| Features: Estrogen-like activity |
| Genistein is a naturally occurring isoflavone predominantly found in soy products. -soy isoflavone Anticancer effects through several mechanisms: -Modulation of Hormone Activity: can bind to estrogen receptors(hormone-dependent cancers like breast and prostate cancer). -Inhibition of Cell Proliferation:- -inducing cell cycle arrest. -Induction of Apoptosis:- by influencing pro- and anti-apoptotic regulators. -Anti-inflammatory and Antioxidant Effects:-antioxidant properties help to neutralize ROS -Anti-angiogenic Activity:may also inhibit tumor angiogenesis Key Cellular Signaling Pathways Involved -Estrogen Receptor Signaling: interacting with estrogen receptors (ERα and ERβ) -PI3K/Akt/mTOR Pathway:inhibits this pro-survival pathway, leading to reduced cell growth -MAPK/ERK Pathway: can contribute to cell cycle arrest. -NF-κB Pathway:may downregulate NF-κB, supporting a reduction in tumor-promoting inflammation. -Wnt/β-catenin Pathway: involved in cell proliferation, differentiation, and oncogenic transformation. Dosages often ranging from approximately 40 mg to 100 mg per day for potential therapeutic effects. Genistein has limited bioavailability when ingested as part of the diet. Efforts to enhance its absorption include the use of specific formulations, such as those that combine genistein with other compounds or utilize novel delivery systems. |
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| Cancer Stem Cells Phytochemicals (natural plant-derived compounds) that may affect CSCs: Curcumin — suppresses self-renewal and pathways (Wnt/Notch/Hedgehog). Resveratrol — shown to reduce CSC populations and sphere formation in multiple models. Sulforaphane (from broccoli sprouts) — reported to inhibit CSC properties and pathways; active in vitro and in vivo. EGCG (epigallocatechin-3-gallate, green tea) — reduces CSC markers and sphere formation in several cancer types. Quercetin — reported to inhibit CSC proliferation, self-renewal and invasiveness (breast, endometrial, others). Berberine — shown to suppress CSC “stemness” and reduce tumorigenic properties in multiple models. Genistein (soy isoflavone) — decreases CSC markers, sphere formation and stemness signaling in prostate/breast/other models. Honokiol (Magnolia bark) — shown to eliminate or suppress CSC-like populations in oral, colon, glioma models. Luteolin — inhibits stemness/EMT and reduces CSC markers and self-renewal in breast, prostate and other models. Withaferin A (from Withania somnifera / ashwagandha) — multiple preclinical reports show WA targets CSCs and reduces tumor growth/metastasis in models. |
| 2998- | GEN, | Cellular and Molecular Mechanisms Modulated by Genistein in Cancer |
| - | Review, | Var, | NA |
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