| Features: |
| Rotary Magnetic field can be generated by a spinning magnet or magnets. Or it can be implemented with 2 or more coils, power with a phase shift between them (90 deg for 2 coil implementation) (60deg for 3 coil implementation) Targets affected are mostly the same as for Magnet fields Main differences - may enhance the EPR effect allowing targeting of drugs to cancer cells - acts as wireless stirrer, especially on magnetic particles(inducing eddy currents in water media) - research for use in nano surgery, and mechanical destruction of cancer cells - continue to highlight ability to raise ROS in cancer cell and lower ROS in normal cells - RMF may be responsible for Ca2+ distribution to pass across the plasma membrane(differental affected for cancer and normal cells) Pathways: - induce ROS production in cancer cells, while decreasing ROS in normal cells. Ca2+ is critical and the Ca2+ balance is increased in cancer cells while decreased in normal cells (example for wound healing) - ROS↑ related: MMP↓(ΔΨm), Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓, Prx, - Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑, - lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : TNF-α↓, IL-6↓, - inhibit Growth/Metastases : TumMeta↓, TumCG↓, MMPs↓, MMP2↓, MMP9↓, IGF-1↓, RhoA↓, NF-κB↓, TGF-β↓, ERK↓ - cause Cell cycle arrest : TumCCA↑, - inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, ERK↓, - Others: PI3K↓, AKT↓, Wnt↓, AMPK, ERK↓, JNK, - Synergies: < Others(review target notes), Neuroprotective, Cognitive, - Selectivity: Cancer Cells vs Normal Cells |
| 3488- | MFrot, | MF, | Rotating magnetic field improves cognitive and memory impairments in APP/PS1 mice by activating autophagy and inhibiting the PI3K/AKT/mTOR signaling pathway |
| - | in-vivo, | AD, | NA |
| 224- | MFrot, | MF, | A pilot study of extremely low-frequency magnetic fields in advanced non-small cell lung cancer: Effects on survival and palliation of general symptoms |
| - | Human, | NSCLC, | NA |
| 225- | MFrot, | MF, | Extremely low frequency magnetic fields regulate differentiation of regulatory T cells: Potential role for ROS-mediated inhibition on AKT |
| - | vitro+vivo, | Lung, | NA |
| 226- | MFrot, | MF, | Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cells |
| - | in-vitro, | NA, | A549 | - | in-vitro, | NA, | LoVo |
| 227- | MFrot, | MF, | Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway |
| - | in-vivo, | Lung, | A549 | - | in-vitro, | Lung, | A549 |
| 228- | MFrot, | MF, | Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17 |
| - | NA, | MS, | NA |
| 229- | MFrot, | MF, | Molecular mechanism of effect of rotating constant magnetic field on organisms |
| - | in-vivo, | Nor, | NA |
| 230- | MFrot, | MF, | Study on the Effect of Rotating Magnetic Field on Cellular Response of Mammalian Cells |
| - | in-vitro, | Nor, | L929 |
| 516- | MFrot, | immuno, | MF, | Anti-tumor effect of innovative tumor treatment device OM-100 through enhancing anti-PD-1 immunotherapy in glioblastoma growth |
| - | vitro+vivo, | GBM, | U87MG |
| 595- | MFrot, | VitC, | MF, | The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells |
| - | in-vitro, | PC, | MIA PaCa-2 | - | in-vitro, | CRC, | SW-620 | - | in-vitro, | NA, | HT1080 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | OS, | U2OS | - | in-vitro, | BC, | MCF-7 | - | in-vitro, | Nor, | CCD-18Co |
| 1737- | MFrot, | Fe, | MF, | Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with Fe3O4 Particles for Killing A375 Melanoma Cells |
| - | in-vitro, | MB, | A375 |
| 2258- | MFrot, | MF, | EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE |
| - | in-vitro, | GBM, | GBM | - | in-vitro, | Nor, | SVGp12 |
| 2259- | MFrot, | MF, | Method and apparatus for oncomagnetic treatment |
| - | in-vitro, | GBM, | NA |
| 2262- | MFrot, | MF, | Effects of 0.4 T Rotating Magnetic Field Exposure on Density, Strength, Calcium and Metabolism of Rat Thigh Bones |
| - | in-vivo, | ostP, | NA |
| 2311- | MFrot, | MF, | Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials |
| - | in-vivo, | Nor, | HaCaT |
| 223- | MFrot, | MF, | The effect of rotating magnetic fields on the growth of Deal's guinea pig sarcoma transplanted subcutaneously in guinea pigs |
| - | in-vivo, | NA, | NA |
| 3489- | MFrot, | MF, | Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice. |
| - | in-vivo, | AD, | NA |
| 3491- | MFrot, | MF, | Magnetically controlled cyclic microscale deformation of in vitro cancer invasion models |
| - | in-vitro, | BC, | MDA-MB-231 |
| 3492- | MFrot, | Chemo, | MF, | Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer Cells |
| 3493- | MFrot, | MF, | Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes |
| - | in-vivo, | GBM, | NA |
| 3494- | MFrot, | MF, | Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance |
| - | in-vitro, | Var, | NA |
| 3495- | MFrot, | MF, | Synthesis of urchin-like nickel nanoparticles with enhanced rotating magnetic field-induced cell necrosis and tumor inhibition |
| - | in-vivo, | BC, | NA |
| 3496- | MFrot, | GoldNP, | MF, | Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticles |
| - | in-vitro, | Cerv, | HeLa |
| 3497- | MFrot, | MF, | The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets |
| - | Human, | Nor, | NA |
| 3499- | MFrot, | MF, | Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans |
| - | in-vitro, | Nor, | HUVECs |
| 3535- | MFrot, | MF, | Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications |
| - | Review, | Nor, | NA |
| 3567- | MFrot, | MF, | The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review |
| - | Review, | Stroke, | NA |
| 3745- | MFrot, | MF, | The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease |
| - | Review, | AD, | NA |
| 4566- | MFrot, | On the mitochondrial aspect of reactive oxygen species action in external magnetic fields |
| - | Study, | Var, | NA |
| 4567- | MFrot, | Oncogenic pathways and the electron transport chain: a dangeROS liaison |
| - | Review, | Var, | NA |
| 203- | MFrot, | MF, | Rotating Magnetic Field Induced Oscillation of Magnetic Particles for in vivo Mechanical Destruction of Malignant Glioma |
| - | vitro+vivo, | GBM, | U87MG |
| 185- | MFrot, | MF, | Case Report: End-Stage Recurrent Glioblastoma Treated With a New Noninvasive Non-Contact Oncomagnetic Device |
| - | Human, | GBM, | NA |
| 186- | MFrot, | MF, | Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields |
| - | in-vitro, | GBM, | GBM | - | in-vitro, | Lung, | NA |
| 187- | MFrot, | MF, | Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in mice |
| - | in-vivo, | GBM, | NA |
| 188- | MFrot, | MF, | Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells |
| - | in-vitro, | GBM, | GBM115 | - | in-vitro, | GBM, | DIPG |
| 189- | MFrot, | MF, | Cancer treatment by magneto-mechanical effect of particles, a review |
| - | vitro+vivo, | Var, | NA |
| - | Human, | Lung, | NA |
| 191- | MFrot, | MF, | Early exposure of rotating magnetic fields promotes central nervous regeneration in planarian Girardia sinensis |
| - | in-vivo, | Nor, | NA |
| 193- | MFrot, | MF, | Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions |
| - | in-vivo, | Arthritis, | NA |
| 195- | MFrot, | MF, | Application of Rotating Magnetic Fields Increase the Activity of Antimicrobials Against Wound Biofilm Pathogens |
| - | Human, | Wounds, | NA |
| 198- | MFrot, | MF, | Biological effects of rotating magnetic field: A review from 1969 to 2021 |
| - | Review, | Var, | NA |
| 199- | MFrot, | MF, | Modulation of Cellular Response to Different Parameters of the Rotating Magnetic Field (RMF)—An In Vitro Wound Healing Study |
| - | in-vivo, | Wounds, | L929 | - | NA, | NA, | HaCaT |
| 200- | MFrot, | MF, | Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice |
| - | in-vivo, | BC, | MDA-MB-231 | - | in-vivo, | BC, | MCF-7 |
| 201- | MFrot, | MF, | Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | BT549 | - | in-vitro, | BC, | MDA-MB-468 |
| 202- | MFrot, | MF, | Systematic simulation of tumor cell invasion and migration in response to time-varying rotating magnetic field |
| - | Analysis, | Var, | MDA-MB-231 |
| 184- | MFrot, | MF, | Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells |
| - | in-vitro, | GBM, | GBM |
| 204- | MFrot, | MF, | Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization |
| - | in-vivo, | AD, | NA |
| 205- | MFrot, | MF, | Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis |
| - | vitro+vivo, | BC, | MDA-MB-231 |
| 209- | MFrot, | MF, | The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study |
| - | Human, | NA, | NA |
| 212- | MFrot, | MF, | Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice |
| - | in-vivo, | AD, | SH-SY5Y |
| 213- | MFrot, | MF, | Rotating Magnetic Field-Assisted Reactor Enhances Mechanisms of Phage Adsorption on Bacterial Cell Surface |
| - | in-vitro, | NA, | NA |
| 214- | MFrot, | MF, | Modification of bacterial cellulose through exposure to the rotating magnetic field |
| - | in-vitro, | Nor, | NA |
| 215- | MFrot, | MF, | Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields |
| - | in-vitro, | PC, | CAF |
| 216- | MFrot, | MF, | Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field |
| - | in-vitro, | GBM, | U87MG |
| 217- | MFrot, | MF, | Effect of low-frequency rotary magnetic fields on advanced gastric cancer |
| - | in-vivo, | GC, | HL-60 | - | in-vivo, | GC, | SK-HEP-1 |
| 218- | MFrot, | MF, | Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells |
| - | in-vitro, | Nor, | NA |
| 219- | MFrot, | MF, | The expression and intranuclear distribution of nucleolin in HL-60 and K-562 cells after repeated, short-term exposition to rotating magnetic fields |
| - | in-vitro, | AML, | HL-60 | - | in-vitro, | AML, | K562 |
| 220- | MFrot, | MF, | Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation |
| - | in-vitro, | Melanoma, | B16-F10 |
| 221- | MFrot, | MF, | Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma |
| - | in-vivo, | Liver, | NA |
| 222- | MFrot, | MF, | LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway |
| - | in-vitro, | Lung, | A549 |
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