DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
1468- SFN,    Cellular responses to dietary cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
ROS↑, DNAdam↑, MMP↓, Cyt‑c↑, TumCCA↑,
1460- SFN,    High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells
- in-vitro, Lung, NA
ROS↑, EGFR↓, eff↓, TumCCA↑, γH2AX↑, DNAdam↑, eff↓,
1472- SFN,    Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3
- in-vitro, ESCC, NA
TumCP↓, ROS↑, DNAdam↑,
1725- SFN,    Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
- Review, Var, NA
*toxicity∅, AntiCan↑, antiOx↑, NRF2↑, DNMTs↓, HDAC↓, Hif1a↓, VEGF↓, P21↑, TumCCA↑, ac‑H3↑, ac‑H4↑, DNAdam↑, Dose↝,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
8778- SFN,    Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
tumCV↓, IL6↓, STAT3↓, Dose↝, JAK2↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, DNAdam↑, chemoPv↑,
2406- SFN,    Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach
- Review, Pca, NA
HK2↓, PKM2↓, LDHA↓, Glycolysis↓, LAMP2↑, Hif1a↓, DNAdam↓, DNArepair↓, Dose↝,
3306- SIL,  Rad,    Radioprotective and radiosensitizing properties of silymarin/silibinin in response to ionizing radiation
- Review, Var, NA
radioP↑, RadioS↑, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, DNAdam↓, ROS↑, *ROS↓, *Inflam↓,
3297- SIL,  Rad,    Studies on radiation sensitization efficacy by silymarin in colon carcinoma cells
- in-vitro, CRC, HCT15 - in-vitro, CRC, RKO
TumCP↓, RadioS↑, TumCCA↑, DNAdam↓, MMP↓, ROS↓, *radioP↑,
1140- SIL,    Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
- in-vitro, PC, AsPC-1 - in-vivo, PC, NA - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCG↓, Glycolysis↓, cMyc↓, STAT3↓, TumCP↓, Weight∅, Strength↑, DNAdam↑, Casp3↑, Casp9↑, GLUT1↓, HK2↓, LDHA↓, GlucoseCon↓, lactateProd↓, PPP↓, Ki-67↓, p‑STAT3↓, cachexia↓,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
1342- SK,    RIP1 and RIP3 contribute to shikonin-induced DNA double-strand breaks in glioma cells via increase of intracellular reactive oxygen species
- in-vitro, GBM, NA - in-vivo, NA, NA
RIP1↑, RIP3↑, DNAdam↑, ROS↑, GSH↓,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2/PTGS2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
5109- SSE,    Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells
- in-vitro, CRC, HCT116
ROS↑, DNAdam↓, ATM↑, eff↓, TumCCA↑,
4610- SSE,  Rad,    Protection during radiotherapy: selenium
- Review, Var, NA
*radioP↑, *antiOx↑, *Inflam↓, *DNAdam↓, *lipid-P↓, *selenoP↑, *GPx1↑, *BUN↓,
4614- SSE,  Rad,    Updates on clinical studies of selenium supplementation in radiotherapy
- Review, Nor, NA
*toxicity∅, Risk↓, *selenoP↑, *ROS↓, *DNAdam↓, *QoL↑, *radioP↑, *Dose↝,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
5330- TFdiG,  Cisplatin,    Theaflavin-3,3′-Digallate Enhances the Inhibitory Effect of Cisplatin by Regulating the Copper Transporter 1 and Glutathione in Human Ovarian Cancer Cells
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
selectivity↑, ChemoSen↑, DNAdam↑, GSH↓, CTR1↑,
2373- TMZ,    The role of pyruvate kinase M2 in anticancer therapeutic treatments
- Review, Var, NA
PKM2↓, DNAdam↑,
2112- TQ,    Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breastcancer cells
- in-vitro, BC, MCF7
Apoptosis↑, DNAdam↑, ROS↑, GSH↓, MMP↓, Casp3↑, Casp7↑, Casp9↑, Bax:Bcl2↑, P53↑, P21↑, cycD1/CCND1↓, GSSG↑, GSH/GSSG↓,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2/PTGS2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27/CDKN1B↑, ROS↑, DNAdam↑, MUC4↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2129- TQ,  doxoR,    Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
- in-vitro, BC, MCF7
ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
7404- Trip,    Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug
- in-vitro, BC, MCF7
tumCV↓, selectivity↑, DNAdam↑, ROS↑, *ROS∅, Dose↓, TumCG↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1/CCL2↓, *MIP‑1α/CCL3↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,
4033- VitB3,    Can nicotinamide riboside protect against cognitive impairment?
- in-vivo, AD, NA
*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE/β-secretase↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,
4032- VitB3,    Modulation of cGAS-STING Pathway by Nicotinamide Riboside in Alzheimer's Disease
- in-vivo, AD, NA
*DNAdam↓, *Inflam↓, *other↓, *cognitive↑, *Mood↑,
4468- VitC,  SSE,    Selenium modulates cancer cell response to pharmacologic ascorbate
- in-vivo, GBM, U87MG - in-vitro, CRC, HCT116
eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,
6894- VitC,  Rad,    Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue
- Review, Var, NA
AntiTum↑, selectivity↑, H2O2↑, RadioS↑, radioP↑, ChemoSen↑, ROS↑, DNAdam↑,
599- VitC,    Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment
- Review, Var, NA
H2O2↑, DNAdam↑, ROS↑, Fenton↑, Apoptosis↑, necrosis↑,
598- VitC,    Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly
- Review, Var, NA
H2O2↑, ROS↑, TET1↑, DNAdam↑, G6PD∅,
627- VitC,    High-Dose Vitamin C for Cancer Therapy
- Review, Var, NA
ROS↑, PARP↑, GAPDH↓, DNAdam↑, ATP↓,
633- VitC,    Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
- Analysis, Var, NA
Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,
629- VitC,  Cu,  Fe,    The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer
- in-vitro, Var, NA
ROS↑, DNAdam↑, NAD↓,
628- VitC,  Mg,    Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
- in-vivo, Colon, CT26 - in-vitro, NA, MCF7 - in-vitro, NA, SkBr3
AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,
3104- VitC,    Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations
- Review, Var, NA
*antiOx↑, *ROS↓, *DNAdam↓, ROS↑, TET1↑, CSCs↓, HIF-1↓, BioAv↑, selectivity↑,
3109- VitC,    Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway
- in-vitro, Lung, H1299
TumMeta↓, NRF2↑, HO-1↑, cl‑Casp3↑, cl‑Casp9↑, DNAdam↑, Apoptosis↑, other↑, selectivity↑,
3128- VitC,    Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages
- in-vitro, Nor, NA
*ROS↓, *DNAdam↓, *TNF-α↓, *IL6↓, *p38↓,
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
1819- VitC,  VitK3,    The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy
- Review, Var, NA
Dose?, TumCD↑, selectivity↑, H2O2↑, ROS↑, DNAdam↑,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, Synergy↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
2284- VitK2,    Menadione-induced DNA damage in a human tumor cell line
- in-vitro, BC, MCF7
DNAdam↑, ROS↑,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*ALB↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,
1832- VitK3,  VitC,    Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
- in-vitro, AML, K562
ROS↑, H2O2↑, NF-kB↑, P53↑, cJun↑, Casp3↑, MMP↓, DNAdam↑, Dose?,

Showing Research Papers: 401 to 450 of 452
Prev Page 9 of 10 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 452

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 7,   Catalase↑, 3,   Catalase∅, 1,   cystine↓, 1,   Fenton↑, 8,   GPx↓, 2,   GPx↑, 4,   GPx4↓, 5,   GSH↓, 30,   GSH↑, 5,   GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 2,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs∅, 1,   H2O2↓, 1,   H2O2↑, 14,   HO-1↓, 7,   HO-1↑, 7,   HO-2↓, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 4,   c-Iron↑, 1,   lipid-P↓, 4,   lipid-P↑, 19,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 3,   i-MDA↑, 1,   mt-NADH↓, 1,   NADPH/NADP+↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 12,   Prx4↑, 1,   PrxII↓, 1,   ROS↓, 22,   ROS↑, 253,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   i-ROS↑, 3,   m-ROS↑, 1,   mt-ROS↑, 6,   SOD↓, 6,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC?, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx↓, 4,   Trx↑, 1,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 10,   TrxR1↓, 2,   TrxR1⇅, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   NCOA4↑, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   ADP:ATP↑, 1,   BCR↓, 1,   CDC2↓, 3,   CDC25↓, 10,   CDC25↝, 1,   compI↓, 2,   EGF↓, 3,   ETC↓, 2,   ETC↝, 1,   Insulin↓, 2,   mitResp↓, 2,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 19,   OCR↓, 1,   mt-OCR↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 2,   PDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 2,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 3,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 17,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 22,   ATP↑, 1,   CRM↑, 1,   ECAR↓, 1,   ECAR↝, 1,   p‑ENO1↓, 1,   FASN↓, 2,   G6PD∅, 1,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlucoseCon∅, 1,   Glycolysis↓, 21,   GSK‐3β↓, 6,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   H2S↑, 1,   Histones↑, 2,   HK2↓, 8,   lactateProd↓, 9,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 6,   LDL↓, 2,   MCT4↓, 1,   NAD↓, 5,   NADPH↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 7,   PPP↓, 1,   Pyruv↓, 2,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 4,   SIRT1↑, 6,   SIRT2↓, 1,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 17,   APAF1↑, 6,   Apoptosis↓, 6,   Apoptosis↑, 208,   mt-Apoptosis↑, 4,   BAD↓, 1,   BAD↑, 8,   Bak↑, 4,   BAX?, 1,   BAX↓, 2,   BAX↑, 74,   Bax:Bcl2↑, 26,   Bcl-2↓, 74,   Bcl-2↑, 2,   Bcl-xL↓, 13,   Bcl-xL↑, 1,   BID↑, 3,   p‑BID↓, 1,   cl‑BID↑, 2,   BIM↑, 5,   Casp↓, 2,   Casp↑, 33,   Casp3↓, 3,   Casp3↑, 129,   cl‑Casp3↑, 19,   proCasp3↑, 1,   pro‑Casp3↑, 2,   Casp6↑, 1,   Casp7↑, 20,   cl‑Casp7↑, 2,   Casp8↑, 28,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 71,   cl‑Casp9↑, 11,   proCasp9↑, 1,   pro‑Casp9↑, 1,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 64,   Diablo↑, 8,   DR5↑, 6,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 13,   FasL↑, 5,   Ferroptosis↑, 8,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 8,   JWA↑, 1,   Mcl-1↓, 8,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 4,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 4,   Necroptosis↑, 5,   necrosis↑, 6,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 4,   p38↑, 13,   p‑p38↑, 2,   Paraptosis↑, 2,   PUMA↑, 4,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 23,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 32,   XIAP↓, 11,   YAP/TEAD↓, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 81,   Akt↑, 2,   p‑Akt↓, 17,   p‑Akt↑, 2,   Akt2↓, 1,   CK2↓, 2,   cMET↓, 1,   cSrc↓, 1,   DDIT4↑, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   ERK↓, 31,   ERK↑, 4,   p‑ERK↓, 5,   p‑ERK↑, 2,   FGFR1↓, 2,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   HRAS↓, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   JAK↓, 5,   p‑JAK↓, 1,   JAK1↓, 4,   JAK1↑, 1,   JAK2↓, 7,   JNK↓, 4,   JNK↑, 13,   p‑JNK↑, 2,   MAPK↓, 23,   MAPK↑, 10,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 3,   MKK4↓, 1,   mTOR↓, 41,   mTOR↑, 2,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC2↓, 2,   NRAS↓, 1,   p70S6↓, 2,   p‑p70S6↑, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 47,   PI3K↑, 4,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PIK3CA↓, 1,   PKCδ↓, 9,   cl‑PKCδ↑, 1,   PTEN↓, 1,   PTEN↑, 13,   Raf↓, 4,   RAS↓, 6,   RIP1↑, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 6,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 34,   STAT3↑, 2,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT5↓, 4,   STAT6↓, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 1,   cMyc↓, 23,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   FOXM1↓, 3,   FOXO↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   FOXO3↝, 1,   FOXO4↑, 2,   ac‑H3↑, 3,   H3K18↓, 1,   ac‑H4↑, 2,   HATs↓, 2,   HDAC↓, 7,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC8↓, 1,   miR-21↓, 2,   miR-210↓, 1,   miR-218↑, 1,   miR-27a-3p↓, 1,   miR-590-3p↑, 1,   Myc↓, 4,   n-MYC↓, 1,   OCT4↓, 7,   other↓, 1,   other↑, 9,   other↝, 9,   OV6↓, 1,   PhotoS↑, 2,   SOX2↓, 5,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   TCF-4↓, 2,   tumCV?, 1,   tumCV↓, 58,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 12,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 35,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 12,   HSF1↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   IRE1↑, 4,   NPL4↓, 1,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 10,   XBP-1↓, 1,   XBP-1↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2,   ATG5↑, 2,   ATG7↑, 1,   autoF↓, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 3,   LC3s↝, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 3,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 6,   p‑ATM↑, 1,   ATR↑, 3,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↓, 14,   DNAdam↑, 377,   mt-DNAdam↑, 2,   DNArepair↓, 3,   FEN1↓, 2,   HR↓, 1,   hTERT/TERT↓, 6,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   NHEJ↓, 1,   p16↑, 2,   P53↓, 3,   P53↑, 67,   P53↝, 3,   p‑P53↑, 5,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 13,   p‑PARP↑, 1,   cl‑PARP↓, 3,   cl‑PARP↑, 56,   cl‑PARP↝, 1,   PARP1↑, 3,   PCNA↓, 21,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 10,   TOP1↓, 6,   TOP1∅, 1,   TOP2↓, 8,   TP53↑, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 25,   p‑γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 3,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 24,   CDK2↑, 1,   CDK4↓, 26,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 11,   CDK6↑, 2,   CDK8↓, 1,   CHK1↓, 4,   CHK1↑, 2,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 5,   p‑Chk2↑, 1,   ChrCon↑, 3,   Cyc↓, 1,   cycA1/CCNA1↓, 6,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 54,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 19,   cycE1↓, 2,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↑, 2,   Ki-67↓, 12,   mitA↑, 3,   P21↓, 3,   P21↑, 55,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 20,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 3,   TumCCA↑, 166,   TumCCA∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7,   ALDH1A1↓, 2,   ALDH1A3↓, 1,   CD133↓, 7,   CD133↑, 1,   cFos↓, 7,   CSCs↓, 34,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 4,   FGF↓, 1,   Gli1↓, 4,   HH↓, 2,   IGF-1↓, 5,   IGF-2↓, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   Ki-67↓, 12,   mTORC1↓, 3,   p‑mTORC1↓, 1,   Nanog↓, 7,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 5,   NOTCH⇅, 1,   NOTCH1↓, 7,   NOTCH1↑, 2,   NOTCH2↓, 1,   p300↓, 1,   PTCH1↓, 3,   SCF↓, 1,   Shh↓, 2,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 63,   TumCG↑, 1,   TumCP↓, 97,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 20,   Wnt/(β-catenin)↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 6,   APC↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 26,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   CD11b↑, 1,   Cdc42↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 17,   EMT↓, 33,   EMT↑, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 3,   GLI2↓, 2,   ITGB1↑, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 42,   MMP3↓, 4,   MMP7↓, 6,   MMP9↓, 43,   MMPs↓, 10,   MUC4↓, 1,   N-cadherin↓, 11,   NCAM↑, 1,   NEDD9↓, 1,   PDGF↓, 1,   RECK↑, 1,   Slug?, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 7,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β↑, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 7,   TRIB3↑, 1,   TSC1↑, 1,   TumCA↓, 2,   TumCI↓, 34,   TumCMig↓, 37,   TumMeta↓, 42,   TumMeta↑, 1,   Twist↓, 5,   TXNIP↑, 1,   uPA↓, 8,   Vim↓, 14,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54,   angioG↑, 2,   CD31/PECAM-1↓, 1,   Endoglin↑, 2,   eNOS↓, 2,   HIF-1↓, 4,   Hif1a↓, 29,   Hif1a↑, 1,   Hypoxia↓, 2,   LOX1↓, 2,   NO↓, 4,   NO↑, 5,   VCAM-1↓, 3,   VEGF↓, 51,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   CellMemb↑, 4,   CLDN1↓, 1,   CTR1↑, 2,   EPR↑, 11,   GLUT1↓, 5,   GLUT2↓, 1,   MMP↓, 115,   MMP↑, 2,   MMP↝, 1,   MPT↓, 1,   MPT↑, 4,   NHE1↓, 1,   SVCT-2↝, 1,   SVCT-2∅, 1,   TRPM7↓, 2,   TRPV1↓, 1,   TRPV1↑, 1,   TRPV1↝, 1,   VGCC↑, 1,   VGSC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 34,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 7,   DR4↑, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 8,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 2,   IL4↓, 2,   IL4↑, 1,   IL6↓, 22,   IL8↓, 3,   Imm↑, 13,   Inflam↓, 19,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 65,   NF-kB↑, 7,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 3,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 14,   PSA↓, 2,   TCF↓, 1,   TCF↑, 1,   TLR4↓, 3,   TNF-α↓, 17,   TNF-α↑, 4,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↑, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 7,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PRL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 20,   BioAv↑, 24,   BioAv↝, 5,   BioEnh↑, 3,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen↓, 2,   ChemoSen↑, 114,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   DDS↑, 1,   Dose?, 6,   Dose↓, 5,   Dose↑, 7,   Dose↝, 34,   Dose∅, 10,   DrugR↓, 1,   eff↓, 48,   eff↑, 88,   eff⇅, 1,   eff↝, 12,   GSTA1↑, 2,   Half-Life↓, 5,   Half-Life↝, 5,   MDR1↓, 8,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 13,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 59,   selectivity?, 2,   selectivity↓, 2,   selectivity↑, 99,   selectivity↝, 1,   Synergy↑, 62,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 1,   AR↓, 7,   AST↓, 1,   BG↓, 2,   BloodF↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↓, 2,   FOXM1↓, 3,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 6,   IL6↓, 22,   KRAS↓, 1,   LDH↓, 6,   LDH↑, 2,   LDH↝, 1,   Myc↓, 4,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 2,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 42,   AntiCan∅, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 11,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 6,   ChemoSideEff↓, 5,   hepatoP↑, 4,   K17↓, 1,   LC↑, 1,   neuroP↑, 3,   NKG2D↑, 1,   NP/CIPN↓, 1,   NP/CIPN↝, 1,   OS↑, 13,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 7,   RenoP↑, 4,   Risk↓, 10,   Strength↑, 1,   toxicity↓, 11,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 13,   TumW↓, 4,   Weight↑, 2,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,   Sepsis↓, 2,  
Total Targets: 831

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 57,   Bil↓, 1,   Catalase↑, 28,   DPPH↓, 1,   Fenton↓, 1,   GPx↑, 21,   GPx1↑, 2,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 24,   GSR↑, 2,   GSTs↑, 9,   H2O2↓, 1,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 4,   HO-1↑, 17,   Keap1↓, 1,   lipid-P↓, 22,   lipid-P↑, 1,   MDA↓, 20,   MPO↓, 3,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 20,   p‑NRF2↑, 1,   Prx↑, 1,   RNS↓, 3,   ROS?, 1,   ROS↓, 75,   ROS↑, 3,   ROS∅, 4,   selenoP↑, 5,   SOD↓, 2,   SOD↑, 31,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 2,   Trx1↑, 1,   uricA↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   FIS1↓, 1,   mtDam↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 4,   ACC↓, 1,   ALAT↓, 7,   AMPK↑, 2,   Buty↑, 1,   DGAT1↓, 1,   FASN↓, 2,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 2,   HMG-CoA↓, 1,   LDL↓, 6,   lipidLev↓, 1,   NADPH↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   BAX↓, 7,   Bax:Bcl2↓, 1,   Bcl-2↑, 5,   Bcl-xL↑, 1,   Casp↓, 1,   Casp3↓, 7,   cl‑Casp3↓, 1,   Casp9↓, 2,   Cyt‑c↓, 2,   iNOS↓, 10,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,   p38↑, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   ERK↓, 2,   ERK↑, 3,   IκB?, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↑, 1,   STAT3↓, 2,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   p‑cJun↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 4,   other↑, 4,   other↝, 3,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

CTSZ↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 63,   DNAdam↑, 3,   DNAdam∅, 1,   DNArepair↑, 2,   SIRT6↑, 2,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↓, 1,   Ki-67↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   FGF↑, 1,   Ki-67↓, 2,   TumCG↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 3,   Ca+2↝, 1,   COL1↓, 1,   COL1↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 1,   MUC1↑, 1,   ROCK1↓, 2,   Snail↑, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↑, 1,   Vim↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 5,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↑, 3,   MUC19↓, 1,   MUC2↓, 1,   TJ↑, 1,   VGCC↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD25+↑, 1,   CD4+↑, 2,   cGAS–STING↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 16,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 5,   IL17↓, 3,   IL1α↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL22↓, 2,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 19,   IL6↑, 1,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 70,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 4,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 19,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 4,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 2,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR1↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 23,   TNF-α↑, 1,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 6,   AChE↑, 1,   AChE↝, 1,   BChE↓, 2,   BDNF↑, 6,   GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   Aβ↓, 7,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GLP-1R↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 25,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 2,   CompStab↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose?, 2,   Dose↓, 2,   Dose↑, 2,   Dose↝, 19,   Dose∅, 1,   eff↓, 1,   eff↑, 16,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 2,   Half-Life∅, 1,   P450↓, 1,   P450↑, 1,   RadioS↑, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALB↑, 1,   ALB↝, 1,   ALP↓, 3,   AST↓, 8,   BG↓, 1,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 5,   BUN↓, 2,   creat↓, 3,   CRP↓, 4,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 19,   IL6↑, 1,   LDH↓, 2,   NOS2↓, 1,   RAGE↓, 2,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 6,   AntiArt↑, 4,   AntiCan↑, 13,   AntiDiabetic↑, 16,   AntiTum↑, 1,   Bone Healing↑, 1,   cardioP↑, 19,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 10,   diuretic↑, 2,   hepatoP↑, 20,   memory↑, 11,   Mood↑, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 27,   Obesity↓, 4,   OS↑, 3,   Pain↓, 3,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 11,   RenoP↑, 7,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity?, 2,   toxicity↓, 27,   toxicity↝, 6,   toxicity∅, 6,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 4,   AntiViral↑, 5,   Bacteria↓, 15,   Diar↓, 1,   GutMicro↑, 8,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 4,  
Total Targets: 339

Scientific Paper Hit Count for: DNAdam, DNA damage
33 Silver-NanoParticles
19 Radiotherapy/Radiation
17 Vitamin C (Ascorbic Acid)
14 Magnetic Fields
12 Curcumin
11 Fisetin
9 Cisplatin
8 Quercetin
8 Lycopene
7 Chemotherapy
7 Ashwagandha(Withaferin A)
7 doxorubicin
7 Chrysin
7 salinomycin
7 Selenium NanoParticles
7 Sulforaphane (mainly Broccoli)
6 Artemisinin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 Gallic acid
5 Kaempferol
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Ferulic acid
4 Garcinol
4 Licorice
4 Magnolol
4 Magnetic Field Rotating
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 chitosan
3 Moringa oleifera
3 Anethole/trans-Anethole
3 Melatonin
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Cat’s Claw
3 Cynaropicrin
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Hibiscus sabdariffa
3 Juglone
3 Lemongrass Extract/Citral
3 Lutein
3 mebendazole
3 Nimbolide
3 Marjoram (Origanum majorana)
3 Phenethyl isothiocyanate
3 Phycocyanin
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Metformin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Fucoidan
2 Gambogic Acid
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Hydrogen Gas
2 Hydroxycinnamic-acid
2 isoorientin
2 methylseleninic acid
2 Morin
2 Mucuna pruriens/Velvet Bean
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 buckwheat sprouts
1 Rutin
1 Zinc
1 carboplatin
1 Catechins
1 chaetocin
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Sesame seeds and Oil
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Germanium inorganic
1 Ginkgetin
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 Hyperthermia
1 HydroxyTyrosol
1 Isobavachalcone
1 isoquercitrin
1 Lapachol
1 Lasiodin
1 Linalool
1 Luteolin
1 MCT, metronomic chemo
1 Methyl salicylate / Sweet Birch oil
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Aromatherapy
1 5-fluorouracil
1 Piperine
1 Plumbagin
1 Rauwolfia serpentina/Indian Snakeroot
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 triptolide
1 Urolithin
1 Iron
1 Magnesium
1 Vitexin
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page