Database Query Results : Shilajit/Fulvic Acid, ,

FulvicA, Shilajit/Fulvic Acid: Click to Expand ⟱
Features:
Fulvic acid is a naturally occurring compound found in soil, compost, and marine sediments. It is a complex mixture of many organic acids and has been studied for its antioxidant, anti-inflammatory, and immune-modulating properties.

AD:
-Fulvic acid may help inhibit tau fibril formatio
-Antioxidant activity
-Anti-inflammatory effects

Cancer:
-Fulvic acid’s role in reducing drug resistance and improving drug absorption has been suggested
-Synergistic effects with chemotherapy

Fulvic Acid database results: Note how it is antioxidant for normal cells, but may produce ROS in cancer cells. (explains synergistic effect with chemo)
LeafSource Fulvic Acid note how they use Fulvic Acid to improve bioavailability of berberine.
Scientific Papers found: Click to Expand⟱
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
4017- FulvicA,    Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease
- NA, AD, NA
*cognitive↑, *tau↓,
4018- FulvicA,  Fe,    Inhibitory Impacts of Fulvic Acid-Coated Iron Oxide Nanoparticles on the Amyloid Fibril Aggregations
- in-vivo, AD, NA
*Inflam↓, *Aβ↓,
4019- FulvicA,    Can nutraceuticals prevent Alzheimer's disease? Potential therapeutic role of a formulation containing shilajit and complex B vitamins
- Review, AD, NA
*neuroP↑,
4020- FulvicA,    Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease
- in-vitro, AD, NA
*tau↓, *cognitive↑,
4021- FulvicA,    Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer’s Disease
- in-vitro, AD, NA
*tau↓, *neuroP↑,
4022- FulvicA,  Chemo,    Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats
- in-vivo, OS, NA
AST↓, ALAT↓, ALP↓, Bil↝, creat↓, uricA↓, ChemoSen↑, chemoP↑,
4023- FulvicA,    Shilajit (Mumio) Elicits Apoptosis and Suppresses Cell Migration in Oral Cancer Cells through Targeting Urokinase-type Plasminogen Activator and Its Receptor and Chemokine Signaling Pathways
- in-vitro, Oral, NA
tumCV↓, selectivity↑, Apoptosis↑, uPA↓, TumCMig↓, Dose↝, CXCc↓,
4024- FulvicA,    ANTI-CARCINOGENIC ACTIVITY OF SHILAJIT REGARDING TO APOPTOSIS ASSAY IN CANCER CELLS: A SYSTEMATIC REVIEW OF IN-VITRO STUDIES
- Review, Var, NA
*Inflam↓, *antiOx↑, TumCG↓, tumCV↓, ROS↑, ChemoSen↑, toxicity↝, NA↝,
4025- FulvicA,    Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment
- in-vitro, Bladder, T24 - Review, AD, NA
tumCV↓, selectivity↑, TumCCA↑, other↝, *neuroP↑, *memory↑, *tau↓, *other↝, *lipid-P↓, *VitC↑, *antiOx↑,
4026- FulvicA,    Shilajitin Cancer Treatment: Probable Mode of Action
- Review, Var, NA
*Inflam↓, *antiOx↑, Dose↝,
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,
4028- FulvicA,    Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells
- in-vitro, Liver, HUH7
Apoptosis↑, TumCP↓, ROS↑, NO↑, Dose↝, MMP↓, Cyt‑c↑, SOD↓, Catalase↓, GSH↑, lipid-P↑, miR-21↓, miR-22↑,
4029- FulvicA,  Chemo,    Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling
- in-vivo, Var, NA
*other↑, *PCNA↑, *SOD↑, *lipid-P↓, *NRF2↑, *Keap1↓, *chemoP↑,
4030- FulvicA,    Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes
- Review, NA, NA
*Inflam↓, TNF-α↓, *COX2↓, *PGE2↓, *ROS↓, *GutMicro↑, *BioEnh↑, *BioEnh↑, *SOD↑, *Catalase↑, *GPx↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Results for Effect on Cancer/Diseased Cells:
ALAT↓,1,   ALP↓,1,   Apoptosis↑,2,   AST↓,1,   Bil↝,1,   BioAv↑,1,   Catalase↓,1,   chemoP↑,1,   ChemoSen↑,2,   creat↓,1,   CTNNB1↓,1,   CXCc↓,1,   Cyt‑c↑,1,   Dose↝,3,   E-cadherin↑,1,   EMT↓,1,   GSH↑,1,   lipid-P↑,1,   miR-21↓,1,   miR-22↑,1,   MMP↓,1,   NA↝,1,   NO↑,1,   NOTCH1↓,1,   other↝,1,   ROS↑,2,   selectivity↑,3,   SOD↓,1,   Src↓,1,   TGF-β↓,1,   TNF-α↓,1,   toxicity↝,1,   TumCCA↑,1,   TumCG↓,1,   TumCMig↓,1,   TumCP↓,1,   tumCV↓,4,   TumMeta↓,1,   Twist↓,1,   uPA↓,1,   uricA↓,1,  
Total Targets: 41

Results for Effect on Normal Cells:
AntiAge↑,1,   antiOx↑,4,   Aβ↓,1,   BioAv↑,1,   BioEnh↑,2,   Catalase↑,1,   chemoP↑,1,   cognitive↑,3,   COX2↓,1,   Dose↝,1,   GPx↑,1,   GutMicro↑,1,   Inflam↓,5,   Keap1↓,1,   lipid-P↓,2,   memory↑,2,   neuroP↑,4,   NRF2↑,1,   other↑,1,   other↝,1,   PCNA↑,1,   PGE2↓,1,   ROS↓,1,   SOD↑,2,   Strength↑,1,   tau↓,5,   toxicity↑,1,   toxicity↝,1,   VitC↑,1,  
Total Targets: 29

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:358  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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