Database Query Results : Selenite, ,

Sel, Selenite: Click to Expand ⟱
Features:
Gypsum - a calcium sulfate mineral
Scientific Papers found: Click to Expand⟱
984- Sel,    Effects of selenite on estrogen receptor-alpha expression and activity in MCF-7 breast cancer cells
- in-vitro, BC, MCF-7
"highlight2" >ERα/ESR1↓, "highlight2" >PR↑, "highlight2" >pS2/TFF1↑, "highlight2" >Catalase↑,
1002- Sel,  Osi,  Adag,    Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference
- in-vitro, Lung, H1975 - in-vitro, Lung, H385
"highlight2" >Apoptosis↑, "highlight2" >Ferroptosis↑, "highlight2" >DNMT1↓, "highlight2" >TET1↑, "highlight2" >TumCCA↑, "highlight2" >cl‑PARP↑, "highlight2" >cl‑Casp3↑, "highlight2" >Cyt‑c↑, "highlight2" >BIM↑, "highlight2" >NOXA↑, "highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >ER Stress↑, "highlight2" >UPR↑,
1003- Sel,    Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression
- vitro+vivo, Lung, NA
"highlight2" >NF-kB↓, "highlight2" >PDK1↓, "highlight2" >p‑p65↑, "highlight2" >p‑IκB↑, "highlight2" >BAX↑, "highlight2" >lactateProd↓, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >mitResp↑, "highlight2" >Apoptosis↑,
1017- Sel,    Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis
- vitro+vivo, CRC, NA
"highlight2" >Akt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >cycD1/CCND1↓, "highlight2" >survivin↓, "highlight2" >Apoptosis↑, "highlight2" >ROS↑,
1018- Sel,    Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, HCT116 - vitro+vivo, CRC, SW480
"highlight2" >TumAuto↑, "highlight2" >LC3s↑, "highlight2" >TumW↓, "highlight2" >Weight∅, "highlight2" >Beclin-1↑, "highlight2" >p62↓, "highlight2" >ROS↑,
1062- Sel,    Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells
- in-vitro, GBM, LN229 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
"highlight2" >HDAC↓, "highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >Casp3↝, "highlight2" >MMP2↓, "highlight2" >*BioAv↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Ferroptosis↑, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

mitResp↑, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

lactateProd↓, 1,   PDK1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 5,   BAX↑, 1,   BIM↑, 1,   Casp3↝, 1,   cl‑Casp3↑, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 1,   NOXA↑, 1,   pS2/TFF1↑, 1,   survivin↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3s↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   PR↑, 1,  

Migration ⓘ

MMP2↓, 1,   TET1↑, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑IκB↑, 1,   NF-kB↓, 1,   p‑p65↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ERα/ESR1↓, 1,  

Clinical Biomarkers ⓘ

ERα/ESR1↓, 1,  

Functional Outcomes ⓘ

TumW↓, 1,   Weight∅, 1,  
Total Targets: 41

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↝, 1,  
Total Targets: 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:148  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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