Database Query Results : Berberine, ,

BBR, Berberine: Click to Expand ⟱
Features:
Berberine is a chemical found in some plants like European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric. Berberine is a bitter-tasting and yellow-colored chemical.
Coptis (commonly referring to Coptidis Rhizoma, a traditional Chinese medicinal herb) contains bioactive alkaloids (most notably berberine and coptisine) that have been studied for their pharmacological effects—including their influence on reactive oxygen species (ROS) and related pathways.

– Berberine is known for its relatively low oral bioavailability, often cited at less than 1%. This low bioavailability is mainly due to poor intestinal absorption and active efflux by transport proteins such as P-glycoprotein.
– Despite the low bioavailability, berberine is still pharmacologically active, and its metabolites may also contribute to its overall effects.

• Effective Dosage in Studies
– Many clinical trials or preclinical studies use dosages in the range of 500 to 1500 mg per day, typically administered in divided doses.
– Therefore, to obtain a bioactive dose of berberine, supplementation in a standardized extract form is necessary.

-IC50 in cancer cell lines: Approximately 10–100 µM (commonly around 20–50 µM in many models)
-IC50 in normal cell lines: Generally higher (often above 100 µM), although this can vary with cell type
- In vivo studies: Dosing regimens in animal models generally range from about 50 to 200 mg/kg
- very effective AChE inhibitor (Alzheimers)
- Berberine may enhance the effects of blood-thinning medications like warfarin and aspirin.


-Note half-life reports vary 2.5-90hrs?.
-low solubility of apigenin in water : BioAv
Pathways:
- induce ROS production
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, UPR↑, cl-PARP↑, HSP↓
- Lowers AntiOxidant defense in Cancer Cells: NRF2↓, GSH↓
- Raises AntiOxidant defense in Normal Cells: NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- PI3K/AKT(Inhibition), JAK/STATs, Wnt/β-catenin, AMPK, MAPK/ERK, and JNK.
- inhibit Growth/Metastases : , MMPs↓, MMP2↓, MMP9↓, IGF-1↓, uPA↓, VEGF↓, ROCK1↓, FAK↓, RhoA↓, NF-κB↓, CXCR4↓, TGF-β↓, α-SMA↓, ERK↓
- reactivate genes thereby inhibiting cancer cell growth : HDAC↓, DNMT1↓, EZH2↓, P53↑, HSP↓
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, FAK↓, ERK↓,
- inhibits glycolysis /Warburg Effect and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDH↓, LDHA↓, HK2↓, PFKs↓, PDKs↓, Glucose↓, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, FGF↓, PDGF↓, EGFR↓, Integrins↓,
- inhibits Cancer Stem Cells : CSC↓, Hh↓, GLi1↓, CD133↓, β-catenin↓, n-myc↓, sox2↓, notch2↓, nestin↓, OCT4↓,
- Others: PI3K↓, AKT↓, JAK↓, STAT↓, Wnt↓, β-catenin↓, AMPK↓, α↓, ERK↓, JNK,
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,
- Selectivity: Cancer Cells vs Normal Cells



Scientific Papers found: Click to Expand⟱
2694- BBR,    Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells
- in-vitro, BC, NA
"highlight2" >IL8↓, "highlight2" >TumCI↓, "highlight2" >EGFR↓, "highlight2" >MEK↓, "highlight2" >ERK↓, "highlight2" >TGF-β1↓, "highlight2" >VEGF↓,
2707- BBR,    Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7
"highlight2" >GLUT1↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >ATP↓, "highlight2" >GlucoseCon↓, "highlight2" >TumCP↓, "highlight2" >Warburg↓, "highlight2" >selectivity↑, "highlight2" >TumCCA↑, "highlight2" >Glycolysis↓,
2706- BBR,    Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake
- in-vitro, HCC, Hep3B - in-vitro, HCC, Bel-7402 - in-vivo, NA, NA
"highlight2" >TumCP↓, "highlight2" >glut↓, "highlight2" >SLC12A5↓, "highlight2" >cMyc↓, "highlight2" >GLS↓,
2705- BBR,    Mechanism underlying berberine's effects on HSP70/TNFα under heat stress: Correlation with the TATA boxes
- in-vivo, Nor, NA - in-vitro, Nor, PC12
"highlight2" >HSP70/HSPA5↓, "highlight2" >TNF-α↓,
2704- BBR,    Inhibitory Effect of Berberine on Zeste Homolog 2 (Ezh2) Enhancement in Human Esophageal Cell Lines
- in-vitro, ESCC, KYSE450
"highlight2" >EZH2↓, "highlight2" >AXL↓,
2703- BBR,  CUR,  SFN,  UA,  GamB  Naturally occurring anti-cancer agents targeting EZH2
- Review, Var, NA
"highlight2" >EZH2↓,
2702- BBR,    The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1
- in-vitro, Lung, A549 - in-vitro, Lung, H1975
"highlight2" >TumCG↓, "highlight2" >MAPK↓, "highlight2" >FOXO3↑, "highlight2" >TumCCA↑, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Sp1/3/4↓, "highlight2" >PDK1↓, "highlight2" >DNMT1↓, "highlight2" >eff↑,
2701- BBR,    Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice
- in-vivo, Diabetic, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*Ferroptosis↓, "highlight2" >*RenoP↑, "highlight2" >*DNMT1↓, "highlight2" >*DNMTs↓, "highlight2" >*KLF4↑,
2700- BBR,    Cell-specific pattern of berberine pleiotropic effects on different human cell lines
- in-vitro, GBM, U343 - in-vitro, GBM, MIA PaCa-2 - in-vitro, Nor, HDFa
"highlight2" >selectivity↑, "highlight2" >TumCCA↑, "highlight2" >Casp3↑, "highlight2" >TumCI↓, "highlight2" >TumCMig↓, "highlight2" >N-cadherin?, "highlight2" >DNMT1↑,
2699- BBR,    Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line
- in-vitro, Lung, A549
"highlight2" >HDAC↓, "highlight2" >TumCCA↑, "highlight2" >TNF-α↓, "highlight2" >COX2↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >P21↑, "highlight2" >P53↑, "highlight2" >Casp↑, "highlight2" >ac‑H3↑, "highlight2" >ac‑H4↑, "highlight2" >ROS↑, "highlight2" >MMP↓,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
"highlight2" >HDAC↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >ER Stress↑, "highlight2" >TumAuto↑, "highlight2" >AMPK↑, "highlight2" >mTOR∅, "highlight2" >HDAC∅, "highlight2" >ac‑α-tubulin↑,
2697- BBR,    Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes
- Analysis, Var, NA
"highlight2" >HDAC↓,
2696- BBR,    Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway
- in-vivo, Nor, NA
"highlight2" >*α-SMA↓, "highlight2" >*TGF-β1↓, "highlight2" >*IL10↑, "highlight2" >*p‑AMPK↑, "highlight2" >*p‑mTOR↓, "highlight2" >*P70S6K↓, "highlight2" >*cardioP↑,
2695- BBR,    The effects of Berberis vulgaris consumption on plasma levels of IGF-1, IGFBPs, PPAR-γ and the expression of angiogenic genes in women with benign breast disease: a randomized controlled clinical trial
- Trial, BC, NA
"highlight2" >IGF-1↓, "highlight2" >PPARγ↓, "highlight2" >VEGF↓, "highlight2" >Hif1a↓, "highlight2" >angioG↓,
2708- BBR,    Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells
- in-vitro, CRC, HCT116
"highlight2" >TumCG↓, "highlight2" >GlucoseCon↓, "highlight2" >GLUT1↓, "highlight2" >LDHA↓, "highlight2" >HK2↓, "highlight2" >Hif1a↓, "highlight2" >mTOR↓, "highlight2" >Glycolysis↓,
2693- BBR,    Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
"highlight2" >Casp1↓, "highlight2" >ERK↓, "highlight2" >IL1β↓, "highlight2" >IL18↓, "highlight2" >EMT↑,
2692- BBR,    Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, SaOS2 - in-vivo, NA, NA
"highlight2" >Casp1↓, "highlight2" >IL1β↓, "highlight2" >TumCG↓, "highlight2" >Dose↝, "highlight2" >Apoptosis↑, "highlight2" >Inflam↓,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
"highlight2" >tumCV↓, "highlight2" >DNAdam↑, "highlight2" >Casp3↑, "highlight2" >Casp7↑, "highlight2" >FasL↑, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >PARP↑, "highlight2" >BAX↑, "highlight2" >BAD↑, "highlight2" >APAF1↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >p‑p38↑, "highlight2" >ERK↑, "highlight2" >MAPK↑,
2690- BBR,    Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice
- in-vivo, Diabetic, NA
"highlight2" >*Inflam↓, "highlight2" >*Th17↓, "highlight2" >*Th1 response↓, "highlight2" >*ERK↑, "highlight2" >*p38↓, "highlight2" >*JNK↓, "highlight2" >*STAT1↓, "highlight2" >*STAT4↓, "highlight2" >*MAPK↓,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
"highlight2" >*ROS↓, "highlight2" >*lipid-P↓, "highlight2" >*DNAdam↓, "highlight2" >*GSH↑, "highlight2" >*SOD↑, "highlight2" >*eff↑, "highlight2" >*cl‑Casp3↓, "highlight2" >*BAX↓, "highlight2" >*neuroP↑, "highlight2" >*Dose↝, "highlight2" >*Ca+2↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
"highlight2" >Inflam↓, "highlight2" >IL6↓, "highlight2" >MCP1↓, "highlight2" >COX2↓, "highlight2" >PGE2↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >DNAdam↑, "highlight2" >eff↝, "highlight2" >Telomerase↓, "highlight2" >Bcl-2↓, "highlight2" >AMPK↑, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >ATP↓, "highlight2" >p‑mTORC1↓, "highlight2" >p‑S6K↓, "highlight2" >ERK↓, "highlight2" >PI3K↓, "highlight2" >PTEN↑, "highlight2" >Akt↓, "highlight2" >Raf↓, "highlight2" >MEK↓, "highlight2" >Dose↓, "highlight2" >Dose↑, "highlight2" >selectivity↑, "highlight2" >TumCCA↑, "highlight2" >eff↑, "highlight2" >EGFR↓, "highlight2" >Glycolysis↓, "highlight2" >Dose?, "highlight2" >p27↑, "highlight2" >CDK2↓, "highlight2" >CDK4↓, "highlight2" >cycD1/CCND1↓, "highlight2" >cycE/CCNE↓, "highlight2" >Bax:Bcl2↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >VEGFR2↓, "highlight2" >ChemoSen↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >PGE2↓, "highlight2" >JAK2↓, "highlight2" >STAT3↓, "highlight2" >CXCR4↓, "highlight2" >CCR7↓, "highlight2" >uPA↓, "highlight2" >CSCs↓, "highlight2" >EMT↓, "highlight2" >Diff↓, "highlight2" >CD133↓, "highlight2" >Nestin↓, "highlight2" >n-MYC↓, "highlight2" >NOTCH↓, "highlight2" >SOX2↓, "highlight2" >Hif1a↓, "highlight2" >VEGF↓, "highlight2" >RadioS↑,
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
"highlight2" >CSCs↓, "highlight2" >CD133↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >n-MYC↓, "highlight2" >SOX2↓, "highlight2" >NOTCH2↓, "highlight2" >Nestin↓, "highlight2" >TumCCA↑, "highlight2" >TumCP↓, "highlight2" >CDK1↓, "highlight2" >Cyc↓, "highlight2" >Apoptosis↑, "highlight2" >Bax:Bcl2↑, "highlight2" >NCAM↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >*Smad1↑, "highlight2" >*HSP70/HSPA5↑, "highlight2" >*LAMs↑,
2684- BBR,    Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly
- in-vivo, Nor, NA
"highlight2" >*MCU↓, "highlight2" >*mt-Ca+2↓, "highlight2" >*cardioP↑,
2683- BBR,    Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells
- in-vitro, Liver, HepG2
"highlight2" >JNK↓, "highlight2" >p‑PERK↓, "highlight2" >p‑eIF2α↓, "highlight2" >*ER Stress↓,
2682- BBR,    Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Apoptosis↑, "highlight2" >necrosis↑, "highlight2" >AQPs↓, "highlight2" >PTEN↑, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >p‑Akt↓, "highlight2" >mTOR↓, "highlight2" >p‑mTOR↓,
2681- BBR,  PDT,    Berberine-photodynamic induced apoptosis by activating endoplasmic reticulum stress-autophagy pathway involving CHOP in human malignant melanoma cells
- in-vitro, Melanoma, NA
"highlight2" >Apoptosis↑, "highlight2" >cl‑Casp3↑, "highlight2" >LC3s↑, "highlight2" >ER Stress↑, "highlight2" >ROS↑, "highlight2" >CHOP↑,
2680- BBR,  PDT,    Photodynamic therapy-triggered nuclear translocation of berberine from mitochondria leads to liver cancer cell death
- in-vitro, Liver, HUH7
"highlight2" >TumCD↑, "highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >ER Stress↑,
7- BBR,    Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
- vitro+vivo, MB, NA
"highlight2" >HH↓, "highlight2" >Gli1↓, "highlight2" >PTCH1↓, "highlight2" >Smo↓,
3681- BBR,    The efficacy and mechanism of berberine in improving aging-related cognitive dysfunction: A study based on network pharmacology
- in-vivo, AD, NA
"highlight2" >*memory↑, "highlight2" >*cognitive↑, "highlight2" >MAPK↑, "highlight2" >*Akt↑, "highlight2" >*PI3K↑, "highlight2" >*TP53↑, "highlight2" >*Jun↓, "highlight2" >*HSP90↑, "highlight2" >*neuroP↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*p16↓, "highlight2" >*ER Stress↓,
4658- BBR,    Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m6A Methylation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
"highlight2" >CSCs↓, "highlight2" >TumCP↓, "highlight2" >cycD1/CCND1↓, "highlight2" >p27↑, "highlight2" >P21↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >ChemoSen↑, "highlight2" >β-catenin/ZEB1↓, "highlight2" >FTO↑, "highlight2" >CD44↓, "highlight2" >CD133↓, "highlight2" >ChemoSen↑,
4340- BBR,    Agonist-dependent differential effects of berberine in human platelet aggregation
- Human, NA, NA
"highlight2" >*AntiAg↑, "highlight2" >*other?,
4300- BBR,    Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer’s disease models: a systematic review and meta-analysis
- Review, AD, NA
"highlight2" >*APP↓, "highlight2" >*cognitive↑, "highlight2" >*Aβ↓, "highlight2" >*BACE↓, "highlight2" >*tau?,
4299- BBR,    Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
- in-vivo, AD, NA
"highlight2" >*memory↑, "highlight2" >*p‑tau↓, "highlight2" >*NF-kB↓, "highlight2" >*GSH↑, "highlight2" >*lipid-P↓, "highlight2" >*cognitive↑, "highlight2" >*ROS↓, "highlight2" >*Inflam↓,
4298- BBR,    Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
- in-vivo, AD, NA
"highlight2" >*cognitive↑, "highlight2" >*p‑tau↓, "highlight2" >*GSK‐3β↓, "highlight2" >*PP2A↑, "highlight2" >*memory↑, "highlight2" >*Akt↑, "highlight2" >*LC3II↑, "highlight2" >*Beclin-1↑,
4275- BBR,    Pharmacological effects of berberine on mood disorders
- Review, NA, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*hepatoP↑, "highlight2" >*eff↑, "highlight2" >*5HT↑, "highlight2" >*Mood↑, "highlight2" >*BDNF↑,
4274- BBR,    Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
- in-vivo, NA, NA
"highlight2" >*IL1β↓, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓, "highlight2" >*CRP↓, "highlight2" >*CREB↑, "highlight2" >*BDNF↑,
3833- BBR,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
"highlight2" >*cardioP↑, "highlight2" >*neuroP↑, "highlight2" >*memory↑, "highlight2" >*Aβ↓,
3754- BBR,  CUR,  EGCG,  Hup,    Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review
"highlight2" >*AChE↓, "highlight2" >*Aβ↓, "highlight2" >*LDL↓, "highlight2" >*RenoP↑, "highlight2" >*BChE↓, "highlight2" >*eff↑, "highlight2" >*BACE↓, "highlight2" >*AChE↓, "highlight2" >*eff↑,
3749- BBR,    Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
- Review, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*AChE↓, "highlight2" >*BChE?,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↓, "highlight2" >*AChE↓, "highlight2" >*BChE↓, "highlight2" >*MAOA↓, "highlight2" >*MAOB↓, "highlight2" >*lipid-P↓, "highlight2" >*GSH↑, "highlight2" >*ROS↓, "highlight2" >*APP↓, "highlight2" >*BACE↓, "highlight2" >*p‑tau↓, "highlight2" >*NF-kB↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*MAPK↓, "highlight2" >*PI3K↓, "highlight2" >*Akt↓, "highlight2" >*neuroP↑, "highlight2" >*memory↑,
3683- BBR,    Characterization of the anti-AChE potential and alkaloids in Rhizoma Coptidis from different Coptis species combined with spectrum-effect relationship and molecular docking
- NA, AD, NA
"highlight2" >*AChE↓,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
"highlight2" >*cognitive↑, "highlight2" >*Aβ↓, "highlight2" >*Apoptosis↓, "highlight2" >*CD31↑, "highlight2" >*VEGF↑, "highlight2" >*N-cadherin↑, "highlight2" >*angioG↑, "highlight2" >*neuroP↑, "highlight2" >*p‑tau↓, "highlight2" >*antiOx↑, "highlight2" >*AChE↓, "highlight2" >*MAOB↓, "highlight2" >*lipid-P↓,
2679- BBR,    Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer’s Disease via Regulation of β-Amyloid Production and Endoplasmic Reticulum Stress
- in-vivo, AD, NA
"highlight2" >*cognitive↑, "highlight2" >PERK↓, "highlight2" >*eIF2α↓, "highlight2" >*neuroP↑, "highlight2" >*ER Stress↓, "highlight2" >*ROS↓,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
"highlight2" >*Akt↑, "highlight2" >*neuroP↑, "highlight2" >*p‑ERK↑, "highlight2" >*Aβ↓, "highlight2" >*Inflam↓, "highlight2" >*ROS↓, "highlight2" >*BioAv↑, "highlight2" >*BBB↑, "highlight2" >*Half-Life↝, "highlight2" >*memory↑, "highlight2" >*cognitive↑, "highlight2" >*HSP90↑, "highlight2" >*APP↓, "highlight2" >*mTOR↓, "highlight2" >*P70S6K↓, "highlight2" >*CD31↑, "highlight2" >*VEGF↑, "highlight2" >*N-cadherin↑, "highlight2" >*Apoptosis↓,
3679- BBR,    Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway
- in-vivo, AD, NA
"highlight2" >*Beclin-1↑, "highlight2" >*LC3B↑, "highlight2" >*p62↓, "highlight2" >*ROS↓, "highlight2" >*lipid-P↓, "highlight2" >*MDA↓, "highlight2" >*Ferroptosis↓, "highlight2" >*TfR1/CD71↓, "highlight2" >*FTH1↑, "highlight2" >*memory↑, "highlight2" >*JNK↓, "highlight2" >*p38↓, "highlight2" >*Aβ↓, "highlight2" >*Inflam↓,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
"highlight2" >*APP↓, "highlight2" >*PPARγ↑, "highlight2" >*NF-kB↓, "highlight2" >*Aβ↓, "highlight2" >*cognitive↑, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*Apoptosis↓, "highlight2" >*BioAv↑, "highlight2" >*BioAv↝, "highlight2" >*BBB↑, "highlight2" >*motorD↑, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*ROS↓, "highlight2" >*p‑Akt↑, "highlight2" >*p‑ERK↑,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*AChE↓, "highlight2" >*BChE↓, "highlight2" >*MAOA↓, "highlight2" >*Aβ↓, "highlight2" >*LDL↓, "highlight2" >*ROS↓, "highlight2" >*RNS↓, "highlight2" >*lipid-P↓, "highlight2" >*Dose↝, "highlight2" >*MAOB↓, "highlight2" >*memory↑, "highlight2" >*toxicity↓, "highlight2" >*BBB↑,
3633- BBR,  LT,  Croc,  QC,    Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy
- Review, AD, NA
"highlight2" >*AChE↓, "highlight2" >*AChE↓,
2715- BBR,  Rad,    Berberine Can Amplify Cytotoxic Effect of Radiotherapy by Targeting Cancer Stem Cells
- in-vitro, BC, MCF-7
"highlight2" >tumCV↓, "highlight2" >OCT4↓, "highlight2" >SOX2↓, "highlight2" >RadioS↑, "highlight2" >CSCs↓,
2714- BBR,    Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
"highlight2" >AMPK↑, "highlight2" >ITGB1↓,
2713- BBR,    Berberine improved the microbiota in lung tissue of colon cancer and reversed the bronchial epithelial cell changes caused by cancer cells
- in-vitro, Nor, BEAS-2B
"highlight2" >*GutMicro↑, "highlight2" >*IL6↑, "highlight2" >*IL10↑, "highlight2" >*IL17↑, "highlight2" >*IFN-γ↑, "highlight2" >PDGF↓, "highlight2" >*RAD51↓,
2712- BBR,    Suppression of colon cancer growth by berberine mediated by the intestinal microbiota and the suppression of DNA methyltransferases (DNMTs)
- in-vitro, Colon, HT29 - in-vivo, NA, NA
"highlight2" >TumCG↓, "highlight2" >GutMicro↑, "highlight2" >other↝, "highlight2" >IL10↓, "highlight2" >cMyc↓, "highlight2" >DNMT1↓, "highlight2" >DNMTs↓,
2711- BBR,    Berberine inhibits the progression of breast cancer by regulating METTL3-mediated m6A modification of FGF7 mRNA
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
"highlight2" >TumCP↓, "highlight2" >TumCI↓, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >FGF↓, "highlight2" >IGFBP3↑,
2710- BBR,    Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
"highlight2" >Warburg↓, "highlight2" >miR-145↑, "highlight2" >HK2↓, "highlight2" >TET3↑, "highlight2" >Glycolysis↓, "highlight2" >PKM2↓, "highlight2" >GLUT1↓, "highlight2" >LDH↓, "highlight2" >PFK2↓, "highlight2" >PDK1↓,
2709- BBR,    Berberine inhibits the glycolysis and proliferation of hepatocellular carcinoma cells by down-regulating HIF-1α
- in-vitro, HCC, HepG2
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Apoptosis↑, "highlight2" >Glycolysis↓, "highlight2" >Hif1a↓, "highlight2" >GLUT1↓, "highlight2" >HK2↓, "highlight2" >PKM2↓, "highlight2" >LDHA↓,
1378- BBR,    Berberine induces non-small cell lung cancer apoptosis via the activation of the ROS/ASK1/JNK pathway
- in-vitro, Lung, NA
"highlight2" >Apoptosis↑, "highlight2" >Casp3↑, "highlight2" >Cyt‑c↑, "highlight2" >MMP↓, "highlight2" >p‑JNK↑, "highlight2" >eff↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*cardioP↑, "highlight2" >*neuroP↑, "highlight2" >TumCCA↑, "highlight2" >cycD1/CCND1↓, "highlight2" >cycE/CCNE↓, "highlight2" >CDC2↓, "highlight2" >AMPK↝, "highlight2" >mTOR↝, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >Cyt‑c↑, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >EMT↓, "highlight2" >MMPs↓, "highlight2" >E-cadherin↓, "highlight2" >Telomerase↓, "highlight2" >*toxicity↓, "highlight2" >GRP78/BiP↓, "highlight2" >EGFR↓, "highlight2" >CDK4↓, "highlight2" >COX2↓, "highlight2" >PGE2↓, "highlight2" >p‑JAK2↓, "highlight2" >p‑STAT3↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >GutMicro↑, "highlight2" >eff↝, "highlight2" >*BioAv↓, "highlight2" >BioAv↑,
1392- BBR,    Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress
- in-vitro, GC, AGS - in-vitro, GC, MKN45
"highlight2" >TumCG↓, "highlight2" >TumCMig↓, "highlight2" >ROS↑, "highlight2" >MDA↑, "highlight2" >SOD↓, "highlight2" >NRF2↓, "highlight2" >HO-1↓, "highlight2" >Hif1a↓, "highlight2" >EMT↓, "highlight2" >Snail↓, "highlight2" >Vim↓,
1390- BBR,  Rad,    Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells
- in-vitro, Pca, PC3
"highlight2" >RadioS↑, "highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >eff↑, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >P53↑, "highlight2" >p38↑, "highlight2" >JNK↑, "highlight2" >Bcl-2↓, "highlight2" >ERK↓, "highlight2" >HO-1↓,
1389- BBR,  Lap,    Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS
- in-vitro, BC, BT474 - in-vitro, BC, AU-565
"highlight2" >ChemoSen↑, "highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >NRF2↓,
1387- BBR,    Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines
- in-vitro, Thyroid, CAL-62
"highlight2" >TumCG↓, "highlight2" >Apoptosis↑, "highlight2" >LC3B↑, "highlight2" >ROS↑, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >mTOR↓,
1386- BBR,    Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >tumCV↓, "highlight2" >ROS↑, "highlight2" >JNK↑, "highlight2" >MMP↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Cyt‑c↑, "highlight2" >AIF↝,
1385- BBR,  5-FU,    Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >eff↓, "highlight2" >ROS↑, "highlight2" >TumCP↑, "highlight2" >NRF2↑, "highlight2" >ChemoSen↓,
1384- BBR,    Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines
- in-vitro, PC, PANC1
"highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >Apoptosis↑,
1382- BBR,    Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells
- in-vitro, Melanoma, SK-MEL-28
"highlight2" >Apoptosis↑, "highlight2" >necrosis↑, "highlight2" >DNAdam↑, "highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >Casp3↑, "highlight2" >p‑P53↑, "highlight2" >ERK↑,
1381- BBR,  Rad,    Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3)
- in-vitro, Ovarian, SKOV3
"highlight2" >RadioS↑, "highlight2" >ROS↑, "highlight2" >GSH↓, "highlight2" >Apoptosis↑,
1380- BBR,  doxoR,    treatment with ROS scavenger N-acetylcysteine (NAC) and JNK inhibitor SP600125 could partially attenuate apoptosis and DNA damage triggered by DCZ0358.
- in-vivo, Nor, NA
"highlight2" >*ROS↓, "highlight2" >*MDA↓, "highlight2" >*SOD↑, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑,
1379- BBR,    Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells
- in-vitro, lymphoma, NA
"highlight2" >TumCP↓, "highlight2" >CDK4↓, "highlight2" >CDK6↓, "highlight2" >cycD1/CCND1↓, "highlight2" >TumCCA↑, "highlight2" >MMP↓, "highlight2" >Ca+2↑, "highlight2" >ATP↓, "highlight2" >mtDam↑, "highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >JNK↑, "highlight2" >eff↓,
1393- BBR,  EPI,    Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest
- in-vitro, Bladder, T24
"highlight2" >ChemoSen↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑Casp9↑, "highlight2" >BAX↑, "highlight2" >P53↑, "highlight2" >P21↑, "highlight2" >Bcl-2↓, "highlight2" >ROS↑,
1377- BBR,    Berberine inhibits autophagy and promotes apoptosis of fibroblast-like synovial cells from rheumatoid arthritis patients through the ROS/mTOR signaling pathway
- in-vitro, Arthritis, NA
"highlight2" >Apoptosis↑, "highlight2" >MMP↓, "highlight2" >Bax:Bcl2↑, "highlight2" >LC3‑Ⅱ/LC3‑Ⅰ↓, "highlight2" >p62↑, "highlight2" >*ROS↓,
1376- BBR,  immuno,    Berberine sensitizes immune checkpoint blockade therapy in melanoma by NQO1 inhibition and ROS activation
- in-vivo, Melanoma, NA
"highlight2" >OS↑, "highlight2" >ROS↑, "highlight2" >NQO1↓, "highlight2" >ICD↑,
1375- BBR,    13-[CH2CO-Cys-(Bzl)-OBzl]-Berberine: Exploring The Correlation Of Anti-Tumor Efficacy With ROS And Apoptosis Protein
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
"highlight2" >ROS↑, "highlight2" >TumCP↓, "highlight2" >XIAP↓, "highlight2" >TumCG↓, "highlight2" >*toxicity↓,
1374- BBR,  PDT,    Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells
- in-vitro, RCC, 786-O - in-vitro, RCC, HK-2
"highlight2" >ROS↑, "highlight2" >TumAuto↑, "highlight2" >Apoptosis↑, "highlight2" >Casp3↑, "highlight2" >eff↑,
1299- BBR,    Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review
- Review, NA, NA
"highlight2" >TumCCA↑, "highlight2" >TP53↑, "highlight2" >COX2↓, "highlight2" >Bax:Bcl2↑, "highlight2" >ROS↑, "highlight2" >VEGFR2↓, "highlight2" >Akt↓, "highlight2" >ERK↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >IL8↑, "highlight2" >P21↑, "highlight2" >p27↑, "highlight2" >E-cadherin↓, "highlight2" >Fibronectin↓, "highlight2" >cMyc↓,
1102- BBR,    Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells
- in-vitro, Melanoma, B16-BL6
"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >EMT↓, "highlight2" >p‑PI3K↓, "highlight2" >p‑Akt↓, "highlight2" >RARα↓, "highlight2" >RARβ↑, "highlight2" >RARγ↑, "highlight2" >E-cadherin↑, "highlight2" >N-cadherin↓,
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, NA, NA
"highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >TumAuto↑, "highlight2" >TumCI↓, "highlight2" >IL1↓, "highlight2" >IL6↓, "highlight2" >TNF-α↓, "highlight2" >LDH↓, "highlight2" >P2X7↓, "highlight2" >proCasp1↓, "highlight2" >Casp1↓, "highlight2" >ASC↓,
1030- BBR,    Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5
- in-vitro, Lung, H460
"highlight2" >PD-L1↓, "highlight2" >TumCG↓, "highlight2" >Ki-67↓, "highlight2" >cl‑Casp3↑,
1010- BBR,    Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells
- vitro+vivo, CRC, NA
"highlight2" >β-catenin/ZEB1↓, "highlight2" >TumCG↓,
956- BBR,    Berberine inhibits HIF-1alpha expression via enhanced proteolysis
- in-vitro, Nor, HUVECs - in-vitro, GC, SCM1
"highlight2" >Hif1a↓, "highlight2" >angioG↓,
940- BBR,    Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression
- vitro+vivo, PC, PANC1 - in-vivo, PC, MIA PaCa-2
"highlight2" >LDHA↓, "highlight2" >lactateProd↓, "highlight2" >AMPKα↓, "highlight2" >TumVol↓, "highlight2" >Ki-67↓,
932- BBR,    The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity
- in-vivo, Nor, NA
"highlight2" >*glucoNG↓, "highlight2" >*Glycolysis↑, "highlight2" >*NH3↑, "highlight2" >*NADPH/NADP+↑, "highlight2" >*ATP↓, "highlight2" >*toxicity↑,
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, NA, NA
"highlight2" >*antiOx?, "highlight2" >*Inflam↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >BAX↑, "highlight2" >eff↑, "highlight2" >VEGF↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >Telomerase↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >Wnt↓, "highlight2" >EGFR↓, "highlight2" >AP-1↓, "highlight2" >NF-kB↓, "highlight2" >COX2↑, "highlight2" >NRF2↓, "highlight2" >RadioS↑, "highlight2" >STAT3↓, "highlight2" >ERK↓, "highlight2" >AR↓, "highlight2" >ROS↑, "highlight2" >eff↑, "highlight2" >selectivity↑, "highlight2" >selectivity↑, "highlight2" >BioAv↓, "highlight2" >DNMT1↓, "highlight2" >cMyc↓,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
"highlight2" >*hepatoP↑, "highlight2" >*LC3II↑, "highlight2" >*Beclin-1↑, "highlight2" >*AMPK↑, "highlight2" >*mTOR↑, "highlight2" >*ER Stress↓, "highlight2" >*CHOP↓, "highlight2" >*JNK↓, "highlight2" >*ROS↓, "highlight2" >*Inflam↓, "highlight2" >*BG↓, "highlight2" >*SOD↑, "highlight2" >*GPx↑, "highlight2" >*Catalase↑, "highlight2" >*IL10↑, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓, "highlight2" >*ALAT↓, "highlight2" >*AST↓, "highlight2" >*ALP↓,
2676- BBR,    Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress
- in-vivo, Nor, NA - in-vivo, CardioV, NA
"highlight2" >*cardioP↑, "highlight2" >*ROS↓, "highlight2" >*ER Stress↓, "highlight2" >*p‑PERK↓, "highlight2" >*p‑eIF2α↓, "highlight2" >*ATF4↓, "highlight2" >CHOP↓, "highlight2" >*JAK2↑, "highlight2" >*STAT3↑, "highlight2" >*UPR↓,
2675- BBR,    The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
- Review, Var, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*ER Stress↓, "highlight2" >*cardioP↑, "highlight2" >*RenoP↑, "highlight2" >*hepatoP↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
"highlight2" >Inflam↓, "highlight2" >AntiCan↑, "highlight2" >Apoptosis↑, "highlight2" >TumAuto↑, "highlight2" >TumCCA↑, "highlight2" >TumMeta↓, "highlight2" >TumCI↓, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >CD4+↓, "highlight2" >TNF-α↓, "highlight2" >IL1↓, "highlight2" >BioAv↓, "highlight2" >BioAv↓, "highlight2" >other↓, "highlight2" >AMPK↑, "highlight2" >MAPK↓, "highlight2" >NF-kB↓, "highlight2" >IL6↓, "highlight2" >MCP1↓, "highlight2" >PGE2↓, "highlight2" >COX2↓, "highlight2" >*ROS↓, "highlight2" >*antiOx↑, "highlight2" >*GPx↑, "highlight2" >*Catalase↑, "highlight2" >AntiTum↑, "highlight2" >TumCP↓, "highlight2" >angioG↓, "highlight2" >Fas↑, "highlight2" >FasL↑, "highlight2" >ROS↑, "highlight2" >ATM↑, "highlight2" >P53↑, "highlight2" >RB1↑, "highlight2" >Casp9↑, "highlight2" >Casp8↑, "highlight2" >Casp3↓, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >IAP1↓, "highlight2" >XIAP↓, "highlight2" >survivin↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >CycB/CCNB1↓, "highlight2" >CDC25↓, "highlight2" >CDC25↓, "highlight2" >Cyt‑c↑, "highlight2" >MMP↓, "highlight2" >RenoP↑, "highlight2" >mTOR↓, "highlight2" >MDM2↓, "highlight2" >LC3II↑, "highlight2" >ERK↓, "highlight2" >COX2↓, "highlight2" >MMP3↓, "highlight2" >TGF-β↓, "highlight2" >EMT↑, "highlight2" >ROCK1↓, "highlight2" >FAK↓, "highlight2" >RAS↓, "highlight2" >Rho↓, "highlight2" >NF-kB↓, "highlight2" >uPA↓, "highlight2" >MMP1↓, "highlight2" >MMP13↓, "highlight2" >ChemoSen↑,
2673- BBR,    Therapeutic potential and recent delivery systems of berberine: A wonder molecule
- Review, Var, NA
"highlight2" >*BioAv↓, "highlight2" >*Half-Life↓, "highlight2" >*neuroP↑, "highlight2" >BBB↑, "highlight2" >toxicity↓,
2672- BBR,    The anti-aging mechanism of Berberine associated with metabolic control
- Review, Var, NA
"highlight2" >*BioAv↝, "highlight2" >*BioAv↝, "highlight2" >*BioAv↝, "highlight2" >*Half-Life↓,
2671- BBR,    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- in-vivo, Diabetic, NA
"highlight2" >*BioAv↓, "highlight2" >*Half-Life↝, "highlight2" >*OCR↓, "highlight2" >*AMPK↑,
2670- BBR,    Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases
- Review, Var, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*Ca+2↓, "highlight2" >*BioAv↓, "highlight2" >*BioAv↑, "highlight2" >*BioAv↑, "highlight2" >*angioG↑, "highlight2" >*MAPK↓, "highlight2" >*AMPK↓, "highlight2" >*NF-kB↓, "highlight2" >VEGF↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >MMP2↓, "highlight2" >Bcl-2↓, "highlight2" >ERK↓,
2337- BBR,    Berberine Inhibited the Proliferation of Cancer Cells by Suppressing the Activity of Tumor Pyruvate Kinase M2
- in-vitro, CRC, HCT116 - in-vitro, Cerv, HeLa
"highlight2" >TumCP↓, "highlight2" >PKM2↓,
2336- BBR,    Berberine Targets PKM2 to Activate the t-PA-Induced Fibrinolytic System and Improves Thrombosis
- in-vivo, Nor, NA
"highlight2" >*PKM2↓,
2335- BBR,    Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer
- in-vitro, CRC, HT29 - in-vitro, CRC, HCT116 - in-vivo, NA, NA
"highlight2" >PKM2↓, "highlight2" >Glycolysis↓, "highlight2" >p‑STAT3↓, "highlight2" >Bcl-2↓, "highlight2" >cycD1/CCND1↓, "highlight2" >TumCG↓, "highlight2" >Ki-67↓, "highlight2" >lactateProd↓, "highlight2" >glucose↓,
2023- BBR,    Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor
- in-vitro, Colon, NA - in-vitro, Nor, YAMC
"highlight2" >TumCD↑, "highlight2" >*toxicity↓, "highlight2" >selectivity↑, "highlight2" >ROS↑, "highlight2" >*ROS∅, "highlight2" >MMP↓, "highlight2" >*MMP∅, "highlight2" >PARP↑, "highlight2" >BioAv↝,
2022- BBR,  GoldNP,  Rad,    Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
- in-vitro, Liver, SMMC-7721 cell - in-vitro, Nor, HL7702
"highlight2" >*toxicity↓, "highlight2" >radioP↑, "highlight2" >BioAv↑, "highlight2" >AntiTum↑, "highlight2" >selectivity↑, "highlight2" >eff↑, "highlight2" >chemoP↑,
1394- BBR,  DL,    Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803
- in-vitro, GC, MGC803
"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >Casp3↑, "highlight2" >Bcl-2↓, "highlight2" >TumCCA↑,
1405- BBR,  Chit,    Chitosan/alginate nanogel potentiate berberine uptake and enhance oxidative stress mediated apoptotic cell death in HepG2 cells
- in-vitro, Liver, HepG2
"highlight2" >*BioAv↑, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >TumCP↓,
1404- BBR,    Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation
- in-vitro, Pca, PC3
"highlight2" >Apoptosis↑, "highlight2" >*Apoptosis∅, "highlight2" >MMP↓, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑Casp9↑, "highlight2" >cl‑PARP↑, "highlight2" >ROS↑, "highlight2" >eff↓, "highlight2" >Cyt‑c↑,
1402- BBR,    Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction
- in-vitro, GBM, T98G
"highlight2" >tumCV↓, "highlight2" >ROS↑, "highlight2" >Ca+2↑, "highlight2" >ER Stress↑, "highlight2" >eff↓, "highlight2" >Bax:Bcl2↑, "highlight2" >MMP↓, "highlight2" >Casp9↑, "highlight2" >Casp3↑, "highlight2" >cl‑PARP↑,
1401- BBR,    Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity
- in-vitro, GBM, U87MG
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >ROS↑,
1400- BBR,    Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells
- in-vitro, Melanoma, U266
"highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >miR-21↓, "highlight2" >Bcl-2↓, "highlight2" >NF-kB↓, "highlight2" >Set9↑,
1399- BBR,  Rad,    Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review
- Review, NA, NA
"highlight2" >*ROS↓, "highlight2" >*MDA↓, "highlight2" >*TNF-α↓, "highlight2" >*TGF-β↓, "highlight2" >*IL10↑, "highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >mtDam↑, "highlight2" >MMP↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >Hif1a↓, "highlight2" >VEGF↓, "highlight2" >RadioS↑,
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >BAX↑, "highlight2" >BAD↑, "highlight2" >Bak↑, "highlight2" >Cyt‑c↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑Casp9↑, "highlight2" >E-cadherin↑, "highlight2" >TIMP1↑, "highlight2" >γH2AX↑, "highlight2" >Bcl-2↓, "highlight2" >N-cadherin↓, "highlight2" >Vim↓, "highlight2" >Snail↓, "highlight2" >RAD51↓, "highlight2" >PCNA↓,
1397- BBR,  Chemo,    Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells
- in-vitro, Lung, A549
"highlight2" >TumCG↓, "highlight2" >ROS↑, "highlight2" >MDR1↓,
1396- BBR,    Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro
- in-vitro, GC, SNU1041 - in-vitro, GC, SNU5
"highlight2" >tumCV↓, "highlight2" >ROS↑, "highlight2" >MMP1↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >MMP7∅,
1395- BBR,    Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation
- in-vitro, GC, NA
"highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >ATP↓, "highlight2" >AMPK↑, "highlight2" >TP53↑, "highlight2" >p‑MAPK↓, "highlight2" >p‑ERK↓,
1383- CUR,  BBR,  RES,    Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases
- Review, NA, NA
"highlight2" >GSK‐3β↝, "highlight2" >ROS↑,
3796- QC,  BBR,    Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances
- Review, AD, NA
"highlight2" >*CDK5↓,
1391- RES,  BBR,    Effects of Resveratrol, Berberine and Their Combinations on Reactive Oxygen Species, Survival and Apoptosis in Human Squamous Carcinoma (SCC-25) Cells
- in-vitro, Tong, SCC25
"highlight2" >ROS↑, "highlight2" >eff↑,
1403- SDT,  BBR,    From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Lung, LLC1
"highlight2" >eff↑, "highlight2" >tumCV↓, "highlight2" >ATP↓, "highlight2" >ROS↑, "highlight2" >Casp3↑, "highlight2" >Casp7↑, "highlight2" >mtDam↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 110

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   HO-1↓, 2,   ICD↑, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 1,   ROS↑, 36,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↝, 1,   ATP↓, 5,   CDC2↓, 1,   CDC25↓, 2,   MEK↓, 2,   MMP↓, 14,   mtDam↑, 3,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 5,   AMPK↝, 1,   cMyc↓, 4,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 2,   glut↓, 1,   Glycolysis↓, 6,   HK2↓, 3,   lactateProd↓, 2,   LDH↓, 2,   LDHA↓, 3,   PDK1↓, 2,   PFK2↓, 1,   PKM2↓, 4,   PPARγ↓, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6K↓, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 8,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 27,   BAD↑, 2,   Bak↑, 1,   BAX↑, 7,   Bax:Bcl2↑, 5,   Bcl-2↓, 10,   Bcl-xL↓, 1,   Casp↑, 1,   Casp1↓, 3,   proCasp1↓, 1,   Casp3↓, 1,   Casp3↑, 10,   cl‑Casp3↑, 5,   Casp7↑, 2,   Casp8↑, 3,   Casp9↑, 5,   cl‑Casp9↑, 3,   Cyt‑c↑, 6,   Fas↑, 1,   FasL↑, 2,   IAP1↓, 1,   JNK↓, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↑, 2,   p‑MAPK↓, 1,   MDM2↓, 1,   necrosis↑, 2,   p27↑, 3,   P2X7↓, 1,   p38↑, 1,   p‑p38↑, 1,   Set9↑, 1,   survivin↓, 1,   Telomerase↓, 3,   TumCD↑, 2,  

Kinase & Signal Transduction ⓘ

AMPKα↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 2,   ac‑H3↑, 1,   ac‑H4↑, 1,   miR-145↑, 1,   miR-21↓, 1,   other↓, 1,   other↝, 1,   TET3↑, 1,   tumCV↓, 6,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   CHOP↑, 1,   p‑eIF2α↓, 1,   ER Stress↑, 4,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   PERK↓, 1,   p‑PERK↓, 1,  

Autophagy & Lysosomes ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 4,   DNMT1↓, 3,   DNMT1↑, 1,   DNMTs↓, 1,   P53↑, 4,   p‑P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 2,   PCNA↓, 1,   RAD51↓, 1,   TP53↑, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 3,   Cyc↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 2,   P21↑, 4,   RB1↑, 1,   TumCCA↑, 20,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 3,   CD44↓, 1,   CSCs↓, 4,   Diff↓, 1,   EMT↓, 4,   EMT↑, 2,   ERK↓, 8,   ERK↑, 2,   p‑ERK↓, 1,   FGF↓, 1,   FOXO3↑, 1,   Gli1↓, 1,   GSK‐3β↝, 1,   HDAC↓, 3,   HDAC∅, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 7,   mTOR↝, 1,   mTOR∅, 1,   p‑mTOR↓, 1,   p‑mTORC1↓, 1,   n-MYC↓, 2,   Nestin↓, 2,   NOTCH↓, 1,   NOTCH2↓, 1,   OCT4↓, 1,   PI3K↓, 5,   p‑PI3K↓, 1,   PTCH1↓, 1,   PTEN↑, 2,   RAS↓, 1,   Smo↓, 1,   SOX2↓, 3,   STAT3↓, 2,   p‑STAT3↓, 2,   TumCG↓, 11,   Wnt↓, 1,  

Migration ⓘ

AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 2,   E-cadherin↓, 2,   E-cadherin↑, 2,   FAK↓, 1,   Fibronectin↓, 1,   FTO↑, 1,   ITGB1↓, 1,   Ki-67↓, 3,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 9,   MMP3↓, 1,   MMP7∅, 1,   MMP9↓, 8,   MMPs↓, 1,   N-cadherin?, 1,   N-cadherin↓, 2,   NCAM↓, 1,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TGF-β1↓, 1,   TIMP1↑, 1,   TumCI↓, 10,   TumCMig↓, 9,   TumCP↓, 14,   TumCP↑, 1,   TumMeta↓, 1,   uPA↓, 2,   Vim↓, 2,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   EGFR↓, 4,   Hif1a↓, 7,   VEGF↓, 6,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

AQPs↓, 1,   BBB↑, 1,   GLUT1↓, 4,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   CCR7↓, 1,   CD4+↓, 1,   COX2↓, 6,   COX2↑, 1,   CXCR4↓, 1,   IL1↓, 2,   IL10↓, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 3,   IL8↓, 1,   IL8↑, 1,   Inflam↓, 3,   JAK2↓, 1,   p‑JAK2↓, 1,   MCP1↓, 2,   NF-kB↓, 4,   PD-L1↓, 1,   PGE2↓, 4,   TNF-α↓, 4,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 6,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 1,   eff↓, 5,   eff↑, 14,   eff↝, 2,   MDR1↓, 1,   RadioS↑, 6,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 4,   EZH2↓, 2,   GutMicro↑, 2,   IL6↓, 3,   Ki-67↓, 3,   LDH↓, 2,   PD-L1↓, 1,   TP53↑, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   chemoP↑, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 266

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 11,   Catalase↑, 2,   Ferroptosis↓, 2,   GPx↑, 2,   GSH↑, 3,   HO-1↑, 2,   lipid-P↓, 6,   MDA↓, 3,   NADPH/NADP+↑, 1,   NRF2↑, 2,   RNS↓, 1,   ROS↓, 14,   ROS∅, 1,   SOD↑, 3,  

Metal & Cofactor Biology ⓘ

FTH1↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP∅, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 2,   p‑AMPK↑, 1,   CREB↑, 1,   glucoNG↓, 1,   Glycolysis↑, 1,   LDL↓, 2,   MCU↓, 1,   NH3↑, 1,   PKM2↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 3,   p‑Akt↑, 1,   Apoptosis↓, 3,   Apoptosis∅, 1,   BAX↓, 1,   cl‑Casp3↓, 1,   Ferroptosis↓, 2,   JNK↓, 3,   MAPK↓, 3,   p38↓, 2,  

Transcription & Epigenetics ⓘ

other?, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 6,   HSP70/HSPA5↑, 1,   HSP90↑, 2,   p‑PERK↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 3,   LC3B↑, 1,   LC3II↑, 2,   p62↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNMT1↓, 1,   DNMTs↓, 1,   p16↓, 1,   RAD51↓, 1,   TP53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   p‑ERK↑, 2,   GSK‐3β↓, 1,   Jun↓, 1,   KLF4↑, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   P70S6K↓, 2,   PI3K↓, 1,   PI3K↑, 1,   STAT1↓, 1,   STAT3↑, 1,   STAT4↓, 1,  

Migration ⓘ

AntiAg↑, 1,   APP↓, 4,   Ca+2↓, 2,   mt-Ca+2↓, 1,   CD31↑, 2,   CDK5↓, 1,   LAMs↑, 1,   N-cadherin↑, 2,   Smad1↑, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 2,   ATF4↓, 1,   VEGF↑, 2,  

Barriers & Transport ⓘ

BBB↑, 3,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   IFN-γ↑, 1,   IL10↑, 4,   IL17↑, 1,   IL1β↓, 2,   IL6↓, 2,   IL6↑, 1,   Inflam↓, 14,   JAK2↑, 1,   NF-kB↓, 4,   Th1 response↓, 1,   Th17↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 9,   BChE?, 1,   BChE↓, 3,   BDNF↑, 2,   MAOA↓, 2,   tau?, 1,   p‑tau↓, 4,  

Protein Aggregation ⓘ

Aβ↓, 8,   BACE↓, 3,   MAOB↓, 3,   PP2A↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 5,   BioAv↝, 4,   Dose↝, 2,   eff↑, 4,   Half-Life↓, 2,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BG↓, 1,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 2,   IL6↑, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 6,   cognitive↑, 8,   hepatoP↑, 3,   memory↑, 8,   Mood↑, 1,   motorD↑, 1,   neuroP↑, 9,   RenoP↑, 3,   toxicity↓, 5,   toxicity↑, 1,  
Total Targets: 144

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:41  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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