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| Rotary Magnetic field can be generated by a spinning magnet or magnets. Or it can be implemented with 2 or more coils, power with a phase shift between them (90 deg for 2 coil implementation) (60deg for 3 coil implementation) Targets affected are mostly the same as for Magnet fields Main differences - may enhance the EPR effect allowing targeting of drugs to cancer cells - acts as wireless stirrer, especially on magnetic particles(inducing eddy currents in water media) - research for use in nano surgery, and mechanical destruction of cancer cells - continue to highlight ability to raise ROS in cancer cell and lower ROS in normal cells - RMF may be responsible for Ca2+ distribution to pass across the plasma membrane(differental affected for cancer and normal cells) Pathways: - induce ROS production in cancer cells, while decreasing ROS in normal cells. Ca2+ is critical and the Ca2+ balance is increased in cancer cells while decreased in normal cells (example for wound healing) - ROS↑ related: MMP↓(ΔΨm), Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓, Prx, - Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑, - lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : TNF-α↓, IL-6↓, - inhibit Growth/Metastases : TumMeta↓, TumCG↓, MMPs↓, MMP2↓, MMP9↓, IGF-1↓, RhoA↓, NF-κB↓, TGF-β↓, ERK↓ - cause Cell cycle arrest : TumCCA↑, - inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, ERK↓, - Others: PI3K↓, AKT↓, Wnt↓, AMPK, ERK↓, JNK, - Synergies: < Others(review target notes), Neuroprotective, Cognitive, - Selectivity: Cancer Cells vs Normal Cells Rotating Magnetic Fields
Time-Scale Flag: TSF = P / R / G P: 0–30 min (physical / electron / radical effects) R: 30 min–3 hr (redox signaling & stress response) G: >3 hr (gene-regulatory adaptation)MPTP: opening represents a mitochondrial commitment event integrating ROS and Ca²⁺ stress; sustained opening indicates irreversible bioenergetic failure. |
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Membrane potential is the voltage difference between the inside and outside of a cell membrane. 𝑉𝑚=𝑉𝑖𝑛𝑠𝑖𝑑𝑒−𝑉𝑜𝑢𝑡𝑠𝑖𝑑𝑒 The outside of the cell is normally defined as 0 mV reference. Therefore most cells have a negative internal voltage. | Cell type | Resting membrane potential | | ---------------- | --------------------------------- | | Neurons | −60 to −70 mV | | Muscle cells | −80 to −90 mV | | Epithelial cells | −30 to −50 mV | | Cancer cells | −10 to −40 mV (often depolarized) | Cancer cells are usually less negative than normal cells. This depolarization correlates with proliferation and metastasis. Depolarization of the membrane potential (Vm) means the membrane potential becomes less negative (more positive). The cell membrane behaves like: -capacitor (lipid bilayer) -resistors (ion channels) Membrane capacitance: 𝐶𝑚≈1 𝜇𝐹/𝑐𝑚2 Cell diameter Area At 1.0 µF/cm² At 1.9 µF/cm² 10 µm 3.14×10−6cm² 3.1 pF 6.0 pF 15 µm 7.07×10−6cm² 7.1 pF 13.4 pF 20 µm 1.26×10−5cm² 12.6 pF 23.9 pF Magnetic fields can transiently increase VGSC/VGCC activity, but that does not necessarily promote cancer because: -the activation is temporary -the perturbation may destabilize cancer cell ion homeostasis. |
| 5535- | MFrot, | Spatiotemporal magnetic fields enhance cytosolic Ca2+ levels and induce actin polymerization via activation of voltage-gated sodium channels in skeletal muscle cells |
| - | in-vitro, | Nor, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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