Database Query Results : Thymoquinone, ,

TQ, Thymoquinone: Click to Expand ⟱

Features: Anti-oxidant, anti-tumor

Thymoquinone is a bioactive compound found in the seeds of Nigella sativa, commonly known as black seed or black cumin.
Pathways:
-Cell cycle arrest, apoptosis induction, ROS generation in cancer cells
-inhibit the activation of NF-κB, Suppress the PI3K/Akt signaling cascade
-Inhibit angiogenic factors such as VEGF, MMPs
-Inhibit HDACs, UHRF1, and DNMTs

-Note half-life 3-6hrs.
BioAv low oral bioavailability due to its lipophilic nature. Note refridgeration of Black seed oil improves the stability of TQ.
DIY: ~1 part lecithin : 2–3 parts black seed oil : 4–5 parts warm water. (chat ai)
Pathways:
- usually induce ROS production in Cancer cells, and lowers ROS in normal cells
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, GRP78↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓, Prx,
- May Low AntiOxidant defense in Cancer Cells: NRF2↓(usually contrary), GSH↓ HO1↓(contrary), GPx↓
- Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : NLRP3↓, IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, FAK↓, NF-κB↓, CXCR4↓, TGF-β↓, ERK↓
- reactivate genes thereby inhibiting cancer cell growth : HDAC↓, DNMTs↓, EZH2↓, P53↑, HSP↓, Sp proteins↓, TET↑
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, FAK↓, ERK↓, EMT↓,
- inhibits glycolysis /Warburg Effect and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDH↓, LDHA↓, HK2↓, PDKs↓, GRP78↑, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, EGFR↓, Integrins↓,
- Others: PI3K↓, AKT↓, JAK↓, STAT↓, Wnt↓, β-catenin↓, AMPK, α↓, ERK↓, JNK,
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,

- Selectivity: Cancer Cells vs Normal Cells

Scientific Papers found: Click to Expand⟱

4774-

5-FU,

TQ,

CoQ10,

Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation

in-vitro,

CRC,

"highlight2" >AntiCan↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >eff↑, "highlight2" >Bcl-2↓, "highlight2" >survivin↓, "highlight2" >P21↑, "highlight2" >p27↑, "highlight2" >BAX↑, "highlight2" >Cyt‑c↑, "highlight2" >Casp3↑, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >Hif1a↓, "highlight2" >PTEN↑, "highlight2" >AMPKα↑, "highlight2" >PDH↑, "highlight2" >LDHA↓, "highlight2" >antiOx↓, "highlight2" >ROS↑, "highlight2" >AntiCan↑,

1920-

JG,

TQ,

Plum,

Natural quinones induce ROS-mediated apoptosis and inhibit cell migration in PANC-1 human pancreatic cancer cell line

in-vitro,

PC,

PANC1

"highlight2" >ROS↑, "highlight2" >TumCMig↓, "highlight2" >MMP9↓,

4670-

RES,

CUR,

EGCG,

TQ,

Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol

Review,

Nor,

"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*AntiAge↑, "highlight2" >*SIRT1↑, "highlight2" >*SIRT3↑, "highlight2" >*FOXO↑, "highlight2" >*ROS↓,

2207-

SNP,

TQ,

Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats

in-vivo,

Nor,

Rats

"highlight2" >*eff↑, "highlight2" >*RenoP↑, "highlight2" >*hepatoP↑, "highlight2" >*MDA↓, "highlight2" >*SOD↑, "highlight2" >*GSH↑, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓,

3406-

TQ,

Se,

A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease

in-vivo,

AD,

nano-selenium (5 mg/kg); thymoquinone (2 mg/kg);

50 albino male rats

"highlight2" >*NRF2↑, "highlight2" >*GSH↑, "highlight2" >*MDA↓, "highlight2" >*TNF-α↓,

3403-

TQ,

A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells

in-vitro,

RCC,

786-O

TQ (1-100 μM) for 24 and 48 h

8.4 uM for 48 h

"highlight2" >tumCV↓, "highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >eff↓, "highlight2" >TumCI↓,

3407-

TQ,

Thymoquinone and its pharmacological perspective: A review

Review,

NA,

"highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*GSTs↑, "highlight2" >*GSR↑, "highlight2" >*GSH↑, "highlight2" >*RenoP↑, "highlight2" >*IL1β↓, "highlight2" >*TNF-α↓, "highlight2" >*MMP13↓, "highlight2" >*COX2↓, "highlight2" >*PGE2↓, "highlight2" >*radioP↑, "highlight2" >Twist↓, "highlight2" >EMT↓, "highlight2" >NF-kB↓, "highlight2" >p‑PI3K↓, "highlight2" >p‑Akt↓, "highlight2" >p‑GSK‐3β↓, "highlight2" >DNMT1↓, "highlight2" >HDAC↓,

3408-

TQ,

Thymoquinone: A small molecule from nature with high therapeutic potential

Review,

AD,

Review,

Park,

"highlight2" >*neuroP↑, "highlight2" >*hepatoP↑, "highlight2" >*cardioP↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >ChemoSen↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >angioG↓, "highlight2" >cycA1/CCNA1↓, "highlight2" >cycD1/CCND1↓, "highlight2" >cycE/CCNE↓, "highlight2" >CDK2↓,

3409-

TQ,

Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives

in-vivo,

Nor,

50 mg/kg

Forty adult male rats

"highlight2" >*MDA↓, "highlight2" >*TGF-β↓, "highlight2" >*CRP↓, "highlight2" >*NF-kB↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*Casp3↓, "highlight2" >*GSH↑, "highlight2" >*NRF2↑, "highlight2" >*IL10↑, "highlight2" >*neuroP↑, "highlight2" >*ROS↓, "highlight2" >*Apoptosis↓, "highlight2" >*Inflam↓,

3410-

TQ,

Anti-inflammatory effects of thymoquinone and its protective effects against several diseases

Review,

Arthritis,

"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*COX2↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*IL1β↓, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓, "highlight2" >*IFN-γ↓, "highlight2" >*PGE2↓, "highlight2" >*cardioP↑, "highlight2" >*Catalase↑, "highlight2" >*SOD↑, "highlight2" >*Thiols↑, "highlight2" >*neuroP↑, "highlight2" >*IL12↓, "highlight2" >*MCP1↓, "highlight2" >*CXCc↓, "highlight2" >*ROS↓,

3411-

TQ,

Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone

Review,

Var,

"highlight2" >p‑STAT3↓, "highlight2" >cycD1/CCND1↓, "highlight2" >JAK2↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >cMyc↓, "highlight2" >MMP7↓, "highlight2" >MET↓, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓, "highlight2" >CXCR4↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >ROS↑, "highlight2" >Cyt‑c↑, "highlight2" >Twist↓, "highlight2" >Zeb1↓, "highlight2" >E-cadherin↑, "highlight2" >p‑p38↑, "highlight2" >p‑MAPK↑, "highlight2" >ERK↑, "highlight2" >eff↑, "highlight2" >ERK↓, "highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓,

3412-

TQ,

Thymoquinone induces oxidative stress-mediated apoptosis through downregulation of Jak2/STAT3 signaling pathway in human melanoma cells

in-vitro,

Melanoma,

SK-MEL-28

in-vivo,

NA,

SK-MEL-28 tumor xenografts

"highlight2" >Apoptosis↑, "highlight2" >JAK2↓, "highlight2" >STAT3↓, "highlight2" >cycD1/CCND1↓, "highlight2" >survivin↓, "highlight2" >ROS↑, "highlight2" >eff↓,

3413-

TQ,

Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase

in-vitro,

CRC,

HCT116

"highlight2" >tumCV↓, "highlight2" >Apoptosis↓, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >Casp9↑, "highlight2" >Casp7↑, "highlight2" >Casp3↑, "highlight2" >cl‑PARP↑, "highlight2" >STAT3↓, "highlight2" >survivin↓, "highlight2" >cMyc↓, "highlight2" >cycD1/CCND1↓, "highlight2" >p27↑, "highlight2" >P21↑, "highlight2" >EGFR↓, "highlight2" >ROS↑,

3414-

TQ,

Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells

in-vitro,

RCC,

Caki-1

"highlight2" >tumCV↓, "highlight2" >Apoptosis↑, "highlight2" >P53↑, "highlight2" >BAX↑, "highlight2" >Cyt‑c↑, "highlight2" >cl‑Casp9↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑PARP↑, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >p‑STAT3↓, "highlight2" >p‑JAK2↓, "highlight2" >STAT3↓, "highlight2" >survivin↓, "highlight2" >cycD1/CCND1↓, "highlight2" >ROS↑, "highlight2" >eff↓,

3415-

TQ,

The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations

in-vitro,

Lung,

H446

1-100uM

"highlight2" >tumCV↓, "highlight2" >TumCCA↑, "highlight2" >ROS↓, "highlight2" >CycB/CCNB1↑, "highlight2" >CycD3↑, "highlight2" >cycA1/CCNA1↓, "highlight2" >cycE/CCNE↓, "highlight2" >cDC2↓, "highlight2" >antiOx↑, "highlight2" >PARP↓, "highlight2" >NRF2↓, "highlight2" >ARE/EpRE↑, "highlight2" >eff↑,

3416-

TQ,

Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway

in-vitro,

Bladder,

T24

 TQ (20–100 μM) for 24 h

in-vitro,

Bladder,

253J

in-vitro,

Nor,

SV-HUC-1

"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >ER Stress↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑Casp8↑, "highlight2" >cl‑Casp7↑, "highlight2" >cl‑PARP↑, "highlight2" >Cyt‑c↑, "highlight2" >PERK↑, "highlight2" >IRE1↑, "highlight2" >ATF6↑, "highlight2" >p‑eIF2α↑, "highlight2" >ATF4↑, "highlight2" >GRP78/BiP↑, "highlight2" >CHOP↑,

3417-

TQ,

Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress

in-vitro,

BC,

MCF-7

in-vitro,

Liver,

HepG2

"highlight2" >TumCP↓, "highlight2" >NF-kB↓, "highlight2" >cl‑Casp3↑, "highlight2" >GRP78/BiP↑, "highlight2" >ER Stress↑, "highlight2" >Apoptosis↑,

3418-

TQ,

Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome

in-vitro,

Melanoma,

A375

in-vivo,

NA,

B16F10) melanoma cell line

"highlight2" >TumMeta↓, "highlight2" >TumCMig↓, "highlight2" >NLRP3↓, "highlight2" >Casp1↓, "highlight2" >IL1β↓, "highlight2" >IL18↓, "highlight2" >ROS↓, "highlight2" >NF-kB↓,

3419-

TQ,

Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients

in-vitro,

BC,

PBMCs isolated from HR+ BC patients were treated with increasing concentrations of TQ (20, 50, and 100 µM) for 24, 48, and 72 h.

 peripheral blood mononuclear cells (PBMCs)

"highlight2" >*NLRP3↓, "highlight2" >*IL1β↓, "highlight2" >*Casp1?,

3420-

TQ,

Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway

in-vitro,

Nor,

HUVECs

in-vitro,

NA,

rat

"highlight2" >*NF-kB↓, "highlight2" >*NLRP3↓, "highlight2" >*angioG↑, "highlight2" >*MMP9↑, "highlight2" >*VEGF↑, "highlight2" >*OS↑, "highlight2" >*Pyro?, "highlight2" >*ROS↓, "highlight2" >*Apoptosis↓, "highlight2" >*SIRT1↑, "highlight2" >*SOD1↑, "highlight2" >*HO-1↑, "highlight2" >*eNOS↑, "highlight2" >*ASC?, "highlight2" >*Casp1↓, "highlight2" >*IL1β↓, "highlight2" >*IL18↓,

3405-

TQ,

doxoR,

Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity and the underlying mechanism

vitro+vivo,

NA,

mice

"highlight2" >*cardioP↑, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*ROS↓, "highlight2" >*NQO1↑, "highlight2" >*COX2↓, "highlight2" >*NOX4↓, "highlight2" >*GPx4↑, "highlight2" >*FTH1↑, "highlight2" >*p‑mTOR↓, "highlight2" >*TGF-β↓,

3404-

TQ,

The Neuroprotective Effects of Thymoquinone: A Review

Review,

Var,

Review,

AD,

Review,

Park,

Review,

Stroke,

"highlight2" >*Inflam↓, "highlight2" >AntiCan↑, "highlight2" >*TNF-α↓, "highlight2" >*IL6↓, "highlight2" >*IL1β↓, "highlight2" >*NF-kB↓, "highlight2" >*iNOS↓, "highlight2" >*NRF2↑, "highlight2" >*neuroP↑, "highlight2" >*MMP↑, "highlight2" >*ROS↓, "highlight2" >*MDA↓, "highlight2" >*GSH↑, "highlight2" >*Catalase↑, "highlight2" >*SOD↑, "highlight2" >*IL12↓, "highlight2" >*MCP1↓, "highlight2" >*IP-10/CXCL-10↓, "highlight2" >*PGE2↓,

3423-

TQ,

Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics

Review,

Var,

"highlight2" >AntiCan↑, "highlight2" >Inflam↓, "highlight2" >hepatoP↑, "highlight2" >RenoP↑, "highlight2" >BAX↑, "highlight2" >Bak↑, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >ROS↑, "highlight2" >P53↑, "highlight2" >PTEN↑, "highlight2" >P21↑, "highlight2" >p27↑, "highlight2" >BRCA1↑, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >MAPK↓, "highlight2" >ERK↓, "highlight2" >p‑ERK↓, "highlight2" >MMPs↓, "highlight2" >FAK↓, "highlight2" >Twist↓, "highlight2" >Zeb1↓, "highlight2" >EMT↓, "highlight2" >TumMeta↓, "highlight2" >angioG↓, "highlight2" >VEGF↓, "highlight2" >HDAC↓, "highlight2" >Maspin↑, "highlight2" >SIRT1↑, "highlight2" >DNMT1↓, "highlight2" >DNMT3A↓, "highlight2" >HDAC1↓, "highlight2" >HDAC4↓,

3402-

TQ,

Enhanced Apoptosis in Pancreatic Cancer Cells through Thymoquinone-rich Nigella sativa L. Methanol Extract: Targeting NRF2/HO-1 and TNF-α Pathways

in-vitro,

PC,

PANC1

in-vitro,

PC,

MIA PaCa-2

"highlight2" >tumCV↓, "highlight2" >NRF2↑, "highlight2" >HO-1↑, "highlight2" >TNF-α↓,

3401-

TQ,

Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review

Review,

Var,

"highlight2" >TumCP↓, "highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >NRF2↑, "highlight2" >NF-kB↓, "highlight2" >TumCCA↑, "highlight2" >*GABA↑, "highlight2" >P53↑, "highlight2" >P21↑, "highlight2" >AMPK↑, "highlight2" >neuroP↑, "highlight2" >cardioP↑, "highlight2" >hepatoP↑,

3400-

TQ,

Chemo,

Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats

in-vitro,

Nor,

10 and 20 mg/kg b.w.)

TQ against CFZ-induced renal toxicity in rats

"highlight2" >*GSH↑, "highlight2" >*SOD↑, "highlight2" >*lipid-P↓, "highlight2" >*IL1β↓, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓, "highlight2" >*Casp3↓, "highlight2" >*Catalase↑, "highlight2" >*NRF2↑, "highlight2" >*RenoP↑,

3399-

TQ,

Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells

in-vitro,

BC,

MDA-MB-231

NA,

BC,

MDA-MB-468

"highlight2" >ROS↓, "highlight2" >H2O2↓, "highlight2" >Catalase↑, "highlight2" >SOD↑, "highlight2" >GSH↑, "highlight2" >NQO1↑, "highlight2" >GCLM↑, "highlight2" >NRF2↑, "highlight2" >PD-L1↓, "highlight2" >GSSG↑, "highlight2" >GPx1⇅, "highlight2" >GPx4↓,

3398-

TQ,

5-FU,

Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo

in-vivo,

Nor,

50-100mg/kg bw

Male albino Wistar rats

"highlight2" >*RenoP↑, "highlight2" >*TAC↑, "highlight2" >*ROS↓, "highlight2" >*lipid-P↓, "highlight2" >*p38↓, "highlight2" >*MAPK↓, "highlight2" >*NF-kB↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*MDA↓, "highlight2" >*GPx↑, "highlight2" >*GSR↑, "highlight2" >*Catalase↑, "highlight2" >*BUN↓, "highlight2" >*LDH↓, "highlight2" >*IL1β↓,

3397-

TQ,

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Review,

CRC,

6-112uM (table 1)

"highlight2" >ChemoSen↑, "highlight2" >*Half-Life↝, "highlight2" >*BioAv↝, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*hepatoP↑, "highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >angioG↑, "highlight2" >selectivity↑, "highlight2" >JNK↑, "highlight2" >p38↑, "highlight2" >p‑NF-kB↑, "highlight2" >ERK↓, "highlight2" >PI3K↓, "highlight2" >PTEN↑, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >EMT↓, "highlight2" >Twist↓, "highlight2" >E-cadherin↓, "highlight2" >ROS⇅, "highlight2" >*Catalase↑, "highlight2" >*SOD↑, "highlight2" >*GSTA1↑, "highlight2" >*GPx↑, "highlight2" >*PGE2↓, "highlight2" >*IL1β↓, "highlight2" >*COX2↓, "highlight2" >*MMP13↓, "highlight2" >MMPs↓, "highlight2" >TumMeta↓, "highlight2" >VEGF↓, "highlight2" >STAT3↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 136

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Sepsis↓, 1,
Total Targets: 310

Pathway results for Effect on Normal Cells:

NA, unassigned ⓘ

chemoPv↑, 1,

Redox & Oxidative Stress ⓘ

antiOx↓, 2, antiOx↑, 20, Catalase↑, 15, GCLC↑, 1, GPx↑, 8, GPx4↑, 1, GSH↑, 23, GSH/GSSG↑, 1, GSR↑, 2, GSSG↓, 2, GSTA1↓, 1, GSTA1↑, 4, GSTs↑, 3, H2O2↓, 3, HO-1↓, 1, HO-1↑, 12, Keap1↓, 1, lipid-P↓, 13, MDA↓, 14, MPO↓, 1, MPO↑, 1, NOX4↓, 1, NQO1↑, 3, NRF2↓, 1, NRF2↑, 15, Prx↑, 1, ROS↓, 35, ROS⇅, 1, SIRT3↑, 1, SOD↑, 23, SOD1↑, 3, TAC↑, 3, Thiols↑, 2, VitC↑, 1, VitE↑, 1,

Metal & Cofactor Biology ⓘ

FTH1↑, 1,

Mitochondria & Bioenergetics ⓘ

MMP↑, 5,

Core Metabolism/Glycolysis ⓘ

ALAT↓, 4, BUN↓, 1, cMyc↓, 1, CREB↑, 1, p‑CREB↑, 1, LDH↓, 2, LDL↓, 1, NAD↑, 1, NADPH↑, 1, PPARγ↑, 1, SIRT1↑, 3,

Cell Death ⓘ

p‑Akt↓, 2, p‑Akt↑, 1, e-Akt↑, 1, Apoptosis↓, 3, BAX↓, 3, Bax:Bcl2↓, 1, Bcl-2↑, 1, Casp1?, 1, Casp1↓, 1, Casp3↓, 7, cl‑Casp3↓, 1, proCasp3↓, 1, Casp7↓, 1, iNOS↓, 3, iNOS↑, 2, JNK↑, 2, MAPK↓, 1, MAPK↑, 1, p38↓, 1, p‑p38↓, 1, Pyro?, 1,

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,

Transcription & Epigenetics ⓘ

Ach↑, 3, p‑cJun↓, 1, other↓, 1, other↝, 1, tumCV∅, 1,

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1, ERK↑, 1, e-ERK↑, 1, FOXO↑, 1, p‑mTOR↓, 1, neuroG↑, 1, PI3K↑, 1,

Migration ⓘ

mt-ATPase↑, 1, MMP13↓, 2, MMP7↓, 1, MMP9↓, 1, MMP9↑, 1, MMPs↓, 1, TGF-β↓, 4, TumCI↓, 1, TumCI∅, 1, TumCMig∅, 1, TumCP↓, 1, TXNIP↓, 1,

Angiogenesis & Vasculature ⓘ

angioG↑, 2, eNOS↑, 1, Hif1a↑, 2, LOX1↓, 1, NO↓, 3, NO↑, 1, VEGF↓, 1, VEGF↑, 2,

Barriers & Transport ⓘ

BBB↑, 2, MRP↓, 1,

Immune & Inflammatory Signaling ⓘ

ASC?, 1, COX2↓, 10, CRP↓, 3, CXCc↓, 1, IFN-γ↓, 2, IFN-γ↑, 1, IL10↑, 3, IL12↓, 3, IL18↓, 1, IL1β↓, 16, IL6↓, 7, Inflam↓, 23, IP-10/CXCL-10↓, 1, IκB↑, 1, MCP1↓, 2, MyD88↓, 3, NF-kB↓, 17, PGE2↓, 4, TLR1↓, 1, TLR2↓, 4, TLR4↓, 4, TNF-α↓, 14, TRIF↓, 2,

Synaptic & Neurotransmission ⓘ

AChE↓, 8, AChE↝, 1, BDNF↑, 1, BDNF∅, 1, ChAT↑, 1, GABA↑, 1, p‑tau↓, 3, TrkB↑, 1,

Protein Aggregation ⓘ

Aβ↓, 8, BACE↓, 1, NLRP3↓, 2,

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 3, BioAv↑, 4, BioAv↝, 2, eff↓, 1, eff↑, 6, Half-Life↝, 2,

Clinical Biomarkers ⓘ

ALAT↓, 4, ALP↓, 1, AST↓, 4, creat↓, 1, CRP↓, 3, IL6↓, 7, LDH↓, 2,

Functional Outcomes ⓘ

AntiAge↑, 2, AntiCan↑, 2, cardioP↑, 8, chemoP↑, 1, cognitive↑, 11, GFR↑, 1, hepatoP↑, 10, memory↑, 10, motorD↑, 2, neuroP↑, 17, OS↑, 2, radioP↑, 6, RenoP↑, 10, toxicity↓, 3, toxicity∅, 1, Weight∅, 1,

Infection & Microbiome ⓘ

Bacteria↓, 1, IRF3↓, 4,
Total Targets: 172

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:162  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : Thymoquinone, ,

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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