Database Query Results : Resveratrol, ,

RES, Resveratrol: Click to Expand ⟱
Features: polyphenol
Found in red grapes and products made with grapes.
Resveratrol is a polyphenol compound found in various plant species, including grapes, berries, and peanuts.
• Anti-inflammatory effects, Antioxidant effects:
- Antiplatelet aggregation for stroke prevention
- BioAvialability use piperine
- some sources may use Japanese knotweed roots (Reynoutria Japonica - root) as source which might contain Emodin (laxative)
-known as Nrf2 activator, both in cancer and normal cells. Which raises controversity of use in ROS↑ therapies. Interestingly there are reports of NRF2↑ and ROS↑ in cancer cells. This raises the question of if it is a chemosensitizer. However other reports indicate NRF2 droping with Res, indicating it maybe a chemosenstizer.
- RES is also considered to be them most effective natural SIRT1↑ -activating compound (STACs).

However, in the presence of certain metals, such as copper or iron, resveratrol can undergo a process called Fenton reaction, which can lead to the generation of reactive oxygen species (ROS). The pro-oxidant effects of resveratrol are often observed at high concentrations, typically above 50-100 μM, and in the presence of certain metals or other pro-oxidant agents. In contrast, the antioxidant effects of resveratrol are typically observed at lower concentrations, typically below 10-20 μM.

Clinical trials have used doses ranging from 150 mg to 5 grams per day. Lower doses (< 1 g/day) are often well-tolerated, but higher doses might be necessary for therapeutic effects and can be associated with side effects.

-Note half-life 1-3 hrs?.
BioAv poor: min 5uM/L required for chemopreventive effects, but 25mg Oral only yeilds 20nM. co-administration of piperine
Pathways:
- usually induce ROS production in cancer cells, while reducing ROS in normal cells.
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, UPR↑, GRP78↑, Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓,
- Lowers AntiOxidant defense in Cancer Cells: NRF2(typically increased), TrxR↓**, SOD↓, GSH↓ Catalase↓ HO1↓(wrong direction), GPx↓
- Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : NLRP3↓, IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, TIMP2, IGF-1↓, uPA↓, VEGF↓, ROCK1↓, FAK↓, RhoA↓, NF-κB↓, CXCR4↓, SDF1↓, TGF-β↓, α-SMA↓, ERK↓
- reactivate genes thereby inhibiting cancer cell growth : HDAC↓, EZH2↓, P53↑, HSP↓, Sp proteins↓,
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, FAK↓, ERK↓, EMT↓, TOP1↓, TET1↓,
- inhibits glycolysis /Warburg Effect and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDH↓, LDHA↓, HK2↓, PFKs↓, PDKs↓, ECAR↓, OXPHOS↓, GRP78↑, Glucose↓, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, FGF↓, PDGF↓, EGFR↓, Integrins↓,
- inhibits Cancer Stem Cells : CSC↓, CK2↓, Hh↓, CD133↓, CD24↓, β-catenin↓, sox2↓, notch2↓, nestin↓, OCT4↓,
- Others: PI3K↓, AKT↓, JAK↓, STAT↓, Wnt↓, β-catenin↓, AMPK, ERK↓, JNK,
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,

- Selectivity: Cancer Cells vs Normal Cells


Scientific Papers found: Click to Expand⟱
2578- ART/DHA,  RES,    Synergic effects of artemisinin and resveratrol in cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa
"highlight2" >Dose↝, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >necrosis↑, "highlight2" >ROS↑, "highlight2" >eff↑,
1383- CUR,  BBR,  RES,    Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases
- Review, NA, NA
"highlight2" >GSK‐3β↝, "highlight2" >ROS↑,
3748- CUR,  RES,  Hup,  Riv,  Gala  Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease
- Review, AD, NA
"highlight2" >*AChE↓, "highlight2" >*Inflam↓, "highlight2" >*Aβ↓, "highlight2" >*cognitive↑, "highlight2" >*ROS↓,
3862- CUR,  RES,    The metalloproteinase ADAM10: A useful therapeutic target?
- Review, AD, NA
"highlight2" >*SIRT1↑, "highlight2" >*ADAM10↑,
128- CUR,  RES,    Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer
- in-vivo, Pca, NA
"highlight2" >lipid-P↓,
134- CUR,  RES,  MEL,  SIL,    Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
"highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >Trx1↓,
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
"highlight2" >p38↓, "highlight2" >MKP5↑,
872- CUR,  RES,    New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
- in-vitro, BC, TUBO - in-vitro, BC, SALTO
"highlight2" >TumCP↓, "highlight2" >tumCV↓, "highlight2" >p62↓, "highlight2" >p62↑, "highlight2" >TumAuto↑, "highlight2" >TumAuto↓, "highlight2" >ROS↑, "highlight2" >ROS↓, "highlight2" >CHOP↑,
685- EGCG,  CUR,  SFN,  RES,  GEN  The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
- Analysis, NA, NA
"highlight2" >Bcl-2↓, "highlight2" >survivin↓, "highlight2" >XIAP↓, "highlight2" >EMT↓, "highlight2" >Apoptosis↑, "highlight2" >Nanog↓, "highlight2" >cMyc↓, "highlight2" >OCT4↓, "highlight2" >Snail↓, "highlight2" >Slug↓, "highlight2" >Zeb1↓, "highlight2" >TCF↓,
1534- LT,  Api,  EGCG,  RES,    Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, PC, Bxpc-3
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >eff↓, "highlight2" >*toxicity↑, "highlight2" >Dose?, "highlight2" >eff↓, "highlight2" >eff↓,
1721- Lyco,  RES,  VitC,    Lycopene, resveratrol, vitamin C and FeSO4 increase damage produced by pro-oxidant carcinogen 4-nitroquinoline-1-oxide in Drosophila melanogaster: Xenobiotic metabolism implications.
- in-vitro, Pca, PC3 - in-vitro, Lung, A549 - in-vitro, Cerv, HeLa - in-vitro, BC, MCF-7 - in-vitro, Liver, HepG2
"highlight2" >ROS↑,
873- QC,  RES,  CUR,  PI,    Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal Absorption
- in-vitro, Nor, NA
"highlight2" >*BioEnh↑,
67- QC,  RES,    Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
"highlight2" >cJun↑, "highlight2" >AR↓, "highlight2" >NA↓,
3077- RES,    Resveratrol attenuates matrix metalloproteinase-9 and -2-regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways
- in-vitro, Chon, HTB94
"highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >SOX9↑, "highlight2" >MMPs↓, "highlight2" >p‑p38↑, "highlight2" >p‑JNK↓, "highlight2" >NF-kB↓, "highlight2" >HO-1↓,
3065- RES,    Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response
- in-vitro, lymphoma, NA
"highlight2" >UPR↑, "highlight2" >IRE1↑, "highlight2" >p‑eIF2α↑, "highlight2" >PERK↑, "highlight2" >ATF6↑, "highlight2" >GRP78/BiP↑, "highlight2" >GRP94↑, "highlight2" >CHOP↑, "highlight2" >GADD34↑, "highlight2" >ATF4↑, "highlight2" >XBP-1↑, "highlight2" >Ca+2↑, "highlight2" >ER Stress↑,
3078- RES,    The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment
- Review, Pca, NA
"highlight2" >*ROS↓, "highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >Apoptosis↑, "highlight2" >Hif1a↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >Cyt‑c↑, "highlight2" >Dose↝, "highlight2" >MMPs↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >EMT↓, "highlight2" >E-cadherin↑, "highlight2" >N-cadherin↓, "highlight2" >AR↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
"highlight2" >angioG↓, "highlight2" >TumMeta↓, "highlight2" >ChemoSen↑, "highlight2" >NADPH↑, "highlight2" >SIRT1↑, "highlight2" >NF-kB↓, "highlight2" >NLRP3↓, "highlight2" >Dose↝, "highlight2" >COX2↓, "highlight2" >MMP9↓, "highlight2" >PGE2↓, "highlight2" >TIMP1↑, "highlight2" >TIMP2↑, "highlight2" >Sp1/3/4↓, "highlight2" >p‑JNK↓, "highlight2" >uPAR↓, "highlight2" >ROS↓, "highlight2" >CXCR4↓, "highlight2" >IL6↓, "highlight2" >Gli1↓, "highlight2" >*ROS↓, "highlight2" >*GSTs↑, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*GPx↑, "highlight2" >*lipid-P↓, "highlight2" >*GSH↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >eff↑,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
"highlight2" >IL6↓, "highlight2" >MMPs↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >BioAv↓, "highlight2" >Half-Life↑, "highlight2" >BioAv↑, "highlight2" >Dose↝, "highlight2" >angioG↓, "highlight2" >IL10↓, "highlight2" >VEGF↓, "highlight2" >NF-kB↓, "highlight2" >COX2↓, "highlight2" >SIRT1↑, "highlight2" >Wnt↓, "highlight2" >cMyc↓, "highlight2" >STAT3↓, "highlight2" >PTEN↑, "highlight2" >ROS↑, "highlight2" >RadioS↑, "highlight2" >Hif1a↓, "highlight2" >E-cadherin↓, "highlight2" >Vim↓, "highlight2" >angioG↓,
3075- RES,  Rad,    The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice
- in-vivo, Nor, NA
"highlight2" >*SIRT1↑, "highlight2" >*radioP↑, "highlight2" >*NLRP3↓, "highlight2" >*Weight↑, "highlight2" >*IL1β↓,
3080- RES,    Resveratrol: A miraculous natural compound for diseases treatment
- Review, Var, NA
"highlight2" >SIRT1↑, "highlight2" >ROCK1↓, "highlight2" >AMPK↑, "highlight2" >*lipid-P↓, "highlight2" >Aβ↓, "highlight2" >COX2↓, "highlight2" >angioG↓, "highlight2" >Hif1a↓, "highlight2" >VEGF↓,
3074- RES,    Possible therapeutic targets for NLRP3 inflammasome-induced breast cancer
- Review, BC, NA
"highlight2" >NLRP3↓, "highlight2" >SIRT1↑,
3073- RES,    Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy
- in-vitro, Nor, NA
"highlight2" >*NLRP3↓, "highlight2" >*mtDam↓, "highlight2" >*p38↑,
3072- RES,    Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
"highlight2" >tumCV↓, "highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >NLRP3↓, "highlight2" >JAK2↓, "highlight2" >STAT3↓, "highlight2" >IL1β↓, "highlight2" >IL18↓, "highlight2" >IL6↓, "highlight2" >TNF-α↓, "highlight2" >Inflam↓,
3071- RES,    Resveratrol and Its Anticancer Effects
- Review, Var, NA
"highlight2" >chemoP↑, "highlight2" >SIRT1↑, "highlight2" >Hif1a↓, "highlight2" >VEGF↓, "highlight2" >STAT3↓, "highlight2" >NF-kB↓, "highlight2" >COX2↓, "highlight2" >PI3K↓, "highlight2" >mTOR↓, "highlight2" >NRF2↑, "highlight2" >NLRP3↓, "highlight2" >H2O2↑, "highlight2" >ROS↑, "highlight2" >P53↑, "highlight2" >PUMA↑, "highlight2" >BAX↑,
3081- RES,    Resveratrol and p53: How are they involved in CRC plasticity and apoptosis?
- Review, CRC, NA
"highlight2" >NF-kB↓, "highlight2" >FAK↓, "highlight2" >Ki-67↓, "highlight2" >MMP9↓, "highlight2" >CSCs↓, "highlight2" >CD44↓, "highlight2" >CD133↓, "highlight2" >ALDH1A1↓, "highlight2" >EMT↓, "highlight2" >ChemoSen↑, "highlight2" >Hif1a↓, "highlight2" >ITGB1↓, "highlight2" >Inflam↓,
3070- RES,    Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma
- in-vitro, RCC, ACHN - in-vitro, RCC, 786-O - in-vivo, NA, NA
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Apoptosis↑, "highlight2" >NLRP3↓,
3082- RES,    Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vivo, NA, NA
"highlight2" >VEGF↓, "highlight2" >CXCL12↓, "highlight2" >IL6↓, "highlight2" >α-SMA↓, "highlight2" >Hif1a↓, "highlight2" >TumCI↓, "highlight2" >EMT↓,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
"highlight2" >AhR↓, "highlight2" >NRF2↑, "highlight2" >*NQO1↑, "highlight2" >*HO-1↑, "highlight2" >*GSH↑, "highlight2" >P53↑, "highlight2" >Cyt‑c↑, "highlight2" >Diablo↑, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >survivin↓, "highlight2" >XIAP↓, "highlight2" >FOXO↑, "highlight2" >p‑PI3K↓, "highlight2" >p‑Akt↓, "highlight2" >BIM↑, "highlight2" >DR4↑, "highlight2" >DR5↑, "highlight2" >p27↑, "highlight2" >cycD1↓, "highlight2" >SIRT1↑, "highlight2" >NF-kB↓, "highlight2" >ATF3↑,
3053- RES,    Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation
- in-vitro, NA, NA
"highlight2" >NRF2↑, "highlight2" >DNAdam↓,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
"highlight2" >TumCG↓, "highlight2" >P21↑, "highlight2" >p27↑, "highlight2" >CycB↓, "highlight2" >ROS↑, "highlight2" >ER Stress↑, "highlight2" >p‑p38↑, "highlight2" >P53↑, "highlight2" >p‑eIF2α↑, "highlight2" >EP4↑, "highlight2" >CHOP↑, "highlight2" >Bcl-2↓, "highlight2" >BAX↓, "highlight2" >TumCCA↑, "highlight2" >NRF2↓, "highlight2" >ChemoSen↑, "highlight2" >GSH↓,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
"highlight2" >BioAv↓, "highlight2" >BioAv↓, "highlight2" >Dose↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >Dose↑, "highlight2" >BioAv↑, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >P21↑, "highlight2" >p27↑, "highlight2" >TumCCA↑, "highlight2" >ChemoSen↑, "highlight2" >COX2↓, "highlight2" >5LO↓, "highlight2" >VEGF↓, "highlight2" >IL1↓, "highlight2" >IL6↓, "highlight2" >IL8↓, "highlight2" >AR↓, "highlight2" >PSA↓, "highlight2" >MAPK↓, "highlight2" >Hif1a↓, "highlight2" >Glycolysis↓, "highlight2" >miR-21↓, "highlight2" >PTEN↑, "highlight2" >Half-Life↝, "highlight2" >*IGF-1↓, "highlight2" >*IGFBP3↑, "highlight2" >Half-Life↓,
3056- RES,    Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice
- in-vivo, Nor, NA
"highlight2" >*AMPK↑, "highlight2" >*P21↑, "highlight2" >*Dose↓, "highlight2" >*chemoP↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
"highlight2" >*NRF2↑, "highlight2" >*Keap1↓, "highlight2" >*ROS↓, "highlight2" >*Apoptosis↓, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*hepatoP↑, "highlight2" >*neuroP↑, "highlight2" >*cardioP↑, "highlight2" >*RenoP↑, "highlight2" >*AntiCan↑, "highlight2" >*memory↑, "highlight2" >*SOD↑, "highlight2" >*GPx↑, "highlight2" >*Catalase↑, "highlight2" >*MDA↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*ROS↓, "highlight2" >*Aβ↓, "highlight2" >*iNOS↓, "highlight2" >*COX2↓, "highlight2" >*GSH↑, "highlight2" >*HO-1⇅, "highlight2" >*SIRT1↑,
3058- RES,    Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways
- in-vivo, NA, NA
"highlight2" >*Nrf1?,
3059- RES,    Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
- in-vivo, Nor, HK-2
"highlight2" >*RenoP↑, "highlight2" >*Inflam↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*SIRT1↑, "highlight2" >*ROS↓, "highlight2" >AntiAge↑,
3060- RES,    Resveratrol targeting NRF2 disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage in mice pulmonary infection
- in-vitro, Nor, RAW264.7 - in-vivo, NA, NA
"highlight2" >*NRF2↑, "highlight2" >*antiOx↑, "highlight2" >*ROS↓,
3069- RES,    Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway
- in-vitro, Nor, N9
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*ROS↓, "highlight2" >*NF-kB↓, "highlight2" >*AMPK↑, "highlight2" >*SIRT1↑, "highlight2" >*miR-155↓, "highlight2" >*NLRP3↓,
3062- RES,    Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis
- in-vivo, Nor, NA
"highlight2" >*antiOx↑, "highlight2" >*Keap1↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*GPx↑, "highlight2" >*SOD↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*AntiAg↑, "highlight2" >*chemoP↑, "highlight2" >ChemoSen↑, "highlight2" >BioAv↑, "highlight2" >Half-Life↝, "highlight2" >COX2↓, "highlight2" >cycD1↓, "highlight2" >CDK2↓, "highlight2" >CDK4↓, "highlight2" >CDK6↓, "highlight2" >P21↑, "highlight2" >MMP9↓, "highlight2" >NF-kB↓, "highlight2" >Telomerase↓, "highlight2" >PSA↓, "highlight2" >MAPK↑, "highlight2" >P53↑,
3064- RES,    Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species–Mediated Hypoxia-Inducible Factor-1α Activation
- in-vitro, CRC, HT-29 - in-vitro, BC, T47D - in-vitro, Lung, LLC1
"highlight2" >FDG↓, "highlight2" >ROS↓, "highlight2" >Hif1a↓, "highlight2" >GLUT1↓, "highlight2" >lactateProd↓,
3088- RES,    Notch signaling mediated repressive effects of resveratrol in inducing caspasedependent apoptosis in MCF-7 breast cancer cells
- in-vitro, BC, MCF-7
"highlight2" >NOTCH1↓, "highlight2" >BAX↑, "highlight2" >CDK4↝, "highlight2" >Casp3↑, "highlight2" >P21↑,
3066- RES,    Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells
"highlight2" >GSK‐3β↑, "highlight2" >Akt↓, "highlight2" >CHOP↑, "highlight2" >ER Stress↑, "highlight2" >PERK↑, "highlight2" >ATF6↑, "highlight2" >UPR↑, "highlight2" >GlucoseCon↓,
3067- RES,    Proteomic Profiling Reveals That Resveratrol Inhibits HSP27 Expression and Sensitizes Breast Cancer Cells to Doxorubicin Therapy
- in-vitro, BC, MCF-7
"highlight2" >Apoptosis↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >HSP27↓,
3068- RES,    Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation
- in-vitro, lymphoma, U937
"highlight2" >p65↓, "highlight2" >SOD2↓, "highlight2" >Prx↓, "highlight2" >Catalase↓, "highlight2" >Trx↓, "highlight2" >TNF-α↓, "highlight2" >IL8↓, "highlight2" >MCP1↓, "highlight2" >SIRT1↑,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*cognitive↑, "highlight2" >*neuroP↑, "highlight2" >*SIRT1↑, "highlight2" >*AMPK↑, "highlight2" >*GPx↑, "highlight2" >*HO-1↑, "highlight2" >*GSK‐3β↑, "highlight2" >*COX2↓, "highlight2" >*PGE2↓, "highlight2" >*NF-kB↓, "highlight2" >*NO↓, "highlight2" >*Casp3↓, "highlight2" >*MMP3↓, "highlight2" >*MMP9↓, "highlight2" >*MMP↑, "highlight2" >*GSH↑, "highlight2" >*other↑, "highlight2" >*BioAv↑, "highlight2" >*memory↑, "highlight2" >*GlutMet↑, "highlight2" >*BioAv↓, "highlight2" >*Half-Life↓, "highlight2" >*toxicity∅,
4289- RES,    Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells
- in-vitro, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*p‑tau↓, "highlight2" >*GSK‐3β↓, "highlight2" >*CaMKII ↓, "highlight2" >*PP2A↑, "highlight2" >*neuroP↑,
4288- RES,    Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β
- in-vivo, AD, NA
"highlight2" >*memory↑, "highlight2" >*GSH↑, "highlight2" >*ROS↓, "highlight2" >*MDA↓, "highlight2" >*p‑tau↓, "highlight2" >*PI3K↑, "highlight2" >*Akt↑, "highlight2" >*AMPK↑, "highlight2" >*PP2A↑, "highlight2" >*GSK‐3β↓,
4287- RES,    Resveratrol targeting tau proteins, amyloid-beta aggregations, and their adverse effects: An updated review
- Review, AD, NA
"highlight2" >*p‑tau↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*GSH↑, "highlight2" >*HO-1↑, "highlight2" >*iNOS↓, "highlight2" >*BDNF↑, "highlight2" >*p‑CREB↑, "highlight2" >*PKA↑, "highlight2" >*Bcl-2↑, "highlight2" >*BAX↓, "highlight2" >*IL1β↓, "highlight2" >*IL6↓, "highlight2" >*MMP9↓, "highlight2" >*memory↑, "highlight2" >*AMPK↑, "highlight2" >*PGC-1α↓, "highlight2" >*NF-kB↓, "highlight2" >*Aβ↓, "highlight2" >*SIRT1↑, "highlight2" >*p‑tau↓, "highlight2" >*PP2A↑, "highlight2" >*lipid-P↓, "highlight2" >*NLRP3↓, "highlight2" >*BACE↓,
4285- RES,    Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy
- in-vivo, AD, NA
"highlight2" >*tau↓, "highlight2" >*cognitive↑, "highlight2" >*Inflam↓,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
"highlight2" >*p‑tau↓, "highlight2" >*PP2A↑, "highlight2" >*neuroP↑, "highlight2" >*antiOx↑, "highlight2" >COX2↓, "highlight2" >*AntiAg↑, "highlight2" >*SIRT1↑, "highlight2" >*AMPK↑, "highlight2" >*Acetyl-CoA↓, "highlight2" >*FAO↑, "highlight2" >*ADAM10↑, "highlight2" >*BACE↓, "highlight2" >*Aβ↓, "highlight2" >*memory↑, "highlight2" >*Inflam↓, "highlight2" >*ROS↓,
4154- RES,    Resveratrol improves postnatal hippocampal neurogenesis and brain derived neurotrophic factor in prenatally stressed rats
- in-vivo, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*BDNF↑,
4153- RES,    Effect of oral resveratrol on the BDNF gene expression in the hippocampus of the rat brain
- in-vivo, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*BDNF↑,
3863- RES,  MEL,  VitA,RetA,    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
- Review, AD, NA - Review, Park, NA
"highlight2" >*ADAM10↑, "highlight2" >*ADAM10↑, "highlight2" >*ADAM10↑,
3858- RES,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*antiOx↑, "highlight2" >*LDL↓, "highlight2" >*ADAM10↑,
3798- RES,    Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure
- in-vivo, NA, NA
"highlight2" >*SIRT1↑, "highlight2" >*BDNF↑, "highlight2" >*PSD95↑, "highlight2" >*memory↑,
3614- RES,    Resveratrol--a boon for treating Alzheimer's disease?
- Review, AD, NA
"highlight2" >*SIRT1↑, "highlight2" >*neuroP↑,
3613- RES,    Resveratrol for Alzheimer's disease
- Review, AD, NA
"highlight2" >*SIRT1↑, "highlight2" >*BioAv↝, "highlight2" >*toxicity↓, "highlight2" >*ROS↓, "highlight2" >*antiOx↑, "highlight2" >*Aβ↓, "highlight2" >*MMP9↓, "highlight2" >*TNF-α↓,
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
"highlight2" >*other↑, "highlight2" >*Aβ↓, "highlight2" >*Inflam↓, "highlight2" >*NF-kB↓, "highlight2" >*neuroP↑, "highlight2" >*HO-1↑, "highlight2" >*lipid-P↓, "highlight2" >*COX2↓, "highlight2" >*AMPK↑, "highlight2" >*Catalase↑, "highlight2" >*SOD↑, "highlight2" >*GSR↑, "highlight2" >*ROS↓, "highlight2" >*MMP9↓, "highlight2" >*cognitive↑, "highlight2" >*SIRT1↑, "highlight2" >*IL1β↓, "highlight2" >*IL6↓,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*BioAv↓, "highlight2" >*Half-Life↓, "highlight2" >*BioAv↑, "highlight2" >*BBB↑, "highlight2" >*NRF2↑, "highlight2" >*BioAv↓, "highlight2" >*BioAv↑, "highlight2" >*SIRT1↑, "highlight2" >*cognitive↑, "highlight2" >*lipid-P↓, "highlight2" >*HO-1↑, "highlight2" >*SOD↑, "highlight2" >*GSH↑, "highlight2" >*GPx↑, "highlight2" >*G6PD↑, "highlight2" >*PPARγ↑, "highlight2" >*AMPK↑, "highlight2" >*Aβ↓,
3083- RES,    Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
"highlight2" >YAP/TEAD↓, "highlight2" >Rho↓, "highlight2" >FAK↓, "highlight2" >MMP9↓, "highlight2" >ChemoSen↑, "highlight2" >RAS↓, "highlight2" >ROCK1↓, "highlight2" >TumCI↓, "highlight2" >TumMeta↓,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
"highlight2" >NOTCH2↓, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >p‑SMAD2↓, "highlight2" >p‑SMAD3↓, "highlight2" >PTCH1↓, "highlight2" >Smo↓, "highlight2" >Gli1↓, "highlight2" >E-cadherin↑, "highlight2" >NOTCH⇅, "highlight2" >TAC?, "highlight2" >NKG2D↑, "highlight2" >DR4↑, "highlight2" >survivin↓, "highlight2" >DR5↑, "highlight2" >BAX↑, "highlight2" >p27↑, "highlight2" >cycD1↓, "highlight2" >Bcl-2↓, "highlight2" >STAT3↓, "highlight2" >STAT5↓, "highlight2" >JAK↓, "highlight2" >DNAdam↑, "highlight2" >γH2AX↑,
3097- RES,    Resveratrol Induces Notch2-mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer
- in-vitro, Thyroid, TT
"highlight2" >TumCG↓, "highlight2" >cl‑Casp3↑, "highlight2" >p‑PARP↑, "highlight2" >NOTCH2↑,
3096- RES,    Identification of potential target genes of non-small cell lung cancer in response to resveratrol treatment by bioinformatics analysis
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >p38↑, "highlight2" >MAPK↑, "highlight2" >STAT3↓, "highlight2" >ROS↑, "highlight2" >SIRT1↑, "highlight2" >SOX2↓,
3095- RES,    Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk
- in-vitro, BC, NA
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >cycD1↓, "highlight2" >cMyc↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >SOX2↓, "highlight2" >Akt↓, "highlight2" >STAT3↓, "highlight2" >α-SMA↓,
3094- RES,    Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >CSCs↓, "highlight2" >tumCV↓, "highlight2" >FASN↑, "highlight2" >BNIP3↑, "highlight2" >*cardioP↑, "highlight2" >*antiOx↑, "highlight2" >NF-kB↓, "highlight2" >COX2↓, "highlight2" >MMP9↓, "highlight2" >IGF-1↓, "highlight2" >ERK↓, "highlight2" >lipid-P↓, "highlight2" >CD24↓,
3093- RES,    Pro-Oxidant Effect of Resveratrol on Human Breast Cancer MCF-7 Cells is Associated with CK2 Inhibition
- in-vitro, BC, MCF-7
"highlight2" >ROS↑, "highlight2" >CK2↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF-7
"highlight2" >TumCP↓, "highlight2" >tumCV↓, "highlight2" >TumCI↓, "highlight2" >TumMeta↓, "highlight2" >*antiOx↑, "highlight2" >*cardioP↑, "highlight2" >*Inflam↓, "highlight2" >*neuroP↑, "highlight2" >*Keap1↓, "highlight2" >*NRF2↑, "highlight2" >*ROS↓, "highlight2" >p62↓, "highlight2" >IL1β↓, "highlight2" >CRP↓, "highlight2" >VEGF↓, "highlight2" >Bcl-2↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >FOXO4↓, "highlight2" >POLD1↓, "highlight2" >CK2↓, "highlight2" >MMP↓, "highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >Beclin-1↓, "highlight2" >Ki-67↓, "highlight2" >ATP↓, "highlight2" >GlutMet↓, "highlight2" >PFK↓, "highlight2" >TGF-β↓, "highlight2" >SMAD2↓, "highlight2" >SMAD3↓, "highlight2" >Vim?, "highlight2" >Snail↓, "highlight2" >Slug↓, "highlight2" >E-cadherin↑, "highlight2" >EMT↓, "highlight2" >Zeb1↓, "highlight2" >Fibronectin↓, "highlight2" >IGF-1↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >HO-1↑, "highlight2" >eff↑, "highlight2" >PD-1↓, "highlight2" >CD8+↑, "highlight2" >Th1 response↑, "highlight2" >CSCs↓, "highlight2" >RadioS↑, "highlight2" >SIRT1↑, "highlight2" >Hif1a↓, "highlight2" >mTOR↓,
3091- RES,    Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, ALVA-41
"highlight2" >CK2↓, "highlight2" >Apoptosis↑,
3090- RES,    The Effects of Resveratrol Targeting MicroRNA-4325P/PDGF-B to Regulate Tumor Angiogenesis in Osteosarcoma Microenvironment
- in-vitro, OS, MG63
"highlight2" >PDGFR-BB↓, "highlight2" >angioG↓,
3089- RES,    The Role of Resveratrol in Cancer Therapy
- Review, Var, NA
"highlight2" >angioG↓, "highlight2" >VEGF↓, "highlight2" >EGFR↓, "highlight2" >FGF↑, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >TIMP1↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >NF-kB↓, "highlight2" >Hif1a↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >MAPK↓, "highlight2" >EMT↓, "highlight2" >AR↓,
2988- RES,    The Antimetastatic Effects of Resveratrol on Hepatocellular Carcinoma through the Downregulation of a Metastasis-Associated Protease by SP-1 Modulation
- in-vitro, HCC, HUH7
"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >uPA↓, "highlight2" >Sp1/3/4↓,
3087- RES,    Resveratrol cytotoxicity is energy-dependent
- Review, Var, NA
"highlight2" >OXPHOS↓, "highlight2" >eff↝, "highlight2" >eff↑,
3086- RES,    Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, DU145
"highlight2" >TET1↑, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >TIMP2↑, "highlight2" >TIMP3↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓,
3085- RES,    Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1
- in-vitro, Cerv, NA
"highlight2" >TET1↑, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓,
3084- RES,    Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D
"highlight2" >TumCP↓, "highlight2" >EZH2↓, "highlight2" >p‑ERK↓,
885- RES,    Resveratrol induces intracellular Ca2 + rise via T-type Ca2 + channels in a mesothelioma cell line
- in-vitro, RCC, REN - in-vitro, Nor, MeT5A
"highlight2" >TumCG↓, "highlight2" >Ca+2↑, "highlight2" >*toxicity↓,
2330- RES,    Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission
- in-vitro, CRC, DLD1 - in-vitro, Cerv, HeLa - in-vitro, BC, MCF-7
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >PKM2↓, "highlight2" >ER Stress↑,
3052- RES,    Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Bxpc-3
"highlight2" >NAF1↓, "highlight2" >ROS↑, "highlight2" >NRF2↑, "highlight2" >eff↑, "highlight2" >TumCG↓,
2328- RES,    Resveratrol Inhibits Cancer Cell Metabolism by Down Regulating Pyruvate Kinase M2 via Inhibition of Mammalian Target of Rapamycin
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7
"highlight2" >PKM2↓, "highlight2" >mTOR↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓,
1511- RES,  Chemo,    Combination therapy in combating cancer
- Review, NA, NA
"highlight2" >eff↑, "highlight2" >*NRF2↑, "highlight2" >*GSH↑, "highlight2" >*ROS↓, "highlight2" >chemoP↑, "highlight2" >ChemoSideEff↓,
1506- RES,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
"highlight2" >DNMTs↓, "highlight2" >BRCA1↑, "highlight2" >HDAC↓, "highlight2" >SIRT1↑, "highlight2" >p300↓, "highlight2" >survivin↓, "highlight2" >HDAC1↓, "highlight2" >HDAC3↓, "highlight2" >HDAC8↓,
1492- RES,    Resveratrol: Biological and pharmaceutical properties as anticancer molecule
- Review, Var, NA
"highlight2" >RadioS↑, "highlight2" >ChemoSen↑,
1491- RES,    Resveratrol Augments Doxorubicin and Cisplatin Chemotherapy: A Novel Therapeutic Strategy
"highlight2" >RadioS↑, "highlight2" >ChemoSen↑,
1490- RES,    Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues
- Review, Var, NA
"highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >Ca+2↑, "highlight2" >MMP↓, "highlight2" >ATP↓, "highlight2" >TOP1?, "highlight2" >P53↑, "highlight2" >p53 Wildtype∅, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >EMT↓, "highlight2" >*BioAv↓,
1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
"highlight2" >RadioS↑, "highlight2" >ChemoSen↑, "highlight2" >*BioAv↓, "highlight2" >*BioAv↑, "highlight2" >Ferroptosis↑, "highlight2" >lipid-P↑, "highlight2" >xCT↓, "highlight2" >GPx4↓, "highlight2" >*BioAv↑, "highlight2" >COX2↓, "highlight2" >cycD1↓, "highlight2" >FasL↓, "highlight2" >FOXP3↓, "highlight2" >HLA↑, "highlight2" >p‑NF-kB↓, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >MALAT1↓,
1391- RES,  BBR,    Effects of Resveratrol, Berberine and Their Combinations on Reactive Oxygen Species, Survival and Apoptosis in Human Squamous Carcinoma (SCC-25) Cells
- in-vitro, Tong, SCC25
"highlight2" >ROS↑, "highlight2" >eff↑,
1282- RES,    Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1
- vitro+vivo, NA, NA
"highlight2" >T-Cell↓, "highlight2" >SIRT1↑, "highlight2" >CD4+↓,
1047- RES,    Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H460
"highlight2" >PD-L1↑, "highlight2" >Snail↑, "highlight2" >E-cadherin↓, "highlight2" >N-cadherin↑, "highlight2" >Fibronectin↑, "highlight2" >Vim↑, "highlight2" >Axin2↓,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
"highlight2" >TumCG↓, "highlight2" >Glycolysis↓, "highlight2" >PPP↓, "highlight2" >ATP↑, "highlight2" >PDH↑, "highlight2" >Ca+2↝, "highlight2" >TumCP↓, "highlight2" >lactateProd↓, "highlight2" >OCR↑, "highlight2" >ECAR↓, "highlight2" >*ECAR∅, "highlight2" >*other?, "highlight2" >cycE↑, "highlight2" >cycA1↑, "highlight2" >TumCCA↑, "highlight2" >cycD1↑, "highlight2" >OXPHOS↑,
967- RES,    Resveratrol binds and inhibits transcription factor HIF-1α in pancreatic cancer
- Analysis, PC, NA
"highlight2" >Hif1a↓,
924- RES,    Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
- in-vitro, OS, U2OS - in-vitro, Lung, A549
"highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >γH2AX↑, "highlight2" >ATM↑, "highlight2" >p‑CHK1↑, "highlight2" >cellSen↑, "highlight2" >CXCR2↑,
2329- RES,    Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis
- in-vitro, Melanoma, A375
"highlight2" >P53↑, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Cyt‑c↑, "highlight2" >ERK↓, "highlight2" >PKM2↓, "highlight2" >Apoptosis↑, "highlight2" >γH2AX↑, "highlight2" >Casp3↑, "highlight2" >cl‑PARP1↑,
884- RES,  PTS,    Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells
- in-vitro, Cerv, HeLa
"highlight2" >TumCD↑, "highlight2" >TumCCA↑, "highlight2" >E6↓, "highlight2" >Casp3↑, "highlight2" >P53↑,
883- RES,    Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy
"highlight2" >HDAC↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >angioG↓, "highlight2" >ROS↑,
882- RES,    Resveratrol: A Double-Edged Sword in Health Benefits
- Review, NA, NA
"highlight2" >AntiTum↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >P53↑, "highlight2" >NAF1↓, "highlight2" >NRF2↑, "highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >HDAC↓, "highlight2" >TumCCA↑, "highlight2" >TumAuto↑, "highlight2" >angioG↓, "highlight2" >iNOS↓,
881- RES,    Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
- in-vitro, BC, MDA-MB-231 - in-vitro, PC, PANC1 - in-vitro, Pca, DU145
"highlight2" >TumCCA↑, "highlight2" >cycD1↓, "highlight2" >Bcl-xL↓, "highlight2" >Mcl-1↓, "highlight2" >other↓,
880- RES,    Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol
- in-vitro, BC, MDA-MB-231
"highlight2" >other↓, "highlight2" >TumW↓, "highlight2" >FOXO↑, "highlight2" >BMP2↑,
879- RES,    Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it
- in-vitro, CRC, HCT116
"highlight2" >TumCP↓, "highlight2" >NF-kB↓,
878- RES,    Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression
- vitro+vivo, CRC, LoVo
"highlight2" >TumMeta↓, "highlight2" >E-cadherin↑, "highlight2" >Vim↓, "highlight2" >TGF-β↓, "highlight2" >SMAD2↓, "highlight2" >EMT↓, "highlight2" >SMAD3↓,
877- RES,    Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, HCT116
"highlight2" >MALAT1↓, "highlight2" >Wnt/(β-catenin)↓, "highlight2" >TumCI↓, "highlight2" >TumMeta↓,
871- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
"highlight2" >T-Cell↑, "highlight2" >Neut↓, "highlight2" >Macrophages↓, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >other↓, "highlight2" >AntiTum↑, "highlight2" >TumVol↓,
105- RES,  QC,    The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell
- in-vitro, Pca, CD133+
"highlight2" >N-cadherin↓, "highlight2" >TNF-α↓, "highlight2" >ACTA2↓,
104- RES,  QC,    Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a
- in-vitro, Colon, HT-29
"highlight2" >Casp3↑, "highlight2" >PARP↑, "highlight2" >survivin↓, "highlight2" >miR-27a-3p↓, "highlight2" >Sp1/3/4↓, "highlight2" >ZBTB10↑,
103- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- vitro+vivo, BC, 4T1
"highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Casp9↑, "highlight2" >T-Cell↑, "highlight2" >TGF-β↓,
102- RES,    Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway
- in-vitro, PC, MIA PaCa-2
"highlight2" >HH↓, "highlight2" >PTCH1↓, "highlight2" >Smo↓, "highlight2" >HH↓, "highlight2" >EMT↓, "highlight2" >PI3K/Akt↓, "highlight2" >NF-kB↓,
101- RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
"highlight2" >HH↓, "highlight2" >Gli1↓, "highlight2" >EMT↓, "highlight2" >Snail↓, "highlight2" >N-cadherin↓, "highlight2" >E-cadherin↑,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
"highlight2" >Glycolysis↓, "highlight2" >GLUT1↓, "highlight2" >PFK1↓, "highlight2" >Hif1a↓, "highlight2" >ROS↑, "highlight2" >PDH↑, "highlight2" >AMPK↑, "highlight2" >TumCG↓, "highlight2" >TumCI↓, "highlight2" >TumCP↓, "highlight2" >p‑NF-kB↓, "highlight2" >SIRT1↑, "highlight2" >SIRT3↑, "highlight2" >LDH↓, "highlight2" >PI3K↓, "highlight2" >mTOR↓, "highlight2" >PKM2↓, "highlight2" >R5P↝, "highlight2" >G6PD↓, "highlight2" >TKT↝, "highlight2" >talin↓, "highlight2" >HK2↓, "highlight2" >GRP78/BiP↑, "highlight2" >GlucoseCon↓, "highlight2" >ER Stress↑, "highlight2" >Warburg↓, "highlight2" >PFK↓,
2991- RES,  Chemo,    Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells
- in-vitro, Melanoma, MSTO-211H - in-vitro, Nor, MeT5A
"highlight2" >eff↑, "highlight2" >selectivity↑, "highlight2" >Sp1/3/4↓,
2990- RES,    Resveratrol reduces cerebral edema through inhibition of de novo SUR1 expression induced after focal ischemia
- in-vivo, Stroke, NA
"highlight2" >*OS↑, "highlight2" >*antiOx↑, "highlight2" >Sp1/3/4↓,
2989- RES,    Resveratrol Represses Pokemon Expression in Human Glioma Cells
- in-vitro, GBM, NA
"highlight2" >FBI-1↓, "highlight2" >Sp1/3/4↓,
2987- RES,    Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1
- in-vivo, Nor, NA
"highlight2" >*VEGF↑, "highlight2" >*iNOS↑, "highlight2" >*NF-kB↑, "highlight2" >*Sp1/3/4↑, "highlight2" >*cardioP↑,
2986- RES,    Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription
- in-vitro, Cerv, HeLa - in-vitro, AML, HL-60
"highlight2" >Sp1/3/4↑,
2985- RES,    Resveratrol Inhibits Diabetic-Induced Müller Cells Apoptosis through MicroRNA-29b/Specificity Protein 1 Pathway
- in-vivo, Nor, NA - vitro+vivo, Diabetic, NA
"highlight2" >*Sp1/3/4↓, "highlight2" >*miR-29b↑,
2984- RES,    Involvement of miR-539-5p in the inhibition of de novo lipogenesis induced by resveratrol in white adipose tissue
- in-vivo, Nor, NA
"highlight2" >*Sp1/3/4↓, "highlight2" >*SREBP1↓, "highlight2" >*FASN↓,
2983- RES,    Resveratrol Improves Diabetic Retinopathy via Regulating MicroRNA-29b/Specificity Protein 1/Apoptosis Pathway by Enhancing Autophagy
- in-vitro, Nor, NA
"highlight2" >*Beclin-1↑, "highlight2" >*p62↓, "highlight2" >*Sp1/3/4↓, "highlight2" >*Apoptosis↓,
2982- RES,    The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1
- in-vitro, Melanoma, MSTO-211H
"highlight2" >tumCV↓, "highlight2" >Apoptosis↑, "highlight2" >Sp1/3/4↓, "highlight2" >p27↓, "highlight2" >P21↓, "highlight2" >cycD1↓, "highlight2" >Mcl-1↓, "highlight2" >survivin↓,
2981- RES,    Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW48
"highlight2" >TumCCA↑, "highlight2" >p27↑, "highlight2" >cycD1↓, "highlight2" >TumCP↓, "highlight2" >IGF-1R↓, "highlight2" >Akt↓, "highlight2" >Wnt↓, "highlight2" >P53↑, "highlight2" >Apoptosis↑, "highlight2" >Sp1/3/4↓, "highlight2" >cl‑PARP↑, "highlight2" >β-catenin/ZEB1↓, "highlight2" >MDM2↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
"highlight2" >NF-kB↓, "highlight2" >P450↓, "highlight2" >COX2↓, "highlight2" >Hif1a↓, "highlight2" >VEGF↓, "highlight2" >*SIRT1↑, "highlight2" >SIRT1↓, "highlight2" >SIRT2↓, "highlight2" >ChemoSen⇅, "highlight2" >cardioP↑, "highlight2" >*memory↑, "highlight2" >*angioG↑, "highlight2" >*neuroP↑, "highlight2" >STAT3↓, "highlight2" >CSCs↓, "highlight2" >RadioS↑, "highlight2" >Nestin↓, "highlight2" >Nanog↓, "highlight2" >TP53↑, "highlight2" >P21↑, "highlight2" >CXCR4↓, "highlight2" >*BioAv↓, "highlight2" >EMT↓, "highlight2" >Vim↓, "highlight2" >Slug↓, "highlight2" >E-cadherin↑, "highlight2" >AMPK↑, "highlight2" >MDR1↓, "highlight2" >DNAdam↑, "highlight2" >TOP2↓, "highlight2" >PTEN↑, "highlight2" >Akt↓, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >cMyc↓, "highlight2" >MMP7↓, "highlight2" >MALAT1↓, "highlight2" >TCF↓, "highlight2" >ALDH↓, "highlight2" >CD44↓, "highlight2" >Shh↓, "highlight2" >IL6↓, "highlight2" >VEGF↓, "highlight2" >eff↑, "highlight2" >HK2↓, "highlight2" >ROS↑, "highlight2" >MMP↓,
2650- RES,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
"highlight2" >ROS↑, "highlight2" >Dose↝, "highlight2" >NRF2↑, "highlight2" >NAF1↓, "highlight2" >ChemoSen↑, "highlight2" >BioAv↓,
2568- RES,    Resveratrol: A Miracle Drug for Vascular Pathologies
- Review, Var, NA
"highlight2" >antiOx↑, "highlight2" >Inflam↓, "highlight2" >cardioP↑,
2567- RES,    Neuroprotective Effects of Resveratrol in Ischemic Brain Injury
- Review, Stroke, NA
"highlight2" >*eff↑, "highlight2" >*neuroP↑, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*cardioP↑, "highlight2" >*AntiAg↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
"highlight2" >*neuroP↑, "highlight2" >*NRF2↑, "highlight2" >*SIRT1↑, "highlight2" >*PGC-1α↑, "highlight2" >*FOXO↑, "highlight2" >*HO-1↑, "highlight2" >*NQO1↑, "highlight2" >*ROS↓, "highlight2" >*BP↓, "highlight2" >*BioAv↓, "highlight2" >*Half-Life↝, "highlight2" >*AMPK↑, "highlight2" >*GSK‐3β↓, "highlight2" >*eff↑, "highlight2" >*AntiAg↑, "highlight2" >*BBB↓, "highlight2" >*Inflam↓, "highlight2" >*MPO↓, "highlight2" >*TLR4↓, "highlight2" >*NF-kB↓, "highlight2" >*p65↓, "highlight2" >*MMP9↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*PPARγ↑, "highlight2" >*MMP↑, "highlight2" >*ATP↑, "highlight2" >*Cyt‑c∅, "highlight2" >*mt-lipid-P↓, "highlight2" >*H2O2↓, "highlight2" >*HSP70/HSPA5↝, "highlight2" >*Mets↝, "highlight2" >*eff↑, "highlight2" >*eff↑, "highlight2" >*motorD↑, "highlight2" >*MDA↓, "highlight2" >*NADH:NAD↑, "highlight2" >eff↑, "highlight2" >eff↑,
2564- RES,    Effect of resveratrol on platelet aggregation by fibrinogen protection
- in-vitro, NA, NA
"highlight2" >AntiAg↑, "highlight2" >antiOx↓, "highlight2" >COX2↓,
2472- RES,    Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model
- in-vivo, Nor, NA
"highlight2" >*SIRT1↑, "highlight2" >*PGC-1α↑, "highlight2" >*cMyc↑, "highlight2" >*PDK1↓,
2471- RES,    Resveratrol Regulates Glucose and Lipid Metabolism in Diabetic Rats by Inhibition of PDK1/AKT Phosphorylation and HIF-1α Expression
- in-vivo, Diabetic, NA
"highlight2" >*p‑PDK1↓, "highlight2" >*p‑Akt↓, "highlight2" >*Hif1a↓, "highlight2" >*GLUT1↓,
2467- RES,    Resveratrol inhibits Ca2+ signals and aggregation of platelets
- in-vitro, Nor, NA
"highlight2" >*AntiAg↑, "highlight2" >Ca+2↓,
2443- RES,    Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
- Review, Var, NA
"highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*PTEN↑, "highlight2" >*Akt↓, "highlight2" >*Catalase↑, "highlight2" >*SOD↑, "highlight2" >*ERK↓, "highlight2" >*GSH↑, "highlight2" >*AMPK↑, "highlight2" >*FOXO1↝, "highlight2" >*RNS↓, "highlight2" >*Catalase↑, "highlight2" >*cardioP↑, "highlight2" >*PI3K↑, "highlight2" >*eNOS↑, "highlight2" >hepatoP↑,
2442- RES,    High absorption but very low bioavailability of oral resveratrol in humans
- in-vitro, Nor, NA
"highlight2" >BioAv↝, "highlight2" >Half-Life↝, "highlight2" >BioAv↓, "highlight2" >eff↝,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
"highlight2" >*toxicity↓, "highlight2" >*BioAv↝, "highlight2" >*Dose↝, "highlight2" >*hepatoP↑, "highlight2" >*neuroP↑, "highlight2" >*AntiAg↑, "highlight2" >*COX2↓, "highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*ROS↑, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >NF-kB↓, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >NRF2↑, "highlight2" >GPx↑, "highlight2" >HO-1↑, "highlight2" >BioEnh?, "highlight2" >PTEN↑, "highlight2" >ChemoSen↑, "highlight2" >eff↑, "highlight2" >mt-ROS↑, "highlight2" >Warburg↓, "highlight2" >Glycolysis↓, "highlight2" >GlucoseCon↓, "highlight2" >GLUT1↓, "highlight2" >lactateProd↓, "highlight2" >HK2↓, "highlight2" >EGFR↓, "highlight2" >cMyc↓, "highlight2" >ROS↝, "highlight2" >MMPs↓, "highlight2" >MMP7↓, "highlight2" >survivin↓, "highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓,
2440- RES,    Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway
- in-vitro, Lung, H460 - in-vivo, Lung, NA - in-vitro, Lung, H1650 - in-vitro, Lung, HCC827
"highlight2" >AntiTum↑, "highlight2" >Glycolysis↓, "highlight2" >HK2↓, "highlight2" >EGFR↓, "highlight2" >Akt↓, "highlight2" >ERK↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >TumCG↓, "highlight2" >Ki-67↓,
2565- RES,    https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2007.06788.x
- in-vitro, NA, NA - in-vivo, NA, NA
"highlight2" >AntiAg↑, "highlight2" >TXA2↑, "highlight2" >PKCδ↑, "highlight2" >Dose↝,
2439- RES,    By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice
- in-vitro, HCC, HCCLM3 - in-vitro, Nor, L02 - in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402 - in-vitro, HCC, HUH7
"highlight2" >HK2↓, "highlight2" >ChemoSen↑, "highlight2" >other↑, "highlight2" >Glycolysis↓, "highlight2" >lactateProd↓, "highlight2" >TumCP↓, "highlight2" >Casp3↑, "highlight2" >cl‑PARP↑, "highlight2" >PKM2↓,
2334- RES,    Glut 1 in Cancer Cells and the Inhibitory Action of Resveratrol as A Potential Therapeutic Strategy
- Review, Var, NA
"highlight2" >GLUT1↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >Dose↝, "highlight2" >SIRT6↑, "highlight2" >PKM2↓, "highlight2" >HK2↓, "highlight2" >PFK1↓, "highlight2" >ChemoSen↑,
2331- RES,    Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1
- in-vivo, Nor, NA
"highlight2" >*LDHA↑, "highlight2" >*PKM2↑, "highlight2" >*SIRT1↑, "highlight2" >*Glycolysis↝,
2333- RES,    Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
- in-vitro, Nor, NA
"highlight2" >*glucose↓, "highlight2" >*Insulin↓, "highlight2" >*IGFR↓, "highlight2" >*IGF-1↓, "highlight2" >*LDHA↑, "highlight2" >*HK2↑, "highlight2" >*PKM2↑, "highlight2" >*Glycolysis↝, "highlight2" >*SIRT2↑,
3034- RosA,  RES,  Ba,    The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells
- in-vitro, BC, MCF-7
"highlight2" >DNMTs↓, "highlight2" >eff↑, "highlight2" >eff↝,
2306- SIL,  CUR,  RES,  EA,    Identification of Natural Compounds as Inhibitors of Pyruvate Kinase M2 for Cancer Treatment
- in-vitro, BC, MDA-MB-231
"highlight2" >PKM2↓, "highlight2" >Dose↝, "highlight2" >Dose↝,
2206- SNP,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
"highlight2" >*hepatoP↑, "highlight2" >*Inflam↓, "highlight2" >*NF-kB↓, "highlight2" >*VEGF↓, "highlight2" >*SIRT1↑, "highlight2" >*ROS↓, "highlight2" >*Dose↝, "highlight2" >*Catalase↑, "highlight2" >*MDA↓, "highlight2" >*MPO↓, "highlight2" >*NO↓, "highlight2" >*ALAT↓, "highlight2" >*AST↓, "highlight2" >*antiOx↑,
119- UA,  CUR,  RES,    Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >ROS⇅, "highlight2" >p‑STAT3↓, "highlight2" >Src↓, "highlight2" >AMPK↑,
3921- VitD3,  RES,    Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice
- in-vivo, AD, NA
"highlight2" >*cognitive↑, "highlight2" >*Aβ↓, "highlight2" >*BACE↓, "highlight2" >*p‑tau↓, "highlight2" >*p‑CREB↑, "highlight2" >*p‑NF-kB↓, "highlight2" >*neuroP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 141

Results for Effect on Cancer/Diseased Cells:
5LO↓,1,   ACTA2↓,1,   AhR↓,1,   Akt↓,11,   p‑Akt↓,1,   ALDH↓,1,   ALDH1A1↓,1,   AMPK↑,4,   angioG↓,8,   AntiAg↑,2,   AntiAge↑,1,   antiOx↓,1,   antiOx↑,1,   AntiTum↑,3,   Apoptosis↑,17,   AR↓,4,   ATF3↑,1,   ATF4↑,1,   ATF6↑,2,   ATM↑,1,   ATP↓,2,   ATP↑,1,   Axin2↓,1,   Aβ↓,1,   BAX↓,1,   BAX↑,7,   Bcl-2↓,9,   Bcl-xL↓,3,   Beclin-1↓,1,   BIM↑,1,   BioAv↓,5,   BioAv↑,3,   BioAv↝,1,   BioEnh?,1,   BMP2↑,1,   BNIP3↑,1,   BRCA1↑,1,   Ca+2↓,1,   Ca+2↑,3,   Ca+2↝,1,   cardioP↑,2,   Casp3↑,8,   cl‑Casp3↑,1,   Casp9↑,4,   Catalase↓,1,   CD133↓,1,   CD24↓,1,   CD4+↓,1,   CD44↓,2,   CD8+↑,1,   CDK2↓,1,   CDK4↓,1,   CDK4↝,1,   CDK6↓,1,   cellSen↑,1,   chemoP↑,2,   ChemoSen↑,13,   ChemoSen⇅,1,   ChemoSideEff↓,1,   p‑CHK1↑,1,   CHOP↑,4,   cJun↑,1,   CK2↓,3,   cMyc↓,5,   COX2↓,11,   CRP↓,1,   CSCs↓,4,   CXCL12↓,1,   CXCR2↑,1,   CXCR4↓,2,   cycA1↑,1,   CycB↓,1,   cycD1↓,8,   cycD1↑,1,   cycE↑,1,   Cyt‑c↑,4,   Diablo↑,1,   DNAdam↓,1,   DNAdam↑,3,   DNMTs↓,2,   Dose?,1,   Dose↑,2,   Dose↝,9,   DR4↑,2,   DR5↑,2,   E-cadherin↓,2,   E-cadherin↑,6,   E6↓,1,   ECAR↓,1,   eff↓,3,   eff↑,17,   eff↝,3,   EGFR↓,3,   p‑eIF2α↑,2,   EMT↓,11,   EP4↑,1,   ER Stress↑,5,   ERK↓,3,   p‑ERK↓,1,   EZH2↓,1,   FAK↓,2,   FasL↓,1,   FASN↑,1,   FBI-1↓,1,   FDG↓,1,   Ferroptosis↑,1,   FGF↑,1,   Fibronectin↓,1,   Fibronectin↑,1,   FOXO↑,2,   FOXO4↓,1,   FOXP3↓,1,   G6PD↓,1,   GADD34↑,1,   Gli1↓,3,   GlucoseCon↓,6,   GLUT1↓,4,   GlutMet↓,1,   Glycolysis↓,6,   GPx↑,1,   GPx4↓,1,   GRP78/BiP↑,2,   GRP94↑,1,   GSH↓,1,   GSK‐3β↑,1,   GSK‐3β↝,1,   H2O2↑,1,   Half-Life↓,1,   Half-Life↑,1,   Half-Life↝,3,   HDAC↓,3,   HDAC1↓,1,   HDAC3↓,1,   HDAC8↓,1,   hepatoP↑,1,   HH↓,3,   Hif1a↓,12,   Hif1a↑,1,   HK2↓,6,   HLA↑,1,   HO-1↓,1,   HO-1↑,2,   HSP27↓,1,   IGF-1↓,2,   IGF-1R↓,1,   IL1↓,1,   IL10↓,1,   IL18↓,1,   IL1β↓,2,   IL6↓,6,   IL8↓,2,   Inflam↓,3,   iNOS↓,1,   IRE1↑,1,   ITGB1↓,1,   JAK↓,1,   JAK2↓,1,   p‑JNK↓,2,   Ki-67↓,3,   lactateProd↓,7,   LDH↓,1,   lipid-P↓,2,   lipid-P↑,1,   Macrophages↓,1,   MALAT1↓,3,   MAPK↓,2,   MAPK↑,2,   Mcl-1↓,2,   MCP1↓,1,   MDM2↓,1,   MDR1↓,1,   miR-21↓,1,   miR-27a-3p↓,1,   MKP5↑,1,   MMP↓,7,   MMP2↓,7,   MMP7↓,2,   MMP9↓,12,   MMPs↓,4,   mTOR↓,7,   N-cadherin↓,3,   N-cadherin↑,1,   NA↓,1,   NADPH↑,1,   NAF1↓,3,   Nanog↓,2,   necrosis↑,1,   Nestin↓,1,   Neut↓,1,   NF-kB↓,13,   p‑NF-kB↓,2,   NKG2D↑,1,   NLRP3↓,5,   NOTCH⇅,1,   NOTCH1↓,1,   NOTCH2↓,1,   NOTCH2↑,1,   NRF2↓,1,   NRF2↑,7,   OCR↑,1,   OCT4↓,1,   other↓,3,   other↑,1,   OXPHOS↓,1,   OXPHOS↑,1,   P21↓,1,   P21↑,5,   p27↓,1,   p27↑,5,   p300↓,1,   p38↓,1,   p38↑,1,   p‑p38↑,2,   P450↓,1,   P53↑,9,   p53 Wildtype∅,1,   p62↓,2,   p62↑,1,   p65↓,1,   PARP↑,1,   p‑PARP↑,1,   cl‑PARP↑,2,   cl‑PARP1↑,1,   PD-1↓,1,   PD-L1↑,1,   PDGFR-BB↓,1,   PDH↑,2,   PERK↑,2,   PFK↓,2,   PFK1↓,2,   PGE2↓,1,   PI3K↓,5,   p‑PI3K↓,1,   PI3K/Akt↓,1,   PKCδ↑,1,   PKM2↓,7,   POLD1↓,1,   PPP↓,1,   Prx↓,1,   PSA↓,2,   PTCH1↓,2,   PTEN↑,4,   PUMA↑,1,   R5P↝,1,   RadioS↑,6,   RAS↓,1,   Rho↓,1,   ROCK1↓,2,   ROS↓,3,   ROS↑,24,   ROS⇅,1,   ROS↝,1,   mt-ROS↑,1,   selectivity↑,1,   Shh↓,1,   SIRT1↓,1,   SIRT1↑,12,   SIRT2↓,1,   SIRT3↑,1,   SIRT6↑,1,   Slug↓,3,   SMAD2↓,2,   p‑SMAD2↓,1,   SMAD3↓,2,   p‑SMAD3↓,1,   Smo↓,2,   Snail↓,3,   Snail↑,1,   SOD2↓,1,   SOX2↓,2,   SOX9↑,1,   Sp1/3/4↓,8,   Sp1/3/4↑,1,   Src↓,1,   STAT3↓,7,   p‑STAT3↓,1,   STAT5↓,1,   survivin↓,7,   T-Cell↓,1,   T-Cell↑,2,   TAC?,1,   talin↓,1,   TCF↓,2,   Telomerase↓,1,   TET1↑,2,   TGF-β↓,3,   Th1 response↑,1,   TIMP1↑,2,   TIMP2↑,2,   TIMP3↑,1,   TKT↝,1,   TNF-α↓,3,   TOP1?,1,   TOP2↓,1,   TP53↑,1,   Trx↓,1,   Trx1↓,1,   TumAuto↓,1,   TumAuto↑,2,   TumCCA↑,11,   TumCD↑,1,   TumCG↓,7,   TumCI↓,11,   TumCMig↓,8,   TumCP↓,15,   tumCV↓,5,   TumMeta↓,5,   TumVol↓,1,   TumW↓,1,   TXA2↑,1,   uPA↓,1,   uPAR↓,1,   UPR↑,2,   VEGF↓,9,   Vim?,1,   Vim↓,3,   Vim↑,1,   Warburg↓,2,   Wnt↓,6,   Wnt/(β-catenin)↓,1,   XBP-1↑,1,   xCT↓,1,   XIAP↓,2,   YAP/TEAD↓,1,   ZBTB10↑,1,   Zeb1↓,2,   α-SMA↓,2,   β-catenin/ZEB1↓,5,   γH2AX↑,3,  
Total Targets: 329

Results for Effect on Normal Cells:
Acetyl-CoA↓,1,   AChE↓,1,   ADAM10↑,6,   Akt↓,1,   Akt↑,1,   p‑Akt↓,1,   ALAT↓,1,   AMPK↑,10,   angioG↑,1,   AntiAg↑,6,   AntiCan↑,1,   antiOx↑,18,   Apoptosis↓,2,   AST↓,1,   ATP↑,1,   Aβ↓,8,   BACE↓,3,   BAX↓,1,   BBB↓,1,   BBB↑,1,   Bcl-2↑,1,   BDNF↑,4,   Beclin-1↑,1,   BioAv↓,7,   BioAv↑,5,   BioAv↝,2,   BioEnh↑,1,   BP↓,1,   CaMKII ↓,1,   cardioP↑,6,   Casp3↓,1,   Catalase↑,6,   chemoP↑,2,   cMyc↑,1,   cognitive↑,6,   COX2↓,4,   p‑CREB↑,2,   Cyt‑c∅,1,   Dose↓,1,   Dose↝,2,   ECAR∅,1,   eff↑,4,   eNOS↑,1,   ERK↓,1,   FAO↑,1,   FASN↓,1,   FOXO↑,1,   FOXO1↝,1,   G6PD↑,1,   glucose↓,1,   GLUT1↓,1,   GlutMet↑,1,   Glycolysis↝,2,   GPx↑,5,   GSH↑,9,   GSK‐3β↓,3,   GSK‐3β↑,1,   GSR↑,1,   GSTs↑,1,   H2O2↓,1,   Half-Life↓,2,   Half-Life↝,1,   hepatoP↑,3,   Hif1a↓,1,   HK2↑,1,   HO-1↑,9,   HO-1⇅,1,   HSP70/HSPA5↝,1,   IGF-1↓,2,   IGFBP3↑,1,   IGFR↓,1,   IL1β↓,4,   IL6↓,2,   Inflam↓,13,   iNOS↓,2,   iNOS↑,1,   Insulin↓,1,   Keap1↓,3,   LDHA↑,2,   LDL↓,1,   lipid-P↓,5,   mt-lipid-P↓,1,   MDA↓,4,   memory↑,7,   Mets↝,1,   miR-155↓,1,   miR-29b↑,1,   MMP↑,2,   MMP3↓,1,   MMP9↓,5,   motorD↑,1,   MPO↓,2,   mtDam↓,1,   NADH:NAD↑,1,   neuroP↑,17,   NF-kB↓,6,   NF-kB↑,1,   p‑NF-kB↓,1,   NLRP3↓,4,   NO↓,2,   NQO1↑,2,   Nrf1?,1,   NRF2↑,9,   OS↑,1,   other?,1,   other↑,2,   P21↑,1,   p38↑,1,   p62↓,1,   p65↓,1,   PDK1↓,1,   p‑PDK1↓,1,   PGC-1α↓,1,   PGC-1α↑,2,   PGE2↓,1,   PI3K↑,2,   PKA↑,1,   PKM2↑,2,   PP2A↑,4,   PPARγ↑,2,   PSD95↑,1,   PTEN↑,1,   radioP↑,1,   RenoP↑,2,   RNS↓,1,   ROS↓,19,   ROS↑,1,   SIRT1↑,18,   SIRT2↑,1,   SOD↑,6,   Sp1/3/4↓,3,   Sp1/3/4↑,1,   SREBP1↓,1,   tau↓,1,   p‑tau↓,6,   TLR4↓,1,   TNF-α↓,2,   toxicity↓,3,   toxicity↑,1,   toxicity∅,1,   VEGF↓,1,   VEGF↑,1,   Weight↑,1,  
Total Targets: 143

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:141  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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