toxicity Cancer Research Results

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Toxicity
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
1341- 3BP,    The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- Review, Var, NA
Glycolysis↓, OXPHOS↓, *toxicity↓, ROS↑, GSH↓, Synergy↑,
7857- 3BP,    A Mechanism of Isoorientin-Induced Apoptosis and Migration Inhibition in Gastric Cancer AGS Cells
- in-vitro, GC, AGS
tumCV↓, selectivity↑, *toxicity↓, Apoptosis↑, ROS↑, eff↓, TumCCA↑, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, TumCMig↓, Twist↓, N-cadherin↑, β-catenin/ZEB1↓, E-cadherin↑,
5295- 5-HTP,    Safety of 5-hydroxy-L-tryptophan
- in-vivo, Nor, NA
*5HT↑, *toxicity↝, *toxicity↓,
9256- Acai, EO,    Pro-apoptotic activities of polyphenolics from açai (Euterpe oleracea Martius) in human SW-480 colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, Colon, SW480
TumCG↓, *toxicity↓, selectivity↑, ROS↓, NF-kB↓, ICAM-1↓, VCAM-1↓, Sp1/3/4↓, Bcl-2↓, VEGF↓, survivin↓, cl‑Cyt‑c↑, cl‑Casp3↑, PARP1↓,
5443- AG,    Pharmacokinetics and tolerance of toal astragalosides after intravenous infusion of astragalosides injection in healthy Chinese volunteers
- Human, Nor, NA
*Dose↝, Half-Life↝, *toxicity↓,
4561- AgNPs,  VitC,    Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts
- in-vitro, CRC, HCT116 - in-vitro, Nor, HEK293
NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP/DDIT3↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
4556- AgNPs,    Biofilm Impeding AgNPs Target Skin Carcinoma by Inducing Mitochondrial Membrane Depolarization Mediated through ROS Production
- in-vitro, Melanoma, A431
MMP↓, ROS↑, *toxicity↓, Bacteria↓,
4600- AgNPs,    Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model
- in-vivo, Nor, NA
*Half-Life↝, *toxicity↓, *Dose↑, *other↝, *eff↝, *BioAv↓,
4581- AgNPs,    Antimicrobial, anticoagulant and antiplatelet activities of green synthesized silver nanoparticles using Selaginella (Sanjeevini) plant extract
- Study, Nor, NA
*Bacteria↓, *AntiAg↑, *toxicity↓,
4360- AgNPs,    Silver Nanoparticles as Real Topical Bullets for Wound Healing
- Study, Nor, NA
*other↝, *toxicity↓, *eff↑, *eff↑, *Inflam↓, *IL6↓, *TGF-β↑, *MMP9↓, *eff↑,
4359- AgNPs,    Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends
- Review, Wounds, NA
*Bacteria↓, *eff↑, *other↝, *toxicity↓,
4434- AgNPs,  SSE,    Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
- vitro+vivo, Nor, NA
*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
4365- AgNPs,    Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview
- Review, Var, NA
ROS↑, *toxicity↓, *Bacteria↓, *Inf↓, *Diff↑, *eff↑, RadioS↑, selectivity↑,
359- AgNPs,    Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Nor, HEK293
Casp3↑, Casp9↑, P53↑, ROS↑, MMP2↓, MMP9↓, TumCCA↑, *toxicity↓, TumCMig↓, TumCI↓,
346- AgNPs,  RSQ,    Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment
- in-vivo, Melanoma, SK-MEL-28 - in-vivo, Melanoma, WM35
ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,
375- AgNPs,  ALA,    Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vivo, NA, NA
mtDam↑, ROS↑, *toxicity↓, Dose∅, selectivity↑,
5353- AL,    Aged Garlic Extract May Be Safe for Patients on Warfarin Therapy
- Human, Nor, NA
*AntiAg↑, *toxicity↓, *cardioP↑, *Dose↝,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
245- AL,    Allicin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,
1235- ALA,  Cisplatin,    α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
- in-vitro, Nor, HEI-OC1 - ex-vivo, NA, NA
ROS↑, HO-1↓, *toxicity↓, chemoP↑, *ROS↓, *HO-1↑, *SOD1↑, *NRF2↑,
285- ALA,  HCA,    Tolerance of oral lipoid acid and hydroxycitrate combination in cancer patients: first approach of the cancer metabolism research group
- Human, Var, NA
PI3K↝, AMPK↝, TumCG↓, *toxicity↓, Weight∅,
6598- Anamu,    Amazonian Plants: A Global Bibliometric Approach to Petiveria alliacea L. Pharmacological and Toxicological Properties
- Review, Var, NA
*AChE↓, *antiOx↓, ATP↓, *toxicity↓,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2/PTGS2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
1999- Api,  doxoR,    Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation
- in-vitro, Nor, NRK52E - in-vitro, Nor, MPC5 - in-vitro, BC, 4T1 - in-vivo, NA, NA
neuroP↑, ChemoSen∅, RenoP↑, selectivity↑, chemoP↑, ROS↑, *ROS∅, *antiOx↑, *toxicity↓,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
2570- ART/DHA,    Discovery, mechanisms of action and combination therapy of artemisinin
- Review, Nor, NA
*BioAv↓, *Half-Life↓, *toxicity↓, *ROS↑, GSH↓, selectivity↑,
1147- ART/DHA,    Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/flk-1
- vitro+vivo, Ovarian, HO-8910 - vitro+vivo, Nor, HUVECs
angioG↓, TumCG↓, VEGF↓, VEGFR2/KDR/Flk1↓, *toxicity↓,
5414- ASA,    Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against
- Review, Var, NA
Risk↓, *toxicity↓, other↑, *COX1↓, TumCP↓, DNArepair↑, ChemoSen↑, other↓,
1368- Ash,  Cisplatin,    Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’
- in-vitro, Colon, HT-29 - in-vitro, BC, MDA-MB-231
tumCV↓, *toxicity↓, ROS↑, mitResp↓, ChemoSen↑,
1365- Ash,    Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells
- in-vitro, Oral, Ca9-22 - in-vitro, Oral, CAL27
ROS↑, *toxicity↓, Apoptosis↑, TumCCA↑, MMP↓, p‑γH2AX↑, DNAdam↑, eff↓,
1173- Ash,    Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling
- in-vitro, EC, K1 - in-vitro, Nor, THESCs
TumCP↓, *toxicity↓, Apoptosis↑, TumCCA↑, TumCMig↓, TumCI↓, p‑SMAD2↓, TGF-β↓, *toxicity↓,
3172- Ash,    Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis
- in-vitro, HCC, HepG2 - in-vitro, Nor, HL7702
Keap1↑, NRF2↓, EMT↓, TumCP↓, TumCI↓, selectivity↑, *toxicity↓, ROS↑, MDA↑, GSH↓, Ferroptosis↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, Synergy↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, Synergy↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, Synergy↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
4986- ATV,  Dipy,    The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer
- Review, Var, NA
HMG-CoA↓, AntiAg↑, Synergy↑, Apoptosis↑, selectivity↑, *toxicity↓, TumCG↓, PDE4↓, other↑,
5371- AV,    Assessment of the immunomodulatory effect of Aloe vera polysaccharides extracts on macrophages functions
- Study, Nor, NA
*eff↑, *IL6↑, *toxicity↓, *Imm↑,
5574- B-Gluc,    Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome
- Review, Obesity, NA
*BioAv↑, *toxicity↓, *Imm↑, *eff↑, *Risk↓, *Weight↓, *eff↝, *BP↓, *GutMicro↑, *eff↓,
5575- B-Gluc,    The effects of β-glucan on human immune and cancer cells
- Review, Var, NA
Imm↑, *toxicity↓, eff↑, Imm↑,
5579- B-Gluc,    Fungal beta-glucans as adjuvants for treating cancer patients – A systematic review of clinical trials
- Review, Var, NA
*toxicity↓, Imm↑, radioP↑, chemoP↑,
5500- Ba,    Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single‐center, randomized, double‐blind, placebo‐controlled multiple‐ascending‐dose study
- Trial, Nor, NA
*toxicity↓, *BioAv↑, *Half-Life↝, *Dose↝,
2614- Ba,    Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders
- Review, Nor, NA
*toxicity↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *MCP1/CCL2↓, *hepatoP↑, *neuroP↑, *antiAll↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2023- BBR,    Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor
- in-vitro, Colon, NA - in-vitro, Nor, YAMC
TumCD↑, *toxicity↓, selectivity↑, ROS↑, *ROS∅, MMP↓, *MMP∅, PARP↑, BioAv↝,
2022- BBR,  GoldNP,  Rad,    Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
- in-vitro, Liver, SMMC-7721 cell - in-vitro, Nor, HL7702
*toxicity↓, radioP↑, BioAv↑, AntiTum↑, selectivity↑, eff↑, chemoP↑,
1375- BBR,    13-[CH2CO-Cys-(Bzl)-OBzl]-Berberine: Exploring The Correlation Of Anti-Tumor Efficacy With ROS And Apoptosis Protein
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
ROS↑, TumCP↓, XIAP↓, TumCG↓, *toxicity↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2/PTGS2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,

Showing Research Papers: 1 to 50 of 346
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 346

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 3,   Catalase↑, 3,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 4,   GSH↓, 15,   GSH/GSSG↓, 1,   GSR↑, 1,   GSTs↑, 1,   H2O2↑, 2,   i-H2O2↓, 1,   HO-1↓, 3,   HO-1↑, 6,   Iron↓, 1,   Iron↑, 2,   i-Iron↑, 1,   Keap1↑, 1,   lipid-P↓, 3,   lipid-P↑, 6,   MDA↓, 2,   MDA↑, 6,   NQO1↓, 1,   NQO1↑, 4,   NRF2↓, 4,   NRF2↑, 7,   PrxI∅, 1,   ox-PrxI↑, 1,   PrxII↑, 1,   PrxII∅, 1,   ROS↓, 4,   ROS↑, 84,   ROS⇅, 3,   ROS↝, 1,   ROS∅, 1,   i-ROS?, 1,   i-ROS↑, 1,   mt-ROS↑, 4,   selenoP↑, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 2,   TAC↓, 1,   TOS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   NCOA4↑, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 3,   compI↓, 2,   compII↓, 1,   ETC↓, 3,   HSP60/HSPD1↓, 1,   MFN2↑, 1,   mitResp↓, 3,   mtDam?, 1,   mtDam↓, 1,   mtDam↑, 11,   OCR↓, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   OXPHOS↝, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 2,   AMPK↓, 1,   AMPK↑, 6,   AMPK↝, 2,   p‑AMPK↑, 3,   ATP↓, 3,   ECAR↓, 2,   GlucoseCon↓, 5,   GlucoseCon↑, 1,   Glycolysis↓, 10,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 5,   HMG-CoA↓, 1,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 2,   NADPH↓, 1,   NADPH↑, 1,   PFK1↓, 1,   PKM2↓, 2,   PKM2↑, 1,   PLA2↓, 1,   SIRT1↑, 2,   SREBP2↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 60,   mt-Apoptosis↑, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 2,   BAX↑, 19,   Bax:Bcl2↑, 9,   Bcl-2↓, 19,   Bcl-2↑, 1,   Bcl-xL↓, 5,   BID↑, 2,   Casp↑, 5,   Casp1↑, 1,   Casp3↑, 45,   cl‑Casp3↑, 10,   cl‑Casp3⇅, 1,   Casp7↑, 6,   Casp8↑, 13,   Casp8∅, 1,   cl‑Casp8↑, 2,   Casp9↑, 26,   cl‑Casp9↑, 5,   CellShr↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 22,   cl‑Cyt‑c↑, 1,   Diablo↑, 1,   DR5↑, 6,   DR5↝, 1,   FADD↑, 2,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↑, 9,   HEY1↓, 1,   IAP1↓, 1,   iNOS↓, 5,   Mcl-1↓, 3,   MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p38↑, 2,   p‑p38↑, 1,   Pyro↑, 1,   survivin↓, 11,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 14,   XIAP↓, 5,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 29,   Akt↑, 1,   p‑Akt↓, 10,   BRAF↑, 1,   cMET↓, 1,   CREB2↓, 1,   EGFR↓, 7,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 7,   ERK↑, 2,   p‑ERK↓, 1,   HER2/EBBR2↓, 4,   Hippo↑, 1,   IGF-1R↓, 2,   JAK1↓, 1,   p‑JAK2↓, 1,   JNK↑, 4,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 5,   MAPK↑, 3,   MAPK↝, 1,   mTOR↓, 16,   mTOR↝, 2,   p‑mTOR↓, 2,   p70S6↓, 1,   p‑p70S6↓, 1,   P70S6K↓, 3,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 20,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 1,   PI3k/Akt/mTOR↓, 1,   PI3k/Akt/mTOR↝, 1,   PKA↓, 2,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 3,   Raf↓, 1,   RAS↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT3↓, 15,   p‑STAT3↓, 1,   STAT5↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 2,   p‑cJun↑, 1,   cMyc↓, 4,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   FOXO1↑, 1,   FOXO3↑, 1,   FOXO4↑, 1,   H3↑, 1,   HATs↓, 2,   HDAC↓, 6,   HDAC↑, 1,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC8↓, 3,   miR-106b↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 2,   miR-200c↑, 1,   miR-21↓, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-422a↑, 1,   MYCN↓, 1,   OCT4↓, 3,   other↓, 4,   other↑, 7,   other↝, 10,   Prot↓, 1,   SOX4↓, 1,   SOX9↓, 1,   tumCV↓, 21,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 4,   CHOP/DDIT3↝, 1,   ER Stress↑, 9,   ER Stress↝, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   ac‑HSP90↑, 1,   HTRA↓, 1,   PERK↑, 2,   PSMB5↓, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 2,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3II↑, 2,   p62↓, 1,   p62↑, 1,   TumAuto↑, 11,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 23,   DNArepair↓, 3,   DNArepair↑, 1,   hTERT/TERT↓, 3,   P53↓, 2,   P53↑, 16,   PARP↑, 8,   cl‑PARP↑, 14,   PARP1↓, 1,   cl‑PARP1↑, 1,   PCNA↓, 6,   RAD51↓, 1,   Telomerase↓, 2,   TOP1↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 4,   CDK4↓, 7,   CHK1↓, 1,   Chk2↓, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 12,   cycE/CCNE↓, 4,   E2Fs↓, 1,   Ki-67↓, 8,   mitA↑, 1,   p19↑, 1,   P21↓, 1,   P21↑, 13,   p27/CDKN1B↑, 1,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↑, 54,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   AXIN1↑, 2,   BMP7/OP1↓, 2,   CD133↓, 1,   cFos↓, 1,   CSCs?, 1,   CSCs↓, 10,   Diff↑, 2,   FGF↓, 1,   Gli1↓, 2,   HH↓, 3,   IGF-1↓, 4,   IGFBP1↑, 1,   Ki-67↓, 8,   Nanog↓, 2,   NICD↓, 1,   NOTCH↓, 2,   NOTCH1↓, 3,   Piezo1↑, 1,   SCF↓, 1,   Shh↓, 1,   Smo↓, 1,   Sufu↑, 1,   TAZ↓, 1,   TumCG↓, 39,   TumCG↑, 1,   TumCP↓, 46,   Wnt↓, 11,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 3,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 10,   Ca+2↝, 1,   Cal9↑, 1,   Cav1↓, 1,   Cdc42↓, 1,   COL1↓, 1,   decorin↑, 1,   DLC1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 8,   EM↑, 1,   EMT↓, 16,   EpCAM↓, 1,   FAK↓, 2,   p‑FAK↓, 2,   Fibronectin↓, 1,   GLI2↓, 2,   GLI3↑, 1,   ITGB4↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 20,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 20,   MMPs↓, 9,   N-cadherin↓, 5,   N-cadherin↑, 1,   PCBP1↓, 1,   Rho↓, 1,   Slug↓, 3,   p‑SMAD2↓, 1,   Snail↓, 6,   TGF-β↓, 2,   TIMP1↑, 2,   TIMP2↓, 1,   TIMP2↑, 2,   pol-TregCell↓, 1,   TumCI↓, 24,   TumCMig↓, 25,   TumMeta↓, 18,   TumMeta↑, 1,   Twist↓, 3,   TXNIP↓, 1,   uPA↓, 1,   Vim↓, 5,   Zeb1↓, 1,   β-catenin/ZEB1↓, 14,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 31,   CD31/PECAM-1↓, 1,   HIF-1↓, 2,   Hif1a↓, 14,   Hif1a↑, 1,   Hypoxia↓, 1,   LOX1↓, 2,   NO↓, 1,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 22,   VEGF↑, 1,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 1,   CLDN1↑, 1,   EPR↑, 2,   GLUT1↓, 4,   IBI↑, 1,   LAT↓, 1,   MMP?, 1,   MMP↓, 33,   MMP↑, 1,   MPT↑, 1,   OCLN↑, 1,   SLC12A5↓, 1,   TJ↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CD4+↑, 3,   CD44↓, 3,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 22,   CXCL1↓, 1,   CXCL9↓, 1,   CXCR4↓, 2,   DCells↑, 1,   DR4↑, 1,   Gal-3?, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 4,   Igs↑, 1,   IL1↓, 1,   IL10↑, 2,   IL12↑, 1,   IL1β↓, 3,   IL2↑, 2,   IL6↓, 4,   Imm↑, 13,   Imm⇅, 1,   Imm↝, 2,   Inflam↓, 5,   IP-10/CXCL-10↓, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MIP-1β↓, 1,   MIP-1β↑, 1,   Neut↑, 1,   NF-kB↓, 28,   NF-kB↑, 3,   p‑NF-kB↑, 1,   NK cell↑, 4,   PD-1↓, 1,   PD-L1↓, 3,   PGE2↓, 5,   PSA↓, 6,   T-Cell↑, 1,   Th1 response↑, 1,   Th17↑, 1,   TNF-α↓, 7,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   pH↝, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN2/PS-2↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↝, 1,   AR↓, 4,   COMT↑, 1,   DHT↓, 1,   ER-α36↓, 1,   ER-α36↝, 1,   ERα/ESR1↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 8,   BioAv↑, 13,   BioAv↝, 5,   BioEnh?, 1,   chemoR↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 49,   ChemoSen∅, 2,   CompStab↓, 1,   CYP1A1↓, 1,   DDS↑, 1,   Dose?, 3,   Dose↑, 1,   Dose↝, 30,   Dose∅, 3,   eff↓, 16,   eff↑, 32,   eff↝, 7,   Half-Life↓, 1,   Half-Life↝, 4,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 3,   RadioS↑, 14,   selectivity↓, 2,   selectivity↑, 53,   Synergy?, 1,   Synergy↑, 38,  

Clinical Biomarkers(tgid=22) ⓘ

anemia↓, 1,   AR↓, 4,   B2M↓, 1,   BG↓, 1,   BloodF↑, 1,   BRAF↑, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EGFR↑, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 1,   HER2/EBBR2↓, 4,   hTERT/TERT↓, 3,   IL6↓, 4,   LDH↓, 3,   LDH↑, 2,   Maspin↑, 1,   NLR↓, 1,   PD-L1↓, 3,   PSA↓, 6,   PSADT↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiCan↑, 24,   antiNeop↑, 2,   AntiTum↑, 16,   AntiTum∅, 1,   cardioP↑, 1,   chemoP↑, 21,   chemoPv↑, 7,   ChemoSideEff↓, 2,   CR↑, 1,   DCR↑, 1,   hepatoP↑, 3,   LC↑, 1,   Nausea↓, 1,   neuroP↑, 3,   NP/CIPN↓, 1,   ORR↑, 1,   OS?, 1,   OS↑, 7,   Pain↓, 2,   PDE4↓, 1,   PFS↑, 1,   QoL↑, 1,   radioP↑, 5,   RenoP↑, 4,   Risk↓, 9,   toxicity↝, 1,   TumVol↓, 11,   TumVol∅, 1,   TumW↓, 6,   TumW∅, 1,   Vomit↓, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,   GutMicro↑, 2,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 5,  
Total Targets: 573

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 69,   ARE↑, 1,   Bil↓, 3,   Bil↑, 1,   Catalase↑, 20,   DPPH↓, 1,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 11,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 18,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 3,   H2O2↓, 2,   HDL↓, 2,   HDL↑, 2,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 9,   Iron↓, 1,   i-Iron↓, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 29,   MDA↓, 21,   MPO↓, 2,   NOX4↓, 1,   NQO1↑, 1,   NQO1↝, 1,   NRF2↑, 21,   Prx↑, 1,   RNS↓, 2,   ROS↓, 81,   ROS↑, 3,   ROS∅, 4,   mt-ROS?, 1,   selenoP↑, 5,   SOD↑, 27,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 4,   TBARS↓, 2,   uricA↓, 2,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   Insulin↑, 1,   mitResp↑, 2,   mtDam↓, 2,   PGC-1α↑, 1,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 5,   ALAT↓, 12,   ALAT∅, 3,   AMPK↑, 2,   ATP↑, 7,   glucose↓, 3,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↑, 1,   H2S↑, 1,   KeyT↑, 1,   LDL↓, 8,   NADPH↓, 2,   NADPH↑, 3,   NH3↓, 1,   PLA2↓, 1,   SIRT1↓, 1,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 7,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 5,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 10,   Casp9↓, 3,   Cyt‑c↓, 1,   Ferroptosis↓, 2,   iNOS↓, 6,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 3,   p‑Akt↓, 1,   p‑Akt↑, 1,   CREB↑, 1,   ERK↓, 1,   JNK↓, 3,   JNK↑, 1,   MAPK↓, 3,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 1,   mTOR↑, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 2,   PKCδ↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 1,   FOXO3↑, 1,   HDAC?, 1,   HDAC↓, 2,   HDAC3↓, 1,   other?, 1,   other↓, 4,   other↑, 8,   other↝, 21,   PhotoS↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 5,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   PERK↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   CTSZ↓, 1,   LC3II↑, 1,   MitoP↑, 1,   p62↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 1,   PARP↓, 1,   PARP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CHIP↑, 1,   Diff↑, 1,   GH↑, 2,   neuroG↑, 1,   TumCG↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   BACH1↓, 1,   Ca+2↓, 4,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   EMT↓, 1,   MMP13↓, 1,   MMP9↓, 2,   MMPs↓, 2,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   Twist↑, 1,   Vim↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 7,   TXA2↓, 1,   VCAM-1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 12,   BBB↝, 2,   EPR↑, 1,   GastroP↑, 4,   IBI↑, 2,   MMP↑, 2,   MMP∅, 1,   TRPA1↑, 1,   TRPV3↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 1,   BALF-Lym↓, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 20,   COX2/PTGS2↑, 1,   CXCL15↓, 1,   Eos↓, 1,   ICAM-1↓, 3,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 2,   IL10↑, 1,   IL13↓, 1,   IL17↓, 1,   IL17↑, 1,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 16,   IL2↓, 2,   IL4↓, 4,   IL4↑, 1,   IL5↓, 1,   IL5↑, 1,   IL6↓, 17,   IL6↑, 2,   IL8↓, 5,   Imm↑, 12,   Imm⇅, 1,   Inflam↓, 83,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 5,   MIP‑1α/CCL3?, 1,   MIP‑1α/CCL3↓, 1,   NeuroI↓, 2,   Neut↓, 1,   Neut↑, 2,   NF-kB↓, 18,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 4,   PAF↓, 1,   PGE2↓, 11,   RANTES↓, 1,   TLR2↓, 2,   TLR4↓, 3,   TNF-α↓, 26,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 2,   5HT↑, 2,   Ach↑, 2,   AChE↓, 18,   BChE↓, 4,   BDNF↑, 11,   proBDNF↑, 1,   ChAT↑, 3,   DA↑, 1,   GABA↝, 1,   MAOA↓, 2,   MAOA↑, 1,   MAOB↓, 1,   NGF↑, 4,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 22,   Aβ∅, 1,   Aβ42↓, 1,   BACE/β-secretase↓, 8,   QPCT/QC↓, 1,   tau↓, 5,   p‑tau↓, 3,   XO↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↓, 1,   PPARα↑, 2,   PPARγ↓, 2,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 23,   BioAv↑, 44,   BioAv↝, 16,   BioEnh↑, 1,   CompStab↑, 1,   CYP2D6↓, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 2,   Dose↝, 53,   eff↓, 5,   eff↑, 30,   eff↝, 5,   GSTA1↓, 1,   Half-Life↓, 3,   Half-Life↑, 7,   Half-Life↝, 11,   Half-Life∅, 1,   P450↓, 1,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALAT∅, 3,   ALB↑, 1,   ALP↓, 3,   AR↓, 1,   AST↓, 12,   AST∅, 3,   Bil↓, 3,   Bil↑, 1,   BloodF↑, 5,   BMD↑, 1,   BP↓, 9,   BP∅, 1,   creat↓, 3,   CRP↓, 4,   HRV↑, 1,   IL6↓, 17,   IL6↑, 2,   KeyT↑, 1,   LDH↓, 2,   NOS2↓, 1,   PV↓, 1,   rHR↓, 1,   TC↓, 3,   TG/TAG↓, 3,   UFR?, 1,   Urea↓, 1,   Verbal↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   AirwayM↓, 1,   Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 12,   AntiArt↑, 1,   AntiCan↑, 13,   antiCG↑, 1,   antiD↑, 2,   AntiDiabetic↑, 16,   AntiMyl↑, 1,   antiPs↑, 1,   AntiTum↑, 4,   ANXi↓, 2,   cardioP↑, 26,   CardioT↓, 1,   chemoP↑, 5,   chemoPv↑, 1,   cognitive↑, 33,   DCR∅, 1,   diuretic↑, 2,   fatigue↓, 2,   hepatoP↑, 29,   IPSS↓, 1,   IPSS↝, 1,   Learn↑, 1,   memory↑, 20,   memory∅, 1,   Mood↑, 1,   motorD↑, 5,   Mucositis↓, 1,   neuroP↑, 49,   Obesity↓, 14,   ORR∅, 1,   OS↑, 4,   Pain↓, 9,   PDE4↓, 1,   PFS∅, 1,   QoL↑, 5,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 12,   Risk↓, 3,   RT↓, 2,   Sleep↑, 8,   Strength↑, 3,   Stress↓, 5,   Stroke↓, 10,   Tinn↓, 2,   toxicity↓, 357,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   Weight↓, 2,   Weight↑, 1,   Weight↝, 1,   Wound Healing↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 10,   AntiFungal↓, 1,   AntiFungal↑, 6,   AntiP↑, 1,   AntiViral↑, 7,   Bacteria↓, 26,   Diar↓, 2,   GutMicro↑, 15,   Inf↓, 2,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 390

Scientific Paper Hit Count for: toxicity, toxicity
19 Selenium NanoParticles
14 Silver-NanoParticles
9 chitosan
9 Sulforaphane (mainly Broccoli)
8 Ginkgo biloba-EGb 761
7 Hydrogen Gas
7 Magnolol
6 Radiotherapy/Radiation
6 Boron
6 Graviola
6 Magnetic Fields
6 Phenylbutyrate
5 Ashwagandha(Withaferin A)
5 Berberine
5 Dandelion Root
5 Honokiol
4 Cisplatin
4 α-Bisabolol / Chamomile oil
4 Carvacrol
4 Chlorogenic acid
4 Chemotherapy
4 D-limonene
4 Ginkgo biloba
4 Germanium Organic/Ge-132 / propagermanium (organogermanium)
4 isoorientin
4 Kaempferol
4 Luteolin
4 Methylsulfonylmethane
4 Urolithin
3 Vitamin C (Ascorbic Acid)
3 Alpha-Lipoic-Acid
3 Allicin (mainly Garlic)
3 HydroxyCitric Acid
3 doxorubicin
3 beta-glucans
3 Baicalein
3 Centella asiatica / Gotu kola → asiaticoside
3 Chlorophyllin
3 Curcumin
3 Docosahexaenoic Acid
3 Fucoidan
3 Gallic acid
3 Garcinol
3 L-Theanine
3 Linalool
3 mebendazole
3 MCT, metronomic chemo
3 Melatonin
3 Marjoram (Origanum majorana)
3 Phycocyanin
3 Pterostilbene
3 Resveratrol
3 Selenium
3 Shikonin
3 Thymoquinone
2 3-bromopyruvate
2 Selenite (Sodium)
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Beta-Caryophyllene
2 Betulinic acid
2 Chrysin
2 Cinnamon
2 Docetaxel
2 Ellagic acid
2 Eugenol
2 Ferulic acid
2 Flickering Light Stimulation
2 Flaxseed/Linseed
2 SDG/lignans
2 Gamma-aminobutyric acid
2 Gambogic Acid
2 Ginkgetin
2 Hibiscus sabdariffa
2 Hyperthermia
2 Hyperoside
2 Inositol
2 isoquercitrin
2 Lactoferrin/Talactoferrin
2 Matrine
2 MCT oil
2 Moringa oleifera
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Mushroom Maitake
2 Piperlongumine
2 Spirulina(Arthrospira/Limnospira)
2 Vitamin K2
1 1,8-Cineole
1 5-Hydroxytryptophan
1 Açaí, Euterpe oleracea
1 Astragalus
1 Resiquimod
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Aspirin
1 Atorvastatin
1 Dipyridamole
1 Aloe anthraquinones
1 Baicalin
1 Gold NanoParticles
1 Biochanin A
1 Bacopa monnieri
1 borneol
1 Boswellia (frankincense)
1 Carnosine
1 chaetocin
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Coenzyme Q10
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cysteamine
1 diet Fermented Foods
1 diet FMD Fasting Mimicking Diet
1 Diindolylmethane
1 Lemongrass Extract/Citral
1 Echinacea
1 Protocatechuic acid
1 EGCG (Epigallocatechin Gallate)
1 Folic Acid, Vit B9
1 Emodin
1 Evodiamine
1 Auditory Gamma Stimulation / 40 Hz Auditory Stimulation
1 Formononetin
1 Flaxseed Oil
1 Vitamin D3
1 Geldanamycin
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 Ginger/6-Shogaol/Gingerol
1 Germacranolide sesquiterpene lactone
1 Hydroxycinnamic-acid
1 HydroxyTyrosol
1 Indole-3-carbinol
1 Isobavachalcone
1 Isoliquiritigenin
1 Isothiocyanates
1 itraconazole
1 Ivermectin
1 Isovitexin
1 L-ornithine
1 Licochalcone A
1 Modified Citrus Pectin
1 Metformin
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Morin
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Peppermint
1 Purple Corn / Purple Maize
1 Phenethyl isothiocyanate
1 Photodynamic Therapy
1 Psoralidin
1 Pumpkin Seed Oil / Cucurbita pepo
1 Tamsulosin
1 Quercetin
1 benzo(a)pyrene
1 EMF
1 Rosmarinic acid
1 Rutin
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Anti-oxidants
1 Date Fruit Extract
1 Capsaicin
1 Silymarin (Milk Thistle) silibinin
1 Taurine
1 Turmerones
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1025  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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