mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Scientific Papers found: Click to Expand⟱
6465- 1,8-Cin,    Eucalyptol targets PI3K/Akt/mTOR pathway to inhibit skin cancer metastasis
- vitro+vivo, Melanoma, NA
TumMeta↓, TumCMig↓, TumCI↓, Vim↓, Snail↓, Slug↓, Twist↓, E-cadherin↓, EMT↓, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓,
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
5462- AF,    Repurposing Auranofin for Oncology and Beyond: A Brief Overview of Clinical Trials as Mono- and Combination Therapy
- Review, Var, NA
AntiTum↑, Bacteria↓, TrxR↓, ChemoSen↑, Dose↝, ROS↑, Apoptosis↑, mTOR↓,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,
1335- AG,    Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
p‑PI3K↓, p‑GS3Kβ↓, p‑Akt↓, p‑mTOR↓,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
385- AgNPs,    Probiotic-derived silver nanoparticles target mTOR/MMP-9/BCL-2/dependent AMPK activation for hepatic cancer treatment
- in-vitro, Hepat, HepG2 - in-vitro, Hepat, WI38
TNF-α↑, IL33↑, mTOR↓, MMP9↓, Bcl-2↓, ROS↑, Apoptosis↑,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
250- AL,    Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells
- in-vitro, Liver, HepG2
P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1/ATG6↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,
3434- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, PI3K↓, p‑Akt↓, p‑P70S6K↓, mTOR↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, LDHA↓, Glycolysis↓, ChemoSen↑,
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
262- ALA,    Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, Akt↓, ERK↓, IGF-1R↓, Furin↓, Ki-67↓, AMPK↑, mTOR↓,
1124- ALA,    Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, HTH-83 - in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, FTC-133 - in-vivo, NA, NA
TumCP↓, AMPK↑, mTOR↓, TumCMig↓, TumCI↓, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, Vim↓, Snail↓, Twist↓, TGF-β↓, p‑SMAD2↓, TumCG↓,
1279- And,    Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Apoptosis↑, Bcl-2↓, BAX↑, ERα/ESR1↓, PI3K↓, mTOR↓,
6393- ANE,    Anethole in cancer therapy: Mechanisms, synergistic potential, and clinical challenges
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCCA↑, TumCP↓, angioG↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, Casp↓, ChemoSen↑,
1008- Api,    Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
Wnt/(β-catenin)↓, β-catenin/ZEB1↓, TumAuto↑, Akt↓, mTOR↓, tumCV↓, TumCCA↑, TumAuto↑, p‑Akt↓, p‑p70S6↓, p‑4E-BP1↓,
270- Api,    Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK
- in-vivo, AML, U937
Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,
242- Api,    Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, C8161
ERK↓, PI3k/Akt/mTOR↓, Casp3↑, PARP↑, p‑mTOR↓, p‑Akt↓,
2631- Api,    Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
- in-vivo, GC, NA - in-vitro, GC, AGS
ER Stress↑, Hif1a↓, EZH2↓, HDAC↓, TumAuto↑, p‑mTOR↓, AMPKα↑, GRP78/BiP↑, ROS↑, MMP↓, Ca+2↑, ATF4↑, CHOP/DDIT3↑,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
1565- Api,    Apigenin-7-glucoside induces apoptosis and ROS accumulation in lung cancer cells, and inhibits PI3K/Akt/mTOR pathway
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1975
TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, Cyt‑c↑, MDA↑, GSH↓, ROS↑, PI3K↓, Akt↓, mTOR↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
5380- ART/DHA,    Artemisinin and Its Derivatives as Potential Anticancer Agents
- Review, Var, NA
TumCG↓, angioG↓, Ferroptosis↑, TumCP↑, TumAuto↑, CSCs↑, eff↑, YAP/TEAD↓, TumCCA↑, ROS↑, ChemoSen↑, N-cadherin↓, Vim↓, MMP9↓, eff↑, STAT3↓, CD133↓, CD44↓, Nanog↓, cMyc↓, OCT4↓, Akt↓, mTOR↓,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, VEGFR2/KDR/Flk1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27/CDKN1B↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,
566- ART/DHA,  2DG,    Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
GlucoseCon↓, ATP↓, lactateProd↓, p‑S6↓, mTOR↓, GLUT1↓, Casp9↑, Casp8↑, Casp3↑, Cyt‑c↑, AIF↑, ROS↑,
2324- ART/DHA,    Research Progress of Warburg Effect in Hepatocellular Carcinoma
- Review, Var, NA
PKM2↓, GLUT1↓, Glycolysis↓, Akt↓, mTOR↓, Hif1a↓, HK2↓, LDH↓, NF-kB↓,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
4678- Ash,    Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer
- vitro+vivo, NSCLC, H1975
ROS↑, AntiTum↑, CSCs↓, mTOR↓, STAT3↓, ChemoSen↑, Keap1↑, NRF2↓,
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
1532- Ba,    Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
- Review, NA, NA
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27/CDKN1B↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
2603- Ba,    Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, Apoptosis↑, Cav1↓, p‑Akt↓, p‑mTOR↓, Bax:Bcl2↑, survivin↓, cl‑PARP↑, BioAv↓,
2599- Ba,    Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, Apoptosis↑, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IKKα↓, IKKα↑, PI3K↓, MMP↓, TumAuto↑, TumVol↓, TumW↓,
2618- Ba,    Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer
- in-vitro, Lung, H1299 - in-vivo, Lung, A549
TumCG↓, TumCP↓, Apoptosis↑, GLUT1↓, GLS↓, mTOR↓, *toxicity∅, cl‑Casp9↓, cl‑Casp3↓, GSH↓, GlutMet↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, NA, NA
*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, eff↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2/PTGS2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,
1387- BBR,    Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines
- in-vitro, Thyroid, CAL-62
TumCG↓, Apoptosis↑, LC3B↑, ROS↑, PI3K↓, Akt↓, mTOR↓,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,

Showing Research Papers: 1 to 50 of 358
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 358

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,   ACE/ACE1↓, 1,   ATG13↑, 1,   ATG16L1↑, 1,   ATGL/PNPLA2↓, 1,   BMP7/OP1↓, 1,   compV↓, 1,   CTSK↓, 1,   ERCC3↑, 1,   FFA/NEFA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   HSP60/HSPD1↓, 1,   Ingr↝, 1,   miR-107↑, 2,   miR-224↓, 2,   miR-375↑, 1,   miR-422a↑, 2,   MMP16↓, 2,   MTA1↓, 1,   OGFr↑, 2,   PDE3B↓, 1,   PTN↓, 1,   Rictor↓, 1,   RUBCN↓, 1,   SCP2↓, 1,   TFE3↑, 2,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   ULK1/ATG1↑, 1,   WEE1↑, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 6,   ATF3↑, 1,   Catalase↓, 5,   Catalase↑, 1,   compI↓, 3,   Copper↓, 1,   Copper↑, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Fenton↑, 2,   Ferroptosis↑, 14,   GPx↓, 2,   GPx4↓, 8,   GSH↓, 21,   GSH↑, 5,   GSR↓, 2,   GSTs↓, 2,   GSTs↑, 1,   GSTZ1↓, 1,   H2O2↓, 1,   H2O2↑, 3,   HK1↓, 1,   HO-1↓, 8,   HO-1↑, 18,   ICD↑, 4,   Iron↓, 2,   Iron↑, 7,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 5,   lipid-P↑, 8,   MDA↓, 2,   MDA↑, 10,   MPO↓, 1,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 2,   NRF2↓, 16,   NRF2↑, 18,   NRF2↝, 1,   p‑NRF2↓, 1,   OXPHOS↓, 4,   OXPHOS↑, 3,   OXPHOS↝, 1,   PARK2↑, 2,   Prx4↑, 1,   PYCR1↓, 2,   ROS↓, 24,   ROS↑, 178,   ROS⇅, 6,   i-ROS↑, 1,   mt-ROS↑, 2,   SIRT3↓, 1,   SIRT3↑, 3,   SOD?, 1,   SOD↓, 5,   SOD↑, 6,   mt-SOD↑, 1,   SOD1↑, 1,   SOD2↓, 3,   SOD2↑, 2,   TAC↓, 1,   TBARS↑, 1,   Thiols↓, 1,   TKT↝, 1,   Trx1↑, 1,   TrxR↓, 8,   TrxR1↓, 3,   VDAC1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↓, 2,   NCOA4↑, 2,   STEAP3↓, 1,   Tf↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 7,   ATP↓, 25,   mt-ATP↓, 2,   BOK↑, 1,   CDC2↓, 6,   CDC25↓, 9,   compIII↓, 1,   EGF↓, 5,   EGF↑, 1,   ETC↓, 2,   ETC↑, 1,   FGFR1↓, 2,   Insulin↓, 1,   MEK↓, 6,   MEK↑, 1,   mitResp↓, 7,   MKK4↓, 1,   MKK7↓, 1,   MMP↓, 77,   MMP↑, 1,   MPT↑, 2,   mtDam↓, 1,   mtDam↑, 16,   OCR↓, 7,   OCR↑, 2,   PINK1↑, 2,   Raf↓, 3,   e-Raf↓, 1,   XIAP↓, 18,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   ACC↓, 1,   ACC↑, 4,   p‑ACC↑, 1,   p‑ACC-α↑, 1,   Acetyl-CoA↓, 1,   ACLY↓, 3,   ACSL4↑, 1,   adiP↑, 1,   AKT1↓, 3,   ALAT↓, 2,   ALDOA↓, 1,   AMP↓, 2,   AMPK↓, 3,   AMPK↑, 49,   p‑AMPK↑, 8,   ATG7↑, 5,   CAIX/CA9↓, 1,   Cav1↓, 1,   cMyc↓, 33,   ECAR↓, 4,   ENO1↓, 1,   FABP4↑, 1,   FASN↓, 5,   FASN↑, 1,   FBPase↑, 1,   FDG↓, 1,   G6PD↓, 2,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 2,   glucoNG↑, 1,   glucose↓, 4,   GlucoseCon↓, 19,   GLUT2↓, 1,   GlutMet↓, 2,   glyC↓, 1,   Glycolysis↓, 46,   p‑GS3Kβ↓, 1,   HK2↓, 19,   HMG-CoA↓, 1,   lactateProd↓, 19,   lactateProd↑, 1,   LDH↓, 6,   LDH↑, 3,   LDHA↓, 11,   LDL↓, 2,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   MCU↓, 1,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↓, 2,   NADPH↓, 2,   NPC1L1↓, 1,   PDH↑, 3,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 4,   PFK1↓, 3,   PFK2↓, 1,   PFKP↓, 1,   PI3K/Akt↓, 5,   PI3k/Akt/mTOR↓, 4,   PIK3CA↓, 1,   PKM2↓, 27,   PKM2↑, 1,   PKM2:PKM1↓, 1,   POLD1↓, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 2,   PPARγ↑, 7,   Pyruv↓, 1,   R5P↝, 1,   p‑S6↓, 3,   S6K↓, 1,   p‑S6K↓, 2,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 8,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   p‑STK11/LKB1↑, 1,   TCA↑, 2,   Warburg↓, 14,  

Cell Death(tgid=5) ⓘ

Akt↓, 216,   Akt↑, 6,   p‑Akt↓, 67,   APAF1↑, 7,   Apoptosis?, 2,   Apoptosis↓, 1,   Apoptosis↑, 159,   mt-Apoptosis↑, 2,   ASK1↑, 1,   ATF2↓, 1,   BAD↓, 3,   BAD↑, 9,   Bak↑, 7,   BAX↓, 1,   BAX↑, 88,   Bax:Bcl2↑, 16,   Bcl-2↓, 95,   Bcl-2↑, 3,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 20,   BID↓, 1,   BID↑, 2,   BIM↓, 1,   BIM↑, 6,   Casp↓, 1,   Casp↑, 26,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp2↑, 1,   Casp3↓, 5,   Casp3↑, 103,   cl‑Casp3↓, 1,   cl‑Casp3↑, 19,   proCasp3↓, 2,   Casp6↓, 1,   Casp7↑, 9,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 22,   Casp8∅, 1,   cl‑Casp8↑, 2,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 55,   cl‑Casp9↓, 1,   cl‑Casp9↑, 10,   CBP↓, 1,   cFLIP↓, 8,   Chk2↓, 1,   p‑Chk2↑, 1,   CK2↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 56,   Diablo↑, 8,   DR4↑, 2,   DR5↓, 1,   DR5↑, 18,   FADD↑, 3,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 15,   FasL↑, 8,   Ferroptosis↑, 14,   GRP58↓, 1,   GSDMD↑, 1,   GSDME↑, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   hTERT/TERT↓, 3,   IAP1↓, 6,   IAP2/BIRC3↓, 3,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 11,   JNK↓, 3,   JNK↑, 13,   p‑JNK↑, 4,   MAPK↓, 29,   MAPK↑, 11,   MAPK↝, 2,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   Mcl-1↓, 23,   MCT1↓, 2,   MDM2↓, 6,   MDM2↑, 1,   p‑MDM2↓, 1,   MKP1↓, 1,   MKP2↓, 1,   MOMP↑, 1,   Myc↓, 6,   NAIP↓, 1,   Necroptosis↑, 1,   necrosis↑, 3,   oncosis↑, 2,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 24,   p38↓, 5,   p38↑, 15,   p‑p38↑, 4,   Proteasome↓, 1,   PUMA↑, 3,   Pyro↑, 3,   RIP1↓, 2,   RIP1↑, 1,   survivin↓, 40,   Telomerase↓, 3,   TNFR 1↑, 1,   TRAIL↑, 5,   TRAILR↑, 2,   TRPV1↑, 2,   TRPV1↝, 1,   TumCD↑, 10,   YAP/TEAD↓, 5,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 4,   CaMKII ↓, 2,   CaMKII ↑, 1,   cSrc↓, 2,   HER2/EBBR2↓, 11,   p‑HER2/EBBR2↓, 1,   p70S6↓, 5,   p‑p70S6↓, 2,   SOX9↓, 1,   Sp1/3/4↓, 8,   TSC2↑, 5,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 7,   cJun↑, 2,   DLEU1↓, 1,   EZH2↓, 4,   H3↓, 1,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 1,   miR-21↓, 5,   miR-21↑, 1,   other↓, 5,   other↝, 3,   PhotoS↑, 1,   pRB↓, 1,   p‑pRB↓, 1,   tumCV?, 2,   tumCV↓, 47,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 22,   eIF2α↓, 3,   eIF2α↑, 3,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 33,   ERStress↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 11,   HSF1↓, 2,   HSP27↓, 6,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSP90↑, 1,   IRE1↑, 4,   PERK↑, 5,   p‑PERK↑, 1,   UPR↑, 6,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 4,   ATG5↑, 9,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 19,   BNIP3↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 7,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↑, 5,   LC3I↓, 1,   LC3II↑, 21,   LC3s↓, 1,   LC3s↑, 1,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 12,   p62↑, 5,   SESN2↑, 3,   TumAuto↓, 1,   TumAuto↑, 69,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↝, 1,   CHK1↓, 1,   p‑CHK1↑, 2,   CYP1B1↑, 1,   DFF45↓, 2,   DFF45↑, 1,   DNAdam↑, 38,   DNArepair↓, 1,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 4,   HR↓, 1,   NBR2↑, 1,   p16↑, 3,   P53?, 1,   P53↓, 2,   P53↑, 65,   p‑P53↑, 3,   p53 Wildtype↑, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 2,   PARP↑, 17,   cl‑PARP↑, 48,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 14,   RAD51↓, 1,   SIRT6↑, 1,   TP53↑, 1,   UHRF1↓, 1,   γH2AX↑, 2,   γH2AX↝, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 11,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 29,   CDK2↑, 1,   CDK4↓, 31,   Cyc↓, 1,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 20,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 53,   cycD1/CCND1↑, 2,   CycD3↓, 3,   cycE/CCNE↓, 15,   cycE1↓, 2,   E2Fs↓, 3,   E2Fs↑, 1,   mitA↓, 1,   mitA↑, 1,   p19↑, 2,   P21↓, 2,   P21↑, 48,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   Securin↓, 3,   TAp63α↑, 1,   TumCCA?, 1,   TumCCA↓, 5,   TumCCA↑, 124,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 4,   4E-BP1↑, 1,   p‑4E-BP1↓, 4,   ALDH↓, 5,   ALDH1A1↓, 1,   Axin2↑, 1,   BMI1↓, 1,   CD133↓, 6,   CD24↓, 3,   CD34↓, 2,   CD44↓, 14,   cDC2↓, 1,   cFos↓, 9,   cFos↑, 1,   cMET↓, 3,   p‑cMET↑, 2,   CREBBP↓, 1,   CSCs↓, 35,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 1,   EIF4E↓, 1,   EMT↓, 62,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 1,   ERK↓, 32,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 6,   p‑ERK↑, 2,   FGF↓, 1,   FOXM1↓, 4,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   Gli1↓, 12,   GSK‐3β↓, 15,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 3,   HDAC↓, 13,   HDAC∅, 1,   HDAC1↓, 3,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 1,   HH↓, 12,   IGF-1↓, 11,   IGF-1R↓, 3,   IGFBP1↑, 3,   IGFBP3↓, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   Jun↓, 1,   Let-7↑, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↑, 4,   miR-429↑, 1,   mTOR↓, 310,   mTOR∅, 1,   p‑mTOR↓, 53,   mTORC1↓, 7,   mTORC2↓, 3,   mTORC2↑, 1,   Nanog↓, 7,   Nestin↓, 1,   NOTCH↓, 17,   NOTCH1↓, 8,   NOTCH1↑, 2,   NOTCH3↓, 2,   OCT4↓, 8,   p300↓, 1,   P70S6K↓, 16,   p‑P70S6K↓, 6,   p85S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 162,   PI3K↑, 2,   PI3K↝, 1,   p‑PI3K↓, 10,   PRKCG↑, 1,   PTCH1↓, 3,   PTEN↓, 3,   PTEN↑, 25,   RAS↓, 11,   RAS↑, 1,   RPS6KA1↓, 1,   Shh↓, 7,   Smo↓, 7,   SOX2↓, 7,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 6,   STAT1↓, 1,   STAT3↓, 68,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 7,   p‑STAT3↑, 1,   STAT6↓, 3,   p‑STAT6↓, 1,   Sufu↓, 1,   TCF↓, 2,   TCF↑, 1,   TCF↝, 1,   TCF-4↓, 2,   TOP1?, 1,   TOP1↓, 5,   TOP2↓, 5,   TOP2↑, 1,   TRPM7↓, 2,   TumCG↓, 63,   TumCG↑, 3,   tyrosinase↓, 1,   Wnt?, 1,   Wnt↓, 44,   Wnt↝, 1,   Wnt/(β-catenin)↓, 8,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 4,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 10,   AXL↓, 2,   CA↓, 2,   Ca+2↓, 4,   Ca+2↑, 23,   Ca+2↝, 1,   i-Ca+2?, 1,   CAFs/TAFs↓, 2,   cal2↓, 1,   CD31/PECAM-1↓, 4,   Cdc42↓, 1,   CDK4/6↓, 2,   CEA↓, 1,   Chl↓, 1,   Chl↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   DLC1↑, 1,   E-cadherin↓, 7,   E-cadherin↑, 35,   ER-α36↓, 1,   F-actin↓, 1,   F-actin↑, 1,   FAK↓, 10,   p‑FAK↓, 1,   Fibronectin↓, 4,   Furin↓, 1,   GIT1↓, 1,   GLI2↓, 5,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB1↑, 1,   Ki-67↓, 21,   KRAS↓, 1,   LEF1↓, 1,   LRP1↓, 1,   LysoPr↑, 1,   MARK4↓, 1,   MET↓, 4,   p‑MET↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-206↑, 1,   miR-29b↓, 1,   miR-340↓, 2,   miR-384↑, 1,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 2,   MMP15↓, 1,   MMP2↓, 63,   MMP2↑, 1,   MMP3↓, 9,   MMP7↓, 10,   MMP9↓, 68,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 24,   MUC4↓, 2,   N-cadherin↓, 29,   NCAM↑, 1,   NEDD9↓, 1,   PAK1↓, 4,   PAK1↑, 1,   PDGF↓, 3,   p‑PKA↓, 1,   PKCδ↓, 5,   Rac1↓, 2,   RAGE↓, 2,   RECK↑, 1,   Rho↓, 3,   Rho↑, 1,   RIP3↓, 1,   RIP3↑, 1,   ROCK1↓, 6,   ROCK1↑, 1,   Slug↓, 8,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   SMAD4↓, 2,   p‑SMAD4↓, 1,   Snail↓, 23,   SOX4↓, 2,   SOX4↑, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 15,   TGF-β↑, 2,   TIMP1↓, 2,   TIMP1↑, 3,   TIMP2↓, 3,   TIMP2↑, 3,   Treg lymp↓, 1,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 69,   TumCMig↓, 59,   TumCMig↑, 2,   TumCP?, 1,   TumCP↓, 115,   TumCP↑, 1,   TumMeta↓, 51,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 18,   Tyro3↓, 1,   uPA↓, 16,   uPAR↓, 1,   VCAM-1↓, 3,   VEGFR1↓, 2,   Vim?, 1,   Vim↓, 31,   Vim↑, 1,   vinculin↓, 1,   Zeb1↓, 9,   ZEB2↓, 1,   ZO-1↑, 2,   α-tubulin↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 49,   β-catenin/ZEB1↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 71,   angioG↑, 3,   ATF4↓, 1,   ATF4↑, 8,   ATF4↝, 1,   EGFR↓, 38,   EGFR↑, 1,   EGR4↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 8,   Hif1a↓, 58,   Hypoxia↓, 1,   LOX1↓, 1,   LymphAG↓, 1,   miR-126↑, 1,   NO↓, 3,   NO↑, 1,   NO↝, 1,   TAMS↓, 1,   VEGF↓, 82,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↓, 1,   BBB↑, 3,   BBB∅, 2,   CellMemb↑, 1,   GLUT1↓, 20,   GLUT4↓, 2,   P-gp/ABCB1↓, 21,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   ASC↑, 1,   CB2 / CNR2↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 51,   COX2/PTGS2↑, 3,   CRP↓, 3,   CXCL1↓, 1,   CXCR4↓, 12,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 2,   IFN-γ↑, 1,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 2,   IL1↓, 4,   IL10↓, 8,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 11,   IL2↓, 1,   IL2↑, 5,   IL33↑, 1,   IL6↓, 27,   IL6↑, 1,   IL8↓, 5,   Imm↑, 6,   Imm↝, 3,   Inflam↓, 18,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 6,   JAK1↓, 4,   JAK2↓, 10,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   NF-kB↓, 103,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   p50↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 3,   PD-L1↓, 10,   PGE2↓, 15,   PSA↓, 7,   SOCS-3↑, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR2↓, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 23,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↑, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 4,   PP2A↑, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 11,   CDK6↓, 14,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 28,   BioAv↑, 31,   BioAv↝, 10,   BioEnh↑, 2,   ChemoSen↑, 103,   Dose?, 1,   Dose↑, 5,   Dose↝, 29,   Dose∅, 1,   eff↓, 28,   eff↑, 110,   eff↝, 6,   Half-Life↓, 10,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 11,   MRP1/ABCC1↓, 2,   P450↓, 1,   RadioS↑, 33,   selectivity↑, 48,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 2,   AR↓, 11,   AST↓, 1,   BG↓, 2,   BMPs↑, 2,   BRCA1↓, 2,   BRCA1↝, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 2,   E7↓, 2,   EGFR↓, 38,   EGFR↑, 1,   ERα/ESR1↓, 1,   EZH2↓, 4,   Ferritin↓, 2,   FOXM1↓, 4,   GutMicro↑, 6,   GutMicro↝, 1,   HemoG↓, 1,   HER2/EBBR2↓, 11,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 27,   IL6↑, 1,   Ki-67↓, 21,   KRAS↓, 1,   LDH↓, 6,   LDH↑, 3,   Myc↓, 6,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 10,   PSA↓, 7,   RAGE↓, 2,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 36,   antiNeop↑, 2,   AntiP↑, 1,   AntiTum↓, 1,   AntiTum↑, 14,   cachexia↓, 1,   cardioP↑, 7,   chemoP↑, 12,   chemoPv↑, 9,   ChemoSideEff↓, 3,   fatigue↓, 2,   hepatoP↑, 2,   neuroP↑, 4,   OS↑, 11,   PRAS40↑, 1,   QoL↑, 4,   QoL∅, 1,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 6,   toxicity↓, 13,   toxicity↝, 8,   toxicity∅, 1,   TumVol↓, 11,   TumVol∅, 1,   TumW↓, 11,   TumW∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 958

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,   colonLen↑, 1,   cough?, 1,   CYP2D6↓, 1,   Ingr↝, 2,   SoreThr?, 1,   Stress↓, 1,   Stroke↓, 2,   TPH1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 44,   ARE↑, 1,   Catalase↑, 22,   Ferroptosis↓, 1,   GPx↑, 15,   GPx4↑, 1,   GSH↑, 15,   GSR↑, 2,   GSTA1↑, 1,   GSTs↑, 6,   H2O2↓, 1,   HDL↓, 1,   HO-1↑, 13,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 14,   MDA↓, 11,   MDA↑, 1,   NQO1↑, 2,   NRF2↑, 26,   RNS↓, 1,   ROS?, 1,   ROS↓, 42,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 18,   SOD1↑, 1,   TAC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   MMP↑, 1,   MMP∅, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 4,   BUN↓, 1,   p‑cMyc↑, 1,   p‑CREB↑, 1,   CRM↑, 1,   cytoP450↓, 1,   FASN↓, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↑, 1,   glyC↓, 1,   H2S↑, 1,   LDH↓, 2,   LDL↓, 2,   NAD↑, 1,   NADPH↓, 1,   NADPH↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↑, 1,   Casp↓, 1,   Casp3↓, 5,   Casp3∅, 1,   Casp9↓, 1,   Cyt‑c∅, 1,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 1,   iNOS↓, 8,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 5,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 4,   other↓, 1,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   DNArepair↑, 1,   p16↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   ERK↓, 2,   ERK↑, 2,   GSK‐3β↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   RAS↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg↑, 5,   AP-1↓, 1,   Ca+2↓, 1,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   TRPC1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   NO↓, 4,   NO↑, 1,   PDGFR-BB↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   GastroP↑, 1,   IBI↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 14,   CRP↓, 2,   HMGB1↓, 1,   IFN-γ↓, 1,   IKKα↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 11,   IL23↓, 1,   IL6↓, 15,   IL8↓, 4,   Imm↑, 1,   Inflam↓, 56,   Inflam↑, 1,   IκB?, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 19,   PGE2↓, 8,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 3,   TNF-α↓, 14,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 4,   BDNF↑, 2,   ChAT↑, 1,   MAOA↓, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   BACE/β-secretase↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 11,   BioAv↝, 13,   Dose↑, 1,   Dose↝, 6,   eff↑, 6,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 6,   Half-Life∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 3,   AST↓, 5,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   CRP↓, 2,   GutMicro↑, 3,   IL6↓, 15,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 5,   AntiCan↓, 1,   AntiCan↑, 8,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 10,   AntiP↑, 9,   AntiTum↑, 2,   cardioP↑, 15,   chemoP↑, 3,   chemoPv↑, 4,   cognitive↑, 1,   hepatoP↑, 18,   memory↑, 6,   neuroP?, 1,   neuroP↑, 26,   Obesity↓, 3,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 3,   Risk↓, 1,   toxicity↓, 16,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 4,   AntiViral↑, 7,   Bacteria↓, 9,   Diar↓, 1,   Sepsis↓, 1,  
Total Targets: 220

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
20 Curcumin
16 Fisetin
15 Quercetin
13 Baicalein
11 Ivermectin
10 Berberine
9 itraconazole
8 Thymoquinone
8 Apigenin (mainly Parsley)
8 Honokiol
8 Resveratrol
7 EGCG (Epigallocatechin Gallate)
7 Isoliquiritigenin
7 Shikonin
6 Luteolin
5 Alpha-Lipoic-Acid
5 Artemisinin
5 diet FMD Fasting Mimicking Diet
5 Sulforaphane (mainly Broccoli)
5 Magnolol
5 Metformin
5 Piperlongumine
4 5-fluorouracil
4 Ashwagandha(Withaferin A)
4 Beta-Caryophyllene
4 Capsaicin
4 Chlorogenic acid
4 Chrysin
4 Cinnamon
4 Citric Acid
4 Dichloroacetate
4 Gambogic Acid
4 Hyperoside
4 Kaempferol
4 Licochalcone A
4 Lycopene
4 Piperine
4 Pterostilbene
4 Rosmarinic acid
3 Astragalus
3 Chemotherapy
3 Cisplatin
3 brusatol
3 Carnosic acid
3 salinomycin
3 Eugenol
3 isoquercitrin
3 Vitexin
3 Licorice
3 Naringin
3 Silymarin (Milk Thistle) silibinin
3 Urolithin
2 Coenzyme Q10
2 Auranofin
2 Allicin (mainly Garlic)
2 Betulinic acid
2 Brucea javanica
2 Boswellia (frankincense)
2 Magnetic Fields
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Propolis -bee glue
2 CUSP9
2 Deguelin
2 diet Short Term Fasting
2 Dandelion Root
2 Ferulic acid
2 Formononetin
2 Garcinol
2 Ginkgolide B
2 HydroxyTyrosol
2 Isovitexin
2 Lasiodin
2 low dose naltrexone
2 Niclosamide (Niclocide)
2 Plumbagin
2 α-Santalol/Sandalwood oil
2 Vitamin D3
1 1,8-Cineole
1 Silver-NanoParticles
1 Andrographis
1 Anethole/trans-Anethole
1 2-DeoxyGlucose
1 Baicalin
1 Biochanin A
1 Bufalin/Huachansu
1 Trastuzumab
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Hydroxycinnamic-acid
1 immunotherapy
1 Radiotherapy/Radiation
1 Ellagic acid
1 Emodin
1 flavonoids
1 Fucoidan
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Ginseng
1 Inulin Prebiotic
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 isoflavones
1 Sorafenib (brand name Nexavar)
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Lactoferrin/Talactoferrin
1 Linalool
1 Nimbolide
1 Oleuropein
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 sericin
1 Phenethyl isothiocyanate
1 doxorubicin
1 Parthenolide
1 Gold NanoParticles
1 acetazolamide
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Usnic acid
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:209  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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