Database Query Results : Rosmarinic acid, , cognitive

RosA, Rosmarinic acid: Click to Expand ⟱
Features: polyphenol
Polyphenol of many herbs - rosemary, perilla, sage mint and basil. Rosmarinic acid (RA) is predominantly found in a variety of medicinal and culinary herbs, especially those belonging to the Lamiaceae family, including rosemary (Rosmarinus officinalis), basil (Ocimum basilicum), sage (Salvia officinalis), thyme (Thymus vulgaris), and mints (Mentha spp.). In addition to the Lamiaceae family, RA is also present in plants from other families, such as Boraginaceae and Apiaceae.
-Rosmarinic acid is one of the hydroxycinnamic acids, and was initially isolated and purified from the extract of rosemary, a member of mint family (Lamiaceae)
-Its chemical structure allows it to act as a free radical scavenger by donating hydrogen atoms to stabilize ROS and free radicals.
RA’s dual nature as both a phenolic acid and a flavonoid-related compound enables it to chelate metal ions and prevent the formation of free radicals, thus interrupting oxidative chain reactions. It can modulate the activity of enzymes involved in OS, such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), underscoring its potential role in preventing oxidative damage at the cellular level.
-divided as rosemary extract, carnosic acid, rosmarinic acid?

Summary:
-Capacity to chelate transition metal ions, particularly ironChelator (Fe2+) and copper (Cu2+)
-RA plus Cu(II)-induced oxidative DNA damage, which causes ROS
-rosmarinic acid (RA) as a potential inhibitor of MARK4↓ (inhibiting to tumor growth, invasion, and metastasis) activity (IC50 = 6.204 µM)

-Note half-life 1.5–2 hours.
BioAv water-soluble, rapid absorbtion
Pathways:
- varying results of ROS up or down in cancer cells. Plus a report of lowering ROS and no effect on Tumor cell viability.
However always seems to lower ROS↓ in normal cells.
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, UPR↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓,
- No indication of Lowering AntiOxidant defense in Cancer Cells:
- Raises AntiOxidant defense in Normal Cells:(and perhaps even in cancer cells) ROS↓, NRF2↑***, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : NLRP3↓, IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, ROCK1↓, RhoA↓, NF-κB↓, ERK↓, MARK4↓
- reactivate genes thereby inhibiting cancer cell growth(weak) : HDAC2↓, DNMTs↓weak, P53↑, HSP↓,
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, ERK↓, EMT↓,
- inhibits glycolysis /Warburg Effect and ATP depletion : HIF-1α↓??, LDHA↓, PFKs↓, GRP78↑, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, EGFR↓,
- inhibits Cancer Stem Cells (few references) : CSC↓, Hh↓, GLi1↓,
- Others: PI3K↓, AKT↓, STAT↓, AMPK, ERK↓, JNK,
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,

- Selectivity: Cancer Cells vs Normal Cells


cognitive, cognitive: Click to Expand ⟱
Source:
Type:
Cognitive


Scientific Papers found: Click to Expand⟱
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, worthy source for curing inflammation, analgesic, anti-anxiety, and memory boosting.
*memory↑,
*toxicity↓, Rosmarinic acid was observed to have very scarce toxicity with an LD50 of 561 mg/kg in mice
*ROS↓, Figure 1
*Catalase↑,
*SOD↑,
*NRF2↑,
*Aβ↓,
*AChE↓, decreased hippocampal AChE activity in bulbectomized mice.
*Ca+2↓,
*NO↓,
*IL2↓,
*COX2↓,
*PGE2↓,
*MMPs↓,
*TNF-α↓,
*iNOS↓,
*TLR4↓,
*cognitive↑, These cognitive-enhancing effects of rosmarinic acid might be beneficial to populations of advanced age
*cortisol↓, aroma of rosemary oil improved performance in exam students by enhancing free radical scavenging activity and decreasing cortisol levels
*lipid-P↓, Anti-oxidant components of rosemary extract (250, 500 and 750 mg/kg) reduced lipid peroxidation

3617- RosA,  Aroma,    Effect of aromatherapy on patients with Alzheimer's disease
- in-vivo, AD, NA
*other↝, Aromatherapy consisted of the use of rosemary and lemon essential oils in the morning, and lavender and orange in the evening
*cognitive↑, All patients showed significant improvement in personal orientation related to cognitive function on both the GBSS-J and TDAS after therapy.
*motorD↑, In addition, some improvement in movement was noted

3621- RosA,    Short-Term Study on the Effects of Rosemary on Cognitive Function in an Elderly Population
- Trial, AD, NA
*cognitive↑, the lowest dose (750 mg) of rosemary had a statistically significant beneficial
*Dose↝, whereas the highest dose (6,000 mg) had a significant impairing effect
*BioAv↑, ursolic acid, rosmarinic acid, and carnosic acid found in rosemary are bioavailable and have characterized physiological effects that may influence cognitive functioning.

3022- RosA,    Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice
- in-vitro, Sepsis, NA
*cognitive↑, Rosmarinic acid alleviates cognitive impairment and glycolytic metabolism abnormality in sepsis mice model.
*neuroP↑, Rosmarinic acid attenuates neuronal injury and microglial activation.
*GlucoseCon↑, promoted whole-brain glucose uptake in mice.
*Hif1a↓, (rescued the decrease of RACK1 and increase of HIF-1α)

3020- RosA,    Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway
- in-vivo, Nor, NA - in-vitro, NA, SH-SY5Y
*cognitive↑, 20 and 40 mg/kg RA significantly improve endotoxin-induced cognitive dysfunction without dose differences
*PERK↓, 40 mg/kg RA treatment significantly decreased the hippocampal level of PERK protein
*GRP78/BiP↓, 120 μM RA pretreatment significantly inhibited LPS-conditioned culture-induced GRP78, PERK, and MANF upregulation in vitro.
*ER Stress↓, improving cognitive impairment and suppressing the endoplasmic reticulum stress mediated by the GRP78/IRE1α/JNK pathway.

4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, Aromatic plants, sage (Salvia officinalis), lavender (Lavandula angustifolia), and rosemary (Salvia Rosmarinus) have already shown anxiolytics, anti-inflammatory, antioxidant, and neuroprotective effects.
*antiOx↑,
*neuroP↑,
*ERK↑, exert neuroprotective effects mainly through increasing neurotransmitters and antioxidants, activating ERK/CREB/BDNF pathway, and inhibition of β-amyloid, pro-inflammatory cytokines, and Acetylcholine esterase (AChE) activity.
*CREB↑,
*BDNF↑,
*Aβ↑,
*AChE↓,
*memory↑, Rosmarinus officinalis led to improvement in long-term memory and cognitive responses in rats, through the inhibition of acetylcholinesterase (AChE) activity
*cognitive↑,


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Results for Effect on Cancer/Diseased Cells:

Total Targets: 0

Results for Effect on Normal Cells:
AChE↓,2,   antiOx↑,1,   Aβ↓,1,   Aβ↑,1,   BDNF↑,1,   BioAv↑,1,   Ca+2↓,1,   Catalase↑,1,   cognitive↑,6,   cortisol↓,1,   COX2↓,1,   CREB↑,1,   Dose↝,1,   ER Stress↓,1,   ERK↑,1,   GlucoseCon↑,1,   GRP78/BiP↓,1,   Hif1a↓,1,   IL2↓,1,   Inflam↓,2,   iNOS↓,1,   lipid-P↓,1,   memory↑,2,   MMPs↓,1,   motorD↑,1,   neuroP↑,2,   NO↓,1,   NRF2↑,1,   other↝,1,   PERK↓,1,   PGE2↓,1,   ROS↓,1,   SOD↑,1,   TLR4↓,1,   TNF-α↓,1,   toxicity↓,1,  
Total Targets: 36

Scientific Paper Hit Count for: cognitive, cognitive
6 Rosmarinic acid
2 Aromatherapy
1 Salvia officinalis
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:142  Target#:557  State#:%  Dir#:%
  wNotes=on  sortOrder:rid,rpid

 

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