Vitamin C (Ascorbic Acid) Cancer Research Results

VitC, Vitamin C (Ascorbic Acid): Click to Expand ⟱
Features:
High-dose vitamin C: Some studies have suggested that high-dose vitamin C may be effective in treating certain types of cancer, such as ovarian cancer and pancreatic cancer.
Symptoms of vitamin C deficiency include fatigue, weakness, poor wound healing, ecchymoses, xerosis, lower extremity edema, and musculoskeletal pain—most of them are often observed in end-stage cancer patients. -Vitamin C is an essential nutrient involved in the repair of tissue, the formation of collagen, and the enzymatic production of certain neurotransmitters. It is required for the functioning of several enzymes and is important for immune system function.
-Ascorbic Acid, Different levels in different Organs
Homeostasis ranging from about 0.2 mM in the muscle and heart, and up to 10 mM in the brain and adrenal gland. -(Note the Oncomagnetic success in the brain also was then under conditions of high Vitamin C)

-Ascorbic acid is an electron donor
Ascorbic Acid, can be a Pro-oxidant
"The pro-oxidative activity of ascorbic acid (Figure 2) is associated with the interaction with transition metal ions (especially iron and copper). Under conditions of high, millimolar ascorbate concentration, vitamin C catalyzes the reduction of free transition metal ions, which causes the formation of oxygen radicals."
Ascorbic Acid, formation of H2O2 (Hydrogen Peroxide)
Many studies indicate the toxicity of ascorbate to cancer cells. Much evidence indicates that the underlying phenomenon is the pro-oxidative activity of ascorbate, which induces the formation of H2O2 and oxidative stress.
"ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H(2)O(2)"
-High dose VitC therapy may not be for those with kidney problems
-Oral supplement up to 10g/day?
-Direct regulator of TET↑
-caution for (G6PD-) deficient patients receiving vitamin C infusions

-Note plasma half-life 30mins to 1hr, 1.5-2hr elimination half-life.
oral BioAv water soluble, but has limitiations as 100mg yeilds 60uM/L in plasma, but 1000mg only yeilds 85uM/L. mM concentration are required for effectiveness on cancer cells. Hence why IV administration is common. Boosting HIF increases the intracellular uptake of oxidized VitC
Pathways:
- high dose induces ROS production in cancer cells. Otherwise well known antioxidant in normal cells.
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, Caspases↑, DNA damage↑, cl-PARP↑,
- Lowers AntiOxidant defense in Cancer Cells: NRF2↓, TrxR↓**, SOD↓, GSH↓ Catalase↓ HO1↓ GPx↓
- Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : NLRP3↓, IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, TIMP2, IGF-1↓, VEGF↓, NF-κB↓,
- reactivate genes thereby inhibiting cancer cell growth : P53↑, TET↑
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, CDK2↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, ERK↓, EMT↓, TET1↓,
- inhibits glycolysis /Warburg Effect and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDH↓, LDHA↓, HK2↓, PFKs↓, PDKs↓, ECAR↓, GRP78↑, Glucose↓, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓,
- Others: PI3K↓, AKT↓, STAT↓, AMPK, ERK↓, JNK,
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Hepatoprotective,

- Selectivity: Cancer Cells vs Normal Cells
Selenium supplementation may protect cells against iron-dependent cell death by supporting increased expression of selenoproteins, including GPX4, which defend against oxidative stress. Meaning it may decrease effectiveness of high dose VitC.(#4468)
Scientific Papers found: Click to Expand⟱
611- VitC,    Characterization of a new malignant human T-cell line (PFI-285) sensitive to ascorbic acid
- in-vitro, NA, NA
TumCD↑,
636- VitC,    Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation
- in-vivo, NA, NA
pH↓, SVCT-2∅,
635- VitC,  VitK3,    The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress
- in-vitro, NA, NA
RNR↓, GSH↓, Trx1↓, GPx↓, lipid-P↑, AIF↑, ROS↑,
634- VitC,    Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
- Analysis, NA, NA
other↓, iNOS↓, eNOS↑,
633- VitC,    Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
- Analysis, NA, NA
Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,
632- VitC,    High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
- Review, NA, NA
SVCT-2∅, ROS↑, Hif1a↓, PARP∅, TET2↑,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,
630- VitC,    Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress
- in-vitro, BC, MCF-7 - in-vitro, BC, HT-29
TCA↑, ATP↓, NAD↓, H2O2↑, GSH/GSSG↓,
629- VitC,  Cu,  Fe,    The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer
- in-vitro, NA, NA
ROS↑, DNAdam↑, NAD↓,
628- VitC,  Mg,    Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
- in-vivo, Colon, CT26 - in-vitro, NA, MCF-7 - in-vitro, NA, SkBr3
AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,
627- VitC,    High-Dose Vitamin C for Cancer Therapy
- Review, NA, NA
ROS↑, PARP↑, GAPDH↓, DNAdam↑, ATP↓,
1215- VitC,  immuno,    Metabolomics reveals ascorbic acid inhibits ferroptosis in hepatocytes and boosts the effectiveness of anti-PD1 immunotherapy in hepatocellular carcinoma
- ex-vivo, HCC, NA - in-vivo, HCC, NA
other↓, *GPx4↑, *GSH↑, GPx4↓, GSH↓, selectivity↑,
625- VitC,    The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review
OS↑, Pain↓,
624- VitC,    Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications
- Review, NA, NA
OS↑,
623- VitC,    The Involvement of Ascorbic Acid in Cancer Treatment
- Review, NA, NA
ROS↑, GLUT1↓, ATP↓,
622- VitC,    Treatment of Pancreatic Cancer with Pharmacological Ascorbate
- vitro+vivo, PC, NA
H2O2↑,
621- VitC,    Sixteen-Year History with High Dose Intravenous Vitamin C Treatment for Various Types of Cancer and Other Diseases
ChemoSideEff∅,
620- VitC,    Case Study: High-Dose Intravenous Vitamin C in the Treatment of a Patient with Adenocarcinoma of the Kidney
- Case Report, NA, NA
OS↑,
619- VitC,    Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress
Catalase↝,
618- VitC,    Low levels of catalase enzyme make cancer cells vulnerable to high-dose ascorbate
Catalase↓,
617- VitC,  Chemo,    The Use of Vitamin C with Chemotherapy in Cancer Treatment: An Annotated Bibliography
- Review, NA, NA
TumCG↓, ChemoSideEff↓,
616- VitC,    Suppression of alkaline phosphatase in prostate cancer patients by high dose intravenous Vitamin C Treatment: Three cases
- Case Report, NA, NA
PSA↓, ALP↓,
615- VitC,    High Dose IV Vitamin C and Metastatic Breast Cancer: A Case Report
- Case Report, NA, NA
OS↑, Remission↑,
614- VitC,    Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use
other↑,
613- VitC,    High-dose Vitamin C (Ascorbic Acid) Therapy in the Treatment of Patients with Advanced Cancer
- Review, NA, NA
H2O2↑,
607- VitC,    Intravenously administered vitamin C as cancer therapy: three cases
- Case Report, NA, NA
necrosis↑, OS↑,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2↓, ER Stress↑, IRE1↑, JNK↑, CHOP↑, Hif1a↓, eff↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, eff↑, TET1↑,
3106- VitC,    Protective effect of vitamin C on oxidative stress: a randomized controlled trial
- Trial, Nor, NA
*ROS↓,
3105- VitC,    ROS-lowering doses of vitamins C and A accelerate malignant melanoma metastasis
- Review, Var, NA
TumMeta↑,
3104- VitC,    Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations
*antiOx↑, *ROS↓, *DNAdam↓, ROS↑, TET1↑, CSCs↓, HIF-1↓, BioAv↑, selectivity↑,
3103- VitC,    Effect of Vitamin C on Reactive Oxygen Species Formation in Erythrocytes of Sickle Cell Anemia Patients
- Human, Nor, NA
*ROS↓,
3102- VitC,    Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
- Review, Var, NA - Review, Stroke, NA
*radioP↑, *Dose↝, ROS↑, *neuroP↑, other↓, *ROS↓, *MMP↑,
3101- VitC,    Vitamin C stimulates or attenuates reactive oxygen and nitrogen species (ROS, RNS) production depending on cell state: Quantitative amperometric measurements of oxidative bursts at PLB-985 and RAW 264.7 cells at the single cell level
- in-vitro, Nor, RAW264.7 - in-vitro, AML, PLB-985
*antiOx↑, *ROS↓, *RNS↓, ROS↑,
2592- VitC,    Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line
- in-vitro, CLL, NA
NRF2↓, GSH↓,
605- VitC,    Therapeutic Use of Vitamin C in Cancer: Physiological Considerations
- Review, NA, NA
ROS↑, ChemoSideEff↓,
2485- VitC,  TACE,    High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma
- Case Report, HCC, NA
ROS↑, Dose↝, Dose↝, TumCG↓, Remission↑,
606- VitC,    Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer
- Review, NA, NA
ROS↑, H2O2↑, Fenton↑,
114- VitC,  QC,    Chemoprevention of prostate cancer cells by vitamin C plus quercetin: role of Nrf2 in inducing oxidative stress
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
GPx↓, GSR↓, NQO1↓, NRF2↓, ROS↑,
612- VitC,  VitK3,    Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action
H2O2↑,
1836- VitC,  VitK3,  Chemo,    Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib
- in-vitro, AML, NA
tumCV↓, selectivity↑, Apoptosis↑, eff↑, ChemoSen↑,
1819- VitC,  VitK3,    The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy
- Review, Var, NA
Dose?, TumCD↑, selectivity↑, H2O2↑, ROS↑, DNAdam↑,
608- VitC,    The Levels of Ascorbic Acid in Blood and Mononuclear Blood Cells After Oral Liposome-Encapsulated and Oral Non-Encapsulated Vitamin C Supplementation, Taken Without and with IV Hydrocortisone
other↑, other↑,
609- VitC,  ALA,  VitK3,  Se,    Vitamin C and Cancer: Is There A Use For Oral Vitamin C?
OS↑,
1220- VitC,  VitB1/Thiamine,    The Effect of Thiamine, Ascorbic Acid, and the Combination of Them on the Levels of Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) in Sepsis Patients
- Trial, Sepsis, NA
MMP9:TIMP1↑, Sepsis↓,
1219- VitC,    Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells
- in-vitro, Melanoma, NA
Hif1a↓,
1218- VitC,  ASA,    Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
- in-vitro, GBM, SK-N-SH
PGE2↓, COX2↓,
1217- VitC,    High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
- in-vitro, BC, Bcap37 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCMig↓, E-cadherin↑, Vim↓, EMT↓,
1216- VitC,    Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer
- in-vitro, Laryn, FaDu - in-vitro, SCC, SCC-154
Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,
4079- VitE,  VitC,    Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance
- Review, AD, NA
*neuroP↑, *antiOx↑, *Dose↝, *cognitive↑,
2278- VitK2,  VitK3,  VitC,    Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect
- Review, Var, NA
ChemoSen↑, ROS↑, eff↑,

Showing Research Papers: 101 to 150 of 154
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 154

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   Catalase↝, 1,   Fenton↑, 2,   Ferroptosis↑, 1,   GPx↓, 2,   GPx4↓, 2,   GSH↓, 4,   GSH/GSSG↓, 1,   GSR↓, 1,   H2O2↑, 6,   Iron↝, 1,   lipid-P↑, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 2,   ROS↑, 20,   Trx1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 5,  

Core Metabolism/Glycolysis ⓘ

GAPDH↓, 1,   Glycolysis↓, 1,   NAD↓, 4,   RNR↓, 1,   TCA↑, 1,  

Cell Death ⓘ

Apoptosis↑, 3,   proCasp3↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   JNK↑, 1,   necrosis↑, 1,   TumCD↑, 3,   YAP/TEAD↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 3,   other↑, 3,   OV6↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   IRE1↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 6,   PARP↑, 2,   PARP∅, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CSCs↓, 1,   EMT↓, 2,   EpCAM↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TumCG↓, 2,  

Migration ⓘ

E-cadherin↑, 1,   Ki-67↓, 1,   MMP9:TIMP1↑, 1,   MMPs↓, 1,   TET1↑, 2,   TumCMig↓, 1,   TumMeta↓, 1,   TumMeta↑, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 3,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   SVCT-2↝, 1,   SVCT-2∅, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   PGE2↓, 1,   PSA↓, 1,  

Cellular Microenvironment ⓘ

pH↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   Dose?, 1,   Dose↝, 2,   eff↑, 4,   selectivity↑, 4,   TET2↑, 1,  

Clinical Biomarkers ⓘ

ALP↓, 1,   Ki-67↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   ChemoSideEff↓, 2,   ChemoSideEff∅, 1,   OS↑, 7,   Pain↓, 1,   Remission↑, 2,   Risk↓, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 91

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   GPx4↑, 1,   GSH↑, 1,   RNS↓, 1,   ROS↓, 6,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 2,  

Functional Outcomes ⓘ

cognitive↑, 1,   neuroP↑, 2,   radioP↑, 1,  
Total Targets: 11

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:166  Target#:%  State#:%  Dir#:%
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