Database Query Results : Curcumin, ,

CUR, Curcumin: Click to Expand ⟱
Features:
Curcumin is the main active ingredient in Tumeric. Member of the ginger family.Curcumin is a polyphenol extracted from turmeric with anti-inflammatory and antioxidant properties.
- Has iron-chelating, iron-chelating properties. Ferritin. But still known to increase Iron in Cancer cells.
- GSH depletion in cancer cells, exhaustion of the antioxidant defense system. But still raises GSH↑ in normal cells.
- Higher concentrations (5-10 μM) of curcumin induce autophagy and ROS production
- Inhibition of TrxR, shifting the enzyme from an antioxidant to a prooxidant
- Strong inhibitor of Glo-I, , causes depletion of cellular ATP and GSH
- Curcumin has been found to act as an activator of Nrf2, (maybe bad in cancer cells?), hence could be combined with Nrf2 knockdown
-may suppress CSC: suppresses self-renewal and pathways (Wnt/Notch/Hedgehog).
Clinical studies testing curcumin in cancer patients have used a range of dosages, often between 500 mg and 8 g per day; however, many studies note that doses on the lower end may not achieve sufficient plasma concentrations for a therapeutic anticancer effect in humans.
• Formulations designed to improve curcumin absorption (like curcumin combined with piperine, nanoparticle formulations, or liposomal curcumin) are often employed in clinical trials to enhance its bioavailability.

-Note half-life 6 hrs.
BioAv is poor, use piperine or other enhancers
Pathways:
- induce ROS production at high concentration. Lowers ROS at lower concentrations
curcumin can act as a pro-oxidant when blue light is applied
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, UPR↑, GRP78↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓
- Lowers AntiOxidant defense in Cancer Cells: GSH↓ Catalase↓ HO1↓ GPx↓
but conversely is known as a NRF2↑ activator in cancer
- Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, uPA↓, VEGF↓, NF-κB↓, CXCR4↓, SDF1↓, TGF-β↓, α-SMA↓, ERK↓
- reactivate genes thereby inhibiting cancer cell growth : HDAC↓, DNMT1↓, DNMT3A↓, EZH2↓, P53↑, HSP↓, Sp proteins↓,
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, CDK2↓, CDK4↓, CDK6↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, ERK↓, EMT↓, TOP1↓, TET1↓,
- inhibits glycolysis /Warburg Effect and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDHA↓, HK2↓, PFKs↓, PDKs↓, HK2↓, ECAR↓, OXPHOS↓, GRP78↑, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, FGF↓, PDGF↓, EGFR↓, Integrins↓,
- inhibits Cancer Stem Cells : CSC↓, CK2↓, Hh↓, GLi1↓, CD133↓, CD24↓, β-catenin↓, n-myc↓, sox2↓, OCT4↓,
- Others: PI3K↓, AKT↓, JAK↓, STAT↓, Wnt↓, β-catenin↓, AMPK↓, ERK↓, JNK, TrxR**,
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,

- Selectivity: Cancer Cells vs Normal Cells


Scientific Papers found: Click to Expand⟱
147- AG,  EGCG,  CUR,    Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, MCF-7
"highlight2" >Bax:Bcl2↑, "highlight2" >NF-kB↓, "highlight2" >PI3K/Akt↓, "highlight2" >STAT3↓,
3446- ALA,  CUR,    The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
- in-vivo, Nor, NA
"highlight2" >*hepatoP↑, "highlight2" >*α-SMA↓, "highlight2" >*COL3A1↓, "highlight2" >*ROS↓, "highlight2" >*GSH↑, "highlight2" >*ALAT↓, "highlight2" >*AST↓, "highlight2" >*ALP↓, "highlight2" >*MDA↓,
2635- Api,  CUR,    Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells
- in-vitro, Cerv, HeLa
"highlight2" >TumCD↑, "highlight2" >eff↑, "highlight2" >TumAuto↑, "highlight2" >ER Stress↑, "highlight2" >Paraptosis↑, "highlight2" >GRP78/BiP↓, "highlight2" >Dose↝,
1024- Api,  CUR,    Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects
- vitro+vivo, Melanoma, A375 - in-vitro, Melanoma, A2058 - in-vitro, Melanoma, RPMI-7951
"highlight2" >TumCG↓, "highlight2" >Apoptosis↑, "highlight2" >PD-L1↓, "highlight2" >STAT1↓, "highlight2" >tumCV↓, "highlight2" >T-Cell↑,
2703- BBR,  CUR,  SFN,  UA,  GamB  Naturally occurring anti-cancer agents targeting EZH2
- Review, Var, NA
"highlight2" >EZH2↓,
3754- BBR,  CUR,  EGCG,  Hup,    Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review
"highlight2" >*AChE↓, "highlight2" >*Aβ↓, "highlight2" >*LDL↓, "highlight2" >*RenoP↑, "highlight2" >*BChE↓, "highlight2" >*eff↑, "highlight2" >*BACE↓, "highlight2" >*AChE↓, "highlight2" >*eff↑,
3514- Bor,  CUR,    Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta
- in-vivo, AD, NA
"highlight2" >*DNAdam↓, "highlight2" >*MDA↓, "highlight2" >*AChE↓, "highlight2" >*neuroP↑, "highlight2" >*ROS↓, "highlight2" >*NO↓,
1426- Bos,  CUR,  Chemo,    Novel evidence for curcumin and boswellic acid induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer
- in-vivo, CRC, NA - in-vitro, CRC, HCT116 - in-vitro, CRC, RKO - in-vitro, CRC, SW480 - in-vitro, RCC, SW-620 - in-vitro, RCC, HT-29 - in-vitro, CRC, Caco-2
"highlight2" >miR-34a↑, "highlight2" >miR-27a-3p↓, "highlight2" >TumCG↓, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >PARP1↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >cMyc↓, "highlight2" >CDK4↓, "highlight2" >CDK6↓, "highlight2" >cycD1/CCND1↓, "highlight2" >ChemoSen↑, "highlight2" >miR-34a↑, "highlight2" >miR-27a-3p↓,
145- CA,  CUR,    The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity
- in-vitro, NA, NA
"highlight2" >AR↓, "highlight2" >ARE/EpRE↑,
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
"highlight2" >AntiCan↑, "highlight2" >TumCG↓, "highlight2" >angioG↓, "highlight2" >TumMeta↓, "highlight2" >BioAv↓, "highlight2" >BioAv↓, "highlight2" >BioAv↑, "highlight2" >selectivity↑, "highlight2" >EPR↑, "highlight2" >eff↓, "highlight2" >ChemoSen↑, "highlight2" >Dose∅, "highlight2" >Half-Life∅, "highlight2" >eff↑,
428- Chit,  docx,  CUR,    Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, H1299 - vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
"highlight2" >MDSCs↓, "highlight2" >TregCell↓, "highlight2" >IL10↓, "highlight2" >NK cell↑,
3628- Croc,  VitE,  CUR,    Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease
- Review, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*lipid-P↓, "highlight2" >*Aβ↓, "highlight2" >*AChE↓, "highlight2" >*cognitive↑, "highlight2" >*Inflam↓,
4650- CUR,    Curcumin and cancer stem cells: curcumin has asymmetrical effects on cancer and normal stem cells
- Review, Var, NA
"highlight2" >SCD1↓, "highlight2" >IL6↓, "highlight2" >IL8↓, "highlight2" >IL1↓, "highlight2" >*selectivity↑, "highlight2" >Wnt↝, "highlight2" >NOTCH↝, "highlight2" >HH↝, "highlight2" >FAK↝,
3752- CUR,    Revealing the molecular interplay of curcumin as Culex pipiens Acetylcholine esterase 1 (AChE1) inhibitor
- in-vivo, AD, NA
"highlight2" >*AChE↓,
4337- CUR,    Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling
- in-vitro, NA, NA
"highlight2" >*AntiAg↑, "highlight2" >*TXA2↓,
4176- CUR,    Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling
- in-vivo, AD, NA
"highlight2" >*BDNF↑, "highlight2" >*CREB↑,
4175- CUR,    Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress
- in-vivo, NA, NA
"highlight2" >*BDNF↑, "highlight2" >*ERK↑,
4171- CUR,    Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons
- in-vivo, NA, NA
"highlight2" >*BDNF↑, "highlight2" >*TrkB↑, "highlight2" >*CREB↑, "highlight2" >*Mood↑, "highlight2" >*neuroP↑,
3862- CUR,  RES,    The metalloproteinase ADAM10: A useful therapeutic target?
- Review, AD, NA
"highlight2" >*SIRT1↑, "highlight2" >*ADAM10↑,
3861- CUR,    Curcumin as a novel therapeutic candidate for cancer: can this natural compound revolutionize cancer treatment?
- Review, Var, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >NF-kB↓, "highlight2" >HH↓, "highlight2" >NOTCH↓, "highlight2" >JAK↓, "highlight2" >STAT3↓, "highlight2" >ADAM10↓,
3860- CUR,    Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice
- in-vivo, AD, NA
"highlight2" >*Aβ↓, "highlight2" >*BACE↓, "highlight2" >*memory↑,
3857- CUR,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*IronCh↑, "highlight2" >*BBB↑, "highlight2" >*ADAM10↝,
3856- CUR,    Curcumin induces IL-6 receptor shedding via the ADAM10 proteinase
- in-vitro, AD, NA
"highlight2" >*ADAM10↑, "highlight2" >*Inflam↓,
3831- CUR,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*ROS↓, "highlight2" >*Ca+2↓, "highlight2" >*MMP↑,
3797- CUR,    Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice
- in-vitro, NA, NA
"highlight2" >*cognitive↑, "highlight2" >*BDNF↑, "highlight2" >*PSD95↑, "highlight2" >*memory↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*AntiAge↑, "highlight2" >*AMPK↑, "highlight2" >*SIRT1↑, "highlight2" >*NF-kB↓, "highlight2" >*mTOR↓, "highlight2" >*NLRP3↓, "highlight2" >*NADPH↓, "highlight2" >*ROS↓, "highlight2" >*COX2↓, "highlight2" >*MCP1↓, "highlight2" >*IL1β↓, "highlight2" >*IL17↓, "highlight2" >*IL23↓, "highlight2" >*TNF-α↓, "highlight2" >*MPO↓, "highlight2" >*IL10↑, "highlight2" >*lipid-P↓, "highlight2" >*SOD↑, "highlight2" >*Aβ↓, "highlight2" >*p‑tau↓, "highlight2" >*GSK‐3β↓, "highlight2" >*CDK5↓, "highlight2" >*TXNIP↓, "highlight2" >*NRF2↑, "highlight2" >*NQO1↑, "highlight2" >*HO-1↑, "highlight2" >*OS↑, "highlight2" >*memory↑, "highlight2" >*BDNF↑, "highlight2" >*neuroP↑, "highlight2" >*BACE↓, "highlight2" >*AChE↓, "highlight2" >*LDL↓,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
"highlight2" >*GSK‐3β↓, "highlight2" >*CDK5↓, "highlight2" >*p‑tau↓, "highlight2" >*IronCh↑, "highlight2" >*ROS↓, "highlight2" >*HO-1↑, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*GSH↑, "highlight2" >*TNF-α↓, "highlight2" >*IL6↓, "highlight2" >*IL12↓, "highlight2" >*NRF2↑, "highlight2" >*PPARγ↑, "highlight2" >*IL4↑, "highlight2" >*AChE↓, "highlight2" >*Dose↝, "highlight2" >*GutMicro↑,
3793- CUR,    Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer’s Disease Rats Abrogating Aβ40/42 and Tau Hyperphosphorylation
- in-vivo, AD, NA
"highlight2" >*Aβ↓, "highlight2" >*p‑tau↓, "highlight2" >*GSK‐3β↓, "highlight2" >*CDK5↓, "highlight2" >*memory↑,
3760- CUR,  GI,  CAP,  RosA,  PI  Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessment
"highlight2" >*AChE↓, "highlight2" >*other↓, "highlight2" >*other↓, "highlight2" >*other↓, "highlight2" >*other↓, "highlight2" >*other↓, "highlight2" >*other↓,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
"highlight2" >*ROS↓, "highlight2" >*SOD↑, "highlight2" >p16↑, "highlight2" >JAK2↓, "highlight2" >STAT3↓, "highlight2" >CXCL12↓, "highlight2" >IL6↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >TGF-β↓, "highlight2" >α-SMA↓, "highlight2" >LAMs↓, "highlight2" >DNAdam↑, "highlight2" >*memory↑, "highlight2" >*cognitive↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*NO↑, "highlight2" >*MDA↓, "highlight2" >*ROS↓, "highlight2" >DNMT1↓, "highlight2" >ROS↑, "highlight2" >Casp3↑, "highlight2" >Apoptosis↑, "highlight2" >miR-21↓, "highlight2" >LC3II↓, "highlight2" >ChemoSen↑, "highlight2" >NF-kB↓, "highlight2" >CSCs↓, "highlight2" >Nanog↓, "highlight2" >OCT4↓, "highlight2" >SOX2↓, "highlight2" >eff↑, "highlight2" >Sp1/3/4↓, "highlight2" >miR-27a-3p↓, "highlight2" >ZBTB10↑, "highlight2" >SOX9?, "highlight2" >ChemoSen↑, "highlight2" >VEGF↓, "highlight2" >XIAP↓, "highlight2" >Bcl-2↓, "highlight2" >cycD1/CCND1↓, "highlight2" >BioAv↑, "highlight2" >Hif1a↓, "highlight2" >EMT↓, "highlight2" >BioAv↓, "highlight2" >PTEN↑, "highlight2" >VEGF↓, "highlight2" >Akt↑, "highlight2" >EZH2↓, "highlight2" >NOTCH1↓, "highlight2" >TP53↑, "highlight2" >NQO1↑, "highlight2" >HO-1↑,
3753- CUR,  Gala,    A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study
- Study, AD, NA
"highlight2" >*BChE↓, "highlight2" >*AChE↓, "highlight2" >*Ach↑, "highlight2" >*cognitive↑, "highlight2" >*memory↑, "highlight2" >*ROS↓, "highlight2" >*Inflam↓, "highlight2" >*NF-kB↓, "highlight2" >*COX2?,
4676- CUR,    Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway
- vitro+vivo, Lung, H460
"highlight2" >CSCs↓, "highlight2" >JAK2↓, "highlight2" >STAT3↓, "highlight2" >TumCP↓, "highlight2" >TumCG↓,
4881- CUR,  SFN,  RES,  EGCG,  Lyco  An update of Nrf2 activators and inhibitors in cancer prevention/promotion
- Review, Var, NA
"highlight2" >*NRF2↑, "highlight2" >*antiOx↑,
4831- CUR,    The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity
- in-vitro, NA, NA
"highlight2" >*NRF2↑, "highlight2" >*P53↓, "highlight2" >*NF-kB↓, "highlight2" >ROS↑, "highlight2" >Inflam↓, "highlight2" >ChemoSen↑,
4830- CUR,    Curcumin and Its Derivatives Induce Apoptosis in Human Cancer Cells by Mobilizing and Redox Cycling Genomic Copper Ions
- in-vitro, Var, NA
"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >TumCG↓, "highlight2" >Apoptosis↑, "highlight2" >eff↓, "highlight2" >Fenton↑, "highlight2" >eff↑,
4829- CUR,    Dual Action of Curcumin as an Anti- and Pro-Oxidant from a Biophysical Perspective
- Review, Var, NA
"highlight2" >*antiOx↑, "highlight2" >ROS↑, "highlight2" >*lipid-P↓, "highlight2" >*iNOS↓, "highlight2" >*BioAv↓,
4828- CUR,    Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)
- Review, Var, NA
"highlight2" >*NF-kB↓, "highlight2" >ROS↑,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↑, "highlight2" >*ROS↓, "highlight2" >Apoptosis↑, "highlight2" >TumCP↓, "highlight2" >BioAv↓, "highlight2" >Half-Life↓, "highlight2" >eff↑, "highlight2" >TumCCA↑, "highlight2" >BAX↑, "highlight2" >Bak↑, "highlight2" >PUMA↑, "highlight2" >BIM↑, "highlight2" >NOXA↑, "highlight2" >TRAIL↑, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >survivin↓, "highlight2" >XIAP↓, "highlight2" >cMyc↓, "highlight2" >Casp↑, "highlight2" >NF-kB↓, "highlight2" >STAT3↓, "highlight2" >AP-1↓, "highlight2" >angioG↓, "highlight2" >TumMeta↑, "highlight2" >VEGF↓, "highlight2" >MMPs↓, "highlight2" >DNMTs↓, "highlight2" >HDAC↓, "highlight2" >ROS↑,
4710- CUR,    Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway
- in-vitro, Lung, A549
"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >miR-206↑, "highlight2" >p‑mTOR↓, "highlight2" >p‑Akt↓,
4709- CUR,    Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
- Review, Var, NA
"highlight2" >miR-21↓, "highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Apoptosis↑, "highlight2" >miR-99↑, "highlight2" >JAK↓, "highlight2" >STAT↓, "highlight2" >cycD1/CCND1↓, "highlight2" >P21↑, "highlight2" >ChemoSen↑, "highlight2" >miR-192-5p↑, "highlight2" >cMyc↓, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >miR-130a↓,
4708- CUR,    Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers
- Review, GC, NA
"highlight2" >chemoPv↑, "highlight2" >AntiCan↑, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >miR-21↓, "highlight2" >miR-34a↑, "highlight2" >miR-200b↑, "highlight2" >miR-27a-3p↓,
4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
"highlight2" >miR-497↑, "highlight2" >miR-200c↑, "highlight2" >miR-409-3p↑, "highlight2" >miR-34a↑, "highlight2" >miR-126↑, "highlight2" >miR-145↑, "highlight2" >miR-206↑, "highlight2" >miR-491↑, "highlight2" >miR-141↑, "highlight2" >miR-429↑, "highlight2" >miR-101↑, "highlight2" >miR-15↑, "highlight2" >miR-21↓, "highlight2" >miR-155↓, "highlight2" >miR-221↓, "highlight2" >miR‐222↓, "highlight2" >miR-17↓, "highlight2" >miR-130a↓, "highlight2" >miR-27a-3p↓, "highlight2" >miR-20↓,
4651- CUR,    Targeting cancer stem cells by curcumin and clinical applications
- Review, Var, NA
"highlight2" >CSCs↓, "highlight2" >*toxicity↓, "highlight2" >*BioAv↝, "highlight2" >chemoP↑,
4675- CUR,    Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines
- in-vitro, NSCLC, A549
"highlight2" >ChemoSen↑, "highlight2" >CSCs↓, "highlight2" >EpCAM↓, "highlight2" >TumCCA↓, "highlight2" >VEGF↓, "highlight2" >MMP9↓, "highlight2" >toxicity↓,
4674- CUR,    Curcumin Shows Promise in Targeting Colorectal Cancer Stem-like Cells: Mechanistic Insights and Clinical Implications
- Review, CRC, NA
"highlight2" >CSCs↓, "highlight2" >Nanog↓,
4673- CUR,    Curcumin and colorectal cancer: An update and current perspective on this natural medicine
- Review, CRC, NA
"highlight2" >AntiCan↑, "highlight2" >GutMicro↝,
4672- CUR,    An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes
- vitro+vivo, CRC, HCT116
"highlight2" >CSCs↓, "highlight2" >Nanog↓, "highlight2" >BioAv↓,
4671- CUR,    Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy
- in-vitro, CRC, NA
"highlight2" >CSCs↓, "highlight2" >TumCG↓, "highlight2" >ChemoSen↑, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >Shh↓, "highlight2" >NOTCH↓, "highlight2" >DNMT1↓, "highlight2" >STAT3↓, "highlight2" >NF-kB↓, "highlight2" >EGFR↓, "highlight2" >IGFR↓, "highlight2" >TumCCA↓, "highlight2" >cl‑PARP↑, "highlight2" >BAX↑, "highlight2" >ECM/TCF↓,
4656- CUR,  EGCG,    Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
"highlight2" >CSCs↓, "highlight2" >CD44↓, "highlight2" >p‑STAT3↓, "highlight2" >NF-kB↓, "highlight2" >TumCI↓,
4655- CUR,    Inhibition of Cancer Stem-like Cells by Curcumin and Other Polyphenol Derivatives in MDA-MB-231 TNBC Cells
- in-vitro, BC, NA
"highlight2" >CSCs↓, "highlight2" >*BioAv↓,
4654- CUR,    Stem Cell Therapy: Curcumin Does the Trick
- Review, Var, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >AntiCan↑, "highlight2" >chemoPv↑, "highlight2" >*AntiAge↑, "highlight2" >*neuroP↑, "highlight2" >*Wound Healing↑,
4653- CUR,    Curcumin: a promising agent targeting cancer stem cells
- Review, Var, NA
"highlight2" >CSCs↓,
4652- CUR,    Anticancer effect of curcumin on breast cancer and stem cells
- Review, BC, NA
"highlight2" >TumCP↓, "highlight2" >TumMeta↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >CSCs↓, "highlight2" >NF-kB↓, "highlight2" >Telomerase↓, "highlight2" >Cyt‑c↑, "highlight2" >Casp9↑, "highlight2" >Casp3↑, "highlight2" >E-cadherin↑,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*ROS↓, "highlight2" >*Inflam↓, "highlight2" >*Apoptosis↓, "highlight2" >*cognitive↑, "highlight2" >*cardioP↑, "highlight2" >other↑, "highlight2" >*COX2↓, "highlight2" >*IL1β↓, "highlight2" >*TNF-α↓, "highlight2" >NF-kB↓, "highlight2" >*PGE2↓, "highlight2" >*iNOS↓, "highlight2" >*NO↓, "highlight2" >*IL2↓, "highlight2" >*IL4↓, "highlight2" >*IL6↓, "highlight2" >*INF-γ↓, "highlight2" >*GSK‐3β↓, "highlight2" >*STAT↓, "highlight2" >*GSH↑, "highlight2" >*MDA↓, "highlight2" >*lipid-P↓, "highlight2" >*SOD↑, "highlight2" >*GPx↑, "highlight2" >*Catalase↑, "highlight2" >*GSR↓, "highlight2" >*LDH↓, "highlight2" >*H2O2↓, "highlight2" >*Casp3↓, "highlight2" >*Casp9↓, "highlight2" >*NRF2↑, "highlight2" >*AIF↓, "highlight2" >*ATP↑,
2978- CUR,    N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells
- in-vitro, Lung, A549
"highlight2" >ROS↑, "highlight2" >hTERT/TERT↓, "highlight2" >Sp1/3/4↓, "highlight2" >eff↓,
2977- CUR,    Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells
- in-vitro, CF, NA
"highlight2" >*TLR2↓, "highlight2" >*Sp1/3/4↓,
2976- CUR,    Curcumin suppresses the proliferation of oral squamous cell carcinoma through a specificity protein 1/nuclear factor‑κB‑dependent pathway
- in-vitro, Oral, HSC3 - in-vitro, HNSCC, CAL33
"highlight2" >tumCV↓, "highlight2" >Sp1/3/4↓, "highlight2" >p65↓, "highlight2" >HSF1↓, "highlight2" >NF-kB↓,
2975- CUR,    Curcumin inhibits proliferation, migration and neointimal formation of vascular smooth muscle via activating miR-22
- in-vivo, Nor, NA
"highlight2" >*miR-22↑, "highlight2" >*Sp1/3/4↓,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >TumCG↓, "highlight2" >TumMeta↓, "highlight2" >Sp1/3/4↓, "highlight2" >HDAC4↓, "highlight2" >FAK↓, "highlight2" >CD24↓, "highlight2" >E-cadherin↑, "highlight2" >EMT↓, "highlight2" >TumCP↓, "highlight2" >NF-kB↓, "highlight2" >AP-1↝, "highlight2" >STAT3↓, "highlight2" >P53?, "highlight2" >β-catenin/ZEB1↓, "highlight2" >NOTCH1↝, "highlight2" >Hif1a↝, "highlight2" >PPARα↝, "highlight2" >Rho↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓,
2823- CUR,    Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis
- Study, Nor, NA
"highlight2" >GLO-I↓,
2822- CUR,    Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies
- Analysis, Nor, NA
"highlight2" >GLO-I↓,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
"highlight2" >*antiOx↑, "highlight2" >*NRF2↑, "highlight2" >*ROS↓, "highlight2" >*Inflam↓, "highlight2" >ROS↑, "highlight2" >p‑ERK↑, "highlight2" >ER Stress↑, "highlight2" >mtDam↑, "highlight2" >Apoptosis↑, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >HO-1↑, "highlight2" >Fenton↑, "highlight2" >GSH↓, "highlight2" >Iron↑, "highlight2" >p‑JNK↑, "highlight2" >Cyt‑c↑, "highlight2" >ATF6↑, "highlight2" >CHOP↑,
2820- CUR,    Hepatoprotective Effect of Curcumin on Hepatocellular Carcinoma Through Autophagic and Apoptic Pathways
- in-vitro, HCC, HepG2
"highlight2" >*hepatoP↑, "highlight2" >*ROS↓, "highlight2" >tumCV↓,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
"highlight2" >*hepatoP↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*lipid-P↓, "highlight2" >*GSH↑, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*GPx↑, "highlight2" >*GSTs↑, "highlight2" >*ROS↓, "highlight2" >*ALAT↓, "highlight2" >*AST↓, "highlight2" >*MDA↓, "highlight2" >*NRF2↑, "highlight2" >*COX2↑, "highlight2" >*NF-kB↓, "highlight2" >*ICAM-1↓, "highlight2" >*MCP1↓, "highlight2" >*HO-1↑, "highlight2" >CXCc↓,
3750- CUR,  PI,    Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro Assay
- in-vitro, AD, SH-SY5Y
"highlight2" >*AChE↓, "highlight2" >*neuroP↑,
2817- CUR,    Neuroprotection by curcumin: A review on brain delivery strategies
- Review, Nor, NA
"highlight2" >*BioAv↝, "highlight2" >neuroP↑,
2816- CUR,    NEUROPROTECTIVE EFFECTS OF CURCUMIN
- Review, AD, NA - Review, Park, NA
"highlight2" >*neuroP↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*BioAv↓, "highlight2" >*AP-1↓, "highlight2" >*NF-kB↓, "highlight2" >*HATs↓, "highlight2" >*HDAC↑, "highlight2" >Dose↑, "highlight2" >*ROS↓, "highlight2" >*cognitive↑, "highlight2" >*Aβ↓,
2815- CUR,    Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin
"highlight2" >*CK2↑,
2814- CUR,    Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management
- Review, Var, NA
"highlight2" >*BioAv↓, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >AntiCan↑, "highlight2" >CK2↓, "highlight2" >GSK‐3β↓, "highlight2" >EGFR↓, "highlight2" >TOP1↓, "highlight2" >TOP2↓, "highlight2" >NF-kB↓, "highlight2" >COX2↓, "highlight2" >CRP↓,
2813- CUR,    Oxidative Metabolites of Curcumin Poison Human Type II Topoisomerases
- Review, NA, NA
"highlight2" >TOP2↑,
2812- CUR,    Curcumin Induces High Levels of Topoisomerase I− and II−DNA Complexes in K562 Leukemia Cells
- in-vitro, AML, K562
"highlight2" >TOP1↑, "highlight2" >TOP2↑, "highlight2" >eff↓,
2811- CUR,    Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study
- Human, Pca, NA
"highlight2" >*antiOx↑, "highlight2" >radioP↑, "highlight2" >RadioS∅, "highlight2" >*TAC↑, "highlight2" >*SOD↓,
2810- CUR,    Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials
- Review, Nor, NA
"highlight2" >*SOD↑, "highlight2" >*lipid-P↓, "highlight2" >*GSH↑, "highlight2" >*Catalase↑, "highlight2" >*ROS↓,
2809- CUR,    Comparative absorption of curcumin formulations
- in-vivo, Nor, NA
"highlight2" >BioAv↑, "highlight2" >BioAv↑, "highlight2" >BioAv↑, "highlight2" >BioAv↑, "highlight2" >BioAv↑, "highlight2" >BioAv↓, "highlight2" >Half-Life↝,
2808- CUR,    Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
- in-vitro, Liver, HUH7
"highlight2" >Ferritin↓, "highlight2" >IronCh↑, "highlight2" >TumAuto↑, "highlight2" >Apoptosis↑, "highlight2" >eff↝, "highlight2" >Dose↝,
2980- CUR,    Inhibition of NF B and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation
- in-vivo, PC, NA
"highlight2" >TumCG↓, "highlight2" >p50↓, "highlight2" >p65↓, "highlight2" >NF-kB↓, "highlight2" >Sp1/3/4↓, "highlight2" >MMP↓, "highlight2" >ROS↑,
3751- CUR,  Gala,    A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders
- in-vivo, AD, NA
"highlight2" >*AChE↓, "highlight2" >*MDA↑, "highlight2" >*GSH↑, "highlight2" >*BBB↑,
3748- CUR,  RES,  Hup,  Riv,  Gala  Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease
- Review, AD, NA
"highlight2" >*AChE↓, "highlight2" >*Inflam↓, "highlight2" >*Aβ↓, "highlight2" >*cognitive↑, "highlight2" >*ROS↓,
3590- CUR,    The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern?
- Review, Var, NA - Review, AD, NA
"highlight2" >*BioAv↓, "highlight2" >*BioAv↑, "highlight2" >Dose↑, "highlight2" >*Dose↝, "highlight2" >*BBB↑, "highlight2" >*cognitive↑, "highlight2" >*BioAv↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
"highlight2" >*cognitive↝, "highlight2" >*BioAv↑, "highlight2" >*Inflam↓, "highlight2" >*COX2↓, "highlight2" >*iNOS↓, "highlight2" >*NF-kB↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1↓, "highlight2" >*IL2↓, "highlight2" >*IL6↓, "highlight2" >*IL8↓, "highlight2" >*IL12↓, "highlight2" >*ROS↓, "highlight2" >*RNS↓, "highlight2" >*antiOx↑, "highlight2" >*BBB↑, "highlight2" >*BioAv↓, "highlight2" >*cognitive↑, "highlight2" >*memory↑, "highlight2" >*tau↓, "highlight2" >*eff↑,
3586- CUR,  PI,    Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
- in-vivo, NA, NA
"highlight2" >*BioAv↑,
3585- CUR,    Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer
- Study, NA, NA
"highlight2" >*BioAv↑,
3584- CUR,    Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids
"highlight2" >*AChE↓, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*Aβ↓, "highlight2" >*ROS↓,
3583- CUR,    Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
- Review, Arthritis, NA
"highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*NF-kB↓, "highlight2" >*PGE2↓, "highlight2" >*COX2↓, "highlight2" >*MMPs↓, "highlight2" >*eff↑,
3582- CUR,  PI,    Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells
"highlight2" >*eff↑, "highlight2" >*IL6↓, "highlight2" >*TGF-β↓, "highlight2" >*BioAv↑,
3581- CUR,    Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease
- NA, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*BBB↑, "highlight2" >*NRF2↑, "highlight2" >*NF-kB↓, "highlight2" >*cognitive↑, "highlight2" >*ROS↓, "highlight2" >*MDA↓, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*INF-γ↓, "highlight2" >*IL4↓, "highlight2" >*memory↑, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓,
3580- CUR,    Curcumin Acts as Post-protective Effects on Rat Hippocampal Synaptosomes in a Neuronal Model of Aluminum-Induced Toxicity
- in-vivo, AD, NA
"highlight2" >*ROS↓, "highlight2" >*Cyt‑c↓, "highlight2" >*Casp3↓, "highlight2" >*neuroP↑,
3579- CUR,  SNP,    Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin
- Review, NA, NA
"highlight2" >*IronCh↑, "highlight2" >*BioAv↑, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*BioAv↑, "highlight2" >ROS↑, "highlight2" >*neuroP↑, "highlight2" >*eff↑,
3578- CUR,  SIL,    Curcumin, but not its degradation products, in combination with silibinin is primarily responsible for the inhibition of colon cancer cell proliferation
- in-vitro, CRC, DLD1
"highlight2" >eff↑, "highlight2" >BioAv↓, "highlight2" >TumCG↓,
3577- CUR,    Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
- Trial, AD, NA
"highlight2" >*cognitive∅, "highlight2" >*BioAv↑,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*memory↑, "highlight2" >*Aβ↓, "highlight2" >*BBB↑, "highlight2" >*cognitive↑, "highlight2" >*tau↓, "highlight2" >*LDL↓, "highlight2" >*AChE↓, "highlight2" >*IL1β↓, "highlight2" >*IronCh↑, "highlight2" >*neuroP↑, "highlight2" >*BioAv↝, "highlight2" >*PI3K↑, "highlight2" >*Akt↑, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*Ferritin↑, "highlight2" >*HO-2↓, "highlight2" >*ROS↓, "highlight2" >*Ach↑, "highlight2" >*GSH↑, "highlight2" >*Bcl-2↑, "highlight2" >*ChAT↑,
3575- CUR,    The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
- in-vivo, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*IL1β↓, "highlight2" >*Aβ↓, "highlight2" >*Inflam↓, "highlight2" >*toxicity↓,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*lipid-P↓, "highlight2" >*cognitive↑, "highlight2" >*memory↑, "highlight2" >*Aβ↓, "highlight2" >*COX2↓, "highlight2" >*ROS↓, "highlight2" >*AP-1↓, "highlight2" >*NF-kB↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*SOD↑, "highlight2" >*GSH↑, "highlight2" >*HO-1↑, "highlight2" >*IronCh↑, "highlight2" >*BioAv↓, "highlight2" >*Half-Life↝, "highlight2" >*Dose↝, "highlight2" >*BBB↑, "highlight2" >*BioAv↑, "highlight2" >*toxicity∅, "highlight2" >*eff↑,
2979- CUR,  GB,    Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death
- in-vitro, Lung, H157 - in-vitro, Lung, H1299
"highlight2" >EGFR↓, "highlight2" >Sp1/3/4↓, "highlight2" >ERK↓, "highlight2" >MEK↓, "highlight2" >Akt↓, "highlight2" >S6K↓,
469- CUR,    The inhibitory effect of curcumin via fascin suppression through JAK/STAT3 pathway on metastasis and recurrence of ovary cancer cells
- in-vitro, Ovarian, SKOV3
"highlight2" >fascin↓, "highlight2" >STAT3↓, "highlight2" >JAK↓,
461- CUR,    Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Apoptosis↑, "highlight2" >miR-30a-5p↑, "highlight2" >PCLAF↓, "highlight2" >Bcl-2↓, "highlight2" >Casp3↓, "highlight2" >BAX↑, "highlight2" >cl‑Casp3↑,
462- CUR,    Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress
- in-vitro, Pca, PC3
"highlight2" >Bcl-2↓, "highlight2" >MMP↓, "highlight2" >cl‑Casp3↑, "highlight2" >BAX↑, "highlight2" >BIM↑, "highlight2" >p‑PARP↑, "highlight2" >PUMA↑, "highlight2" >p‑P53↑, "highlight2" >ROS↑, "highlight2" >p‑ERK↑, "highlight2" >p‑eIF2α↑, "highlight2" >CHOP↑, "highlight2" >ATF4↑,
463- CUR,    Curcumin induces autophagic cell death in human thyroid cancer cells
- in-vitro, Thyroid, K1 - in-vitro, Thyroid, FTC-133 - in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, 8505C
"highlight2" >TumAuto↑, "highlight2" >LC3II↑, "highlight2" >Beclin-1↑, "highlight2" >p‑p38↑, "highlight2" >p‑JNK↑, "highlight2" >p‑ERK↑, "highlight2" >p62↓, "highlight2" >p‑PDK1↓, "highlight2" >p‑Akt↓, "highlight2" >p‑p70S6↓, "highlight2" >p‑PIK3R1↓, "highlight2" >p‑S6↓, "highlight2" >p‑4E-BP1↓,
464- CUR,    Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, TPC-1
"highlight2" >TumCI↓, "highlight2" >TumCI↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >EMT↓, "highlight2" >STAT3↓, "highlight2" >miR-301a-3p↓, "highlight2" >STAT↓, "highlight2" >N-cadherin↓, "highlight2" >Vim↓, "highlight2" >Fibronectin↓, "highlight2" >p‑JAK↓, "highlight2" >p‑JAK2↓, "highlight2" >p‑JAK3↓, "highlight2" >p‑STAT1↓, "highlight2" >p‑STAT2↓, "highlight2" >E-cadherin↑,
465- CUR,    Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, HUH7 - vitro+vivo, Liver, MHCC-97H
"highlight2" >TumCG↓, "highlight2" >MDSCs↓, "highlight2" >TLR4↓, "highlight2" >NF-kB↓, "highlight2" >IL6↓, "highlight2" >IL1↓, "highlight2" >PGE2↓, "highlight2" >COX2↓, "highlight2" >GM-CSF↓, "highlight2" >angioG↓, "highlight2" >VEGF↓, "highlight2" >CD31↓, "highlight2" >GM-CSF↓, "highlight2" >α-SMA↓, "highlight2" >p‑IKKα↓, "highlight2" >MyD88↓,
466- CUR,    Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1
- in-vitro, Liver, HepG2 - in-vitro, Liver, HuT78
"highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >pH↑, "highlight2" >NO↑, "highlight2" >LAR↓, "highlight2" >Hif1a↓, "highlight2" >LDHA↓, "highlight2" >MCT1↓, "highlight2" >MDR1↓, "highlight2" >STAT3↓, "highlight2" >HCAR1↓,
467- CUR,    Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling
- in-vitro, Liver, HepG2
"highlight2" >TumCP↓, "highlight2" >TumCI↓, "highlight2" >TumMeta↓, "highlight2" >Apoptosis↑, "highlight2" >HSP70/HSPA5↓, "highlight2" >e-HSP70/HSPA5↓, "highlight2" >TLR4↓,
468- CUR,  5-FU,    Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, 402 - vitro+vivo, Liver, Bel7
"highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >PI3k/Akt/mTOR↓, "highlight2" >p‑PI3K↓, "highlight2" >Bacteria↑, "highlight2" >cl‑Casp3↑,
458- CUR,    Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion
- vitro+vivo, GC, SGC-7901
"highlight2" >Casp3↑, "highlight2" >Apoptosis↑, "highlight2" >TumCP↓,
470- CUR,    Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line
- in-vitro, Ovarian, SKOV3
"highlight2" >Wnt/(β-catenin)↓, "highlight2" >EMT↓, "highlight2" >DNMT3A↓, "highlight2" >cycD1/CCND1↓, "highlight2" >cMyc↓, "highlight2" >Fibronectin↓, "highlight2" >Vim↓, "highlight2" >E-cadherin↑, "highlight2" >SFRP5↑,
471- CUR,    Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
"highlight2" >Apoptosis↑, "highlight2" >TumAuto↑, "highlight2" >p62↓, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓, "highlight2" >p‑P70S6K↓, "highlight2" >Casp9↑, "highlight2" >PARP↑, "highlight2" >ATG3↑, "highlight2" >Beclin-1↑, "highlight2" >LC3‑Ⅱ/LC3‑Ⅰ↑,
472- CUR,    Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis
- vitro+vivo, Ovarian, SKOV3 - vitro+vivo, Ovarian, A2780S
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >PCNA↓, "highlight2" >miR-320a↓, "highlight2" >BAX↑, "highlight2" >cl‑Casp3↑, "highlight2" >circ‑PLEKHM3↑, "highlight2" >SMG1↑,
473- CUR,    Curcumin inhibits epithelial-mesenchymal transition in oral cancer cells via c-Met blockade
- in-vitro, Oral, HSC4 - in-vitro, Oral, Ca9-22
"highlight2" >Vim↓, "highlight2" >p‑cMET↓, "highlight2" >p‑ERK↓, "highlight2" >pro‑MMP9↓, "highlight2" >E-cadherin↑,
474- CUR,    Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
"highlight2" >TumCD↑, "highlight2" >Apoptosis↑, "highlight2" >DNAdam↑, "highlight2" >γH2AX↑, "highlight2" >TumCCA↑,
475- CUR,    Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway
- in-vitro, PC, PANC1
"highlight2" >Apoptosis↑, "highlight2" >cl‑Casp3↑, "highlight2" >miR-340↑, "highlight2" >cl‑PARP↑, "highlight2" >XIAP↓,
476- CUR,    The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
- in-vitro, PC, PATU-8988 - in-vitro, PC, PANC1
"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Apoptosis↑, "highlight2" >NEDD9↓, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓, "highlight2" >PTEN↑, "highlight2" >p73↑, "highlight2" >β-TRCP↑,
477- CUR,    Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
- in-vitro, Cerv, SiHa
"highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >TumAuto↑, "highlight2" >CycB/CCNB1↓, "highlight2" >CDC25↓, "highlight2" >ROS↑, "highlight2" >p62↑, "highlight2" >LC3‑Ⅱ/LC3‑Ⅰ↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑PARP↑, "highlight2" >P53↑, "highlight2" >P21↑,
478- CUR,    Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells
- in-vitro, Cerv, SiHa
"highlight2" >EMT↓, "highlight2" >N-cadherin↓, "highlight2" >Vim↓, "highlight2" >Slug↓, "highlight2" >Zeb1↓, "highlight2" >PIR↓, "highlight2" >Pirin↓, "highlight2" >E-cadherin↑,
449- CUR,    Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a
- vitro+vivo, CRC, SW480
"highlight2" >TumCP↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >TCF↓, "highlight2" >miR-21↓, "highlight2" >NKD2↑, "highlight2" >miR-130a↓,
438- CUR,    Curcumin Reduces Colorectal Cancer Cell Proliferation and Migration and Slows In Vivo Growth of Liver Metastases in Rats
- vitro+vivo, CRC, CC531
"highlight2" >TumCP↓, "highlight2" >TumVol↓, "highlight2" >Albumin↑, "highlight2" >ALP↑, "highlight2" >AST↑, "highlight2" >ALAT↑, "highlight2" >cholinesterase↓,
439- CUR,    Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway
- in-vitro, CRC, LGR5
"highlight2" >Apoptosis↑, "highlight2" >TumAuto↑, "highlight2" >GP1BB↓, "highlight2" >COL9A3↓, "highlight2" >COMP↓, "highlight2" >AGRN↓, "highlight2" >ITGB4↓, "highlight2" >LAMA5↓, "highlight2" >COL2A1↓, "highlight2" >ITGB6↓, "highlight2" >LGR5↓, "highlight2" >TFAP2A↓, "highlight2" >ECM/TCF↓,
440- CUR,    Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, HT-29
"highlight2" >NNMT↓, "highlight2" >p‑STAT3↓, "highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >ROS↑,
441- CUR,    Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p
- in-vitro, CRC, HCT116
"highlight2" >ERCC1↓, "highlight2" >Bcl-2↓, "highlight2" >GSTP1/GSTπ↓, "highlight2" >MRP↓, "highlight2" >P-gp↓, "highlight2" >miR-409-3p↑, "highlight2" >survivin↓,
442- CUR,  5-FU,    Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress
- in-vitro, CRC, HCT116
"highlight2" >Apoptosis↑, "highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >TET1↑, "highlight2" >NKD2↑, "highlight2" >Wnt↓, "highlight2" >EMT↓, "highlight2" >Vim↑, "highlight2" >E-cadherin↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >TCF↓, "highlight2" >AXIN1↓,
9- CUR,    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo
- vitro+vivo, MG, U87MG - vitro+vivo, MG, T98G
"highlight2" >HH↓, "highlight2" >Shh↓, "highlight2" >Gli1↓, "highlight2" >cycD1/CCND1↓, "highlight2" >Bcl-2↓, "highlight2" >FOXM1↓, "highlight2" >Bax:Bcl2↑,
444- CUR,  Cisplatin,    LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells
- vitro+vivo, CRC, HCT8
"highlight2" >TumVol↓, "highlight2" >Apoptosis↑, "highlight2" >Bcl-2↓, "highlight2" >Cyt‑c↑, "highlight2" >BAX↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑PARP1↑, "highlight2" >miR-497↑, "highlight2" >KCNQ1OT1↓,
445- CUR,    Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, HCT8 - in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
"highlight2" >p‑AMPK↑, "highlight2" >p‑ACC-α↑, "highlight2" >NBR2↑, "highlight2" >p‑S6K↓, "highlight2" >mTOR↓,
446- CUR,    The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells
- in-vitro, CRC, SW480
"highlight2" >IR↓, "highlight2" >IGF-1↓, "highlight2" >Myc↓, "highlight2" >TumCMig↓, "highlight2" >TumCP↓,
447- CUR,  OXA,    Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway
- vitro+vivo, CRC, HCT116
"highlight2" >p‑p65↓, "highlight2" >Bcl-2↓, "highlight2" >Casp3↑, "highlight2" >EMT↓, "highlight2" >p‑SMAD2↓, "highlight2" >p‑SMAD3↓, "highlight2" >N-cadherin↓, "highlight2" >TGF-β↓, "highlight2" >E-cadherin↑, "highlight2" >TumVol↓, "highlight2" >TumCMig↓,
448- CUR,    Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation
- in-vitro, CRC, HT-29
"highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >p‑Akt↓, "highlight2" >Akt↓, "highlight2" >Bcl-2↓, "highlight2" >p‑BAD↓, "highlight2" >BAD↑, "highlight2" >cl‑PARP↑, "highlight2" >ROS↑, "highlight2" >HSP27↑, "highlight2" >Beclin-1↑, "highlight2" >p62↑, "highlight2" >GPx1↓, "highlight2" >GPx4↓,
460- CUR,    Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer
- in-vitro, Bladder, T24 - in-vitro, Bladder, TCCSUP - in-vitro, Bladder, J82
"highlight2" >miR-7641↓, "highlight2" >p16↑, "highlight2" >Apoptosis↑, "highlight2" >TumCI↓,
450- CUR,    Curcumin may be a potential adjuvant treatment drug for colon cancer by targeting CD44
- in-vitro, CRC, HCT116 - in-vitro, CRC, HCT8
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >CD44↓, "highlight2" >CSCs↓,
451- CUR,    The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancer
- vitro+vivo, HNSCC, SCC15 - vitro+vivo, HNSCC, SNU1076 - vitro+vivo, HNSCC, SNU1041
"highlight2" >TumCMig↓, "highlight2" >TumCG↓, "highlight2" >PD-L1↓, "highlight2" >PD-L2↓, "highlight2" >Galectin-9↓, "highlight2" >EMT↓, "highlight2" >T-Cell↑, "highlight2" >TILs↑, "highlight2" >PD-1↓, "highlight2" >TIM-3↓, "highlight2" >CD4+↓, "highlight2" >CD25+↓, "highlight2" >FoxP3+↓, "highlight2" >E-cadherin↑, "highlight2" >CD8+↑, "highlight2" >IFN-γ↑,
452- CUR,    Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells
- vitro+vivo, HNSCC, SCC9 - vitro+vivo, HNSCC, FaDu - vitro+vivo, HNSCC, HaCaT
"highlight2" >TumCCA↑, "highlight2" >PI3k/Akt/mTOR↓, "highlight2" >Casp3↑, "highlight2" >EGFR↓, "highlight2" >EGF↑, "highlight2" >PRKCG↑, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓, "highlight2" >RPS6KA1↓, "highlight2" >EIF4E↓, "highlight2" >proCasp3↓,
453- CUR,    Cellular uptake and apoptotic properties of gemini curcumin in gastric cancer cells
- in-vitro, GC, AGS
"highlight2" >Bcl-2↓, "highlight2" >survivin↓, "highlight2" >BAX↑, "highlight2" >TumCCA↑,
454- CUR,    Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway
- in-vitro, GC, MGC803
"highlight2" >TumCMig↓, "highlight2" >TumCP↓, "highlight2" >ROS↑, "highlight2" >mtDam↑, "highlight2" >DNAdam↑, "highlight2" >Apoptosis↑, "highlight2" >ATR↑, "highlight2" >P21↑, "highlight2" >p‑P53↑, "highlight2" >GADD45A↑, "highlight2" >p‑γH2AX↑,
455- CUR,    Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin
- in-vitro, GC, SGC-7901
"highlight2" >Shh↓, "highlight2" >Gli1↓, "highlight2" >FOXM1↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >Wnt↓, "highlight2" >EMT↓, "highlight2" >E-cadherin↑, "highlight2" >Vim↓,
456- CUR,    Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells
- vitro+vivo, GC, SGC-7901
"highlight2" >miR-34a↑, "highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >TumCCA↑, "highlight2" >Bcl-2↓, "highlight2" >CDK4/6↓, "highlight2" >cycD1/CCND1↓,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >TumAuto↑, "highlight2" >P53↑, "highlight2" >PI3K↓, "highlight2" >P21↑, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >LC3I↓, "highlight2" >BAX↑, "highlight2" >Beclin-1↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑PARP↑, "highlight2" >LC3II↑, "highlight2" >ATG3↑, "highlight2" >ATG5↑,
482- CUR,  PDT,    The Antitumor Effect of Curcumin in Urothelial Cancer Cells Is Enhanced by Light Exposure In Vitro
- in-vitro, Bladder, RT112 - in-vitro, Bladder, UMUC3
"highlight2" >Apoptosis↑, "highlight2" >TumCG↓, "highlight2" >TumCP↓,
459- CUR,    Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells
- in-vitro, Bladder, T24 - in-vitro, Bladder, RT4
"highlight2" >Trop2↓, "highlight2" >Apoptosis↑, "highlight2" >cycE1↓, "highlight2" >p27↑, "highlight2" >TumCCA↑,
1980- CUR,  Rad,    Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
"highlight2" >selectivity↑, "highlight2" >RadioS↑, "highlight2" >TrxR↓, "highlight2" >ROS↑, "highlight2" >ERK↑, "highlight2" >Dose∅, "highlight2" >cl‑PARP↑,
1488- CUR,    Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma
"highlight2" >RadioS↑, "highlight2" >ChemoSen↑,
1505- CUR,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
"highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >DNMTs↓, "highlight2" >HDAC↓, "highlight2" >HATs↓, "highlight2" >TumCP↓, "highlight2" >p300↓, "highlight2" >HDAC1↓, "highlight2" >HDAC3↓, "highlight2" >HDAC8↓, "highlight2" >NF-kB↓,
1510- CUR,  Chemo,    Combination therapy in combating cancer
- Review, NA, NA
"highlight2" >*NRF2↑, "highlight2" >*GSH↑, "highlight2" >*ROS↓, "highlight2" >ChemoSideEff↓, "highlight2" >eff↑, "highlight2" >OS↓, "highlight2" >chemoP↑,
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
"highlight2" >eff↑, "highlight2" >Dose∅, "highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >P53↑, "highlight2" >P21↑, "highlight2" >BAX↑, "highlight2" >Dose∅,
1616- CUR,  EA,    Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid
- in-vitro, Nor, NA
"highlight2" >*MAOA↓, "highlight2" >*Dose∅, "highlight2" >Dose?,
1792- CUR,  LEC,    Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1β via an anti-inflammatory mechanism
- in-vitro, Arthritis, RAW264.7 - NA, NA, HCC-38
"highlight2" >*Inflam↓, "highlight2" >*NF-kB↓, "highlight2" >*iNOS↓, "highlight2" >*COX2↓, "highlight2" >*NO↓, "highlight2" >*PGE2↓, "highlight2" >*MMPs↑, "highlight2" >*TIMP1↑, "highlight2" >*BioEnh↑,
1809- CUR,  Oxy,    Long-term stabilisation of myeloma with curcumin
- Case Report, Melanoma, NA
"highlight2" >*OS↑, "highlight2" >QoL↑, "highlight2" >Dose↑, "highlight2" >Dose↑, "highlight2" >IL6↓, "highlight2" >STAT3↓, "highlight2" >NF-kB↓, "highlight2" >COX2↓,
1977- CUR,    Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
- in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
"highlight2" >TrxR↓, "highlight2" >Dose↝, "highlight2" >eff↑,
1978- CUR,    Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells
- in-vitro, Cerv, HeLa
"highlight2" >TrxR1↓, "highlight2" >ROS↑, "highlight2" >DNA-PK↑, "highlight2" >eff↑, "highlight2" >Trx↓, "highlight2" >Trx1↓,
1979- CUR,  Rad,    Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase
- in-vitro, Lung, A549
"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >GSH/GSSG↓, "highlight2" >TrxR↓, "highlight2" >selectivity↑,
1487- CUR,    Relationship and interactions of curcumin with radiation therapy
- Review, Var, NA
"highlight2" >RadioS↑, "highlight2" >ChemoSen↑,
1981- CUR,    Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity
- in-vitro, Lung, NA
"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >mt-GSH↓, "highlight2" >Bax:Bcl2↑, "highlight2" >Cyt‑c↑, "highlight2" >MMP↓, "highlight2" >Casp3↑, "highlight2" >Trx2↓, "highlight2" >TrxR↓, "highlight2" >mt-DNAdam↑,
1982- CUR,    Inhibition of thioredoxin reductase by curcumin analogs
- in-vitro, NA, NA
"highlight2" >eff↑, "highlight2" >TrxR↓,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
"highlight2" >Glycolysis↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >PKM2↓, "highlight2" >mTOR↓, "highlight2" >Hif1a↓, "highlight2" >selectivity↑, "highlight2" >Dose↝, "highlight2" >tumCV↓,
2305- CUR,    Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN
- in-vitro, BC, MCF-7
"highlight2" >BioAv↑, "highlight2" >PKM2↓, "highlight2" >FASN↓, "highlight2" >Glycolysis↓,
2307- CUR,    Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin
- in-vitro, Colon, HT29 - in-vitro, Laryn, FaDu
"highlight2" >PKM2↓, "highlight2" >Warburg↓, "highlight2" >mTOR↓, "highlight2" >Hif1a↓, "highlight2" >Glycolysis↓,
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
"highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >ECAR↓, "highlight2" >NO↓, "highlight2" >ROS↑, "highlight2" >HK2↓, "highlight2" >PFK1↓, "highlight2" >GAPDH↓, "highlight2" >PKM2↓, "highlight2" >LDHA↓, "highlight2" >FASN↓, "highlight2" >GLUT1↓, "highlight2" >MCT1↓, "highlight2" >MCT4↓, "highlight2" >HCAR1↓, "highlight2" >SDH↑, "highlight2" >ChemoSen↑, "highlight2" >ROS↑, "highlight2" >BioAv↑, "highlight2" >P53↑, "highlight2" >NF-kB↓, "highlight2" >pH↑,
2312- CUR,    Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy
- Review, Var, NA
"highlight2" >ROS↑, "highlight2" >PKM2↓,
2466- CUR,    Regulatory Effects of Curcumin on Platelets: An Update and Future Directions
- Review, Nor, NA
"highlight2" >*AntiAg↑, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*12LOX↑, "highlight2" >COX1↓, "highlight2" >COX2↓, "highlight2" >MMP9↓, "highlight2" >NF-kB↓,
2579- CUR,  ART/DHA,    Curcumin-Artemisinin Combination Therapy for Malaria
- in-vivo, NA, NA
"highlight2" >OS↑, "highlight2" >toxicity↓,
2654- CUR,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
"highlight2" >ROS↑, "highlight2" >Catalase↓, "highlight2" >SOD1↓, "highlight2" >GLO-I↓, "highlight2" >NADPH↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >Akt↓, "highlight2" >ER Stress↑, "highlight2" >JNK↑, "highlight2" >STAT3↓, "highlight2" >BioAv↑,
1034- CUR,  immuno,    Enhanced anti‐tumor effects of the PD‐1 blockade combined with a highly absorptive form of curcumin targeting STAT3
- in-vivo, NA, NA
"highlight2" >DCells↑, "highlight2" >T-Cell↑,
480- CUR,    Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells
- in-vitro, GBM, SNB19
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >NEDD9↓, "highlight2" >NOTCH1↓, "highlight2" >p‑Akt↓,
481- CUR,  CHr,  Api,    Flavonoid-induced glutathione depletion: Potential implications for cancer treatment
- in-vitro, Liver, A549 - in-vitro, Pca, PC3 - in-vitro, AML, HL-60
"highlight2" >GSH↓, "highlight2" >mtDam↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑,
443- CUR,    Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells
- in-vitro, CRC, SW480
"highlight2" >DNMT1↓, "highlight2" >DNMT3A↓, "highlight2" >N-cadherin↓, "highlight2" >Vim↓, "highlight2" >Wnt↓, "highlight2" >Snail↓, "highlight2" >Twist↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >E-cadherin↑, "highlight2" >EMT↓, "highlight2" >CDX2↓,
483- CUR,  PDT,    Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin
- in-vivo, NA, A431
"highlight2" >TumVol↓, "highlight2" >TumCP↓, "highlight2" >Apoptosis↑,
484- CUR,  PDT,    Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light
- in-vitro, Melanoma, NA
"highlight2" >Cyt‑c↑, "highlight2" >Casp9↑, "highlight2" >Casp8↑, "highlight2" >NF-kB↓, "highlight2" >EGFR↓,
485- CUR,  PDT,    Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin
- in-vitro, Melanoma, NA
"highlight2" >NF-kB↓, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >p‑Akt↓, "highlight2" >p‑ERK↓,
872- CUR,  RES,    New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
- in-vitro, BC, TUBO - in-vitro, BC, SALTO
"highlight2" >TumCP↓, "highlight2" >tumCV↓, "highlight2" >p62↓, "highlight2" >p62↑, "highlight2" >TumAuto↑, "highlight2" >TumAuto↓, "highlight2" >ROS↑, "highlight2" >ROS↓, "highlight2" >CHOP↑,
933- CUR,  EP,    Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics study
- in-vitro, BC, NA
"highlight2" >Apoptosis↑, "highlight2" >ALDOA↓, "highlight2" >ENO2↓, "highlight2" >LDHA↓, "highlight2" >LDHB↓, "highlight2" >PFKP↓, "highlight2" >PGK1↓, "highlight2" >PGM1↓, "highlight2" >PGAM1↓, "highlight2" >OXPHOS↑, "highlight2" >TCA↑,
990- CUR,    Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
"highlight2" >HK2↓, "highlight2" >Glycolysis↓, "highlight2" >Apoptosis↑,
1006- CUR,    The effect of Curcuma longa extract and its active component (curcumin) on gene expression profiles of lipid metabolism pathway in liver cancer cell line (HepG2)
- in-vitro, Liver, HepG2
"highlight2" >TumCP↓, "highlight2" >PGC1A↑, "highlight2" >CPT1A↑, "highlight2" >ACOX1↑, "highlight2" >SCD1↓, "highlight2" >SREBF2↓, "highlight2" >DGAT1↓,
479- CUR,    Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments
- in-vitro, Tong, CAL27
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >cl‑Casp3↑,
1108- CUR,    Curcumin: a potent agent to reverse epithelial-to-mesenchymal transition
- Review, NA, NA
"highlight2" >EMT↓,
1383- CUR,  BBR,  RES,    Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases
- Review, NA, NA
"highlight2" >GSK‐3β↝, "highlight2" >ROS↑,
1408- CUR,    Antiproliferative and ROS Regulation Activity of Photoluminescent Curcumin-Derived Nanodots
- in-vitro, Lung, A549
"highlight2" >ROS↓, "highlight2" >ROS↑,
1409- CUR,    Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma
- in-vivo, CCA, Walker256
"highlight2" >TumCG↓, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >STAT3↓, "highlight2" >TumCCA↑, "highlight2" >eff↓,
1410- CUR,    Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway
- vitro+vivo, OS, MG63
"highlight2" >tumCV↓, "highlight2" >Apoptosis↑, "highlight2" >TumCG↓, "highlight2" >NRF2↓, "highlight2" >GPx4↓, "highlight2" >HO-1↓, "highlight2" >xCT↓, "highlight2" >ROS↑, "highlight2" >MDA↑, "highlight2" >GSH↓,
1411- CUR,  Cisplatin,    Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects
- Review, Var, NA
"highlight2" >ChemoSen↑, "highlight2" >*ROS↓, "highlight2" >*NF-kB↓, "highlight2" >TumCCA↑,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
"highlight2" >*COX2↓, "highlight2" >*Inflam↓, "highlight2" >*5LO↓, "highlight2" >*NO↓, "highlight2" >*NF-kB↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1↓, "highlight2" >*IL2↑, "highlight2" >*IL6↓, "highlight2" >*IL8↓, "highlight2" >*IL12↓, "highlight2" >*MCP1↓, "highlight2" >*PGE2↓, "highlight2" >*MMP2↓, "highlight2" >*MMP3↓, "highlight2" >*MMP9↓, "highlight2" >*NLRP3↓, "highlight2" >*ROS↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
"highlight2" >ChemoSen↑, "highlight2" >NF-kB↓, "highlight2" >*STAT3↓, "highlight2" >*COX2↓, "highlight2" >*Akt↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*GPx↑, "highlight2" >*NADPH↑, "highlight2" >*GSH↑, "highlight2" >*ROS↓, "highlight2" >*p300↓, "highlight2" >radioP↑, "highlight2" >chemoP↑, "highlight2" >RadioS↑,
1486- CUR,    Curcumin and lung cancer--a review
- Review, Lung, NA
"highlight2" >RadioS↑, "highlight2" >ChemoSen↑,
144- CUR,  Bical,    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
- in-vitro, Pca, PC3 - in-vitro, NA, DU145 - in-vitro, NA, LNCaP
"highlight2" >p‑ERK↑, "highlight2" >p‑JNK↓, "highlight2" >MUC1↓, "highlight2" >p65↓,
132- CUR,    Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells
- in-vitro, Pca, NA
"highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >TumAuto↑, "highlight2" >UPR↑,
133- CUR,    Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis
- in-vitro, Pca, NA
"highlight2" >miR-143↑, "highlight2" >PDK1↓, "highlight2" >FOXD3↑,
134- CUR,  RES,  MEL,  SIL,    Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
"highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >Trx1↓,
135- CUR,    Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >TfR1/CD71↑, "highlight2" >IRP1↑,
136- CUR,  docx,    Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >Mcl-1↓, "highlight2" >BAX↑, "highlight2" >BID↑, "highlight2" >PARP↑, "highlight2" >NF-kB↓, "highlight2" >CDK1↓, "highlight2" >COX2↓, "highlight2" >RTK-RAS↓, "highlight2" >PI3K/Akt↓, "highlight2" >EGFR↓, "highlight2" >HER2/EBBR2↓, "highlight2" >P53↑,
137- CUR,    Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling
- in-vitro, Pca, DU145
"highlight2" >NOTCH1↓, "highlight2" >cycD1/CCND1↓, "highlight2" >CDK2↓, "highlight2" >P21↑, "highlight2" >p27↑, "highlight2" >P53↑, "highlight2" >Bcl-2↓, "highlight2" >Casp3↑, "highlight2" >Casp9↑,
140- CUR,    Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
- in-vitro, Pca, PC3
"highlight2" >CAFs/TAFs↓, "highlight2" >EMT↓, "highlight2" >ROS↓, "highlight2" >CXCR4↓, "highlight2" >IL6↓, "highlight2" >MAOA↓, "highlight2" >mTOR↓, "highlight2" >HIF-1↓,
141- CUR,    Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer
- in-vivo, Pca, PC3
"highlight2" >BAX↑, "highlight2" >Bcl-2↓,
142- CUR,    Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin in LNCaP xenografts
- in-vivo, Pca, LNCaP
"highlight2" >AR↓, "highlight2" >PSA↓,
143- CUR,    Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >ER Stress↑, "highlight2" >CHOP↑, "highlight2" >GRP78/BiP↑, "highlight2" >ROS↑,
131- CUR,    Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer
- vitro+vivo, Pca, LNCaP - vitro+vivo, Pca, 22Rv1
"highlight2" >AKR1C2↓, "highlight2" >CYP11A1↓, "highlight2" >HSD3B↓, "highlight2" >DHT↓, "highlight2" >testos↓, "highlight2" >StAR↓, "highlight2" >SRD5A1↑,
146- CUR,  EGCG,    Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
"highlight2" >P21↑,
151- CUR,    Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP
"highlight2" >AR↓,
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
"highlight2" >β-catenin/ZEB1↓, "highlight2" >AR↓, "highlight2" >STAT3↓, "highlight2" >p‑Akt↓, "highlight2" >Mcl-1↓, "highlight2" >Bcl-xL↓, "highlight2" >cl‑PARP↑, "highlight2" >miR-21↓, "highlight2" >miR-205↑,
153- CUR,    Curcumin Inhibits Prostate Cancer Bone Metastasis by Up-Regulating Bone Morphogenic Protein-7 in Vivo
- in-vivo, Pca, C4-2B
"highlight2" >PSA↓, "highlight2" >TGF-β↓, "highlight2" >BMPs↑,
154- CUR,    Curcumin inhibits expression of inhibitor of DNA binding 1 in PC3 cells and xenografts
- vitro+vivo, Pca, PC3
"highlight2" >Id1↓,
155- CUR,    Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
- in-vitro, Pca, PC3
"highlight2" >p‑ERK↓, "highlight2" >VEGF↓, "highlight2" >angioS↑,
157- CUR,    Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
"highlight2" >cJun↓, "highlight2" >AR↓,
158- CUR,    Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis
- vitro+vivo, Pca, LNCaP
"highlight2" >MMP9↓, "highlight2" >Matr↓,
159- CUR,    Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment
- in-vitro, Pca, DU145
"highlight2" >ROS↑, "highlight2" >p‑Jun↑, "highlight2" >p‑p38↑,
121- CUR,    Screening for Circulating Tumour Cells Allows Early Detection of Cancer and Monitoring of Treatment Effectiveness: An Observational Study
- in-vivo, Pca, NA
"highlight2" >CTC↓,
10- CUR,    Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
"highlight2" >HH↓, "highlight2" >Wnt/(β-catenin)↓, "highlight2" >Shh↓, "highlight2" >Smo↓, "highlight2" >Gli1↝, "highlight2" >GLI2↝,
11- CUR,    Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway
- in-vitro, PC, PANC1
"highlight2" >HH↓, "highlight2" >Shh↓, "highlight2" >Smo↓, "highlight2" >Gli1↓, "highlight2" >N-cadherin↓, "highlight2" >E-cadherin↑, "highlight2" >Vim↓,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
"highlight2" >HH↓, "highlight2" >Shh↓, "highlight2" >Gli1↓, "highlight2" >PTCH1↓, "highlight2" >cMyc↓, "highlight2" >n-MYC↓, "highlight2" >cycD1/CCND1↓, "highlight2" >Bcl-2↓, "highlight2" >NF-kB↓, "highlight2" >Akt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >survivin↓,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
"highlight2" >P53↑, "highlight2" >DR5↑, "highlight2" >JNK↑, "highlight2" >NRF2↑, "highlight2" >PPARγ↑, "highlight2" >HER2/EBBR2↓, "highlight2" >IR↓, "highlight2" >ER(estro)↓, "highlight2" >Fas↑, "highlight2" >PDGF↓, "highlight2" >TGF-β↓, "highlight2" >FGF↓, "highlight2" >EGFR↓, "highlight2" >JAK↓, "highlight2" >PAK↓, "highlight2" >MAPK↓, "highlight2" >ATPase↓, "highlight2" >COX2↓, "highlight2" >MMPs↓, "highlight2" >IL1↓, "highlight2" >IL2↓, "highlight2" >IL5↓, "highlight2" >IL6↓, "highlight2" >IL8↓, "highlight2" >IL12↓, "highlight2" >IL18↓, "highlight2" >NF-kB↓, "highlight2" >NOTCH1↓, "highlight2" >STAT1↓, "highlight2" >STAT4↓, "highlight2" >STAT5↓, "highlight2" >STAT3↓,
14- CUR,    Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway
- vitro+vivo, Pca, PC3
"highlight2" >PI3K/mTOR/ETS2↓, "highlight2" >MDM2↓, "highlight2" >P21↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
"highlight2" >NF-kB↝, "highlight2" >Akt↝, "highlight2" >AR↝, "highlight2" >Apoptosis↝, "highlight2" >Bcl-2↝, "highlight2" >Casp3↝, "highlight2" >BAX↝, "highlight2" >P21↝, "highlight2" >ROS↝, "highlight2" >Apoptosis↝, "highlight2" >Bcl-xL↝, "highlight2" >JNK↝, "highlight2" >MMP2↝, "highlight2" >P53↝, "highlight2" >PSA↝, "highlight2" >VEGF↝, "highlight2" >COX2↝, "highlight2" >cycD1/CCND1↝, "highlight2" >EGFR↝, "highlight2" >IL6↝, "highlight2" >β-catenin/ZEB1↝, "highlight2" >mTOR↝, "highlight2" >NRF2↝, "highlight2" >p‑Akt↝, "highlight2" >AP-1↝, "highlight2" >Cyt‑c↝, "highlight2" >PI3K↝, "highlight2" >PTEN↝, "highlight2" >Cyc↝, "highlight2" >TNF-α↝,
117- CUR,    Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells
- in-vivo, Pca, RM-1 - in-vivo, Pca, DU145
"highlight2" >ROS↑,
118- CUR,    Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
"highlight2" >ROS↑, "highlight2" >Bcl-2↓, "highlight2" >PARP↑, "highlight2" >cDC2↓, "highlight2" >CycB/CCNB1↓, "highlight2" >MDM2↓,
120- CUR,    A randomized, double-blind, placebo-controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivation
- Human, Pca, NA
"highlight2" >PSA↓,
436- CUR,    Integrated microRNA and gene expression profiling reveals the crucial miRNAs in curcumin anti‐lung cancer cell invasion
- in-vitro, Lung, A549
"highlight2" >miR-25-5p↓, "highlight2" >miR-330-5p↑, "highlight2" >MAPK↓, "highlight2" >Wnt↓,
122- CUR,  isoFl,    Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen
- Human, Pca, LNCaP
"highlight2" >PSA↓, "highlight2" >AR↓,
123- CUR,    Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells
- in-vitro, Colon, LoVo - in-vitro, Colon, COLO205 - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
"highlight2" >NF-kB↓,
124- CUR,    Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
"highlight2" >TGF-β↓, "highlight2" >Wnt↓, "highlight2" >PI3k/Akt/mTOR↓, "highlight2" >NF-kB↓, "highlight2" >PTEN↑, "highlight2" >Apoptosis↑,
125- CUR,    Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway
- in-vitro, adrenal, H295R
"highlight2" >CYP17A1↓, "highlight2" >CYP19↓,
126- CUR,    Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145
"highlight2" >miR-34a↑, "highlight2" >β-catenin/ZEB1↓, "highlight2" >cMyc↓, "highlight2" >P21↑, "highlight2" >cycD1/CCND1↓, "highlight2" >PCNA↓,
127- CUR,    The chromatin remodeling protein BRG1 links ELOVL3 trans-activation to prostate cancer metastasis
- in-vitro, Pca, NA
"highlight2" >Elvol3↓,
128- CUR,  RES,    Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer
- in-vivo, Pca, NA
"highlight2" >lipid-P↓,
129- CUR,    Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation
- vitro+vivo, Pca, LNCaP
"highlight2" >JNK↓,
130- CUR,    Maspin Enhances the Anticancer Activity of Curcumin in Hormone-refractory Prostate Cancer Cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >BAD↝, "highlight2" >BAX↝, "highlight2" >eff↑,
423- CUR,    Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >TLR4↓, "highlight2" >IRF3↓, "highlight2" >IFN-γ↓, "highlight2" >TRIF↓,
406- CUR,    Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2
- in-vitro, BC, MCF-7 - in-vitro, Hepat, HepG2
"highlight2" >GSH↓, "highlight2" >Apoptosis↑, "highlight2" >Bcl-2↓, "highlight2" >cMyc↓,
407- CUR,    Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress
- in-vitro, Melanoma, A375
"highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >GSH↓, "highlight2" >MMP↓,
160- CUR,    Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2
"highlight2" >CXCc↓, "highlight2" >IκB↓, "highlight2" >NF-kB↓, "highlight2" >COX2↓, "highlight2" >SPARC↓, "highlight2" >EFEMP↓,
409- CUR,    Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity
- in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
"highlight2" >GLO-I↓, "highlight2" >GSH↓, "highlight2" >ATP↓,
410- CUR,    Nrf2 depletion enhanced curcumin therapy effect in gastric cancer by inducing the excessive accumulation of ROS
- vitro+vivo, GC, AGS - vitro+vivo, GC, HGC27
"highlight2" >ROS↑, "highlight2" >NRF2↑,
411- CUR,    Curcumin inhibits the invasion and metastasis of triple negative breast cancer via Hedgehog/Gli1 signaling pathway
- in-vitro, BC, MDA-MB-231
"highlight2" >HH↓, "highlight2" >EMT↓, "highlight2" >Gli1↓,
412- CUR,    Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >ROS↑, "highlight2" >PTP1B↓,
413- CUR,    Curcumin attenuates lncRNA H19-induced epithelial-mesenchymal transition in tamoxifen-resistant breast cancer cells
- in-vitro, BC, MCF-7
"highlight2" >N-cadherin↓, "highlight2" >E-cadherin↑, "highlight2" >H19↓,
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >Ferroptosis↑, "highlight2" >Iron↑, "highlight2" >ROS↑, "highlight2" >lipid-P↑, "highlight2" >MDA↑, "highlight2" >GSH↓, "highlight2" >HO-1↑, "highlight2" >NRF2↑, "highlight2" >GPx↓, "highlight2" >ROS↑, "highlight2" >Iron↑, "highlight2" >GPx4↓, "highlight2" >HSP70/HSPA5↑, "highlight2" >ATFs↑, "highlight2" >CHOP↑, "highlight2" >MDA↑, "highlight2" >FTL↑, "highlight2" >FTH1↑, "highlight2" >BACH1↑, "highlight2" >REL↑, "highlight2" >USF1↑, "highlight2" >NFE2L2↑,
415- CUR,    Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142-3p/PSMB5 axis
- vitro+vivo, BC, MDA-MB-231
"highlight2" >PSMB5↓, "highlight2" >CT-I↓, "highlight2" >miR-142-3p↑, "highlight2" >EP300↓,
417- CUR,    Curcumin inhibits the growth of triple‐negative breast cancer cells by silencing EZH2 and restoring DLC1 expression
- vitro+vivo, BC, MCF-7 - vitro+vivo, BC, MDA-MB-231 - vitro+vivo, BC, MDA-MB-468
"highlight2" >EZH2↓, "highlight2" >DLC1↑, "highlight2" >cycA1/CCNA1↓, "highlight2" >CDK1↓, "highlight2" >Bcl-2↓, "highlight2" >Casp9↑, "highlight2" >DLC1↑,
420- CUR,    Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >Vim↓, "highlight2" >Fibronectin↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >E-cadherin↓, "highlight2" >CD44↑, "highlight2" >CD24↓, "highlight2" >OCT4↓, "highlight2" >Nanog↓, "highlight2" >SOX2↓,
422- CUR,    Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines
- in-vitro, BC, HCC-38 - in-vitro, BC, T47D
"highlight2" >BRCA1↑, "highlight2" >TET1↑, "highlight2" >DNMT3A↑, "highlight2" >DNMT1↓, "highlight2" >SNCG↓, "highlight2" >miR-29b↓, "highlight2" >miR-29b↑,
408- CUR,    Cytotoxic, chemosensitizing and radiosensitizing effects of curcumin based on thioredoxin system inhibition in breast cancer cells: 2D vs. 3D cell culture system
- in-vitro, BC, MCF-7
"highlight2" >Trx1↓,
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >Src↓, "highlight2" >p‑STAT1↓, "highlight2" >p‑Akt↓, "highlight2" >p‑p44↓, "highlight2" >p‑p42↓, "highlight2" >RAS↓, "highlight2" >Raf↓, "highlight2" >Vim↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >P53↓, "highlight2" >Bcl-2↓, "highlight2" >Mcl-1↓, "highlight2" >PIAS-3↑, "highlight2" >SOCS-3↑, "highlight2" >SOCS1↑, "highlight2" >ROS↑, "highlight2" >NF-kB↓, "highlight2" >PAO↑, "highlight2" >SSAT↑, "highlight2" >P21↑, "highlight2" >Bak↑,
425- CUR,    Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
"highlight2" >CDC25↓, "highlight2" >cDC2↓, "highlight2" >P21↑, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Casp3↑,
426- CUR,    Use of cancer chemopreventive phytochemicals as antineoplastic agents
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, CAL51
"highlight2" >Bcl-2↓, "highlight2" >ROS↑, "highlight2" >BAX↑, "highlight2" >RAD51↑, "highlight2" >γH2AX↑,
427- CUR,    Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460 - vitro+vivo, Lung, A549
"highlight2" >ITGB1↓, "highlight2" >circ-PRKCA↓, "highlight2" >miR-384↑,
429- CUR,    TAp63α Is Involved in Tobacco Smoke-Induced Lung Cancer EMT and the Anti-cancer Activity of Curcumin via miR-19 Transcriptional Suppression
- in-vitro, Lung, H1299 - in-vitro, Lung, A549
"highlight2" >TAp63α↑, "highlight2" >E-cadherin↑, "highlight2" >ZO-1↑, "highlight2" >Vim↓, "highlight2" >N-cadherin↓, "highlight2" >miR-19b↓,
430- CUR,    Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signaling
- vitro+vivo, Lung, A549
"highlight2" >PTEN↑, "highlight2" >MEG3↑,
431- CUR,    Curcumin suppresses the stemness of non-small cell lung cancer cells via promoting the nuclear-cytoplasm translocation of TAZ
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
"highlight2" >ALDH1A1↓, "highlight2" >CD133↓, "highlight2" >EpCAM↓, "highlight2" >OCT4↓, "highlight2" >TAZ↓, "highlight2" >Hippo↑, "highlight2" >p‑TAZ↑,
432- CUR,    Curcumin-Induced Global Profiling of Transcriptomes in Small Cell Lung Cancer Cells
- in-vitro, Lung, H446
"highlight2" >Bcl-2↓, "highlight2" >cycF↓, "highlight2" >LOX1↓, "highlight2" >VEGF↓, "highlight2" >MRGPRF↓, "highlight2" >BAX↑, "highlight2" >Cyt‑c↑, "highlight2" >miR-548ah-5p↑,
433- CUR,    Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression
- in-vitro, Lung, A549
"highlight2" >E-cadherin↓, "highlight2" >Vim↓, "highlight2" >Slug↓, "highlight2" >N-cadherin↓, "highlight2" >Snail↓, "highlight2" >MMP9↓, "highlight2" >EMT↓,
434- CUR,    Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad
- in-vitro, Lung, A549
"highlight2" >14-3-3 proteins↓, "highlight2" >p‑BAD↓, "highlight2" >p‑Akt↓, "highlight2" >Akt↓, "highlight2" >cl‑Casp9↑, "highlight2" >cl‑PARP↑,
435- CUR,    Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway
- in-vitro, Lung, A549
"highlight2" >Apoptosis↑, "highlight2" >TumAuto↑, "highlight2" >LC3‑Ⅱ/LC3‑Ⅰ↑, "highlight2" >Beclin-1↑, "highlight2" >p62↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓,
437- CUR,    Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids
- vitro+vivo, CRC, TCO1 - vitro+vivo, CRC, TCO2
"highlight2" >cycD1/CCND1↓, "highlight2" >cMyc↓, "highlight2" >p‑ERK↓, "highlight2" >CD44↓, "highlight2" >CD133↓, "highlight2" >LGR5↓, "highlight2" >TumCCA↑, "highlight2" >TumVol↓, "highlight2" >CSCs↓,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
"highlight2" >Mcl-1↑, "highlight2" >Mcl-1↓, "highlight2" >MPT↑, "highlight2" >AIF↑,
165- CUR,    Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP
"highlight2" >AR↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >p‑Akt↓, "highlight2" >GSK‐3β↓, "highlight2" >p‑β-catenin/ZEB1↑, "highlight2" >cycD1/CCND1↓, "highlight2" >cMyc↓,
167- CUR,    Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
- in-vitro, Pca, PC3
"highlight2" >MAPK↑, "highlight2" >JNK↑, "highlight2" >Casp3↑, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >AIF↑,
164- CUR,    Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitro
- in-vitro, Pca, PC3
"highlight2" >NF-kB↓, "highlight2" >AP-1↓,
163- CUR,    Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells
- in-vitro, Pca, LNCaP
"highlight2" >MeCP2↓, "highlight2" >Neurog1↑, "highlight2" >HDAC↓,
168- CUR,    Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism
- in-vitro, Pca, PC3
"highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >AMPK↑, "highlight2" >TAp63α↑,
169- CUR,    Curcumin inhibits the expression of vascular endothelial growth factor and androgen-independent prostate cancer cell line PC-3 in vitro
- in-vitro, Pca, PC3
"highlight2" >VEGF↓,
162- CUR,  EGCG,  SFN,    Shattering the underpinnings of neoplastic architecture in LNCap: synergistic potential of nutraceuticals in dampening PDGFR/EGFR signaling and cellular proliferation
- in-vitro, Pca, LNCaP
"highlight2" >p‑PDGF↓,
170- CUR,    Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis
- vitro+vivo, Pca, PC3
"highlight2" >TRAILR↑, "highlight2" >BAX↑, "highlight2" >P21↑, "highlight2" >p27↑, "highlight2" >NF-kB↓, "highlight2" >cycD1/CCND1↓, "highlight2" >VEGF↓, "highlight2" >uPA↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓,
181- CUR,    The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo
- vitro+vivo, Pca, DU145
"highlight2" >MMP2↓, "highlight2" >MMP9↓,
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
"highlight2" >p38↓, "highlight2" >MKP5↑,
183- CUR,    Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
"highlight2" >AR↓, "highlight2" >AP-1↓, "highlight2" >NF-kB↓, "highlight2" >CBP↓,
404- CUR,    Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1299
"highlight2" >TumAuto↑, "highlight2" >TumCG↓, "highlight2" >TumCP↓, "highlight2" >Iron↑, "highlight2" >GSH↓, "highlight2" >lipid-P↑, "highlight2" >GPx↓, "highlight2" >mtDam↑, "highlight2" >autolysosome↑, "highlight2" >Beclin-1↑, "highlight2" >LC3s↑, "highlight2" >p62↓, "highlight2" >Ferroptosis↑,
405- CUR,  5-FU,    Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis
- vitro+vivo, CRC, HCT116
"highlight2" >Apoptosis↑, "highlight2" >TumCMig↓, "highlight2" >NRF2↑, "highlight2" >ROS↑, "highlight2" >MET↑, "highlight2" >miR-34a↑,
1617- EA,  CUR,    The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
- in-vitro, Nor, NA
"highlight2" >Dose∅, "highlight2" >GSTs↓,
1619- EA,  CUR,    Antimutagenic Effect of the Ellagic Acid and Curcumin Combinations
- in-vitro, Nor, NA
"highlight2" >eff↑,
649- EGCG,  CUR,  PI,    Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
"highlight2" >*BioEnh↑, "highlight2" >EGFR↓, "highlight2" >HER2/EBBR2↓, "highlight2" >IGF-1↓, "highlight2" >MAPK↓, "highlight2" >ERK↓, "highlight2" >RAS↓, "highlight2" >Raf↓, "highlight2" >NF-kB↓, "highlight2" >p‑pRB↓, "highlight2" >TumCCA↑, "highlight2" >Glycolysis↓, "highlight2" >Warburg↓, "highlight2" >HK2↓, "highlight2" >Pyruv↓,
652- EGCG,  VitK2,  CUR,    Case Report of Unexpectedly Long Survival of Patient With Chronic Lymphocytic Leukemia: Why Integrative Methods Matter
- Case Report, CLL, NA
"highlight2" >Remission↑,
685- EGCG,  CUR,  SFN,  RES,  GEN  The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
- Analysis, NA, NA
"highlight2" >Bcl-2↓, "highlight2" >survivin↓, "highlight2" >XIAP↓, "highlight2" >EMT↓, "highlight2" >Apoptosis↑, "highlight2" >Nanog↓, "highlight2" >cMyc↓, "highlight2" >OCT4↓, "highlight2" >Snail↓, "highlight2" >Slug↓, "highlight2" >Zeb1↓, "highlight2" >TCF↓,
3715- FA,  CUR,  PS,    The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice
- in-vivo, AD, NA
"highlight2" >*cognitive↑, "highlight2" >*IL1β↓, "highlight2" >*Ach↑, "highlight2" >*Aβ↓, "highlight2" >*p‑tau↓, "highlight2" >*BDNF↑, "highlight2" >*APP↓,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
"highlight2" >Apoptosis↑, "highlight2" >Casp3↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >proCasp9↑, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >PARP↓, "highlight2" >DNAdam↑, "highlight2" >DFF45↓,
797- GAR,  CUR,    Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
- in-vitro, BC, MCF-7 - in-vitro, OS, U2OS - in-vitro, OS, SaOS2
"highlight2" >TumCP↓, "highlight2" >H3K18↓, "highlight2" >DNAdam↑,
808- GAR,  CUR,    Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
"highlight2" >tumCV↓, "highlight2" >Apoptosis↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑,
4664- GEN,  CUR,  RES,  EGCG,  SFN  Targeting cancer stem cells by nutraceuticals for cancer therapy
- Review, Var, NA
"highlight2" >CSCs↓, "highlight2" >other↝, "highlight2" >eff↑, "highlight2" >CD44↓, "highlight2" >p‑STAT3↓,
1998- Myr,  CUR,    Thioredoxin-dependent system. Application of inhibitors
- Review, Var, NA
"highlight2" >TrxR↓, "highlight2" >ROS↑,
150- NRF,  CUR,  docx,    Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells
- in-vitro, Pca, C4-2B
"highlight2" >p‑Akt↓, "highlight2" >p‑eIF2α↑, "highlight2" >ER Stress↑, "highlight2" >ATFs↑, "highlight2" >CHOP↑, "highlight2" >TRIB3↑,
138- QC,  CUR,    Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >DNMTs↓,
873- QC,  RES,  CUR,  PI,    Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal Absorption
- in-vitro, Nor, NA
"highlight2" >*BioEnh↑,
918- QC,  CUR,  VitC,    Anti- and pro-oxidant effects of oxidized quercetin, curcumin or curcumin-related compounds with thiols or ascorbate as measured by the induction period method
- Analysis, NA, NA
"highlight2" >ROS↑, "highlight2" >ROS↑,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
"highlight2" >*AntiCan↑, "highlight2" >*Inflam↓, "highlight2" >*Bacteria↓, "highlight2" >*AntiDiabetic↑, "highlight2" >*ROS↓, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*GSH↑, "highlight2" >*NRF2↑, "highlight2" >*Trx↑, "highlight2" >*IronCh↑, "highlight2" >*MDA↑, "highlight2" >cycD1/CCND1↓, "highlight2" >PI3K↓, "highlight2" >Casp3↑, "highlight2" >BAX↑, "highlight2" >ChemoSen↑, "highlight2" >ROS↑, "highlight2" >eff↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >Akt↓, "highlight2" >ERK↓,
156- Ralox,  Tam,  GEN,  CUR,    Modulators of estrogen receptor inhibit proliferation and migration of prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >ERβ↑,
103- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- vitro+vivo, BC, 4T1
"highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Casp9↑, "highlight2" >T-Cell↑, "highlight2" >TGF-β↓,
871- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
"highlight2" >T-Cell↑, "highlight2" >Neut↓, "highlight2" >Macrophages↓, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >other↓, "highlight2" >AntiTum↑, "highlight2" >TumVol↓,
4670- RES,  CUR,  EGCG,  TQ,    Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol
- Review, Nor, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*AntiAge↑, "highlight2" >*SIRT1↑, "highlight2" >*SIRT3↑, "highlight2" >*FOXO↑, "highlight2" >*ROS↓,
4667- RES,  CUR,  SFN,    Physiological modulation of cancer stem cells by natural compounds: Insights from preclinical models
- Review, Var, NA
"highlight2" >CSCs↓, "highlight2" >ChemoSen↑, "highlight2" >RadioS↑, "highlight2" >ALDH↓, "highlight2" >CD44↓, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >NOTCH↓, "highlight2" >HH↓, "highlight2" >NF-kB↓,
3755- RosA,  CUR,    Development of Acetylcholinesterase (AChE) Inhibitor
- Study, AD, NA
"highlight2" >*AChE↓, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
"highlight2" >CSCs↓, "highlight2" >TumCCA↑, "highlight2" >EMT↓, "highlight2" >other↝, "highlight2" >TumAuto↑, "highlight2" >Iron↑, "highlight2" >Ferroptosis↑, "highlight2" >BioAv↓, "highlight2" >ROS↑, "highlight2" >lipid-P↑, "highlight2" >GPx4↓, "highlight2" >eff↑,
4752- Se,  CUR,  Chemo,    Curcumin-Modified Selenium Nanoparticles Improve S180 Tumour Therapy in Mice by Regulating the Gut Microbiota and Chemotherapy
- in-vitro, Cerv, HeLa - in-vitro, sarcoma, S180
"highlight2" >tumCV↓, "highlight2" >ROS↑, "highlight2" >*GutMicro↑, "highlight2" >BioAv↑, "highlight2" >other↝, "highlight2" >Dose↝,
2306- SIL,  CUR,  RES,  EA,    Identification of Natural Compounds as Inhibitors of Pyruvate Kinase M2 for Cancer Treatment
- in-vitro, BC, MDA-MB-231
"highlight2" >PKM2↓, "highlight2" >Dose↝, "highlight2" >Dose↝,
4415- SNP,  SDT,  CUR,    Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells
- in-vitro, BC, MCF-7
"highlight2" >tumCV↓, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >Bcl-2↓, "highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >sonoS↑, "highlight2" >eff↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑,
139- Tomatine,  CUR,    Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells
- in-vitro, Pca, PC3
"highlight2" >NF-kB↓, "highlight2" >Bcl-2↓, "highlight2" >p‑Akt↓, "highlight2" >p‑ERK↓,
2133- TQ,  CUR,  Cisplatin,    Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling
- in-vitro, Nor, HEK293 - in-vivo, NA, NA
"highlight2" >*creat↓, "highlight2" >*TNF-α↓, "highlight2" >*IL6↓, "highlight2" >*MRP↓, "highlight2" >*GFR↑, "highlight2" >*mt-ATPase↑, "highlight2" >*p‑Akt↑, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*Casp3↓, "highlight2" >*NF-kB↓, "highlight2" >*RenoP↑,
119- UA,  CUR,  RES,    Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >ROS⇅, "highlight2" >p‑STAT3↓, "highlight2" >Src↓, "highlight2" >AMPK↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 290

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 2,  

Redox & Oxidative Stress ⓘ

ARE/EpRE↑, 1,   Catalase↓, 1,   Fenton↑, 2,   Ferroptosis↑, 3,   GPx↓, 2,   GPx1↓, 1,   GPx4↓, 4,   GSH↓, 8,   mt-GSH↓, 1,   GSH/GSSG↓, 1,   GSTP1/GSTπ↓, 1,   GSTs↓, 1,   HO-1↓, 1,   HO-1↑, 3,   Iron↑, 5,   IRP1↑, 1,   lipid-P↓, 1,   lipid-P↑, 3,   MDA↑, 3,   NFE2L2↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 4,   NRF2↝, 1,   OXPHOS↑, 1,   PAO↑, 1,   ROS↓, 3,   ROS↑, 52,   ROS⇅, 1,   ROS↝, 1,   SOD1↓, 1,   Trx↓, 1,   Trx1↓, 3,   Trx2↓, 1,   TrxR↓, 6,   TrxR1↓, 1,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↓, 1,   CDC25↓, 2,   EGF↑, 1,   MEK↓, 1,   MKP5↑, 1,   MMP↓, 11,   MPT↑, 1,   mtDam↑, 4,   p‑p42↓, 1,   Raf↓, 2,   SDH↑, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis ⓘ

p‑ACC-α↑, 1,   ACOX1↑, 1,   ALAT↑, 1,   ALDOA↓, 1,   AMPK↑, 2,   p‑AMPK↑, 1,   cMyc↓, 10,   CPT1A↑, 1,   DGAT1↓, 1,   ECAR↓, 1,   Elvol3↓, 1,   ENO2↓, 1,   ERCC1↓, 1,   FASN↓, 2,   GAPDH↓, 1,   GLO-I↓, 4,   GlucoseCon↓, 3,   Glycolysis↓, 5,   HK2↓, 3,   IR↓, 2,   lactateProd↓, 3,   LAR↓, 1,   LDHA↓, 3,   LDHB↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NNMT↓, 1,   PDK1↓, 1,   p‑PDK1↓, 1,   PFK1↓, 1,   PFKP↓, 1,   PGAM1↓, 1,   PGC1A↑, 1,   PGK1↓, 1,   PGM1↓, 1,   PI3K/Akt↓, 2,   PI3k/Akt/mTOR↓, 3,   PI3K/mTOR/ETS2↓, 1,   p‑PIK3R1↓, 1,   PKM2↓, 6,   PPARα↝, 1,   PPARγ↑, 1,   PSMB5↓, 1,   Pyruv↓, 1,   p‑S6↓, 1,   S6K↓, 1,   p‑S6K↓, 1,   SCD1↓, 2,   SREBF2↓, 1,   SSAT↑, 1,   TCA↑, 1,   Warburg↓, 2,  

Cell Death ⓘ

14-3-3 proteins↓, 1,   Akt↓, 10,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 17,   p‑Akt↝, 1,   Apoptosis↑, 46,   Apoptosis↝, 2,   BAD↑, 1,   BAD↝, 1,   p‑BAD↓, 2,   Bak↑, 2,   BAX↑, 21,   BAX↝, 2,   Bax:Bcl2↑, 3,   Bcl-2↓, 31,   Bcl-2↝, 1,   Bcl-xL↓, 5,   Bcl-xL↝, 1,   BID↑, 1,   BIM↑, 2,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 13,   Casp3↝, 1,   cl‑Casp3↑, 9,   proCasp3↓, 1,   Casp8↑, 3,   Casp9↑, 9,   cl‑Casp9↑, 1,   proCasp9↑, 1,   CBP↓, 1,   CK2↓, 1,   Cyt‑c↑, 10,   Cyt‑c↝, 1,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 3,   Hippo↑, 1,   hTERT/TERT↓, 1,   JNK↓, 1,   JNK↑, 3,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK↓, 3,   MAPK↑, 1,   Mcl-1↓, 4,   Mcl-1↑, 1,   MCT1↓, 2,   MDM2↓, 2,   MEG3↑, 1,   miR-497↑, 2,   miR-548ah-5p↑, 1,   miR-7641↓, 1,   Myc↓, 1,   NOXA↑, 1,   p27↑, 3,   p38↓, 1,   p‑p38↑, 2,   Paraptosis↑, 1,   PUMA↑, 2,   survivin↓, 5,   Telomerase↓, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 2,   β-TRCP↑, 1,  

Kinase & Signal Transduction ⓘ

FOXD3↑, 1,   H3K18↓, 1,   HER2/EBBR2↓, 3,   miR-25-5p↓, 1,   p‑p70S6↓, 1,   PAK↓, 1,   RTK-RAS↓, 1,   SOX9?, 1,   Sp1/3/4↓, 6,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   COMP↓, 1,   EZH2↓, 3,   H19↓, 1,   HATs↓, 1,   KCNQ1OT1↓, 1,   Matr↓, 1,   MeCP2↓, 1,   miR-143↑, 1,   miR-145↑, 1,   miR-192-5p↑, 1,   miR-205↑, 1,   miR-21↓, 6,   miR-27a-3p↓, 5,   miR-30a-5p↑, 1,   miR-409-3p↑, 2,   other↓, 1,   other↑, 1,   other↝, 3,   p‑pRB↓, 1,   sonoS↑, 1,   tumCV↓, 9,   USF1↑, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   ATFs↑, 2,   CHOP↑, 6,   p‑eIF2α↑, 2,   ER Stress↑, 5,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSF1↓, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   e-HSP70/HSPA5↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG3↑, 2,   ATG5↑, 1,   autolysosome↑, 1,   Beclin-1↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3I↓, 1,   LC3II↓, 1,   LC3II↑, 2,   LC3s↑, 1,   p62↓, 5,   p62↑, 3,   TumAuto↓, 1,   TumAuto↑, 12,  

DNA Damage & Repair ⓘ

ATR↑, 1,   BRCA1↑, 1,   DFF45↓, 1,   DNA-PK↑, 1,   DNAdam↑, 7,   mt-DNAdam↑, 1,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMT3A↑, 1,   DNMTs↓, 3,   GADD45A↑, 1,   NBR2↑, 1,   p16↑, 2,   P53?, 1,   P53↓, 1,   P53↑, 7,   P53↝, 1,   p‑P53↑, 2,   p73↑, 1,   PARP↓, 1,   PARP↑, 3,   p‑PARP↑, 1,   cl‑PARP↑, 8,   PARP1↓, 1,   cl‑PARP1↑, 1,   PCLAF↓, 1,   PCNA↓, 2,   RAD51↑, 1,   SMG1↑, 1,   TP53↑, 1,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 1,   CDK4↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 13,   cycD1/CCND1↝, 1,   cycE1↓, 1,   cycF↓, 1,   P21↑, 12,   P21↝, 1,   TAp63α↑, 2,   TFAP2A↓, 1,   TumCCA↓, 2,   TumCCA↑, 24,  

Proliferation, Differentiation & Cell State ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 1,   AXIN1↓, 1,   CD133↓, 2,   CD24↓, 2,   CD44↓, 5,   CD44↑, 1,   cDC2↓, 2,   CDX2↓, 1,   p‑cMET↓, 1,   CSCs↓, 16,   EIF4E↓, 1,   EMT↓, 16,   EP300↓, 1,   EpCAM↓, 2,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 5,   p‑ERK↑, 4,   FGF↓, 1,   FOXM1↓, 2,   Gli1↓, 5,   Gli1↝, 1,   GSK‐3β↓, 2,   GSK‐3β↝, 1,   HDAC↓, 3,   HDAC1↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   HH↓, 7,   HH↝, 1,   Id1↓, 1,   IGF-1↓, 2,   IGFR↓, 1,   p‑Jun↑, 1,   LGR5↓, 2,   miR-101↑, 1,   miR-142-3p↑, 1,   miR-330-5p↑, 1,   miR-34a↑, 7,   miR-429↑, 1,   miR-99↑, 1,   mTOR↓, 8,   mTOR↝, 1,   p‑mTOR↓, 7,   n-MYC↓, 1,   Nanog↓, 5,   Neurog1↑, 1,   NKD2↑, 2,   NOTCH↓, 3,   NOTCH↝, 1,   NOTCH1↓, 4,   NOTCH1↝, 1,   OCT4↓, 4,   p300↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 4,   PI3K↝, 1,   p‑PI3K↓, 1,   PIAS-3↑, 1,   Pirin↓, 1,   circ‑PLEKHM3↑, 1,   PRKCG↑, 1,   PTCH1↓, 1,   PTEN↑, 4,   PTEN↝, 1,   RAS↓, 2,   RPS6KA1↓, 1,   SFRP5↑, 1,   Shh↓, 6,   Smo↓, 2,   SOX2↓, 2,   Src↓, 2,   STAT↓, 2,   STAT1↓, 2,   p‑STAT1↓, 2,   p‑STAT2↓, 1,   STAT3↓, 15,   p‑STAT3↓, 4,   STAT4↓, 1,   STAT5↓, 1,   TAZ↓, 1,   p‑TAZ↑, 1,   TCF↓, 3,   TOP1↓, 1,   TOP1↑, 1,   TOP2↓, 1,   TOP2↑, 2,   TumCG↓, 15,   Wnt↓, 9,   Wnt↝, 1,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

AGRN↓, 1,   AKR1C2↓, 1,   AP-1↓, 3,   AP-1↝, 2,   ATPase↓, 1,   BACH1↑, 1,   CAFs/TAFs↓, 1,   CD31↓, 1,   CDK4/6↓, 1,   circ-PRKCA↓, 1,   COL2A1↓, 1,   COL9A3↓, 1,   CXCL12↓, 1,   DLC1↑, 2,   E-cadherin↓, 3,   E-cadherin↑, 13,   EFEMP↓, 1,   FAK↓, 1,   FAK↝, 1,   fascin↓, 1,   Fibronectin↓, 3,   Galectin-9↓, 1,   GLI2↝, 1,   GP1BB↓, 1,   ITGB1↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   LAMA5↓, 1,   LAMs↓, 1,   MET↑, 1,   miR-130a↓, 3,   miR-141↑, 1,   miR-155↓, 1,   miR-19b↓, 1,   miR-20↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-206↑, 2,   miR-221↓, 1,   miR-29b↓, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-320a↓, 1,   miR-340↑, 1,   miR-384↑, 1,   miR-491↑, 1,   miR‐222↓, 1,   MMP2↓, 5,   MMP2↝, 1,   MMP9↓, 9,   pro‑MMP9↓, 1,   MMPs↓, 2,   MRGPRF↓, 1,   MUC1↓, 1,   N-cadherin↓, 8,   NEDD9↓, 2,   p‑p44↓, 1,   PDGF↓, 1,   p‑PDGF↓, 1,   PIR↓, 1,   PTP1B↓, 1,   Rho↓, 1,   Slug↓, 3,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 3,   SPARC↓, 1,   TET1↑, 2,   TGF-β↓, 6,   TregCell↓, 1,   TRIB3↑, 1,   Trop2↓, 1,   TumCI↓, 11,   TumCMig↓, 15,   TumCP↓, 28,   TumMeta↓, 4,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 1,   Vim↓, 11,   Vim↑, 1,   Zeb1↓, 2,   ZO-1↑, 1,   α-SMA↓, 2,   β-catenin/ZEB1↓, 15,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   angioS↑, 1,   ATF4↑, 1,   ECM/TCF↓, 2,   EGFR↓, 8,   EGFR↝, 1,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   Hif1a↝, 1,   LOX1↓, 1,   miR-126↑, 1,   miR-15↑, 1,   miR-17↓, 1,   NO↓, 1,   NO↑, 1,   REL↑, 1,   VEGF↓, 9,   VEGF↝, 1,   ZBTB10↑, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   MRP↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD25+↓, 1,   CD4+↓, 1,   COX1↓, 1,   COX2↓, 7,   COX2↝, 1,   CRP↓, 1,   CXCc↓, 2,   CXCR4↓, 1,   DCells↑, 1,   FoxP3+↓, 1,   GM-CSF↓, 2,   HCAR1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   p‑IKKα↓, 1,   IL1↓, 3,   IL10↓, 1,   IL12↓, 1,   IL18↓, 1,   IL2↓, 1,   IL5↓, 1,   IL6↓, 6,   IL6↝, 1,   IL8↓, 2,   Inflam↓, 1,   IκB↓, 1,   JAK↓, 4,   p‑JAK↓, 1,   JAK2↓, 2,   p‑JAK2↓, 1,   p‑JAK3↓, 1,   Macrophages↓, 1,   MDSCs↓, 2,   MyD88↓, 1,   Neut↓, 1,   NF-kB↓, 33,   NF-kB↝, 1,   NK cell↑, 1,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 2,   PD-L2↓, 1,   PGE2↓, 1,   PSA↓, 4,   PSA↝, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   T-Cell↑, 5,   TILs↑, 1,   TLR4↓, 3,   TNF-α↝, 1,   TRIF↓, 1,  

Cellular Microenvironment ⓘ

pH↑, 2,   TIM-3↓, 1,  

Synaptic & Neurotransmission ⓘ

ADAM10↓, 1,   cholinesterase↓, 1,   MAOA↓, 1,  

Protein Aggregation ⓘ

SNCG↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 8,   AR↝, 1,   CDK6↓, 1,   CYP11A1↓, 1,   CYP19↓, 1,   DHT↓, 1,   ER(estro)↓, 1,   ERβ↑, 1,   HSD3B↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 8,   BioAv↑, 11,   ChemoSen↑, 16,   CT-I↓, 1,   CYP17A1↓, 1,   Dose?, 1,   Dose↑, 4,   Dose↝, 7,   Dose∅, 5,   eff↓, 5,   eff↑, 21,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   Half-Life∅, 1,   MDR1↓, 1,   RadioS↑, 6,   RadioS∅, 1,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

ALAT↑, 1,   Albumin↑, 1,   ALP↑, 1,   AR↓, 8,   AR↝, 1,   AST↑, 1,   BMPs↑, 1,   BRCA1↑, 1,   CRP↓, 1,   CTC↓, 1,   EGFR↓, 8,   EGFR↝, 1,   EZH2↓, 3,   Ferritin↓, 1,   FOXM1↓, 2,   GutMicro↝, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 1,   IL6↓, 6,   IL6↝, 1,   Myc↓, 1,   PD-L1↓, 2,   PSA↓, 4,   PSA↝, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 5,   AntiTum↑, 1,   chemoP↑, 3,   ChemoSideEff↓, 1,   neuroP↑, 1,   OS↓, 1,   OS↑, 1,   QoL↑, 1,   radioP↑, 2,   Remission↑, 1,   toxicity↓, 2,   TumVol↓, 6,  

Infection & Microbiome ⓘ

Bacteria↑, 1,   CD8+↑, 1,   IRF3↓, 1,  
Total Targets: 618

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 25,   Catalase↑, 6,   GPx↑, 3,   GSH↑, 11,   GSR↓, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↑, 7,   HO-2↓, 1,   lipid-P↓, 7,   MDA↓, 6,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 13,   RNS↓, 1,   ROS↓, 30,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 9,   TAC↑, 1,   Trx↑, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↑, 1,   IronCh↑, 6,  

Mitochondria & Bioenergetics ⓘ

AIF↓, 1,   ATP↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↑, 1,   ALAT↓, 2,   AMPK↑, 1,   CREB↑, 2,   LDH↓, 1,   LDL↓, 3,   NADPH↓, 1,   NADPH↑, 1,   PPARγ↑, 1,   SIRT1↑, 3,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp9↓, 1,   CK2↑, 1,   Cyt‑c↓, 1,   iNOS↓, 4,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

Ach↑, 3,   HATs↓, 1,   other↓, 6,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   P53↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 4,   HDAC↑, 1,   mTOR↓, 1,   p300↓, 1,   PI3K↑, 1,   STAT↓, 1,   STAT3↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 2,   AP-1↓, 2,   APP↓, 1,   mt-ATPase↑, 1,   Ca+2↓, 1,   CDK5↓, 3,   COL3A1↓, 1,   miR-22↑, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMPs↓, 1,   MMPs↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TXNIP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 4,   NO↑, 1,   TXA2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 7,   MRP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2?, 1,   COX2↓, 8,   COX2↑, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL10↑, 1,   IL12↓, 3,   IL17↓, 1,   IL1β↓, 8,   IL2↓, 2,   IL2↑, 1,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 6,   IL8↓, 2,   INF-γ↓, 2,   Inflam↓, 28,   Inflam↑, 1,   MCP1↓, 3,   NF-kB↓, 14,   PGE2↓, 4,   TLR2↓, 1,   TNF-α↓, 9,  

Synaptic & Neurotransmission ⓘ

AChE↓, 15,   ADAM10↑, 2,   ADAM10↝, 1,   BChE↓, 2,   BDNF↑, 6,   ChAT↑, 1,   MAOA↓, 1,   PSD95↑, 1,   tau↓, 2,   p‑tau↓, 4,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 12,   BACE↓, 3,   NLRP3↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 7,   BioAv↑, 10,   BioAv↝, 3,   BioEnh↑, 3,   Dose↝, 3,   Dose∅, 1,   eff↑, 7,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   creat↓, 1,   Ferritin↑, 1,   GutMicro↑, 2,   IL6↓, 6,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 3,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 13,   cognitive↝, 1,   cognitive∅, 1,   GFR↑, 1,   hepatoP↑, 3,   memory↑, 10,   Mood↑, 1,   neuroP↑, 11,   OS↑, 2,   RenoP↑, 2,   toxicity↓, 2,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 158

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:65  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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