Quercetin Cancer Research Results

QC, Quercetin: Click to Expand ⟱
Features:
Plant pigment (flavonoid) found in red wine, onions, green tea, apples and berries.
Quercetin is thought to contribute to anticancer effects through several mechanisms:
-Antioxidant Activity:
-Induction of Apoptosis:modify Bax:Bcl-2 ratio
-Anti-inflammatory Effects:
-Cell Cycle Arrest:
-Inhibition of Angiogenesis and Metastasis: (VEGF)

Cellular Pathways:
-PI3K/Akt/mTOR Pathway: central to cell proliferation, survival, and metabolism.
-MAPK/ERK Pathway: influencing cell proliferation, differentiation, and apoptosis.
-NF-κB Pathway: downregulate NF-κB
-JAK/STAT Pathway: interfere with the activation of STAT3
-Apoptotic Pathways: intrinsic (mitochondrial) and extrinsic (death receptor-mediated) pathways

Quercetin has been used at doses around 500–1000 mg per day
Quercetin’s bioavailability from foods or standard supplements can be low.

-Note half-life 11 to 28 hours.
BioAv low 1-10%, poor water-solubility, consuming with fat may improve bioavialability. also piperine or VitC.
Pathways:
- induce ROS production in cancer cells (higher dose). Typicallys Lowers ROS in normal cells(unless it is high dose?)or depends on Redox status?. "quercetin paradox"
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, UPR↑, GRP78↑, Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓, Prx,
- Confusing info about Lowering AntiOxidant defense in Cancer Cells: NRF2↓(some contrary), TrxR↓**, SOD↓(contrary), GSH↓ Catalase↓(contrary), HO1↓(some contrary), GPx↓(some contrary)
- Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : NLRP3↓, IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, TIMP2, IGF-1↓, uPA↓, VEGF↓, ROCK1↓, FAK↓, NF-κB↓, CXCR4↓, SDF1↓, TGF-β↓, α-SMA↓, ERK↓
- reactivate genes thereby inhibiting cancer cell growth : HDAC↓, DNMTs↓, EZH2↓, P53↑, HSP↓, Sp proteins↓, TET↑
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, FAK↓, ERK↓, EMT↓, TOP1↓, TET1,
- inhibits glycolysis and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDH↓, LDHA↓, HK2↓, PFKs↓, PDKs↓, ECAR↓, OXPHOS↓, GRP78↑, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, FGF↓, PDGF↓, EGFR↓,
- some indication of inhibiting Cancer Stem Cells : CSC↓, CK2↓, Hh↓, CD24↓, β-catenin↓, Notch2↓,
- Others: PI3K↓, AKT↓, JAK↓, STAT↓, Wnt↓, β-catenin↓, AMPK, α↓, ERK↓, JNK, - SREBP (related to cholesterol).
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,

- Selectivity: Cancer Cells vs Normal Cells

Rank Pathway / Axis Cancer Cells Normal Cells Label Primary Interpretation Notes
1 Reactive oxygen species (ROS) ↑ ROS (dose-, metal-, context-dependent) ↓ ROS Conditional Driver Biphasic redox modulation Quercetin exhibits pro-oxidant behavior in cancer cells while protecting normal cells
2 Mitochondrial integrity / intrinsic apoptosis ↓ ΔΨm; ↑ caspase activation ↔ preserved Driver Execution of intrinsic apoptosis Mitochondrial dysfunction is a central apoptosis route in cancer cells
3 PI3K → AKT → mTOR axis ↓ AKT / ↓ mTOR ↔ adaptive suppression Driver Growth and survival inhibition AKT/mTOR suppression is a consistently reported upstream effect in cancer models
4 NF-κB signaling ↓ NF-κB activation ↓ inflammatory NF-κB tone Secondary Reduced survival and inflammatory transcription NF-κB inhibition contributes to chemosensitization and apoptosis susceptibility
5 MAPK signaling (JNK / p38) ↑ JNK / ↑ p38 ↔ minimal Secondary Stress-mediated apoptosis signaling MAPK activation supports apoptosis downstream of redox stress
6 Cell cycle regulation ↑ G1/S or G2/M arrest ↔ largely spared Phenotypic Cytostatic growth control Cell-cycle arrest reflects disruption of growth signaling
7 HIF-1α hypoxia signaling ↓ HIF-1α ↔ minimal Secondary Reduced hypoxia tolerance Quercetin interferes with hypoxia-driven transcriptional programs
8 NRF2 antioxidant response ↑ NRF2 (adaptive, context-dependent) ↑ NRF2 (protective) Adaptive Stress compensation NRF2 induction reflects redox buffering rather than primary cytotoxicity


Scientific Papers found: Click to Expand⟱
380- AgNPs,  QC,  CA,  Chit,    Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
- in-vitro, MG, U118MG
"highlight2" >TumCG↓, cell viability has constantly decreased by increasing the concentration

6- Ba,  Api,  QC,    Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer
- in-vitro, Pca, PC3
"highlight2" >HH↓, Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer
"highlight2" >Gli1↓, three compounds, apigenin, baicalein, and quercetin, decreased Gli1 mRNA concentration but not Gli reporter activity

3633- BBR,  LT,  Cro,  QC,    Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy
- Review, AD, NA
"highlight2" >*AChE↓, Alzheimer's disease (AD) is a main cause of dementia, accounting for up to 75% of all dementia cases. Pathophysiological processes described for AD progression involve neurons and synapses degeneration, mainly characterized by cholinergic impairment.
"highlight2" >*AChE↓, Fig1: Berberine(1uM), Luteolin(80uM), Crocetin(100uM), Quercetin(120uM)

5643- BCA,  GEN,  QC,  SIL,  KaempF  P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review
- in-vitro, NA, NA
"highlight2" >P-gp↓, large number of flavonoids on P-gp inhibition. Biochanin-A, genistein, quercetin, chalcone, silymarin, phloretin, morin, and kaempferol

5753- CA,  QC,  MEL,    Effects of Caffeic Acid and Quercetin on In Vitro Permeability, Metabolism and In Vivo Pharmacokinetics of Melatonin in Rats: Potential for Herb-Drug Interaction
- in-vivo, Colon, Caco-2
"highlight2" >BioAv↑, These findings suggest that caffeic acid and quercetin improved oral exposure of melatonin via CYP1A inhibition pathway.
"highlight2" >CYP1A1↓,

6027- CGA,  CUR,  EGCG,  QC,  RES  Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol
- Review, Nor, NA
"highlight2" >*ROS↓, polyphenols have similar chemical and biological properties in that they can act as antioxidants and exert the anticancer effects via cell signaling pathways involving their reactive oxygen species (ROS)-scavenging activity.
"highlight2" >ROS↑, These polyphenols may also act as pro-oxidants under certain conditions, especially at high concentrations.

24- EGCG,  GEN,  QC,    Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin
- in-vitro, Pca, 22Rv1
"highlight2" >NQO1↑, Genistein and quercetin, as individual phytochemicals, increased NQO1 expression by ~3.78- and ~6.42-fold, respectively,
"highlight2" >P53↑, Taken together, these results support the existence of synergy between EGCG, genistein and quercetin in the control of AR, p53 and NQO1 expression
"highlight2" >NQO2↑,
"highlight2" >chemoPv↑, synergy between bioactive dietary agents, thus broadening the chemopreventive index
"highlight2" >TumCP↓, Analyzing the results from colony formation and cell proliferation together, the relative potency and efficacy of the three phytochemicals was ranked as EGCG>quercetin>genistein.
"highlight2" >AR↓, EGCG or quercetin (2.5 μM) separately, inhibited AR expression by 67% and 47%, respectively compared to the control,

25- EGCG,  QC,    Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
"highlight2" >COMT↓, fact that EGCG primarily inhibited COMT activity, whereas quercetin reduced the amount of COMT protein.
"highlight2" >TumCP↑, Quercetin and EGCG in combination synergistically inhibited cell proliferation, caused cell cycle arrest, and induced apoptosis in PC-3 cells.
"highlight2" >TumCCA↑,
"highlight2" >Apoptosis↑,

26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
"highlight2" >BAD↓,
"highlight2" >cl‑PARP↑,
"highlight2" >Casp7↑,
"highlight2" >IκB↓,
"highlight2" >Ki-67↓,
"highlight2" >VEGF↓,
"highlight2" >EGFR↓,
"highlight2" >FGF↓,
"highlight2" >TGF-β↓,
"highlight2" >TNF-α↓,
"highlight2" >SCF↓,
"highlight2" >Bax:Bcl2↑,
"highlight2" >NF-kB↓,
"highlight2" >chemoP↑, This study provides a novel regimen to enhance the therapeutic effect of Doc in a less-toxic manner and reduce its risk of side effects in treatment of CRPC.
"highlight2" >ChemoSen↑, GT and Q with LD Doc significantly enhanced the potency of Doc 2-fold and reduced tumor growth by 62 % compared to LD Doc in 7-weeks intervention.
"highlight2" >TumVol↓,

2458- EGCG,  QC,    Identification of plant-based hexokinase 2 inhibitors: combined molecular docking and dynamics simulation studies
- Analysis, Nor, NA
"highlight2" >HK2↓, Overall, this study concludes that EGCG and quercitrin might possess the inhibitory potential for HK2.

2642- Flav,  QC,  Api,  KaempF,  MCT  In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type
- in-vitro, Nor, NA - in-vivo, Nor, NA
"highlight2" >*BioAv↑, Overall, the bioavailability and antioxidant activity of flavonoids increased when they were coingested with excipient emulsions.
"highlight2" >*eff↝, However, in vivo pharmacokinetic experiments showed that the flavonoid concentrations in rat serum were comparable for all carrier oils
"highlight2" >BioEnh↑, MCT is the bioenhancer for the Flavonoids (which have low soluability in water)

4687- LT,  QC,    Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells
- in-vitro, Pca, DU145
"highlight2" >CSCs↓, Since luteolin and quercetin were able to target CSC cells and prevent cancer cell invasiveness, may serve as potential anti-angiogenesis and anti-metastasis agents.
"highlight2" >EMT↓, Furthermore, reversed epithelial-mesenchymal transition (EMT) to reduce MMP secretion by Lu and Qu exert inhibition of migration and invasion abilities in A431 cells
"highlight2" >MMPs↓,
"highlight2" >TumCMig↓,
"highlight2" >TumCI↓,

1997- Myr,  QC,    Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity
- in-vitro, Lung, A549
"highlight2" >TrxR↓, Myricetin and quercetin were found to have strong inhibitory effects on mammalian TrxRs with IC50 values of 0.62 and 0.97 micromol/L, respectively
"highlight2" >eff↑, Oxygen-derived superoxide anions enhanced the inhibitory effect whereas anaerobic conditions attenuated inhibition.
"highlight2" >TumCCA↑, cell cycle was arrested in S phase by quercetin and an accumulation of cells in sub-G1 was observed in response to myricetin.
"highlight2" >eff↓, presence of superoxide dismutase diminished the inhibition dramatically
"highlight2" >ROS↑, show that ROS played a critical role in the inhibition of TrxR by flavonoids. ...may occur as a result of their easy oxidization to flavonol semiquinone species.

981- NarG,  QC,    Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer
- in-vivo, NA, NA
"highlight2" >TumVol↓,
"highlight2" >CYP19↓, Reduction in aromatase levels in solid tumors was also observed in treated groups (Aromatase inhibitor)

910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
"highlight2" >tumCV↓,
"highlight2" >Apoptosis↑,
"highlight2" >PI3k/Akt/mTOR↓, QUE induces cell death by inhibiting PI3K/Akt/mTOR and STAT3 pathways in PEL cells
"highlight2" >Wnt/(β-catenin)↓, reducing β-catenin
"highlight2" >MAPK↝,
"highlight2" >ERK↝, ERK1/2
"highlight2" >TumCCA↑, cell cycle arrest at the G1 phase
"highlight2" >H2O2↑,
"highlight2" >ROS↑,
"highlight2" >TumAuto↑,
"highlight2" >MMPs↓, Consistently, QUE was able to reduce the protein levels of MMP-2, MMP-9, VEGF and mTOR, and p-Akt in breast cancer cell lines
"highlight2" >P53↑,
"highlight2" >Casp3↑,
"highlight2" >Hif1a↓, by inactivating the Akt-mTOR pathway [64,74] and HIF-1α
"highlight2" >cFLIP↓,
"highlight2" >IL6↓, QUE decreased the release of interleukin-6 (IL-6) and IL-10
"highlight2" >IL10↓,
"highlight2" >lactateProd↓,
"highlight2" >Glycolysis↓, It is suggested that QUE alters glucose metabolism by inhibiting monocarboxylate transporter (MCT) activity
"highlight2" >PKM2↓,
"highlight2" >GLUT1↓,
"highlight2" >COX2↓,
"highlight2" >VEGF↓,
"highlight2" >OCR↓,
"highlight2" >ECAR↓,
"highlight2" >STAT3↓,
"highlight2" >MMP2↓, Consistently, QUE was able to reduce the protein levels of MMP-2, MMP-9, VEGF and mTOR, and p-Akt in breast cancer cell lines
"highlight2" >MMP9:TIMP1↓,
"highlight2" >mTOR↓,

911- QC,  SFN,    Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial
"highlight2" >TumCG↓,
"highlight2" >Risk↓, decreased risk of extra-prostatic manifestation of prostate cancer: cruciferous vegetables, in particular broccoli which is rich in sulforaphane and quercetin

909- QC,    Exploring the therapeutic potential of quercetin in cancer treatment: Targeting long non-coding RNAs
- Review, NA, NA
"highlight2" >other↓, quercetin suppresses oncogenic lncRNAs
"highlight2" >other↑, while enhancing tumor-suppressive lncRNAs

908- QC,    Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update
- Review, NA, NA
"highlight2" >AntiCan↑, quercetin exerts anticancer effect by binding to cellular receptors and proteins
"highlight2" >ROS↑, The short-term effect causes scavenging of free radicals and it is mostly antioxidative and antiapoptotic in nature, while the long term effect is pro-oxidative

907- QC,    A Comprehensive Study on the Anti-cancer Effects of Quercetin and Its Epigenetic Modifications in Arresting Progression of Colon Cancer Cell Proliferation
- Review, NA, NA
"highlight2" >AntiCan↑, fascinated attention to quercetin as an anti-inflammatory plant product since it exerts specific effects only on cancer cells rather than on normal

906- QC,    The interplay between reactive oxygen species and antioxidants in cancer progression and therapy: a narrative review
- Review, NA, NA
"highlight2" >ROS↑, quercetin at higher concentrations (>50 µM) can initiate ROS generation especially O2•−

905- QC,    Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation. Quercetin as an effective antioxidant against pro-oxidant effects of urate
- Analysis, NA, NA
"highlight2" >ROS↑, pro-oxidant behavior depends on the Cu(2+) concentration

904- QC,    Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase
- Analysis, NA, NA
"highlight2" >ROS↑, Quercetin significantly increased oxidation of GAPDH observed in the presence of ferrous ions
"highlight2" >H2O2↑,

903- QC,    Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow
- in-vivo, NA, NA
"highlight2" >ROS⇅, antioxidant and prooxidant effects largely relates to its dose

902- QC,    Prooxidant activities of quercetin, p-courmaric acid and their derivatives analysed by quantitative structure–activity relationship
- Analysis, NA, NA
"highlight2" >ROS↑, metal ion and concentration of tested phenolics are widely suggested to affect the prooxidant activity of phenolics

901- QC,    Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2
- Analysis, Var, NA
"highlight2" >ROS↑, presence/ absence of metal ions modulates the biological or pharmacological behavior of flavonoids to act as an antioxidant or prooxidant

900- QC,    Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
- in-vivo, Nor, NA
"highlight2" >*Weight↓, overall weight
"highlight2" >*TAC∅, no significant decrease
"highlight2" >*ROS↑, working hypothesis is that quercetin interferes with mitochondrial function exacerbating mitochondrial ROS generation and altering the physiology of tissues highly dependent on iron metabolism

99- QC,    Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1
- in-vitro, Pca, PC3
"highlight2" >EMT↓, quercetin suppressed EMT process, promote apoptosis and deactivated PI3K/Akt signaling pathway in PC-3 cells
"highlight2" >E-cadherin↑, Quercetin increased E-cadherin expression and decreased the level of N-cadherin
"highlight2" >N-cadherin↓,
"highlight2" >Ki-67↓, while the production of Ki67 was significantly reduced by quercetin
"highlight2" >PI3K/Akt↓,
"highlight2" >MALAT1↓, MALAT1 expression was significantly downregulated in quercetin-treated PC cells at a dose- and time-dependent manne
"highlight2" >TumCG↓, Quercetin Inhibited Tumor Growth by Targeting MALAT1 in vivo

912- QC,  2DG,    Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities
"highlight2" >Apoptosis↑,
"highlight2" >ROS↓, 2-DG (5 mM) and Quer (10–40 μM) reduced the basal intracellular ROS content in HL60 cells
"highlight2" >GSH∅, GSH levels were not significantly affected by treatment for 3 h
"highlight2" >other↑, activated apoptosis throughout the mitochondrial (“intrinsic”) executioner pathway

899- QC,    Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites
- in-vivo, Var, NA
"highlight2" >ROS↑, effects of quercetin on cells seem to be dependent both on cell type and in particular on the concentration of quercetin
"highlight2" >GSH↓,

898- QC,    Anti- and pro-oxidant activity of rutin and quercetin derivatives
- Analysis, Var, NA
"highlight2" >ROS↑, quercetin derivatives with free catechol moiety or free hydroxyl in position 3 (or both) were pro-oxidant

897- QC,    Anti- and prooxidant effects of chronic quercetin administration in rats
- in-vivo, Nor, NA
"highlight2" >*MDA↓, in rat livers (decrease was more pronounced in vitamin E-deprived rats)
"highlight2" >*GSH⇅, in liver
"highlight2" >*ROS⇅, results suggest that quercetin may act not only as an antioxidant, but also as a prooxidant in rats.

896- QC,    Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin: Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA
- in-vivo, Var, NA
"highlight2" >ROS↑, Hence these naturally-occurring substances can have pro-oxidant effects under some reaction conditions and cannot be classified simplistically as “antioxidants”.

895- QC,    Theoretical Study of the Antioxidant Activity of Quercetin Oxidation Products
- Analysis, Var, NA
"highlight2" >ROS⇅,

894- QC,    The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis
- in-vitro, Nor, NA
"highlight2" >Apoptosis↑, capable of inducing apoptosis in tumor cell
"highlight2" >*NF-kB↓, the G/GO-mediated increase in NF-kB activity was clearly inhibited when the cells were pretreated with 50uM quercetin
"highlight2" >*AP-1↓, activation is suppressed by quercetin treatment.
"highlight2" >*P53↝, G/GO-mediated oxidative stress activates nuclear translocation and activation of the wild-type p53 in thymocytes and that this activation is inhibited by quercetin.
"highlight2" >*ROS↓, normal mouse thymocytes glucose oxidase stress

893- QC,    Quercetin: Prooxidant Effect and Apoptosis in Cancer
- Analysis, Var, NA
"highlight2" >ROS↑, proposal that the capacity of quercetin as a phytochemical that is able to trigger apoptosis in several tumor cell lineages might be related to its prooxidant features.

892- QC,    Antioxidant vs. pro-oxidant activities of quercetin in aqueous phase: A Density Functional Theory study
- Analysis, Var, NA
"highlight2" >ROS↑, influenced by concentration, pH of environment and the presence of redox metal.

891- QC,    Chapter 9 - Quercetin: Prooxidant Effect and Apoptosis in Cancer
- in-vitro, Var, NA
"highlight2" >ROS↑, substantial evidence that its prooxidant features are also relevant regarding its tumoricidal effects
"highlight2" >AntiTum↑, promote tumoricidal effects.

890- QC,    PROOXIDANT ACTIVITIES OF ANTIOXIDANTS AND THEIR IMPACT ON HEALTH
- Review, Var, NA
"highlight2" >ROS↑, in the presence of the transition metal

889- QC,    The multifaceted role of quercetin derived from its mitochondrial mechanism
- vitro+vivo, Var, NA
"highlight2" >MMP↓,
"highlight2" >ATP↝,
"highlight2" >OXPHOS↝,
"highlight2" >ROS↑, a prooxidant effect

873- QC,  RES,  CUR,  PI,    Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal Absorption
- in-vitro, Nor, NA
"highlight2" >*BioEnh↑, Resveratrol received the greatest enhancement in permeability when combined with other agents: quercetin (310%), curcumin (300%), quercetin and curcumin (323%, 350% with piperine)

138- QC,  CUR,    Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >DNMTs↓, treatment with Q+C was much more effective than either Q or C in inhibiting DNMT,
"highlight2" >AR↑, Treatment with Q or C or Q+C resulted in a marked increase in the expression of AR protein levels in PC3 and DU145 cell lines,
"highlight2" >MMP↓, combined treatment with Q+C was stronger than that of individual treatments (Q or C) in depolarizing the mitochondrial membrane potential

100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
"highlight2" >cycD1/CCND1↓, CCND1, CCND2, CCND3
"highlight2" >cycE/CCNE↓, CCNE1, CCNE2
"highlight2" >CDK2↓,
"highlight2" >CDK4/6↓, CDK4, CDK8
"highlight2" >E2Fs↓, E2F2, E2F3
"highlight2" >PCNA↓,
"highlight2" >cDC2↓,
"highlight2" >PTEN↑,
"highlight2" >MSH2↑,
"highlight2" >P21↑,
"highlight2" >EP300↑, p300
"highlight2" >BRCA1↑,
"highlight2" >NF2↑,
"highlight2" >TSC1↑,
"highlight2" >TGFβR1↑, TGFβR2
"highlight2" >P53↑,
"highlight2" >RB1↑, Rb
"highlight2" >AKT1↓,
"highlight2" >cMyc↓,
"highlight2" >CDC7↓,
"highlight2" >cycF↓, CCNF
"highlight2" >CDC16↓,
"highlight2" >CUL4B↑, CUL4B, a member of the cullin gene family that is also known to be involved in control of the cell cycle, was significantly up-regulated by quercetin.
"highlight2" >CBP↑,
"highlight2" >TSC2↑,
"highlight2" >HER2/EBBR2↓, erb-2
"highlight2" >BCR↓,
"highlight2" >TumCCA↑, quercetin significantly inhibited the expression of specific oncogenes and genes controlling G1, S, G2, and M phases of the cell cycle.
"highlight2" >chemoPv↑, Our results correlate with those of nutritional studies that support the roles of dietary bioflavonoids as cancer chemopreventive agents.

3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
"highlight2" >*antiOx↑, The antioxidant mechanism of quercetin in vivo is mainly reflected in its effects on glutathione (GSH), signal transduction pathways, reactive oxygen species (ROS), and enzyme activities.
"highlight2" >*GSH↑,
"highlight2" >*ROS↓,
"highlight2" >*Dose↑, antioxidant properties of quercetin show a concentration dependence in the low dose range but too much of the antioxidant brings about the opposite result
"highlight2" >*NADPH↓, quercetin counteracts atherosclerosis by reversing the increased expression of NADPH oxidase i
"highlight2" >*AMP↓, decreases in activation of AMP-activated protein kinase, thereby inhibiting NF-κB signaling
"highlight2" >*NF-kB↓,
"highlight2" >*p38↑, quercetin improves the antioxidant capacity of cells by activating the intracellular p38 MAPK pathway, increasing intracellular GSH levels and providing a source of hydrogen donors in the scavenging of free radical reactions.
"highlight2" >*MAPK↑,
"highlight2" >*SOD↑, quercetin achieves protection against acute spinal cord injury by up-regulating the activity of SOD, down-regulating the level of malondialdehyde (MDA), and inhibiting the p38MAPK/iNOS signaling pathway
"highlight2" >*MDA↓,
"highlight2" >*iNOS↓,
"highlight2" >*Catalase↑, quercetin reduces imiquimod (IMQ)-induced MDA levels in skin tissues and enhances catalase, SOD, and GSH activities, which together improve the antioxidant properties of the body
"highlight2" >*PI3K↑, It also controls the development of atherosclerosis induced by high fructose diet by enhancing PI3K/AKT and inhibiting ROS
"highlight2" >*Akt↑,
"highlight2" >*lipid-P↓, Quercetin enhances antioxidant activity and inhibits lipid cultivation, and it is effective in the treatment of oxidative liver damag
"highlight2" >*memory↑, reversed hypoxia-induced memory impairment
"highlight2" >*radioP↑, Quercetin protects cells from radiation and genotoxicity-induced damage by increasing endogenous antioxidant and scavenging free radical levels
"highlight2" >*neuroP↑, This suggests that quercetin may be a potential neuroprotective agent against ischemia, which protects CA1 vertebral neurons from I/R injury in the hippocampal region of animals
"highlight2" >*MDA↓, quercetin significantly reduced MDA levels and increased SOD and catalase levels.

1493- QC,    New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer
- NA, Bladder, NA
"highlight2" >RadioS↑,
"highlight2" >ChemoSen↑,

3337- QC,    Endoplasmic Reticulum Stress-Relieving Effect of Quercetin in Thapsigargin-Treated Hepatocytes
- in-vitro, NA, HepG2
"highlight2" >*Inflam↓, quercetin exerts anti-inflammatory and anti–insulin resistance actions by suppressing UPR in cells experiencing ER stress
"highlight2" >*UPR↓,
"highlight2" >*GRP58↓, (GRP78) and the downstream proteins such as X-box binding protein 1 (XBP1). The increased expression was significantly inhibited by quercetin, indicating that this compound can relieve ER stress
"highlight2" >*XBP-1↓,
"highlight2" >*ER Stress↓, previous reports as well as our results, we suggest that quercetin can inhibit ER stress in hepatocytes
"highlight2" >*antiOx↑, Quercetin, a well-known antioxidant, is one of the most abundant flavonols in vegetables and fruits and has been shown to have many pharmacological actions
"highlight2" >TNF-α↓, Quercetin suppressed the increased expression of TNF-α significantly and dose-dependently
"highlight2" >p‑eIF2α↓, quercetin treatment suppressed the phosphorylation of eIF2α, IRE1α and JNK and the mRNA expression of XBP-1, GRP78 and CHOP
"highlight2" >p‑IRE1↓,
"highlight2" >p‑JNK↓,
"highlight2" >CHOP↓,

3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
"highlight2" >*neuroP↑, Neuroprotection by quercetin has been reported in several in vitro studies
"highlight2" >*lipid-P↓, It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation.
"highlight2" >*antiOx↑, In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways.
"highlight2" >*Aβ↓,
"highlight2" >*Inflam↓,
"highlight2" >*BBB↝, It also has low BBB penetrability, thus limiting its efficacy in combating neurodegenerative disorders.
"highlight2" >*NF-kB↓, downregulating pro-inflammatory cytokines, such as NF-kB and iNOS, while stimulating neuronal regeneration
"highlight2" >*iNOS↓,
"highlight2" >*memory↑, Quercetin has shown therapeutic efficacy, improving learning, memory, and cognitive functions in AD
"highlight2" >*cognitive↑,
"highlight2" >*AChE↓, Quercetin administration resulted in the inhibition of AChE
"highlight2" >*MMP↑, quercetin ameliorates mitochondrial dysfunction by restoring mitochondrial membrane potential, decreases ROS production, and restores ATP synthesis
"highlight2" >*ROS↓,
"highlight2" >*ATP↑,
"highlight2" >*AMPK↑, It also increased the expression of AMP-activated protein kinase (AMPK), which is a key cell regulator of energy metabolism.
"highlight2" >*NADPH↓, Activated AMPK can decrease ROS generation by inhibiting NADPH oxidase activity
"highlight2" >*p‑tau↓, Inhibition of AβAggregation and Tau Phosphorylation

3335- QC,    Recent advances on the improvement of quercetin bioavailability
- Review, NA, NA
"highlight2" >*BioAv↓, bioavailability of quercetin is relatively low (<10%)

3334- QC,    Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans
- Trial, Nor, NA
"highlight2" >*Half-Life↑, elimination half-time (t1/2 ) of females (93.8 h for AP and 15.2 h for OP) was much higher than that of males t1/2 of (29.9 h for AP and 13.4 h for OP).

2431- QC,    The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells
- in-vitro, Nor, TM4
"highlight2" >*Apoptosis↓, 40 μM quercetin improved cell viability, reduced apoptosis, and preserved cell functions.
"highlight2" >*ROS↓, Quercetin also decreased reactive oxygen species (ROS) levels in TM4 cells exposed to FB1
"highlight2" >*antiOx↓, enhanced the expression of antioxidant genes
"highlight2" >*MMP↑, improved mitochondrial membrane potential.
"highlight2" >*GPI↑, elevated the mRNA and protein expression of glycolysis-related genes, including (Gpi1), (Hk2), (Aldoa), (Pkm), lactate (Ldha) and (Pfkl)
"highlight2" >*HK2↑,
"highlight2" >*ALDOA↑,
"highlight2" >*PKM1↑,
"highlight2" >*LDHA↑,
"highlight2" >*PFKL↑,

2344- QC,    Quercetin: A natural solution with the potential to combat liver fibrosis
- Review, Nor, NA
"highlight2" >*HK2↓, By reducing the activity of key glycolytic enzymes—including hexokinase II (HK2), phosphofructokinase platelet (PFKP), and pyruvate kinase M2 (PKM2)—quercetin lowers energy production in LSECs, potentially slowing fibrosis progression.
"highlight2" >*PFKP↓,
"highlight2" >*PKM2↓,
"highlight2" >*hepatoP↑, Quercetin lowered levels of liver enzymes (ALT, AST) and total bile acid, markers of liver injury.
"highlight2" >*ALAT↓,
"highlight2" >*AST↓,
"highlight2" >*Glycolysis↓, quercetin inhibited glycolysis in LSECs, reducing lactate production, glucose consumption, and the expression of glycolytic enzymes
"highlight2" >*lactateProd↓,
"highlight2" >*GlucoseCon↓,
"highlight2" >*CXCL1↓, By suppressing CXCL1 secretion, quercetin decreased neutrophil infiltration, a key factor in liver fibrosis, thereby effecting inflammation control.
"highlight2" >*Inflam↓,


Showing Research Papers: 1 to 50 of 214
Page 1 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 214

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CYP1A1↓, 1,   GSH↓, 1,   GSH∅, 1,   H2O2↑, 2,   NQO1↑, 1,   OXPHOS↝, 1,   ROS↓, 1,   ROS↑, 17,   ROS⇅, 2,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↝, 1,   BCR↓, 1,   CDC16↓, 1,   MMP↓, 2,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   cMyc↓, 1,   ECAR↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 4,   BAD↓, 1,   Bax:Bcl2↑, 1,   Casp3↑, 1,   Casp7↑, 1,   CBP↑, 1,   cFLIP↓, 1,   p‑JNK↓, 1,   MAPK↝, 1,  

Kinase & Signal Transduction ⓘ

CDC7↓, 1,   HER2/EBBR2↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   p‑eIF2α↓, 1,   p‑IRE1↓, 1,   NQO2↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   DNMTs↓, 1,   P53↑, 3,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   cycF↓, 1,   E2Fs↓, 1,   P21↑, 1,   RB1↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

cDC2↓, 1,   CSCs↓, 1,   EMT↓, 2,   EP300↑, 1,   ERK↝, 1,   FGF↓, 1,   Gli1↓, 1,   HH↓, 1,   mTOR↓, 1,   NF2↑, 1,   PTEN↑, 1,   SCF↓, 1,   STAT3↓, 1,   TumCG↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

CDK4/6↓, 1,   E-cadherin↑, 1,   Ki-67↓, 2,   MALAT1↓, 1,   MMP2↓, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 2,   MSH2↑, 1,   N-cadherin↓, 1,   TGF-β↓, 1,   TSC1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumCP↑, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↓, 1,   IL6↓, 1,   IκB↓, 1,   NF-kB↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   AR↑, 1,   COMT↓, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 2,   eff↓, 1,   eff↑, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   AR↑, 1,   BRCA1↑, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   Risk↓, 1,   TGFβR1↑, 1,   TumVol↓, 2,  
Total Targets: 123

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 1,   GSH↑, 1,   GSH⇅, 1,   lipid-P↓, 2,   MDA↓, 3,   ROS↓, 5,   ROS↑, 1,   ROS⇅, 1,   SOD↑, 1,   TAC∅, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   ALDOA↑, 1,   AMP↓, 1,   AMPK↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   GPI↑, 1,   HK2↓, 1,   HK2↑, 1,   lactateProd↓, 1,   LDHA↑, 1,   NADPH↓, 2,   PFKL↑, 1,   PFKP↓, 1,   PKM1↑, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,   GRP58↓, 1,   iNOS↓, 2,   MAPK↑, 1,   p38↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   UPR↓, 1,   XBP-1↓, 1,  

DNA Damage & Repair ⓘ

P53↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Migration ⓘ

AP-1↓, 1,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

CXCL1↓, 1,   Inflam↓, 3,   NF-kB↓, 3,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   Dose↑, 1,   eff↝, 1,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   hepatoP↑, 1,   memory↑, 2,   neuroP↑, 2,   radioP↑, 1,   Weight↓, 1,  
Total Targets: 63

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:140  Target#:%  State#:%  Dir#:%
  wNotes=on  sortOrder:rid,rpid

 

Home Page