Scientific Papers found: Click to Expand⟱

477-

CUR,

Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells

-

in-vitro,

Cerv,

SiHa

5, 15, 30 and 50 µM, 6, 12, 24 and 48 h

TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB/CCNB1↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,

480-

CUR,

Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells

-

in-vitro,

GBM,

SNB19

10, 15, 20 and 25 µM, 48 and 72 h

TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, NEDD9↓, NOTCH1↓, p‑Akt↓,

437-

CUR,

Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids

-

vitro+vivo,

CRC,

TCO1

0.6, 2, 6 and 20 µg/mL, 72 h; 20 mg/day, 21 days

-

vitro+vivo,

CRC,

TCO2

cycD1/CCND1↓, cMyc↓, p‑ERK↓, CD44↓, CD133↓, LGR5↓, TumCCA↑, TumVol↓, CSCs↓,

456-

CUR,

Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells

-

vitro+vivo,

GC,

SGC-7901

50 μM, 24, 48 and 96 h

miR-34a↑, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, Bcl-2↓, CDK4/6↓, cycD1/CCND1↓,

455-

CUR,

Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin

-

in-vitro,

GC,

SGC-7901

10, 20, 40 and 80 µM, 48 h

Shh↓, Gli1↓, FOXM1↓, β-catenin/ZEB1↓, TumCMig↓, Apoptosis↑, TumCCA↑, Wnt↓, EMT↓, E-cadherin↑, Vim↓,

453-

CUR,

Cellular uptake and apoptotic properties of gemini curcumin in gastric cancer cells

-

in-vitro,

GC,

AGS

10,- 100 µM, 24, 48 and 72 h; 50 mg/kg, 6weeks

Bcl-2↓, survivin↓, BAX↑, TumCCA↑,

452-

CUR,

Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells

-

vitro+vivo,

HNSCC,

SCC9

0, 25, 10, 5, 2.5, 1.25 and 0.75 μM, 24 and 48 h

41uM

-

vitro+vivo,

HNSCC,

FaDu

-

vitro+vivo,

HNSCC,

HaCaT

TumCCA↑, PI3k/Akt/mTOR↓, Casp3↑, EGFR↓, EGF↑, PRKCG↑, p‑Akt↓, p‑mTOR↓, RPS6KA1↓, EIF4E↓, proCasp3↓,

448-

CUR,

Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation

-

in-vitro,

CRC,

HT-29

15, 20 and 25 μM, 48 h

Apoptosis↑, TumCCA↑, p‑Akt↓, Akt↓, Bcl-2↓, p‑BAD↓, BAD↑, cl‑PARP↑, ROS↑, HSP27↑, Beclin-1↑, p62↑, GPx1↓, GPx4↓,

442-

CUR,

5-FU,

Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress

-

in-vitro,

CRC,

HCT116

0-40uM

Apoptosis↑, TumCP↓, TumCCA↑, TET1↑, NKD2↑, Wnt↓, EMT↓, Vim↑, E-cadherin↓, β-catenin/ZEB1↓, TCF↓, AXIN1↓,

440-

CUR,

Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells

-

vitro+vivo,

CRC,

SW480

10, 20, 30, 40, 50 and 60 µM, 24 h; 100 mg/kg/day, 3 weeks

-

vitro+vivo,

CRC,

HT-29

13.69 μM

NNMT↓, p‑STAT3↓, TumCP↓, TumCCA↑, ROS↑,

137-

CUR,

Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling

-

in-vitro,

Pca,

DU145

NOTCH1↓, cycD1/CCND1↓, CDK2↓, P21↑, p27/CDKN1B↑, P53↑, Bcl-2↓, Casp3↑, Casp9↑, TumCCA↑, TumCP↓, Apoptosis↑,

146-

CUR,

EGCG,

Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells

-

in-vitro,

Pca,

PC3

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

DU145

P21↑, TumCCA↑, TumCP↓, BioAv↓,

117-

CUR,

Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells

-

in-vivo,

Pca,

RM-1

-

in-vivo,

Pca,

DU145

ROS↑, tumCV↓, Apoptosis↑, TumCCA↑, Ca+2↑, eff↓, ER Stress↑,

118-

CUR,

Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells

-

in-vitro,

Pca,

PC3

 2.2 μM

 for WZ35 analog. For Curcumin it is 20.9μM

-

in-vitro,

Pca,

DU145

ROS↑, Bcl-2↓, PARP↑, cDC2↓, CycB/CCNB1↓, MDM2↓, eff↓, eIF2α↑, ATF4↑, CHOP/DDIT3↑, ER Stress↑, TumCCA↑,

124-

CUR,

Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

C4-2B

TGF-β↓, Wnt↓, PI3k/Akt/mTOR↓, NF-kB↓, PTEN↑, Apoptosis↑, TumCCA↑,

132-

CUR,

Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells

-

in-vitro,

Pca,

PC3

TumCCA↑, ROS↑, TumAuto↑, UPR↑, ER Stress↑, Casp3↑, Casp9↑, Casp12↑, PARP↑, other↝, GRP78/BiP↑, PDI↑, eIF2α↑, other↝,

9-

CUR,

Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo

-

vitro+vivo,

MG,

U87MG

 15uM

-

vitro+vivo,

MG,

T98G

 31uM
31 uM

HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,

164-

CUR,

Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitro

-

in-vitro,

Pca,

PC3

NF-kB↓, AP-1↓, TumCG↓, TumCCA↑,

6227-

CUR,

Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations

-

Review,

Var,

NA

Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑,

6214-

CUR,

Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve

TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, eff↑, PhotoS↑, eff↑, ROS↑, GSH↓,

6231-

CUR,

Curcumin induces apoptosis in human hepatocellular carcinoma cells by decreasing the expression of STAT3/VEGF/HIF-1α signaling

-

in-vitro,

Liver,

HepG2

Apoptosis↑, TumCCA↑, STAT3↓, VEGF↓, Hif1a↓,

6223-

CUR,

Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects

-

Review,

Var,

NA

Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,

6221-

CUR,

Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer

-

Review,

Var,

NA

NF-kB↓, Imm↑, *TAC↑, *MDA↓, ROS↑, TumAuto↑, TumCCA↑, Keap1↑, ChemoSen↑, ER Stress↑, eff↓, TrxR↓, STAT3↓, *BioAv↓,

6720-

CUR,

SFN,

DHCA,

Synergistic Combinations of Curcumin, Sulforaphane, and Dihydrocaffeic Acid against Human Colon Cancer Cells

-

in-vitro,

Colon,

HT29

-

in-vitro,

Colon,

Caco-2

-

in-vitro,

Nor,

FHC

selectivity↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, ROS⇅, ERK↑, JNK↑, MAPK↑, P21↑, cycD1/CCND1↓, Cyt‑c↑,

6246-

Cyc,

Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

MDA-MB-231

HH↓, TumCP↓, TumCCA↓, TumCI↓, NF-kB↓, MMP2↓, MMP9↓, ERα/ESR1↓, cycD1/CCND1↓,

6247-

Cyc,

Sonic Hedgehog Pathway Contributes to Gastric Cancer Cell Growth and Proliferation

-

vitro+vivo,

GC,

MKN45

Shh↓, TumCP↓, TumCCA↓, Apoptosis↓, TumCG↓, cycD1/CCND1↓,

7450-

CYN,

Cynaropicrin Induces Cell Cycle Arrest and Apoptosis by Inhibiting PKM2 to Cause DNA Damage and Mitochondrial Fission in A549 Cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Nor,

BEAS-2B

PKM2↓, P53↑, PARP↓, TumCCA↑, selectivity↑, DNAdam↑, NRF2↓, NQO1↓, TrxR↓, Trx↓, ROS↑, MMP↓, Cyt‑c↑, Casp3↑, Apoptosis↑,

7449-

CYN,

Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines

-

in-vitro,

lymphoma,

U937

-

in-vitro,

AML,

Jurkat

TumCP↓, selectivity↑, Apoptosis↑, TumCCA↑, DNAdam↑, eff↓, ROS↑, tumCV↓,

7447-

CYN,

Antiproliferative Effects of Cynaropicrin on Anaplastic Thyroid Cancer Cells

-

in-vitro,

Thyroid,

8505C

-

in-vitro,

Thyroid,

CAL62

-

in-vitro,

Thyroid,

SW1736

tumCV↓, TumCCA↑, NF-kB↓, p‑STAT3↓, lipid-P↑, ROS∅,

7442-

CYN,

Cynaropicrin induces the apoptosis of colorectal cancer cells by elevating reactive oxygen species and activating the JNK/p38 MAPK

-

in-vitro,

CRC,

HCT116

Apoptosis↑, p‑JNK↑, p‑MAPK↑, ROS↑, eff↓, TumCCA↑, Bcl-2↓,

7437-

CYN,

Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma

-

in-vitro,

Mye,

AMO1

-

in-vivo,

Mye,

NA

Zebrafish

-

in-vitro,

Mye,

KMS11

-

in-vitro,

Mye,

JJN3

-

in-vitro,

Mye,

MolP8

-

in-vitro,

Mye,

L363

-

in-vitro,

Mye,

H929

tumCV↓, cMyc↓, STAT3↓, Akt↓, ERK↓, TumCCA↑, DNAdam↑, PARP1↑, AIF↑, TumCG↓,

1878-

DCA,

5-FU,

Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer

-

in-vitro,

CRC,

LS174T

57mM

-

in-vitro,

CRC,

LoVo

29mM

-

in-vitro,

CRC,

SW-620

38mM

-

in-vitro,

CRC,

HT-29

47mM

tumCV↓, eff↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,

1870-

DCA,

Rad,

Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation

-

in-vitro,

Pca,

PC3

TumCCA↑, Apoptosis↑, MMP↓, eff↑, RadioS↑,

6675-

Deg,

Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

BT474

-

in-vitro,

BC,

T47D

-

in-vitro,

BC,

MDA-MB-231

TumCG↓, TumCCA↑, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, TNF-α↓, PI3K↓, Akt↓,

6676-

Deg,

Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry

-

Review,

Var,

NA

TumCP↓, Apoptosis↑, NF-kB↓, Wnt↓, TumCCA↑, TumMeta↑, antiOx↑, Inflam↓, angioG↓, Half-Life↑, MMP2↓, MMP9↓, Casp9↑, Casp3↑, EMT↓, PTEN↑, ChemoSen↑, toxicity↑, *BBB↑,

1442-

Deg,

Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention

-

Review,

Var,

NA

PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27/CDKN1B↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,

1444-

Deg,

Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer

-

in-vitro,

GC,

MKN-28

1uM 24hrs

cell line SNU-484

Casp9↑, Casp3↑, Hif1a↓, VEGF↓, TumCCA↑, TumCG↓, DNAdam↑, p‑Akt↓,

6705-

DFC,

Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases

-

Review,

Var,

NA

*Inflam↓, *Pain↓, *COX1↓, *COX2/PTGS2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,

6708-

DFC,

Repurposing Drugs as Expanding Cancer Treatment Palette: Diclofenac

lactateProd↓, LDHA↓, TumCCA↑, TumCG↓, eff↑,

4456-

DFE,

Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells

-

in-vitro,

Pca,

PC3

TumCD↑, MMP↓, mt-ROS↑, Apoptosis↑, TumCCA↑,

4455-

DFE,

Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest

-

in-vitro,

BC,

MCF7

5, 10, 15, 20 and 25 mg/ml) of MEAD for 24, 48 and 72 h

18.2 mg/ml

-

in-vitro,

Nor,

3T3

 50 mg/ml

TumCCA↑, P53↑, BAX↑, Casp3↑, MMP↓, Fas↑, FasL↑, Bcl-2↓, Apoptosis↑, TumCP↓, TUNEL↑, eff↑, selectivity↑,

4454-

DFE,

Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells

-

in-vitro,

Liver,

HepG2

16.78 mg/mL

ROS↑, MMP↓, TumCCA↑, Apoptosis↑, selectivity↑, MMP↓, TumCCA↑,

1183-

DHA,

Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo

-

in-vitro,

BC,

4T1

-

in-vitro,

BC,

MCF7

-

in-vivo,

BC,

NA

 5% fish oil-supplemented diet

mice

TumCG↓, TumCCA↑, β-catenin/ZEB1↓, TCF↓, LEF1↓, cMyc↓, cycD1/CCND1↓, Wnt/(β-catenin)↓, TumMeta↓,

6719-

DHCA,

Anticancer potential of dihydrocaffeic acid: a chlorogenic acid metabolite

-

in-vitro,

BC,

MCF7

-

in-vitro,

Pca,

PC3

-

in-vitro,

Liver,

HepG2

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Nor,

HDFa

*antiOx↑, *cardioP↑, *neuroP↑, selectivity↑, selectivity↓, TumCCA↑, ROS↑, mtDam↑,

1844-

dietFMD,

Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment

-

Review,

NA,

NA

Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,

1897-

dietMet,

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

-

Review,

Var,

NA

OS↑, TumCG↓, TumCCA↑, ChemoSen↑, RadioS↑,

5190-

dietMet,

Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

MDA-MB-468

p‑eIF2α↑, ATF4↑, SESN2↑, TumCCA↑, Apoptosis↑, other↑,

6729-

Dipy,

Dipyridamole prevents triple-negative breast-cancer progression

-

Trial,

BC,

MDA-MB-231

TumCG↓, TumMeta↑, β-catenin/ZEB1↓, *AntiAg↑, TumCCA↑, Wnt↓, NF-kB↓,

6266-

DL,

Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer

-

Trial,

BC,

NA

forty-three women with newly diagnosed operable breast cancer

chemoPv↑, cycD1/CCND1↓, IGF-1↑, TumCCA↑, TumCP↓,

6281-

DL,

Applications of Limonene in Neoplasms and Non-Neoplastic Diseases

-

Review,

Var,

NA

-

Review,

AD,

NA

-

Review,

Diabetic,

NA

*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2/PTGS2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,

Showing Research Papers: 351 to 400 of 982
Prev Page 8 of 20 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 982

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1, Ferroptosis↑, 2, GPx1↓, 1, GPx4↓, 2, GSH↓, 2, HO-1↑, 1, Iron↑, 1, Keap1↑, 1, lipid-P↑, 2, MDA↑, 1, NADH↓, 1, NQO1↓, 1, NRF2↓, 2, NRF2↑, 2, OXPHOS↓, 1, ROS↑, 21, ROS⇅, 1, ROS∅, 1, mt-ROS↑, 1, SOD↑, 1, SOD2↓, 1, Trx↓, 1, TrxR↓, 2,

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1, ATP↓, 1, CDC25↓, 1, EGF↑, 1, ETC↓, 1, mitResp↑, 1, MMP↓, 8, mtDam↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMP↓, 1, AMPK↑, 3, cMyc↓, 4, FASN↓, 1, G6PD↓, 1, GLS↓, 1, GlucoseCon↓, 1, Glycolysis↓, 2, HK2↓, 1, lactateProd↓, 3, lactateProd↑, 1, LDHA↓, 2, NNMT↓, 1, PDK1↓, 1, PDKs↓, 1, PI3K/Akt↓, 1, PI3k/Akt/mTOR↓, 2, PKM2↓, 2, SCD1↓, 1, SIRT1↑, 1, SREBP2↓, 1, Warburg↓, 1,

Cell Death(tgid=5) ⓘ

Akt↓, 7, p‑Akt↓, 5, Apoptosis↓, 1, Apoptosis↑, 26, BAD↑, 1, p‑BAD↓, 1, BAX↑, 5, Bax:Bcl2↑, 1, Bcl-2↓, 11, Casp↑, 2, Casp12↑, 1, Casp3↑, 11, cl‑Casp3↑, 1, proCasp3↓, 1, Casp9↓, 1, Casp9↑, 5, Cyt‑c↑, 2, Fas↑, 1, FasL↑, 1, Ferroptosis↑, 2, iNOS↓, 2, JNK↑, 1, p‑JNK↑, 1, MAPK↓, 1, MAPK↑, 1, p‑MAPK↑, 1, MCT1↓, 1, MDM2↓, 1, Myc↓, 1, p27/CDKN1B↑, 2, survivin↓, 3, TumCD↓, 1, TumCD↑, 1, TUNEL↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1, other↝, 2, PhotoS↑, 2, sonoS↑, 1, tumCV↓, 5,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1, eIF2α↑, 2, p‑eIF2α↑, 1, ER Stress↑, 5, GRP78/BiP↑, 1, HSP27↑, 1, HSP90↓, 1, UPR↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1, Beclin-1↑, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, p62↑, 2, SESN2↑, 1, TumAuto↑, 3,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5, DNMTs↓, 1, P53↓, 1, P53↑, 6, p73↑, 1, PARP↓, 1, PARP↑, 3, cl‑PARP↑, 2, PARP1↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2, CycB/CCNB1↓, 4, cycD1/CCND1↓, 11, cycE/CCNE↓, 1, P21↑, 4, TumCCA↓, 2, TumCCA↑, 49,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AXIN1↓, 1, Axin2↑, 1, CD133↓, 1, CD44↓, 1, cDC2↓, 1, CSCs↓, 1, EIF4E↓, 1, EMT↓, 3, ERK↓, 1, ERK↑, 1, p‑ERK↓, 1, FOXM1↓, 2, Gli1↓, 2, GSK‐3β↓, 1, GSK‐3β↑, 1, HDAC↓, 1, HH↓, 2, IGF-1↓, 1, IGF-1↑, 1, LGR5↓, 1, miR-34a↑, 1, mTOR↓, 4, p‑mTOR↓, 1, NKD2↑, 1, NOTCH↓, 1, NOTCH1↓, 2, PI3K↓, 3, PI3K↑, 1, PRKCG↑, 1, PTEN↑, 3, RPS6KA1↓, 1, Shh↓, 3, STAT3↓, 5, p‑STAT3↓, 2, TCF↓, 2, TumCG↓, 11, Wnt↓, 8, Wnt/(β-catenin)↓, 1,

Migration(tgid=13) ⓘ

5LO↓, 1, AP-1↓, 2, Ca+2↑, 1, CDK4/6↓, 1, E-cadherin↓, 1, E-cadherin↑, 1, LEF1↓, 1, MMP2↓, 2, MMP9↓, 2, MMPs↓, 2, NEDD9↓, 1, TET1↑, 1, TGF-β↓, 1, TumCI↓, 5, TumCMig↓, 5, TumCP↓, 15, TumMeta↓, 3, TumMeta↑, 2, Vim↓, 1, Vim↑, 1, β-catenin/ZEB1↓, 7,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3, ATF4↑, 2, EGFR↓, 1, Hif1a↓, 5, PDI↑, 1, VEGF↓, 4,

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3, IKKα↓, 1, IL2↓, 1, Imm↑, 3, Inflam↓, 1, JAK↓, 1, NF-kB↓, 12, NK cell↑, 1, TNF-α↓, 2,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERα/ESR1↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2, BioAv↑, 1, ChemoSen↑, 7, eff↓, 5, eff↑, 7, eff↝, 1, Half-Life↓, 1, Half-Life↑, 1, RadioS↑, 3, selectivity↓, 1, selectivity↑, 6,

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1, ERα/ESR1↓, 1, FOXM1↓, 2, GutMicro↑, 2, Myc↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1, cardioP↑, 1, chemoP↑, 1, chemoPv↑, 1, hepatoP↑, 1, OS↑, 3, Risk↓, 1, toxicity↓, 1, toxicity↑, 1, TumVol↓, 1, TumVol↑, 1,
Total Targets: 225

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 2, GPx↑, 1, GSH↑, 1, lipid-P↓, 1, MDA↓, 1, ROS↓, 2, SOD↑, 1, TAC↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,

Migration(tgid=13) ⓘ

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1, GastroP↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1, COX2/PTGS2↓, 1, Inflam↓, 3,

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 2,

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1, AntiTum↓, 1, cardioP↑, 1, hepatoP↑, 1, neuroP↑, 4, Obesity↓, 1, Pain↓, 1, radioP↑, 1, toxicity↓, 1, toxicity↑, 1, toxicity↝, 1,
Total Targets: 33

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest

41 Curcumin
31 Quercetin
29 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Capsaicin
15 Piperlongumine
14 Radiotherapy/Radiation
14 Shikonin
13 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
11 Graviola
11 Magnolol
11 Lycopene
10 Propolis -bee glue
9 Cisplatin
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 5-fluorouracil
8 Allicin (mainly Garlic)
8 Carvacrol
8 Crocetin
8 Ferulic acid
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
8 Luteolin
7 Chemotherapy
7 chitosan
7 Evodiamine
7 Fucoidan
7 Indole-3-carbinol
7 Phenylbutyrate
7 Pterostilbene
6 doxorubicin
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Paclitaxel/Taxol
6 Gambogic Acid
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Juglone
4 Laetrile B17 Amygdalin
4 Linalool
4 Magnetic Field Rotating
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 Piperine
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Inositol
3 Isoliquiritigenin
3 Metformin
3 Propyl gallate
3 Parthenolide
2 Glucose
2 Gold NanoParticles
2 Photodynamic Therapy
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Melatonin
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 diet Methionine-Restricted Diet
2 Echinacea
2 Electrical Pulses
2 carboplatin
2 Geraniol
2 Hyperthermia
2 isoflavones
2 isoquercitrin
2 itraconazole
2 Vitexin
2 Licorice
2 Methylene blue
2 Magnesium
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Methylglyoxal
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Sanguinarine
1 Psoralidin
1 Kaempferol
1 Rhein
1 Rutin
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Home Page