Keap1 Cancer Research Results

Keap1, Kelch-like ECH-associated protein 1: Click to Expand ⟱
Source:
Type:
Kelch-like ECH-associated protein 1 (Keap1) is a key regulator of the transcription factor Nrf2.

-In several tumor types, loss of Keap1 function (either due to gene mutations or low protein expression) results in unrestrained Nrf2 activity.
• Persistent Nrf2 activation is thought to:
 - Provide tumor cells with enhanced protection against oxidative stress.
 - Contribute to chemoresistance and radioresistance.
 - Promote metabolic reprogramming that fuels tumor growth.

• Thus, in many cancers, altered Keap1 status can serve as an indicator of poor prognosis and has been investigated as a potential target for therapeutic intervention.
Scientific Papers found: Click to Expand⟱
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
4991- ART/DHA,  doxoR,    Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy
- in-vivo, Nor, H9c2
*cardioP↑, *ROS↓, *Ferroptosis↓, *NRF2↑, Keap1↓,
3173- Ash,    Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
- in-vitro, neuroblastoma, NA
GPx4↓, HO-1↑, lipid-P↑, Keap1↓, NRF2↑, Ferroptosis↑,
3172- Ash,    Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis
- in-vitro, HCC, HepG2 - in-vitro, Nor, HL7702
Keap1↑, NRF2↓, EMT↓, TumCP↓, TumCI↓, selectivity↑, *toxicity↓, ROS↑, MDA↑, GSH↓, Ferroptosis↑,
4678- Ash,    Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer
- vitro+vivo, NSCLC, H1975
ROS↑, AntiTum↑, CSCs↓, mTOR↓, STAT3↓, ChemoSen↑, Keap1↑, NRF2↓,
2720- BetA,    Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo
- in-vitro, Cerv, HeLa
Keap1↝, ROS↑, Ca+2↑, Beclin-1↓, GRP78/BiP↑, LC3II↑, p62↑, ERStress↑, TumAuto↑,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL6↑, *MMP13↓,
2394- CAP,    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
- in-vitro, Nor, GES-1
*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6225- CUR,    Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance
- Review, Var, NA
ox-Trx1↑, TrxR1↓, TrxR↓, ROS↑, GSH/GSSG↓, eff↓, Fenton↑, H2O2↑, *NRF2↑, *Keap1↓, *HO-1↑, *NQO1↑, ChemoSen↑,
6221- CUR,    Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer
- Review, Var, NA
NF-kB↓, Imm↑, *TAC↑, *MDA↓, ROS↑, TumAuto↑, TumCCA↑, Keap1↑, ChemoSen↑, ER Stress↑, eff↓, TrxR↓, STAT3↓, *BioAv↓,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
3219- EGCG,    Nano-chemotherapeutic efficacy of (−) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2/Keap1signaling
- in-vitro, Lung, A549
ROS↑, RNS↓, MMP↓, NRF2↑, Keap1↓,
3216- EGCG,    Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation
- NA, Colon, Caco-2
NRF2↑, TumCP↓, mt-ROS↓, Keap1↓,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1↑, *p62↑, *COX2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, eff↑, *toxicity↓, *BioAv↑, *BioAv↑, *eff↑,
4029- FulvicA,  Chemo,    Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling
- in-vivo, Var, NA
*other↑, *PCNA↑, *SOD↑, *lipid-P↓, *NRF2↑, *Keap1↓, *chemoP↑,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
4800- Lyco,    Recent insights on pharmacological potential of lycopene and its nanoformulations: an emerging paradigm towards improvement of human health
- Review, Var, NA
*antiOx↑, Keap1↝, NF-kB↝, NRF2↝, PI3K↝, Akt↝, mTOR↝, *GutMicro↑,
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
2955- PL,    Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
ROS?, *ROS∅, other⇅, HO-1↑, *HO-1↑, NRF2↑, Keap1↓, cl‑PARP↑, selectivity↑, GSH↓, GSSG↑,
2954- PL,    The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy
- Review, Var, NA
NRF2↑, ROS↑, ER Stress↑, MAPK↑, CHOP/DDIT3↑, selectivity↑, Keap1↝, HO-1↑, Ferroptosis↑,
1985- PTL,    KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing Radiosensitive Effects of Parthenolide in Normal and Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Nor, PrEC - in-vivo, NA, NA
ROS↑, NADPH↑, RadioS↑, radioP↑, Trx↓, *ox-Keap1↑, ox-Keap1↓, rd-Keap1↑, *NRF2↑, NRF2∅, NF-kB↓,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
5028- QC,    Quercetin inhibited LPS-induced cytokine storm by interacting with the AKT1-FoxO1 and Keap1-Nrf2 signaling pathway in macrophages
- vitro+vivo, Nor, RAW264.7
*ROS↓, *Keap1↓, *NRF2↑,
3363- QC,    The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
- in-vitro, Nor, HBMECs
*Apoptosis↓, *angioG↑, *NRF2↑, *Keap1↓, *ATF6↓, *GRP78/BiP↓, *CLDN5↑, *ZO-1↑, *MMP↑, *BBB↑, *ROS↓, *ER Stress↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3062- RES,    Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis
- in-vivo, Nor, NA
*antiOx↑, *Keap1↓, *NRF2↑, *HO-1↑, *GPx↑, *SOD↑,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT↓, GPx4↓, GSH/GSSG↓, Keap1↑,
2009- SK,    Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer
- in-vitro, Bladder, NA
TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, eff↑,
2126- TQ,    Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway
- Review, Nor, NA
*antiOx↑, *Bacteria↓, *RenoP↑, *hepatoP↑, *neuroP↑, *Inflam↓, *Keap1↓, *NRF2↑, *other↝,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*Albumin↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,

Showing Research Papers: 1 to 36 of 36

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 36

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 1,   Ferroptosis↑, 5,   GPx4↓, 2,   GSH↓, 4,   GSH/GSSG↓, 2,   GSSG↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 4,   Iron↑, 2,   Keap1↓, 7,   Keap1↑, 5,   Keap1↝, 3,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↑, 3,   MDA↑, 2,   NRF2↓, 3,   NRF2↑, 7,   NRF2↝, 1,   NRF2∅, 1,   RNS↓, 1,   ROS?, 1,   ROS↑, 15,   mt-ROS↓, 1,   SOD↑, 1,   Trx↓, 1,   ox-Trx1↑, 1,   TrxR↓, 2,   TrxR1↓, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   MMP↓, 2,   mtDam↑, 2,   OCR↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ECAR↓, 1,   GlutMet↓, 1,   Glycolysis↓, 1,   NADPH↑, 1,   PFK↓, 1,   PI3K/Akt↓, 1,   POLD1↓, 1,   SIRT1↑, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   Akt↝, 1,   Apoptosis↑, 2,   Bak↓, 1,   BAX↑, 4,   Bcl-2↓, 5,   BID↑, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 4,   Casp8↑, 2,   Casp9↑, 4,   cFLIP↓, 1,   CK2↓, 1,   Cyt‑c↑, 4,   Fas↑, 2,   Ferroptosis↑, 5,   iNOS↓, 2,   JNK↑, 1,   MAPK↑, 3,   Mcl-1↓, 2,   Necroptosis↑, 1,   p27↑, 1,   p38↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other⇅, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   ERStress↑, 1,   GRP78/BiP↑, 1,   HSP27↝, 1,   HSP70/HSPA5↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 2,   LC3II↑, 1,   p62↓, 1,   p62↑, 2,   p‑p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   P53?, 1,   P53↓, 1,   P53↑, 3,   PARP↑, 2,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   mitA↑, 1,   P21↑, 3,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 3,   EMT↓, 2,   ERK↓, 2,   ERK↑, 1,   FGF↓, 1,   FOXM1↓, 1,   FOXO4↓, 1,   GSK‐3β↑, 1,   IGF-1↓, 2,   mTOR↓, 5,   mTOR↝, 1,   Nanog↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 3,   PI3K↝, 1,   RAS↓, 1,   SOX2↓, 1,   STAT3↓, 4,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   Ca+2↑, 1,   CEA↓, 1,   E-cadherin↑, 1,   p‑FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   LAMs↓, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 2,   Rho↑, 1,   ROCK1↑, 1,   Slug↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP2↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 8,   TumMeta↓, 1,   Twist↓, 1,   Vim?, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   EGFR↓, 2,   EGFR↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   NO↓, 1,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 4,   CRP↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 2,   Imm↑, 1,   JAK2↓, 1,   M2 MC↓, 1,   NF-kB↓, 5,   NF-kB↑, 2,   NF-kB↝, 1,   PD-1↓, 2,   PGE2↓, 1,   Th1 response↑, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,   ChemoSen↑, 7,   eff↓, 3,   eff↑, 5,   RadioS↑, 3,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

BMPs↑, 1,   CEA↓, 1,   CRP↓, 1,   EGFR↓, 2,   EGFR↑, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 2,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   chemoP↑, 1,   NP/CIPN↓, 1,   radioP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 198

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,   Stroke↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 12,   Catalase↑, 7,   Catalase↝, 1,   Ferroptosis↓, 1,   GPx↑, 7,   GPx↝, 1,   GSH↑, 8,   GSH/GSSG↓, 1,   GSR↑, 1,   GSS↑, 1,   GSTs↑, 1,   HDL↑, 1,   HO-1↓, 2,   HO-1↑, 7,   HO-1⇅, 1,   Keap1↓, 17,   Keap1↑, 2,   Keap1↝, 1,   ox-Keap1↑, 1,   lipid-P↓, 4,   MDA↓, 8,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 22,   ROS↓, 17,   ROS∅, 1,   mt-ROS?, 1,   SIRT3↑, 1,   SOD↑, 9,   SOD↝, 1,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 2,   Trx↑, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 2,   Insulin↑, 1,   MMP↑, 3,   mtDam↓, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 4,   glucose↓, 1,   glucose↝, 1,   GLUT2↑, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDH↓, 2,   LDHA↓, 1,   PKM2↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 3,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 4,   Casp9↓, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 6,   MAPK↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PARP1↓, 1,   PCNA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   p‑ERK↑, 1,   PI3K↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   MMP13↓, 1,   Rho↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   VCAM-1↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CLDN5↑, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2↓, 6,   COX2↑, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 4,   IL6↓, 4,   IL6↑, 1,   Imm↑, 1,   Inflam↓, 10,   pol-M2 MC↑, 1,   NF-kB↓, 6,   PGE2↓, 1,   TLR4↓, 2,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   NGF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   BACE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 5,   BioAv↝, 1,   eff↑, 3,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   Albumin↑, 1,   ALP↓, 1,   AST↓, 4,   BMD↑, 1,   BP↓, 1,   creat↓, 2,   GutMicro↑, 3,   IL6↓, 4,   IL6↑, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   antiPs↑, 1,   cardioP↑, 8,   chemoP↑, 2,   cognitive↑, 2,   hepatoP↑, 6,   memory↑, 4,   motorD↑, 1,   neuroP↑, 10,   Obesity↓, 1,   Pain↓, 1,   RenoP↑, 4,   toxicity↓, 4,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   CD8+↑, 1,  
Total Targets: 159

Scientific Paper Hit Count for: Keap1, Kelch-like ECH-associated protein 1
3 Ashwagandha(Withaferin A)
3 Quercetin
3 Resveratrol
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Lycopene
2 Piperlongumine
2 Shikonin
1 Allicin (mainly Garlic)
1 Artemisinin
1 doxorubicin
1 Betulinic acid
1 Boron
1 Selenium
1 α-Bisabolol / Chamomile oil
1 Capsaicin
1 Chlorogenic acid
1 Disulfiram
1 Copper and Cu NanoParticles
1 Fisetin
1 Formononetin
1 Shilajit/Fulvic Acid
1 Chemotherapy
1 Ginkgetin
1 Honokiol
1 Magnetic Fields
1 Parthenolide
1 Thymoquinone
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1174  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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