Boswellia is an herbal extract from the Boswellia serrata tree that may help reduce inflammation.
May help with rheumatoid arthritis, inflammatory bowel disease, asthma, and cancer.
-Naturally occurring pentacyclic triterpenoids include ursolic acid (UA), oleanolic acid (OA), betulinic acid (BetA), bosewellic acid (BA), Asiatic acid (AA), α-amyrin, celastrol, glycyrrhizin, 18-β-glycyrrhetinic acid, lupeol, escin, madecassic acid, momordin I, platycodon D, pristimerin, saikosaponins, soyasapogenol B, and avicin
Boswellia refers to a group of resinous extracts obtained from Boswellia trees (e.g., Boswellia serrata). Traditionally used in Ayurvedic and traditional Chinese medicine, Boswellia is reputed for its anti-inflammatory, analgesic, and immunomodulatory properties. Its bioactive components—such as boswellic acids.
Six major α and β-boswellic acids:
3-acetyl-11-keto-β-boswellic acid (AKBA)
11-keto-β-boswellic acid (KBA)
α-boswellic acid (αBA)
β-boswellic acid (βBA)
3-acetyl-α-boswellic acid (AαBA)
3-acetyl-β-boswellic acid (AβBA)
-Anti-inflammatory Activity (blocking the enzyme 5-lipoxygenase)
5LOX↓,.
-AKBA used to reduce
Methionine ***** (help in Methionine reduced diet)
Boswellia extracts are often administered in doses ranging from 300 mg to 1,200 mg per day
AKBA (Acetyl-11-keto-β-boswellic acid) is a bioactive compound derived from Boswellia serrata, a plant used traditionally for its anti-inflammatory properties. (upto 30% AKBA in
Boswellia MEGA AKBA)
AKBA also available in Inflasanum @ 90% AKDA (MCSformulas)
-Note half-life reports vary 2.5-90hrs?.
BioAv (bio availability increases with high fat meal)
Pathways:
- induce or lower
ROS production (not consistant increase for cancer cells)
- ROS↑ related:
MMP↓(ΔΨm),
ER Stress↑,
GRP78↑,
Ca+2↑,
Cyt‑c↑,
Caspases↑,
DNA damage↑,
cl-PARP↑,
- Raises
AntiOxidant
defense in Normal Cells:
ROS↓,
NRF2↑,
SOD↑,
GSH↑,
Catalase↑,
- lowers
Inflammation :
NF-kB↓,
COX2↓,
p38↓, Pro-Inflammatory Cytokines :
IL-1β↓,
TNF-α↓,
IL-6↓,
- inhibit Growth/Metastases :
,
MMPs↓,
MMP2↓,
MMP9↓,
VEGF↓,
NF-κB↓,
CXCR4↓,
ERK↓
- cause Cell cycle arrest :
TumCCA↑,
cyclin D1↓,
cyclin E↓,
CDK2↓,
CDK4↓,
CDK6↓,
- inhibits Migration/Invasion :
TumCMig↓,
TumCI↓,
ERK↓,
TOP1↓,
- inhibits
angiogenesis↓ :
VEGF↓,
Notch↓,
PDGF↓,
- Others: PI3K↓,
AKT↓,
STAT↓,
Wnt↓,
β-catenin↓,
AMPK↓,
ERK↓,
JNK,
- Synergies:
chemo-sensitization,
chemoProtective,
RadioProtective,
Others(review target notes),
Neuroprotective,
Cognitive,
Hepatoprotective,
- Selectivity:
Cancer Cells vs Normal Cells
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