CSCs Cancer Research Results

CSCs, Cancer Stem Cells: Click to Expand ⟱

Source:

Type:

Cancer Stem Cells

Phytochemicals (natural plant-derived compounds) that may affect CSCs:
Curcumin
— suppresses self-renewal and pathways (Wnt/Notch/Hedgehog).
Resveratrol
— shown to reduce CSC populations and sphere formation in multiple models.
Sulforaphane (from broccoli sprouts)
— reported to inhibit CSC properties and pathways; active in vitro and in vivo.
EGCG (epigallocatechin-3-gallate, green tea)
— reduces CSC markers and sphere formation in several cancer types.
Quercetin
— reported to inhibit CSC proliferation, self-renewal and invasiveness (breast, endometrial, others).
Berberine
— shown to suppress CSC “stemness” and reduce tumorigenic properties in multiple models.
Genistein (soy isoflavone)
— decreases CSC markers, sphere formation and stemness signaling in prostate/breast/other models.
Honokiol (Magnolia bark)
— shown to eliminate or suppress CSC-like populations in oral, colon, glioma models.
Luteolin
— inhibits stemness/EMT and reduces CSC markers and self-renewal in breast, prostate and other models.
Withaferin A (from Withania somnifera / ashwagandha)
— multiple preclinical reports show WA targets CSCs and reduces tumor growth/metastasis in models.

Circadian disruption in cancer and regulation of cancer stem cells by circadian clock genes: An updated review
Potential Role of the Circadian Clock in the Regulation of Cancer Stem Cells and Cancer Therapy
Can we utilise the circadian clock to target cancer stem cells?

Scientific Papers found: Click to Expand⟱

2166-

SFN,

Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction

-

in-vitro,

Oral,

NA

-

in-vivo,

NA,

NA

CSCs↓, selectivity↑, TumCMig↓, TumCI↓,

1458-

SFN,

Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

-

Review,

Bladder,

NA

HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,

1731-

SFN,

Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts

-

Review,

Var,

NA

CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2/PTGS2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,

1732-

SFN,

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

-

in-vitro,

BC,

MCF7

1~5 μM

16 μM

-

in-vitro,

BC,

SUM159

10 μM

-

in-vivo,

NA,

NA

Daily injection with 50 mg/kg

mice

TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,

1733-

SFN,

Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal

-

in-vitro,

PC,

PanCSC

-

in-vitro,

Nor,

HPNE

-

in-vitro,

Nor,

HNPSC

CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,

1726-

SFN,

Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential

-

Review,

Var,

NA

Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,

1730-

SFN,

Sulforaphane: An emergent anti-cancer stem cell agent

-

Review,

Var,

NA

BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,

3301-

SIL,

Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid

-

Review,

Var,

NA

Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,

5103-

SK,

Attenuation of PI3K-Akt-mTOR Pathway to Reduce Cancer Stemness on Chemoresistant Lung Cancer Cells by Shikonin and Synergy with BEZ235 Inhibitor

-

in-vitro,

NSCLC,

A549

CSCs↓, TumCP↓, Nanog↓, OCT4↓, p‑Akt↓, P70S6K↓, PI3K↓, mTOR↓, Synergy↑,

4739-

SSE,

Chemo,

Rad,

Therapeutic Benefits of Selenium in Hematological Malignancies

-

Review,

Var,

NA

ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,

5337-

TFdiG,

Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells

-

in-vitro,

Melanoma,

A375

-

in-vitro,

Melanoma,

A2058

TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,

5022-

UA,

Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks

-

Review,

Var,

NA

TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,

3104-

VitC,

Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations

*antiOx↑, *ROS↓, *DNAdam↓, ROS↑, TET1↑, CSCs↓, HIF-1↓, BioAv↑, selectivity↑,

7887-

VT,

IVT,

Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention

-

Review,

AD,

NA

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 251 to 264 of 264
Prev Page 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 264

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3, Catalase↓, 1, Fenton↑, 1, GPx4↓, 4, GSH↓, 8, GSH↑, 3, GSH/GSSG↓, 1, GSR↓, 2, GSR↑, 1, ox-GSSG↑, 1, GSTs↑, 1, H2O2↑, 1, HO-1↓, 1, HO-1↑, 9, Iron↑, 5, Keap1↑, 1, lipid-P↓, 1, lipid-P↑, 4, MDA↓, 2, MPO↓, 1, NQO1↓, 1, NQO1↑, 4, NRF2↓, 6, NRF2↑, 9, RNS↑, 1, ROS↓, 6, ROS↑, 100, mt-ROS↑, 1, SOD↓, 3, SOD↑, 2, mt-SOD↑, 1, SOD1↓, 2, SOD2↑, 1, Thiols↓, 2, Trx↓, 1, TrxR↓, 2, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1, CDC2↓, 2, CDC25↓, 3, compI↓, 4, compII↓, 1, compIV↓, 1, compV↓, 1, EGF↓, 1, ETC↝, 1, IDH2↓, 1, mitResp↓, 7, mitResp↑, 2, Mortalin↓, 1, mtDam↑, 8, OCR↓, 4, OCR↑, 1, OXPHOS↓, 6, OXPHOS↑, 3, SIRT3↓, 2, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2, ACLY↓, 2, ALAT↓, 1, AMP↑, 1, AMPK↓, 1, AMPK↑, 10, p‑AMPK↑, 1, ATP↓, 18, ECAR↓, 1, FAO↓, 1, FASN↓, 1, FASN↑, 1, GAPDH↓, 1, glucoNG↓, 1, GlucoseCon↓, 4, GlutMet↓, 1, Glycolysis↓, 16, GSK‐3β↓, 4, GSK‐3β↑, 2, GSK‐3β↝, 1, p‑GSK‐3β↓, 4, Histones↑, 1, HK2↓, 3, HMG-CoA↓, 4, lactateProd↓, 5, LDHA↓, 2, lipoGen↓, 1, NAD↓, 1, NADPH↓, 1, NADPH↑, 3, PDK1 / PDPK1↓, 3, PDKs↓, 2, PFK↓, 2, PFK1↓, 1, PKM2↓, 1, PKM2↑, 1, PPP↑, 1, SIRT1↓, 3, SIRT1↑, 1, SIRT2↓, 1, SLC25A1↓, 1, SREBP1/SREBF1↓, 1, TCA↓, 2, Warburg↓, 2,

Cell Death(tgid=5) ⓘ

AIF↑, 5, Apoptosis↓, 2, Apoptosis↑, 76, Apoptosis∅, 1, mt-Apoptosis↑, 2, BAD↓, 1, Bak↑, 2, BAX↑, 27, Bax:Bcl2↑, 13, Bcl-2↓, 35, Bcl-xL↓, 4, BIM↑, 1, BNIP3↑, 1, Casp↓, 1, Casp↑, 11, Casp10↑, 1, Casp12↑, 2, Casp3↓, 1, Casp3↑, 37, cl‑Casp3↑, 6, Casp7↑, 6, Casp8↑, 8, Casp8∅, 1, Casp9↑, 22, p‑Casp9↑, 1, cl‑Casp9↑, 3, Cyt‑c↑, 20, Diablo↑, 2, DR5↑, 10, Fas↑, 7, FasL↑, 1, Ferroptosis↑, 7, HEY1↓, 2, IAP1↓, 2, ICAD↓, 1, ICD↑, 3, iNOS↓, 3, Mcl-1↓, 6, Mcl-1↑, 1, MOMP↑, 2, Necroptosis↑, 1, necrosis↑, 2, p38↓, 2, p38↑, 7, p‑p38↓, 1, PUMA↑, 1, Pyro↑, 1, survivin↓, 20, survivin↝, 1, TNFR 1↑, 1, TRAIL↑, 1, TRAIL⇅, 1, TRAILR↑, 3, TumCD↑, 14, XIAP↓, 11, YAP/TEAD↓, 5, YAP/TEAD↝, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 44, Akt↑, 1, p‑Akt↓, 9, AKT1↓, 2, CaMKII ↓, 1, CK2↓, 3, cMET↓, 1, DDIT4↑, 1, EF-1α↓, 1, EGFR↓, 14, ERK↓, 6, ERK↑, 3, p‑ERK↓, 4, FGFR1↓, 1, HER2/EBBR2↓, 8, HGF/c-Met↓, 1, Hippo↓, 1, IGF-1R↓, 1, IGFR↓, 1, IKKα↓, 4, JAK↓, 2, JAK1↓, 1, JAK2↓, 5, JNK↓, 1, JNK↑, 8, p‑JNK↓, 1, MAPK↓, 10, MAPK↑, 6, MARK4↓, 1, MEK↓, 1, mTOR↓, 34, p‑mTOR↓, 2, p70S6↓, 1, P70S6K↓, 1, PDGFR-BB↓, 2, PDGFRA↓, 2, PI3K↓, 36, p‑PI3K↓, 2, PI3K/Akt↓, 2, PI3k/Akt/mTOR↓, 1, PKCδ↓, 2, PKCδ↑, 1, PTEN↑, 5, Raf↓, 2, c-Raf↓, 1, RAS↓, 1, RET↓, 1, p‑S6K↓, 1, Sp1/3/4↓, 5, STAT↓, 3, STAT3↓, 40, STAT3↝, 1, p‑STAT3↓, 4, STAT5↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1, ATF4↑, 2, CBP↓, 1, cJun↓, 3, cJun↑, 1, cMyc↓, 23, cMyc↑, 1, DNMT1↓, 5, DNMT3A↓, 1, DNMTs⇅, 1, EZH2↓, 3, FOXM1↓, 1, FOXO↑, 2, FOXO3↑, 4, FOXO3↝, 1, FOXO4↓, 1, FOXO4↑, 1, GATA3↓, 1, H3↓, 1, H3↑, 2, H3K27ac↓, 1, H3K9↓, 1, H4↑, 1, HATs↓, 2, HATs↑, 1, HATs⇅, 1, HDAC↓, 6, HDAC⇅, 1, HDAC1↓, 1, HDAC3↓, 1, HOTAIR↓, 1, miR-10a-5p↝, 1, miR-133a-3p↑, 1, miR-141↑, 1, miR-145↑, 1, miR-155↝, 1, miR-200c↑, 2, miR-21↓, 1, miR-21↑, 1, miR-218↑, 1, miR-27a-3p↓, 1, miR-34a↓, 1, miR-34a↑, 5, miR-34a↝, 1, miR-375↑, 1, miR-448↑, 1, miR-485↑, 1, Myc↓, 1, Myc↑, 1, MYCN↑, 1, n-MYC↓, 2, NDRG1↑, 1, OCT4↓, 37, OCT4↑, 1, OLIG2↓, 1, other↓, 3, other↑, 1, other↝, 8, PCAF↓, 1, SOX2↓, 25, SOX4↓, 3, SOX4↑, 1, SOX9?, 1, SOX9↓, 2, SUV39H↓, 2, SUZ12↓, 1, TCF-4↓, 1, TFE3↑, 2, tumCV↓, 16, YMcells↑, 1, ZBTB10↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 12, cl‑CHOP/DDIT3↑, 1, eIF2α↓, 1, ER Stress↑, 18, ERStress↑, 1, GRP78/BiP↓, 3, GRP78/BiP↑, 3, HSP27↓, 3, HSP70/HSPA5↓, 4, HSP90↓, 8, HSPs↑, 1, Proteasome?, 1, Proteasome↓, 2, UPR↑, 5,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2, ATG7↑, 1, autoF↓, 2, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 3, CTSB↓, 1, CTSK↓, 1, CTSL↓, 1, CTSS↓, 1, CTSZ↓, 1, LC3B-II↑, 2, LC3II↓, 1, LC3II↑, 5, LC3s↓, 1, lysoMP↑, 1, lysosome↓, 1, lysosome↝, 1, MitoP↑, 1, p62↓, 4, p62↑, 1, SESN2↑, 1, TumAuto↓, 1, TumAuto↑, 22,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1, BRCA1↓, 1, BRCA1↑, 1, DFF45↑, 1, DNAdam↓, 1, DNAdam↑, 31, DNArepair↓, 1, ERCC1↓, 1, m-FAM72A↓, 1, hTERT/TERT↓, 1, MGMT↓, 1, p16↑, 2, P53↑, 30, p‑P53↑, 1, PARP↓, 1, PARP↑, 4, cl‑PARP↑, 15, cl‑PARP↝, 1, PCNA↓, 9, POLD1↓, 1, RAD51↓, 1, SIRT6↓, 2, Telomerase↓, 5, TOP2↓, 2, TOP2↑, 1, TP53↑, 2, γH2AX↑, 4,

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1, CC(CDKs/cyclins)↓, 1, CDK1↓, 9, CDK1↑, 1, p‑CDK1↓, 1, CDK2↓, 8, CDK2↑, 1, CDK4↓, 15, CDK4↑, 1, CDK6↓, 4, CDK6↑, 1, CHK1↓, 2, CHK1↑, 1, Chk2↓, 2, Chk2↑, 1, Cyc↓, 1, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 7, CycB/CCNB1↑, 2, cycD1/CCND1↓, 29, cycD1/CCND1↑, 3, CycD3↓, 1, cycE/CCNE↓, 7, E2Fs↓, 4, E2Fs↑, 1, Ki-67↓, 7, mitA↓, 1, p19↑, 1, P21?, 1, P21↓, 1, P21↑, 17, p27/CDKN1B↑, 8, p‑pRB↓, 1, RB1↑, 1, p‑RB1↓, 3, Securin↓, 1, TumCCA?, 1, TumCCA↓, 4, TumCCA↑, 66,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 18, ALDH1A1↓, 13, ALDH1A3↓, 1, BMI1↓, 4, CD133↓, 37, CD133↑, 1, CD24↓, 12, CD34↓, 2, cFos↓, 3, CLOCK↓, 1, cMYB↓, 1, CSCs?, 2, CSCs↓, 259, CSCs↑, 4, CSCs↝, 1, CSCsMark↓, 4, Diff↓, 2, Diff↑, 3, FGF↓, 1, Gli↓, 4, Gli1↓, 12, Gli1↝, 1, HH↓, 13, HH↝, 1, HMGCR↓, 2, IGF-1↓, 4, IGFBP3↑, 1, Ki-67↓, 7, LGR5↓, 1, LRP6↓, 3, p‑LRP6↓, 1, mTORC1↓, 3, p‑mTORC1↓, 1, Nanog↓, 40, Nanog↑, 1, Nestin↓, 5, NOTCH↓, 13, NOTCH1↓, 15, NOTCH2↓, 1, NOTCH3↓, 4, p300↓, 2, PTCH1↓, 5, PTCH2↓, 1, Shh↓, 13, Smo↓, 8, TumCG↓, 51, TumCG↑, 1, TumCP↓, 58, TumCP↑, 1, Wnt↓, 43, Wnt↑, 1, Wnt/(β-catenin)↓, 3,

Migration(tgid=13) ⓘ

ACTA2↓, 1, annexin II↓, 1, AP-1↓, 3, Ca+2↓, 1, Ca+2↑, 11, Ca+2↝, 1, cal2↓, 1, cal2↑, 1, CCN2/CTGF↓, 2, CD11b↓, 1, Chl↓, 1, Chl↑, 1, COL1↓, 1, COL3A1↓, 1, E-cadherin↓, 3, E-cadherin↑, 23, EMT↓, 68, EpCAM↓, 5, FAK↓, 6, Fibronectin↓, 3, Furin↓, 1, GLI2↓, 5, GLI2↝, 1, ITGB1↓, 1, ITGB4↓, 1, LAMs↓, 1, LEF1↓, 5, MALAT1↓, 1, MMP1↓, 1, MMP2↓, 33, MMP2↑, 1, MMP7↓, 2, MMP9↓, 38, MMPs↓, 11, MUC1↓, 1, MUC1-C↓, 1, N-cadherin↓, 15, NCAM↓, 1, PAK1↓, 3, PAK1↑, 1, PDGF↓, 2, RECK↑, 1, Rho↓, 1, ROCK1↓, 1, Slug↓, 13, Smad1↓, 1, SMAD2↓, 3, SMAD3↓, 3, Snail↓, 21, TET1↓, 1, TET1↑, 1, TGF-β↓, 10, TIMP1↓, 1, TIMP1↑, 2, TIMP2↓, 1, TIMP2↑, 2, TRIB3↑, 2, TSP-1↑, 5, TumCI↓, 38, TumCMig↓, 35, TumMeta↓, 34, TumMeta↑, 1, TumPF↓, 1, Twist↓, 6, uPA↓, 8, uPAR↓, 1, Vim?, 1, Vim↓, 26, Zeb1↓, 8, α-SMA↓, 1, β-catenin/ZEB1↓, 49, β-catenin/ZEB1↑, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 42, angioG↑, 2, CCN1/CYR61↓, 1, CD31/PECAM-1↓, 1, ECM/TCF↓, 1, Endoglin↓, 1, HIF-1↓, 2, Hif1a↓, 24, Hypoxia↓, 1, LymphAG↓, 1, NO↑, 1, VCAM-1↓, 1, VEGF↓, 39, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 5,

Barriers & Transport(tgid=15) ⓘ

EPR↑, 1, GLUT1↓, 1, GLUT2↓, 1, MMP↓, 46, MMP↑, 1, MPT↑, 5, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

ALC∅, 1, CCR7↓, 1, CD25+↓, 1, CD4+↓, 2, CD44↓, 56, CD8+↑, 2, COX2/PTGS2↓, 24, COX2/PTGS2↑, 1, CXCL12↓, 2, CXCR4↓, 9, DCells↑, 1, DR4↑, 3, FoxP3+↓, 1, HMGB1↓, 3, ICAM-1↓, 1, IFN-γ↓, 1, IL1↓, 1, IL10↓, 2, IL10↑, 1, IL12↓, 3, IL1β↓, 8, IL2↓, 1, IL6↓, 20, IL8↓, 6, Imm↑, 11, Imm↝, 1, Inflam↓, 14, M2 MC↓, 2, MCP1/CCL2↓, 3, NF-kB?, 1, NF-kB↓, 62, NF-kB↑, 1, p‑NF-kB↓, 1, NLRP3↓, 1, p50↓, 1, p65↓, 1, PAF↓, 1, PD-1↓, 1, PD-L1↓, 1, PD-L1↑, 1, PGE2↓, 6, PSA↓, 1, RAGE↓, 1, T-Cell↑, 1, TCF↓, 3, TCF↝, 1, TCF7/TCF1↓, 1, Th1 response↑, 1, TLR4↓, 2, TNF-α↓, 9,

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1, pH↝, 1, e-pH↑, 1, i-pH↓, 1,

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2, ER-α36↓, 2, ER-α36↝, 1, FGF21↓, 1, PPARγ↑, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 2, ABCG2↓, 4, BioAv↓, 13, BioAv↑, 17, BioAv↝, 5, BioEnh↑, 1, chemoR↓, 3, ChemoSen↑, 81, ChemoSen⇅, 1, CompStab↓, 1, Dose?, 1, Dose↓, 2, Dose↑, 3, Dose⇅, 1, Dose↝, 20, Dose∅, 2, DrugR↓, 1, eff?, 1, eff↓, 16, eff↑, 40, eff↝, 10, eff∅, 1, GSTA1↓, 1, GSTA1↑, 1, GSTZ1↓, 1, GSTZ1↝, 1, Half-Life↓, 5, Half-Life↑, 2, Half-Life↝, 4, MDR1↓, 7, P-gp/ABCB1↓, 15, P450↓, 3, RadioS↑, 29, selectivity↑, 36, selectivity↝, 2, Synergy↑, 61,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AR↓, 2, AST↓, 1, BRCA1↓, 1, BRCA1↑, 1, CRP↓, 2, E6↓, 2, E7↓, 2, EGFR↓, 14, EZH2↓, 3, Ferritin↓, 3, FOXM1↓, 1, HER2/EBBR2↓, 8, hTERT/TERT↓, 1, IL6↓, 20, LDH↓, 4, LDH↑, 2, Myc↓, 1, Myc↑, 1, PD-L1↓, 1, PD-L1↑, 1, PSA↓, 1, RAGE↓, 1, SUZ12↓, 1, TG/TAG↓, 1, TP53↑, 2, TRIB3↑, 2,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 17, antiNeop↑, 4, AntiTum↓, 1, AntiTum↑, 7, cardioP↑, 1, chemoP?, 1, chemoP↑, 8, chemoPv↑, 4, ChemoSideEff↓, 3, fatigue↓, 1, FTO↑, 1, hepatoP↑, 3, neuroP↑, 1, NP/CIPN↓, 1, NP/CIPN↑, 1, OS↑, 6, PFS↑, 1, Pin1↓, 2, QoL↑, 3, radioP↑, 2, Remission↑, 1, RenoP↑, 1, Risk↓, 4, toxicity↓, 11, toxicity↑, 2, toxicity⇅, 1, toxicity↝, 5, TumVol↓, 11, TumW↓, 4,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1, GutMicro↑, 2, GutMicro↝, 1, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,
Total Targets: 691

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 17, Catalase↑, 4, GPx↑, 4, GPx1↑, 1, GPx4↑, 2, GSH↑, 5, GSTs↑, 4, H2O2↑, 1, HDL↑, 1, HO-1↓, 1, HO-1↑, 6, i-Iron↓, 1, Keap1↓, 2, lipid-P↓, 3, MDA↓, 5, MPO↓, 1, NRF2↑, 9, Prx↑, 1, ROS↓, 19, ROS↑, 1, ROS∅, 1, selenoP↑, 1, SOD↑, 7, SOD1↑, 2, SOD2↑, 2, xCT/SLC7A11↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1, MFN2↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, ALAT↓, 1, AMPK↓, 1, AMPK↑, 4, ATP↓, 1, ATP↑, 2, glucose↓, 1, glucose↝, 1, GlucoseCon↑, 2, GSK‐3β↑, 1, HMG-CoA↓, 1, NAD↓, 1, SIRT1↑, 2,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1, BAX↓, 1, Bcl-2↓, 1, Casp3?, 1, Casp3↓, 3, Casp9↓, 2, Cyt‑c↓, 1, Fas↓, 1, Ferroptosis↓, 2, iNOS↓, 5, p38↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 1, ERK↓, 1, p‑ERK↑, 1, HGF/c-Met↑, 1, JNK↓, 1, p‑JNK↓, 1, MAPK↓, 2,

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1, ATF4↓, 1, FOXO3↑, 1, HDAC↓, 1, HDAC3↓, 1, other↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 1, GRP78/BiP↑, 1, GRP94↑, 1, HSP70/HSPA5↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1, LC3II↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1, P53↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1, Ki-67↓, 1, P21↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1, Ki-67↓, 1, NOTCH↓, 1, Wnt↓, 1, Wnt↑, 1,

Migration(tgid=13) ⓘ

Ca+2↑, 1, FAK↑, 1, LAMs↑, 1, MMP3↓, 1, MMP9↓, 1, Smad1↑, 1, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2, Hif1a↑, 1, NO↓, 2, NO↑, 2, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1, BBB↑, 1, GLUT2↑, 2, GLUT3↑, 1, GLUT4↑, 2, H+/K+-ATPase↓, 1, MMP↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1, COX2/PTGS2↓, 5, IFN-γ↓, 1, IL10↓, 1, IL17↓, 1, IL18↓, 1, IL1β↓, 3, IL6↓, 6, IL8↓, 1, Imm↓, 1, Imm↑, 1, Inflam↓, 16, Inflam↑, 1, NF-kB↓, 2, PGE2↓, 2, PGE2↑, 1, Th1 response↓, 1, Th2↑, 2, TLR4↓, 2, TNF-α↓, 8,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2, BDNF↓, 1,

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, ACE2↓, 1, p‑PPARγ↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7, BioAv↑, 11, BioAv↝, 7, CompStab↑, 1, Dose↑, 1, eff↑, 1, Half-Life↓, 1, Half-Life↝, 2, Half-Life∅, 1, Synergy↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AST↓, 1, BMD↑, 1, CRP↓, 1, IL6↓, 6, IRes↝, 1, LDH↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2, antiAll↑, 2, AntiArt↑, 1, AntiCan↑, 2, AntiDiabetic↑, 5, cardioP↑, 6, CardioT↓, 1, chemoP↑, 1, chemoPv↑, 2, cognitive↑, 1, hepatoP↑, 7, memory↑, 2, neuroP↑, 14, Obesity↓, 2, Pain↓, 1, RenoP↑, 2, Stroke↓, 1, toxicity↓, 11, toxicity↝, 3,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1, AntiFungal↑, 1, AntiP↑, 2, AntiViral↑, 1, Bacteria↓, 4, GutMicro↑, 3,
Total Targets: 171

Scientific Paper Hit Count for: CSCs, Cancer Stem Cells

28 salinomycin
19 Curcumin
15 Resveratrol
15 EGCG (Epigallocatechin Gallate)
14 Sulforaphane (mainly Broccoli)
14 Quercetin
12 Ashwagandha(Withaferin A)
10 Phenethyl isothiocyanate
10 Pterostilbene
6 HydroxyTyrosol
6 Ivermectin
5 Apigenin (mainly Parsley)
5 Disulfiram
5 Honokiol
4 Silver-NanoParticles
4 Artemisinin
4 Berberine
4 Dichloroacetate
4 Emodin
4 Genistein (soy isoflavone)
4 metronomic chemo
4 Parthenolide
3 Isovitexin
3 Radiotherapy/Radiation
3 Bufalin/Huachansu
3 Copper and Cu NanoParticles
3 Eugenol
3 Evodiamine
3 Chemotherapy
3 isoflavones
3 Juglone
2 Astragalus
2 Alpha-Lipoic-Acid
2 Atorvastatin
2 Baicalein
2 Propolis -bee glue
2 chaetocin
2 immunotherapy
2 Fisetin
2 Garcinol
2 Glabrescione B
2 Hyperthermia
2 Isoliquiritigenin
2 Luteolin
2 Magnetic Fields
2 Psoralidin
1 3-bromopyruvate
1 Auranofin
1 Allicin (mainly Garlic)
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Berbamine
1 bempedoic acid
1 Betulinic acid
1 temozolomide
1 Brutieridin–Melitidin Mixture
1 Boswellia (frankincense)
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 Celecoxib
1 Chlorogenic acid
1 Cucurbitacin
1 CUSP9
1 Dandelion Root
1 5-fluorouracil
1 Electrical Pulses
1 Gallic acid
1 Ginkgolide B
1 Isobavachalcone
1 iodine
1 isoorientin
1 itraconazole
1 Kaempferol
1 Licorice
1 Lemongrass Extract/Citral
1 Magnolol
1 mebendazole
1 Metformin
1 Melatonin
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 Oleuropein
1 Piperine
1 Plumbagin
1 Polyphenols
1 doxorubicin
1 Rosmarinic acid
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitexin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:795  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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