cFLIP Cancer Research Results

cFLIP, CFLAR, cellular FLICE-like inhibitory protein: Click to Expand ⟱
Source:
Type: protein
c-FLIP (cellular FLICE-like inhibitory protein) also know as FLIP
- is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death.
It is a key regulator of the extrinsic pathway of apoptosis, which is mediated by death receptors such as Fas and TNF-R1.
c-FLIP is a pseudokinase that can inhibit the activation of caspase-8, a key enzyme in the extrinsic pathway of apoptosis. By inhibiting caspase-8 activation, c-FLIP can prevent the initiation of the apoptotic cascade and promote cell survival.
In cancer, c-FLIP is often overexpressed, which can contribute to the development and progression of the disease.

CFLAR (CASP8 and FADD Like Apoptosis Regulator; c-FLIP) — Apoptosis-regulatory protein structurally related to caspase-8 but lacking caspase protease activity. CFLAR/c-FLIP is recruited to the death-inducing signaling complex (DISC), where it regulates activation of caspase-8 and signaling downstream of death receptors such as FAS and TRAIL receptors.

Typical modulation in cancer: ↑ CFLAR/c-FLIP is generally tumor-promoting because it suppresses death-receptor-mediated apoptosis, supports cancer-cell survival, and can contribute to resistance to TRAIL, FAS signaling, chemotherapy, and other anticancer treatments. CFLAR ↓ or inhibition generally sensitizes tumor cells to extrinsic apoptosis.

Typical modulation in Alzheimer’s disease: No well-established Alzheimer’s disease-specific direction. CFLAR may influence inflammatory and apoptosis-related signaling, but it is not currently a core AD target.

Typical mechanistic relationship: CFLAR/c-FLIP ↑ → caspase-8 activation ↓ → extrinsic apoptosis ↓; CFLAR/c-FLIP ↓ → caspase-8 activation ↑ → apoptosis ↑.
Scientific Papers found: Click to Expand⟱
1524- Ba,    Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, Synergy↑, chemoPv↑, BioAv↓,
6672- Deg,    Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice
- vitro+vivo, CRC, COLO205 - in-vitro, CRC, HCT116
Akt↑, AntiTum↑, IL8↓, p‑IKKα↓, NF-kB↓, TumCD↑, Apoptosis↑, cFLIP↓, Bcl-2↓, Bcl-xL↓, TumVol↓,
1057- EVO,    Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion
- in-vitro, Var, NA
NF-kB↓, TNF-α↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, MMP9↓, ICAM-1↓, MDR1↓, XIAP↓, Bcl-2↓, Bcl-xL↓, IAP1↓, IAP2/BIRC3↓, cFLIP↓, Bfl-1↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
794- GAR,    Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
- in-vitro, RCC, NA - in-vitro, Lung, A549 - in-vitro, Nor, NA
DR5↑, cFLIP↓, *toxicity↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, Var, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
2884- HNK,    Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP
- in-vitro, Lung, A549 - in-vitro, Lung, H460
EMT↓, cFLIP↓, N-cadherin↓, Snail↓, p‑SMAD2↓, p‑SMAD3↓, IKKα↑, TumCMig↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
8152- lamb,  TRAIL/rTRAIL,    Lambertianic Acid Sensitizes Non-Small Cell Lung Cancers to TRAIL-Induced Apoptosis via Inhibition of XIAP/NF-κB and Activation of Caspases and Death Receptor 4
- in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
TumCD↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, cFLIP↓, XIAP↓, BID↑, DR4↑, p‑NF-kB↓, p‑IκB↓,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8231- LCA,    Maintenance of the Expression of c-FLIPL by Hsp70 to Resist Licochalcone A-Induced Anti-Colorectal Cancer Effect through ERK-Mediated Autophagy Induction
- in-vitro, CRC, NA
TumCP↓, Apoptosis↑, HSP70/HSPA5↓, cFLIP↓, ERK↑, p38↑,
8717- MeJa,    Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, Lung, Calu-1 - in-vitro, Lung, H157 - in-vitro, Lung, H1792
TumCCA↑, Apoptosis↑, selectivity↑, cFLIP↓, ROS↑, DR5↑, CHOP/DDIT3↑, TumAuto↑,
8859- MOR,    Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
- in-vitro, Melanoma, U266 - in-vitro, BC, MCF7 - in-vitro, SCC, SCC4 - in-vitro, BC, MCF-10AT
STAT3↓, Src↓, JAK1↓, JAK2↓, PIAS-3↑, ChemoSen↑, SHP1↑, XIAP↓, cFLIP↓, Mcl-1↓, survivin↓, Bcl-2↓, Bcl-xL↓, IAP2/BIRC3↓, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, selectivity↑,
8967- mushLions,    Recent developments in mushrooms as anti-cancer therapeutics: a review
- Review, Var, NA
ChemoSen↑, cFLIP↓, JNK↑, NF-kB↓, TumW↓, VEGF↓, COX2/PTGS2↓, 5LO↓, angioG↓, Ingr↝,
8963- PatchO,    The Effect of Patchouli Oil (Pogostemon cablin) on Apoptosis through NF-κB Inhibition in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
NF-kB↓, tumCV↓, cl‑Casp3↑, Bcl-2↓, XIAP↓, cFLIP↓,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
- Review, Var, NA
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2/PTGS2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
916- QC,    Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
- Review, Ovarian, NA
COX2/PTGS2↓, CRP↓, ER Stress↑, Apoptosis↑, GRP78/BiP↑, CHOP/DDIT3↑, p‑STAT3↓, PI3K↓, Akt↓, mTOR↓, cMyc↓, cycD1/CCND1↓, cFLIP↓, IL6↓, IL10↓,
914- QC,    Quercetin and Cancer Chemoprevention
- Review, Var, NA
GSH↓, ROS↑, TumCCA↑, Ca+2↑, MMP↓, Casp3↑, Casp8↑, Casp9↑, β-catenin/ZEB1↓, AMPKα↑, ASK1↑, p38↑, TRAIL↑, DR5↑, cFLIP↓, Apoptosis↑,

Showing Research Papers: 1 to 24 of 24

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 2,   H2O2↑, 1,   HO-1↓, 1,   ROS↓, 1,   ROS↑, 9,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Bfl-1↓, 1,   OCR↓, 2,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   AMPK↑, 3,   ATP↓, 1,   ECAR↓, 2,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   PKM2↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 10,   ASK1↑, 1,   BAD↓, 1,   BAX↑, 7,   Bcl-2↓, 10,   Bcl-xL↓, 3,   BID↓, 1,   BID↑, 3,   Casp3↓, 1,   Casp3↑, 12,   cl‑Casp3↑, 1,   Casp8↑, 7,   Casp9↑, 9,   cl‑Casp9↑, 1,   cFLIP↓, 25,   Cyt‑c↑, 5,   Diablo↑, 1,   DR5↓, 1,   DR5↑, 8,   FADD↑, 3,   FasL↑, 4,   IAP1↓, 2,   IAP2/BIRC3↓, 2,   iNOS↓, 1,   Mcl-1↓, 2,   p38↑, 3,   survivin↓, 5,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 1,   p‑Akt↓, 2,   AMPKα↑, 1,   p‑cMET↑, 1,   EGFR↓, 3,   ERK↓, 2,   ERK↑, 2,   ERK↝, 1,   p‑ERK↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   p‑IκB↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↝, 1,   mTOR↓, 7,   p‑mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 6,   PI3k/Akt/mTOR↓, 1,   PIAS-3↑, 1,   PKCδ↓, 2,   PTEN↑, 1,   RAS↓, 1,   RAS↑, 1,   RIP1↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 1,   Src↓, 1,   STAT3↓, 7,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 4,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXM1↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 2,   miR-29b↓, 1,   Myc↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 2,   ER Stress↑, 5,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   PERK↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

hTERT/TERT↓, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 6,   PARP1↑, 1,   PCNA↓, 2,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   CDK6↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 5,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   Ki-67↓, 1,   P21↑, 3,   p27/CDKN1B↑, 2,   TumCCA↑, 7,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   BMPs↑, 2,   CD133↓, 1,   IGFBP1↑, 1,   Ki-67↓, 1,   Nestin↓, 1,   Shh↓, 1,   TumCG↓, 2,   TumCP↓, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   Ca+2↑, 2,   E-cadherin↑, 1,   EMT↓, 2,   MET↓, 1,   MMP2↓, 5,   MMP9↓, 4,   MMP9:TIMP1↓, 1,   MMPs↓, 4,   N-cadherin↓, 2,   Rho↑, 1,   ROCK1↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TSP-1↑, 1,   TumCI↓, 2,   TumCMig↓, 4,   TumMeta↓, 2,   Twist↓, 2,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 5,   NO↓, 1,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN2↓, 1,   GLUT1↓, 1,   MMP↓, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 6,   CXCL12↓, 1,   CXCR4↓, 2,   DR4↑, 1,   DR4∅, 1,   FOXP3↑, 1,   ICAM-1↓, 1,   IL10↓, 3,   IL6↓, 3,   IL8↓, 1,   Imm↝, 1,   NF-kB↓, 8,   p‑NF-kB↓, 1,   PD-L1↓, 1,   T-Cell↑, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 2,   BioAv↑, 2,   ChemoSen↑, 4,   eff↓, 3,   MDR1↓, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   selectivity↑, 2,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   EGFR↓, 3,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   TumVol↓, 1,   TumW↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 213

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 1,   GSH↑, 2,   HO-1↑, 1,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 4,   ROS↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   FASN↓, 1,   glucose↝, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 1,   IKKα↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   p‑Rac1↓, 1,   Rho↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MUC5AC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX2/PTGS2↓, 1,   IL10↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 5,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   eff↓, 1,   P-gp/ABCB1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 1,   cardioP↑, 3,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 3,   RenoP↑, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 1,  
Total Targets: 55

Scientific Paper Hit Count for: cFLIP, CFLAR, cellular FLICE-like inhibitory protein
5 Quercetin
3 Garcinol
3 Honokiol
2 Baicalein
2 Licochalcone A
1 Berberine
1 Deguelin
1 Evodiamine
1 Gambogic Acid
1 lambertianic acid
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Methyl Jasmonate
1 Morin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Patchouli Oil (Pogostemon cablin)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:885  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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