Quercetin Cancer Research Results

QC, Quercetin: Click to Expand ⟱
Features:
Plant pigment (flavonoid) found in red wine, onions, green tea, apples and berries.
Quercetin is thought to contribute to anticancer effects through several mechanisms:
-Antioxidant Activity:
-Induction of Apoptosis:modify Bax:Bcl-2 ratio
-Anti-inflammatory Effects:
-Cell Cycle Arrest:
-Inhibition of Angiogenesis and Metastasis: (VEGF)

Cellular Pathways:
-PI3K/Akt/mTOR Pathway: central to cell proliferation, survival, and metabolism.
-MAPK/ERK Pathway: influencing cell proliferation, differentiation, and apoptosis.
-NF-κB Pathway: downregulate NF-κB
-JAK/STAT Pathway: interfere with the activation of STAT3
-Apoptotic Pathways: intrinsic (mitochondrial) and extrinsic (death receptor-mediated) pathways

Quercetin has been used at doses around 500–1000 mg per day
Quercetin’s bioavailability from foods or standard supplements can be low.

-Note half-life 11 to 28 hours.
BioAv low 1-10%, poor water-solubility, consuming with fat may improve bioavialability. also piperine or VitC.
Pathways:
- induce ROS production in cancer cells (higher dose). Typicallys Lowers ROS in normal cells(unless it is high dose?)or depends on Redox status?. "quercetin paradox"
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, UPR↑, GRP78↑, Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓, Prx,
- Confusing info about Lowering AntiOxidant defense in Cancer Cells: NRF2↓(some contrary), TrxR↓**, SOD↓(contrary), GSH↓ Catalase↓(contrary), HO1↓(some contrary), GPx↓(some contrary)
- Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : NLRP3↓, IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, TIMP2, IGF-1↓, uPA↓, VEGF↓, ROCK1↓, FAK↓, NF-κB↓, CXCR4↓, SDF1↓, TGF-β↓, α-SMA↓, ERK↓
- reactivate genes thereby inhibiting cancer cell growth : HDAC↓, DNMTs↓, EZH2↓, P53↑, HSP↓, Sp proteins↓, TET↑
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, FAK↓, ERK↓, EMT↓, TOP1↓, TET1,
- inhibits glycolysis and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDH↓, LDHA↓, HK2↓, PFKs↓, PDKs↓, ECAR↓, OXPHOS↓, GRP78↑, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, FGF↓, PDGF↓, EGFR↓,
- some indication of inhibiting Cancer Stem Cells : CSC↓, CK2↓, Hh↓, CD24↓, β-catenin↓, Notch2↓,
- Others: PI3K↓, AKT↓, JAK↓, STAT↓, Wnt↓, β-catenin↓, AMPK, α↓, ERK↓, JNK, - SREBP (related to cholesterol).
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,

- Selectivity: Cancer Cells vs Normal Cells

Rank Pathway / Axis Cancer Cells Normal Cells Label Primary Interpretation Notes
1 Reactive oxygen species (ROS) ↑ ROS (dose-, metal-, context-dependent) ↓ ROS Conditional Driver Biphasic redox modulation Quercetin exhibits pro-oxidant behavior in cancer cells while protecting normal cells
2 Mitochondrial integrity / intrinsic apoptosis ↓ ΔΨm; ↑ caspase activation ↔ preserved Driver Execution of intrinsic apoptosis Mitochondrial dysfunction is a central apoptosis route in cancer cells
3 PI3K → AKT → mTOR axis ↓ AKT / ↓ mTOR ↔ adaptive suppression Driver Growth and survival inhibition AKT/mTOR suppression is a consistently reported upstream effect in cancer models
4 NF-κB signaling ↓ NF-κB activation ↓ inflammatory NF-κB tone Secondary Reduced survival and inflammatory transcription NF-κB inhibition contributes to chemosensitization and apoptosis susceptibility
5 MAPK signaling (JNK / p38) ↑ JNK / ↑ p38 ↔ minimal Secondary Stress-mediated apoptosis signaling MAPK activation supports apoptosis downstream of redox stress
6 Cell cycle regulation ↑ G1/S or G2/M arrest ↔ largely spared Phenotypic Cytostatic growth control Cell-cycle arrest reflects disruption of growth signaling
7 HIF-1α hypoxia signaling ↓ HIF-1α ↔ minimal Secondary Reduced hypoxia tolerance Quercetin interferes with hypoxia-driven transcriptional programs
8 NRF2 antioxidant response ↑ NRF2 (adaptive, context-dependent) ↑ NRF2 (protective) Adaptive Stress compensation NRF2 induction reflects redox buffering rather than primary cytotoxicity


Scientific Papers found: Click to Expand⟱
380- AgNPs,  QC,  CA,  Chit,    Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
- in-vitro, MG, U118MG
"highlight2" >TumCG↓,
6- Ba,  Api,  QC,    Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer
- in-vitro, Pca, PC3
"highlight2" >HH↓, "highlight2" >Gli1↓,
3633- BBR,  LT,  Cro,  QC,    Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy
- Review, AD, NA
"highlight2" >*AChE↓, "highlight2" >*AChE↓,
5643- BCA,  GEN,  QC,  SIL,  KaempF  P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review
- in-vitro, NA, NA
"highlight2" >P-gp↓,
5753- CA,  QC,  MEL,    Effects of Caffeic Acid and Quercetin on In Vitro Permeability, Metabolism and In Vivo Pharmacokinetics of Melatonin in Rats: Potential for Herb-Drug Interaction
- in-vivo, Colon, Caco-2
"highlight2" >BioAv↑, "highlight2" >CYP1A1↓,
6027- CGA,  CUR,  EGCG,  QC,  RES  Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol
- Review, Nor, NA
"highlight2" >*ROS↓, "highlight2" >ROS↑,
24- EGCG,  GEN,  QC,    Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin
- in-vitro, Pca, 22Rv1
"highlight2" >NQO1↑, "highlight2" >P53↑, "highlight2" >NQO2↑, "highlight2" >chemoPv↑, "highlight2" >TumCP↓, "highlight2" >AR↓,
25- EGCG,  QC,    Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
"highlight2" >COMT↓, "highlight2" >TumCP↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
"highlight2" >BAD↓, "highlight2" >cl‑PARP↑, "highlight2" >Casp7↑, "highlight2" >IκB↓, "highlight2" >Ki-67↓, "highlight2" >VEGF↓, "highlight2" >EGFR↓, "highlight2" >FGF↓, "highlight2" >TGF-β↓, "highlight2" >TNF-α↓, "highlight2" >SCF↓, "highlight2" >Bax:Bcl2↑, "highlight2" >NF-kB↓, "highlight2" >chemoP↑, "highlight2" >ChemoSen↑, "highlight2" >TumVol↓,
2458- EGCG,  QC,    Identification of plant-based hexokinase 2 inhibitors: combined molecular docking and dynamics simulation studies
- Analysis, Nor, NA
"highlight2" >HK2↓,
2642- Flav,  QC,  Api,  KaempF,  MCT  In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type
- in-vitro, Nor, NA - in-vivo, Nor, NA
"highlight2" >*BioAv↑, "highlight2" >*eff↝, "highlight2" >BioEnh↑,
4687- LT,  QC,    Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells
- in-vitro, Pca, DU145
"highlight2" >CSCs↓, "highlight2" >EMT↓, "highlight2" >MMPs↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓,
1997- Myr,  QC,    Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity
- in-vitro, Lung, A549
"highlight2" >TrxR↓, "highlight2" >eff↑, "highlight2" >TumCCA↑, "highlight2" >eff↓, "highlight2" >ROS↑,
981- NarG,  QC,    Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer
- in-vivo, NA, NA
"highlight2" >TumVol↓, "highlight2" >CYP19↓,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
"highlight2" >tumCV↓, "highlight2" >Apoptosis↑, "highlight2" >PI3k/Akt/mTOR↓, "highlight2" >Wnt/(β-catenin)↓, "highlight2" >MAPK↝, "highlight2" >ERK↝, "highlight2" >TumCCA↑, "highlight2" >H2O2↑, "highlight2" >ROS↑, "highlight2" >TumAuto↑, "highlight2" >MMPs↓, "highlight2" >P53↑, "highlight2" >Casp3↑, "highlight2" >Hif1a↓, "highlight2" >cFLIP↓, "highlight2" >IL6↓, "highlight2" >IL10↓, "highlight2" >lactateProd↓, "highlight2" >Glycolysis↓, "highlight2" >PKM2↓, "highlight2" >GLUT1↓, "highlight2" >COX2↓, "highlight2" >VEGF↓, "highlight2" >OCR↓, "highlight2" >ECAR↓, "highlight2" >STAT3↓, "highlight2" >MMP2↓, "highlight2" >MMP9:TIMP1↓, "highlight2" >mTOR↓,
911- QC,  SFN,    Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial
"highlight2" >TumCG↓, "highlight2" >Risk↓,
909- QC,    Exploring the therapeutic potential of quercetin in cancer treatment: Targeting long non-coding RNAs
- Review, NA, NA
"highlight2" >other↓, "highlight2" >other↑,
908- QC,    Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update
- Review, NA, NA
"highlight2" >AntiCan↑, "highlight2" >ROS↑,
907- QC,    A Comprehensive Study on the Anti-cancer Effects of Quercetin and Its Epigenetic Modifications in Arresting Progression of Colon Cancer Cell Proliferation
- Review, NA, NA
"highlight2" >AntiCan↑,
906- QC,    The interplay between reactive oxygen species and antioxidants in cancer progression and therapy: a narrative review
- Review, NA, NA
"highlight2" >ROS↑,
905- QC,    Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation. Quercetin as an effective antioxidant against pro-oxidant effects of urate
- Analysis, NA, NA
"highlight2" >ROS↑,
904- QC,    Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase
- Analysis, NA, NA
"highlight2" >ROS↑, "highlight2" >H2O2↑,
903- QC,    Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow
- in-vivo, NA, NA
"highlight2" >ROS⇅,
902- QC,    Prooxidant activities of quercetin, p-courmaric acid and their derivatives analysed by quantitative structure–activity relationship
- Analysis, NA, NA
"highlight2" >ROS↑,
901- QC,    Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2
- Analysis, Var, NA
"highlight2" >ROS↑,
900- QC,    Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
- in-vivo, Nor, NA
"highlight2" >*Weight↓, "highlight2" >*TAC∅, "highlight2" >*ROS↑,
99- QC,    Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1
- in-vitro, Pca, PC3
"highlight2" >EMT↓, "highlight2" >E-cadherin↑, "highlight2" >N-cadherin↓, "highlight2" >Ki-67↓, "highlight2" >PI3K/Akt↓, "highlight2" >MALAT1↓, "highlight2" >TumCG↓,
912- QC,  2DG,    Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities
"highlight2" >Apoptosis↑, "highlight2" >ROS↓, "highlight2" >GSH∅, "highlight2" >other↑,
899- QC,    Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites
- in-vivo, Var, NA
"highlight2" >ROS↑, "highlight2" >GSH↓,
898- QC,    Anti- and pro-oxidant activity of rutin and quercetin derivatives
- Analysis, Var, NA
"highlight2" >ROS↑,
897- QC,    Anti- and prooxidant effects of chronic quercetin administration in rats
- in-vivo, Nor, NA
"highlight2" >*MDA↓, "highlight2" >*GSH⇅, "highlight2" >*ROS⇅,
896- QC,    Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin: Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA
- in-vivo, Var, NA
"highlight2" >ROS↑,
895- QC,    Theoretical Study of the Antioxidant Activity of Quercetin Oxidation Products
- Analysis, Var, NA
"highlight2" >ROS⇅,
894- QC,    The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis
- in-vitro, Nor, NA
"highlight2" >Apoptosis↑, "highlight2" >*NF-kB↓, "highlight2" >*AP-1↓, "highlight2" >*P53↝, "highlight2" >*ROS↓,
893- QC,    Quercetin: Prooxidant Effect and Apoptosis in Cancer
- Analysis, Var, NA
"highlight2" >ROS↑,
892- QC,    Antioxidant vs. pro-oxidant activities of quercetin in aqueous phase: A Density Functional Theory study
- Analysis, Var, NA
"highlight2" >ROS↑,
891- QC,    Chapter 9 - Quercetin: Prooxidant Effect and Apoptosis in Cancer
- in-vitro, Var, NA
"highlight2" >ROS↑, "highlight2" >AntiTum↑,
890- QC,    PROOXIDANT ACTIVITIES OF ANTIOXIDANTS AND THEIR IMPACT ON HEALTH
- Review, Var, NA
"highlight2" >ROS↑,
889- QC,    The multifaceted role of quercetin derived from its mitochondrial mechanism
- vitro+vivo, Var, NA
"highlight2" >MMP↓, "highlight2" >ATP↝, "highlight2" >OXPHOS↝, "highlight2" >ROS↑,
873- QC,  RES,  CUR,  PI,    Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal Absorption
- in-vitro, Nor, NA
"highlight2" >*BioEnh↑,
138- QC,  CUR,    Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >DNMTs↓, "highlight2" >AR↑, "highlight2" >MMP↓,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
"highlight2" >cycD1/CCND1↓, "highlight2" >cycE/CCNE↓, "highlight2" >CDK2↓, "highlight2" >CDK4/6↓, "highlight2" >E2Fs↓, "highlight2" >PCNA↓, "highlight2" >cDC2↓, "highlight2" >PTEN↑, "highlight2" >MSH2↑, "highlight2" >P21↑, "highlight2" >EP300↑, "highlight2" >BRCA1↑, "highlight2" >NF2↑, "highlight2" >TSC1↑, "highlight2" >TGFβR1↑, "highlight2" >P53↑, "highlight2" >RB1↑, "highlight2" >AKT1↓, "highlight2" >cMyc↓, "highlight2" >CDC7↓, "highlight2" >cycF↓, "highlight2" >CDC16↓, "highlight2" >CUL4B↑, "highlight2" >CBP↑, "highlight2" >TSC2↑, "highlight2" >HER2/EBBR2↓, "highlight2" >BCR↓, "highlight2" >TumCCA↑, "highlight2" >chemoPv↑,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
"highlight2" >*antiOx↑, "highlight2" >*GSH↑, "highlight2" >*ROS↓, "highlight2" >*Dose↑, "highlight2" >*NADPH↓, "highlight2" >*AMP↓, "highlight2" >*NF-kB↓, "highlight2" >*p38↑, "highlight2" >*MAPK↑, "highlight2" >*SOD↑, "highlight2" >*MDA↓, "highlight2" >*iNOS↓, "highlight2" >*Catalase↑, "highlight2" >*PI3K↑, "highlight2" >*Akt↑, "highlight2" >*lipid-P↓, "highlight2" >*memory↑, "highlight2" >*radioP↑, "highlight2" >*neuroP↑, "highlight2" >*MDA↓,
1493- QC,    New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer
- NA, Bladder, NA
"highlight2" >RadioS↑, "highlight2" >ChemoSen↑,
3337- QC,    Endoplasmic Reticulum Stress-Relieving Effect of Quercetin in Thapsigargin-Treated Hepatocytes
- in-vitro, NA, HepG2
"highlight2" >*Inflam↓, "highlight2" >*UPR↓, "highlight2" >*GRP58↓, "highlight2" >*XBP-1↓, "highlight2" >*ER Stress↓, "highlight2" >*antiOx↑, "highlight2" >TNF-α↓, "highlight2" >p‑eIF2α↓, "highlight2" >p‑IRE1↓, "highlight2" >p‑JNK↓, "highlight2" >CHOP↓,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*lipid-P↓, "highlight2" >*antiOx↑, "highlight2" >*Aβ↓, "highlight2" >*Inflam↓, "highlight2" >*BBB↝, "highlight2" >*NF-kB↓, "highlight2" >*iNOS↓, "highlight2" >*memory↑, "highlight2" >*cognitive↑, "highlight2" >*AChE↓, "highlight2" >*MMP↑, "highlight2" >*ROS↓, "highlight2" >*ATP↑, "highlight2" >*AMPK↑, "highlight2" >*NADPH↓, "highlight2" >*p‑tau↓,
3335- QC,    Recent advances on the improvement of quercetin bioavailability
- Review, NA, NA
"highlight2" >*BioAv↓,
3334- QC,    Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans
- Trial, Nor, NA
"highlight2" >*Half-Life↑,
2431- QC,    The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells
- in-vitro, Nor, TM4
"highlight2" >*Apoptosis↓, "highlight2" >*ROS↓, "highlight2" >*antiOx↓, "highlight2" >*MMP↑, "highlight2" >*GPI↑, "highlight2" >*HK2↑, "highlight2" >*ALDOA↑, "highlight2" >*PKM1↑, "highlight2" >*LDHA↑, "highlight2" >*PFKL↑,
2344- QC,    Quercetin: A natural solution with the potential to combat liver fibrosis
- Review, Nor, NA
"highlight2" >*HK2↓, "highlight2" >*PFKP↓, "highlight2" >*PKM2↓, "highlight2" >*hepatoP↑, "highlight2" >*ALAT↓, "highlight2" >*AST↓, "highlight2" >*Glycolysis↓, "highlight2" >*lactateProd↓, "highlight2" >*GlucoseCon↓, "highlight2" >*CXCL1↓, "highlight2" >*Inflam↓,

Showing Research Papers: 1 to 50 of 214
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 214

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CYP1A1↓, 1,   GSH↓, 1,   GSH∅, 1,   H2O2↑, 2,   NQO1↑, 1,   OXPHOS↝, 1,   ROS↓, 1,   ROS↑, 17,   ROS⇅, 2,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↝, 1,   BCR↓, 1,   CDC16↓, 1,   MMP↓, 2,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   cMyc↓, 1,   ECAR↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 4,   BAD↓, 1,   Bax:Bcl2↑, 1,   Casp3↑, 1,   Casp7↑, 1,   CBP↑, 1,   cFLIP↓, 1,   p‑JNK↓, 1,   MAPK↝, 1,  

Kinase & Signal Transduction ⓘ

CDC7↓, 1,   HER2/EBBR2↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   p‑eIF2α↓, 1,   p‑IRE1↓, 1,   NQO2↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   DNMTs↓, 1,   P53↑, 3,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   cycF↓, 1,   E2Fs↓, 1,   P21↑, 1,   RB1↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

cDC2↓, 1,   CSCs↓, 1,   EMT↓, 2,   EP300↑, 1,   ERK↝, 1,   FGF↓, 1,   Gli1↓, 1,   HH↓, 1,   mTOR↓, 1,   NF2↑, 1,   PTEN↑, 1,   SCF↓, 1,   STAT3↓, 1,   TumCG↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

CDK4/6↓, 1,   E-cadherin↑, 1,   Ki-67↓, 2,   MALAT1↓, 1,   MMP2↓, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 2,   MSH2↑, 1,   N-cadherin↓, 1,   TGF-β↓, 1,   TSC1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumCP↑, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↓, 1,   IL6↓, 1,   IκB↓, 1,   NF-kB↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   AR↑, 1,   COMT↓, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 2,   eff↓, 1,   eff↑, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   AR↑, 1,   BRCA1↑, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   Risk↓, 1,   TGFβR1↑, 1,   TumVol↓, 2,  
Total Targets: 123

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 1,   GSH↑, 1,   GSH⇅, 1,   lipid-P↓, 2,   MDA↓, 3,   ROS↓, 5,   ROS↑, 1,   ROS⇅, 1,   SOD↑, 1,   TAC∅, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   ALDOA↑, 1,   AMP↓, 1,   AMPK↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   GPI↑, 1,   HK2↓, 1,   HK2↑, 1,   lactateProd↓, 1,   LDHA↑, 1,   NADPH↓, 2,   PFKL↑, 1,   PFKP↓, 1,   PKM1↑, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,   GRP58↓, 1,   iNOS↓, 2,   MAPK↑, 1,   p38↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   UPR↓, 1,   XBP-1↓, 1,  

DNA Damage & Repair ⓘ

P53↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Migration ⓘ

AP-1↓, 1,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

CXCL1↓, 1,   Inflam↓, 3,   NF-kB↓, 3,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   Dose↑, 1,   eff↝, 1,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   hepatoP↑, 1,   memory↑, 2,   neuroP↑, 2,   radioP↑, 1,   Weight↓, 1,  
Total Targets: 63

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:140  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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