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| Luteolin a Flavonoid found in celery, parsley, broccoli, onion leaves, carrots, peppers, cabbages, apple skins, and chrysanthemum flowers. -MDR1 expression, MMP-9, IGF-1 and Epithelial to mesenchymal transition. -Note half-life 2–3 hours BioAv low, but could be improved with Res, or blend of castor oil, kolliphor and polyethylene glycol Pathways: - induce ROS production in cancer cell but a few reports of reduction. Always seems to reduce ROS in normal cells. - ROS↑ related: MMP↓(ΔΨm), ER Stress↑, UPR↑, GRP78↑, Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓ - Lowers AntiOxidant defense in Cancer Cells: NRF2↓, SOD↓, GSH↓ Catalase↓ HO1↓ GPx↓ - Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑, - lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : IL-1β↓, TNF-α↓, IL-6↓, - inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMP2↓, MMP9↓, TIMP2, IGF-1↓, VEGF↓, FAK↓, RhoA↓, NF-κB↓, CXCR4↓, ERK↓ - reactivate genes thereby inhibiting cancer cell growth : HDAC↓, DNMT1↓, DNMT3A↓, EZH2↓, P53↑, HSP↓, - cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓, - inhibits Migration/Invasion : TumCMig↓, FAK↓, ERK↓, EMT↓, TOP1↓, TET1↓, - inhibits glycolysis and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, LDHA↓, HK2↓, GRP78↑, - inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, PDGF↓, EGFR↓, Integrins↓, - Others: PI3K↓, AKT↓, STAT↓, Wnt↓, β-catenin↓, AMPK, ERK↓, JNK, TrxR**, - Shown to modulate the nuclear translocation of SREBP-2 (related to cholesterol). - Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, Others(review target notes), Neuroprotective, Renoprotection, Hepatoprotective, CardioProtective, - Selectivity: Cancer Cells vs Normal Cells Luteolin — Cancer vs Normal Cell Effects
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| FADD (Fas-associated protein with death domain) is a protein that plays a crucial role in the apoptotic signaling pathway, particularly in the process of programmed cell death. It is involved in the signaling of death receptors, such as Fas (CD95), which, when activated, can lead to apoptosis in cells. FADD has a dual role. On one hand, it can promote apoptosis in response to certain signals, which is a mechanism that can prevent the proliferation of cancer cells. On the other hand, some cancer cells may exploit the apoptotic pathways to evade cell death, leading to tumor survival and growth. Expression: FADD is often expressed in breast cancer cells, and its levels can vary among different subtypes. Prognosis: High levels of FADD expression have been associated with increased apoptosis in response to certain therapies, which may correlate with better treatment outcomes. However, in some contexts, FADD can also promote cell survival, complicating its role in prognosis. |
| 2912- | LT, | Luteolin: a flavonoid with a multifaceted anticancer potential |
| - | Review, | Var, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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