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| Boswellia is an herbal extract from the Boswellia serrata tree that may help reduce inflammation. May help with rheumatoid arthritis, inflammatory bowel disease, asthma, and cancer. -Naturally occurring pentacyclic triterpenoids include ursolic acid (UA), oleanolic acid (OA), betulinic acid (BetA), bosewellic acid (BA), Asiatic acid (AA), α-amyrin, celastrol, glycyrrhizin, 18-β-glycyrrhetinic acid, lupeol, escin, madecassic acid, momordin I, platycodon D, pristimerin, saikosaponins, soyasapogenol B, and avicin Boswellia refers to a group of resinous extracts obtained from Boswellia trees (e.g., Boswellia serrata). Traditionally used in Ayurvedic and traditional Chinese medicine, Boswellia is reputed for its anti-inflammatory, analgesic, and immunomodulatory properties. Its bioactive components—such as boswellic acids. -Anti-inflammatory Activity (blocking the enzyme 5-lipoxygenase) 5LOX↓,. -AKBA used to reduce Methionine ***** (help in Methionine reduced diet) Boswellia extracts are often administered in doses ranging from 300 mg to 1,200 mg per day AKBA (Acetyl-11-keto-β-boswellic acid) is a bioactive compound derived from Boswellia serrata, a plant used traditionally for its anti-inflammatory properties. (upto 30% AKBA in Boswellia MEGA AKBA) AKBA also available in Inflasanum @ 90% AKDA (MCSformulas) -Note half-life reports vary 2.5-90hrs?. BioAv Pathways: - induce or lower ROS production (not consistant increase for cancer cells) - ROS↑ related: MMP↓(ΔΨm), ER Stress↑, GRP78↑, Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, - Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑, - lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : IL-1β↓, TNF-α↓, IL-6↓, - inhibit Growth/Metastases : , MMPs↓, MMP2↓, MMP9↓, VEGF↓, NF-κB↓, CXCR4↓, ERK↓ - cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓, - inhibits Migration/Invasion : TumCMig↓, TumCI↓, ERK↓, TOP1↓, - inhibits angiogenesis↓ : VEGF↓, Notch↓, PDGF↓, - Others: PI3K↓, AKT↓, STAT↓, Wnt↓, β-catenin↓, AMPK↓, ERK↓, JNK, - Synergies: chemo-sensitization, chemoProtective, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Hepatoprotective, - Selectivity: Cancer Cells vs Normal Cells |
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| Tumor cells display a peculiar “methionine dependency” (i.e. an increased need for exogenous methionine), and many enzymes in methionine metabolism are dysregulated in malignancy. MAT1A,– Primarily expressed in adult liver. -Decreased MAT1A expression or loss of MAT1A activity is associated with reduced production of S‐adenosylmethionine (SAM) and can contribute to malignant transformation. MAT2A -Elevated MAT2A expression is often correlated with enhanced proliferation and a worse prognosis, given its role in maintaining SAM levels in rapidly dividing tumor cells. -In cancers outside the liver, upregulation of MAT2A and methionine transporters (along with downstream effects on methylation) signify aggressive behavior and may be used as prognostic indicators. May be desirable to reduce Methionine in diet, and/or use AKBA to help reduce it, before chemo. |
| 2779- | Bos, | Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes |
| - | in-vitro, | Nor, | HaCaT | - | in-vitro, | PSA, | NA |
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