Hcy/homoC Cancer Research Results

Hcy/homoC, homocysteine: Click to Expand ⟱
Source:
Type: Biomarker
Homocysteine is a sulfur-containing amino acid produced during the metabolism of methionine. Elevated homocysteine levels and alterations in its metabolic enzymes have been associated with various pathological processes, including oxidative stress, DNA damage, and inflammation.
-Elevated plasma homocysteine levels (hyperhomocysteinemia) are a well‐established risk factor for cardiovascular diseases.
-Some studies have suggested that high levels of homocysteine might be associated with an increased risk of certain cancers.
-Vitamins like folate, B6, and B12 are key regulators of homocysteine metabolism, some research has examined whether supplementation might modulate cancer risk. However, clinical outcomes have been mixed and further research is needed.

-Various clinical trials have shown that the oral supplementation of folic acid, B6, and B12 vitamins significantly lowers circulating homocysteine levels.
Scientific Papers found: Click to Expand⟱
4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *cognitive↑, *Inflam↓, *Hcy/homoC↓, *TNF-α↓, *other↝, *memory↑,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, Hcy/homoC↓, eff↝, other↝,
4261- Chol,  VitB12,  FA,  VitB2,    B-Vitamin and Choline Supplementation Changes the Ischemic Brain
- Study, Stroke, NA
*BDNF↑, *Hcy/homoC↓,
4068- FA,    Hyperhomocysteinemia in Alzheimer's disease: the hen and the egg?
- in-vivo, AD, NA
*Hcy/homoC↓, *Aβ↓,
4064- FA,  VitB6,  VitB12,    High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
- Trial, AD, NA
*Hcy/homoC↓, *cognitive∅,
4075- FA,    Folic acid, ageing, depression, and dementia
- Review, AD, NA
*Mood↑, *cognitive↑, *other↝, *memory↑, *QoL↑, *Hcy/homoC↝, *other↝, *Dose↝,
4074- FA,  VitB12,    Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study
- Trial, AD, NA
*cognitive↑, *Hcy/homoC↓, *other↝, *other↝,
4044- FA,    Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial
- Trial, AD, NA
*Hcy/homoC↓, *memory↑, *cognitive↑,
6870- FA,    Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial
- Trial, AD, NA
*Dose↝, *cognitive↑, *Hcy/homoC↓, *MMP9↓, *Risk↓,
6962- FA,  VitB12,    Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design
- Trial, AD, NA
*Hcy/homoC↝, *IL6↓, *TNF-α↓, *MCP1/CCL2↝, *eff↑, *cognitive↑, *Inflam↓,
6951- FA,    Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI
- Trial, AD, NA
*Dose↝, *cognitive↑, *Hcy/homoC↓, *IL6↓, *TNF-α↓,
6949- FA,  VitB12,    A controlled trial of homocysteine lowering and cognitive performance
- Trial, AD, NA
*Hcy/homoC↓, *cognitive∅,
6948- FA,  VitB12,    A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people
- Trial, AD, NA
*Dose↝, *Hcy/homoC↓, *cognitive∅,
6947- FA,    Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial
- Trial, AD, NA
*Hcy/homoC↓, *cognitive↑,
6946- FA,    Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
- Review, Var, NA
Hcy/homoC↓, Risk∅, toxicity↓,
6954- FA,    Folic acid as a potential therapeutic agent for Alzheimer's disease: Effects on inflammatory cytokines, amyloid deposition, and neurotransmitter metabolism
- Trial, AD, NA
*Inflam↓, *Aβ↓, *IL1β↓, *IL6↓, *TNF-α↓, *tau↓, *GABA↑, *5HT↑, *Ach↑, *Albumin↑, *HemoG↑, *neuroP↑, *Hcy/homoC↓,
6956- FA,  VitB12,    A randomized placebo-controlled trial of using B vitamins to prevent cognitive decline in older mild cognitive impairment patients
- Trial, AD, NA
*Dose↝, *Hcy/homoC↓, *cognitive↑, *eff↓,
6961- FA,  VitB12,  VitB6,  Silicon,  Alum  B Vitamins Prevent Iron-Associated Brain Atrophy and Domain-Specific Effects of Iron, Copper, Aluminum, and Silicon on Cognition in Mild Cognitive Impairment
- Trial, AD, NA
*BrainVol↝, *cognitive↝, *cognitive↑, *Dose↝, *other↝, *Hcy/homoC↓, *Risk↓, *BrainVol∅, *BrainVol↑, *other↝, *cognitive↑, *cognitive↑, *other↝, *Risk↝,
2173- FA,  VitB12,    Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer
- Study, CRC, NA
Risk↓, eff↝, eff↝, Hcy/homoC↓,
2174- FA,  VitB12,   
- Analysis, Var, NA
Hcy/homoC↓, eff↑, eff↑, eff↑, eff↝, Hcy/homoC↝, other?,
2176- FA,  VitB12,    Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions
- Review, Var, NA
Hcy/homoC↓, eff↝,
4063- Flav,  VitB12,  VitB6,    Homocysteine and Dementia: An International Consensus Statement
- Review, AD, NA
*Hcy/homoC↓, *cognitive↑,
4058- VitB12,  VitB6,  FA,    The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis
- Review, AD, NA
*Hcy/homoC↓, *cognitive↑,
4054- VitB12,  VitB6,  FA,    Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial
- Study, AD, NA
*Hcy/homoC↓, *neuroP↑, *cognitive↑,
4053- VitB12,  VitB6,  FA,    Vitamins in Alzheimer’s Disease—Review of the Latest Reports
- Review, AD, NA
*cognitive↑, *Hcy/homoC↓, *SAM-e↓,
4048- VitB12,    Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer’s Disease: A Case-Control Study
- Study, AD, NA
*Hcy/homoC↓, *other↝, *other↝,
4045- VitB12,  FA,    Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
- Trial, AD, NA
*Hcy/homoC↓, *cognitive↑, *memory↑, *other↑,
4043- VitB12,  FA,    Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment
- Trial, AD, NA
*other↑, *other↑, *eff↝, *Hcy/homoC↓, *cognitive↑,
4318- VitB12,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Hcy/homoC↓, *cognitive↑,
4315- VitB2,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
*GlucoseCon↑, *ATP↑, *Hcy/homoC↓, *ROS↓, *Aβ↓, *Aβ↓, *Inflam↓,
4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *Hcy/homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,

Showing Research Papers: 1 to 31 of 31

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 31

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↓, 1,   other↝, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 3,   eff↝, 5,  

Clinical Biomarkers(tgid=22) ⓘ

Hcy/homoC↓, 5,   Hcy/homoC↝, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,   Risk∅, 1,   toxicity↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,   SAM-e↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↑, 3,   other↝, 11,  

Migration(tgid=13) ⓘ

MMP9↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 3,   Inflam↓, 4,   MCP1/CCL2↝, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   BDNF↑, 1,   BrainVol↑, 1,   BrainVol↝, 1,   BrainVol∅, 1,   GABA↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 7,   eff↓, 1,   eff↑, 1,   eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Albumin↑, 1,   Hcy/homoC↓, 24,   Hcy/homoC↝, 2,   HemoG↑, 1,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 21,   cognitive↝, 1,   cognitive∅, 3,   memory↑, 4,   Mood↑, 1,   neuroP↑, 2,   QoL↑, 1,   Risk↓, 7,   Risk↝, 1,  
Total Targets: 40

Scientific Paper Hit Count for: Hcy/homoC, homocysteine
27 Folic Acid, Vit B9
22 Vitamin B12
8 Vitamin B6,pyridoxine
2 Vitamin B2,Riboflavin
1 beta-carotene(VitA)
1 Vitamin B3,Niacin
1 Chemotherapy
1 Choline
1 Silicic Acid
1 Aluminum
1 flavonoids
1 Vitamin D3
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1257  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page